{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T08:11:50Z","timestamp":1791619910598,"version":"4.3.4"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the National Health Commission of the People\u2019s Republic of China"},{"name":"the Heilongjiang Academy of Medical Sciences","award":["CR201801"],"award-info":[{"award-number":["CR201801"]}]},{"name":"the central government\uff0cChina"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-024-03079-4","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T08:33:38Z","timestamp":1736325218000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Interaction study of the effects of environmental exposure and gene polymorphisms of inflammatory and immune-active factors on chronic obstructive pulmonary disease"],"prefix":"10.1186","volume":"26","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaona","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuncheng","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenpeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianjun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"3079_CR1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arbr.2021.10.003","author":"M Calle Rubio","year":"2020","unstructured":"Calle Rubio M, Rodriguez Hermosa JL, Miravitlles M, Lopez-Campos JL. Knowledge of Chronic obstructive pulmonary disease, presence of chronic respiratory symptoms and use of spirometry among the Spanish population: CONOCEPOC 2019 study. Arch Bronconeumol. 2020. https:\/\/doi.org\/10.1016\/j.arbr.2021.10.003.","journal-title":"Arch Bronconeumol"},{"issue":"5","key":"3079_CR2","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/S2213-2600(22)00130-8","volume":"10","author":"NS Hopkinson","year":"2022","unstructured":"Hopkinson NS. COPD, smoking, and social justice. Lancet Respir Med. 2022;10(5):428\u201330.","journal-title":"Lancet Respir Med"},{"key":"3079_CR3","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.2147\/RMHP.S376546","volume":"15","author":"R Wang","year":"2022","unstructured":"Wang R, Zhang W, Li Y, et al. Evaluation of risk factors for chronic obstructive pulmonary disease in the middle-aged and elderly rural Population of Northeast China using logistic regression and principal component analysis. Risk Manag Healthc Policy. 2022;15:1717\u201326.","journal-title":"Risk Manag Healthc Policy"},{"key":"3079_CR4","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1183\/09031936.00096508","volume":"34","author":"BEU Gooptu","year":"2009","unstructured":"Gooptu BEU, Lomas DA. Mechanisms of emphysema in \u03b11-antitrypsin deficiency: molecular and cellular insights. Eur Respir J. 2009;34:475\u201388.","journal-title":"Eur Respir J"},{"key":"3079_CR5","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3389\/fgene.2020.00882","volume":"11","author":"A Ortega-Mart\u00ednez","year":"2020","unstructured":"Ortega-Mart\u00ednez A, P\u00e9rez-Rubio G, Ambrocio-Ortiz E, Nava-Quiroz KJ, Hern\u00e1ndez-Zenteno RJ, Abarca-Rojano E, Rodr\u00edguez-Llamazares S, Hern\u00e1ndez-P\u00e9rez A, Garc\u00eda-G\u00f3mez L, Ram\u00edrez-Venegas A, Falf\u00e1n-Valencia R. The SNP rs13147758 in the HHIP gene is associated with COPD susceptibility, serum, and sputum protein levels in smokers. Front Genet. 2020;11:882.","journal-title":"Front Genet"},{"key":"3079_CR6","doi-asserted-by":"publisher","first-page":"917","DOI":"10.2147\/COPD.S151153","volume":"13","author":"JX Li","year":"2018","unstructured":"Li JX, Fu WP, Zhang J, Zhang XH, Sun C, Dai LM, Zhong L, Yu L, Zhang YP. A functional SNP upstream of the ADRB2 gene is associated with COPD. Int J Chron Obstruct Pulmon Dis. 2018;13:917\u201325.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"8","key":"3079_CR7","doi-asserted-by":"publisher","first-page":"1839","DOI":"10.1113\/EP089523","volume":"106","author":"X Gao","year":"2021","unstructured":"Gao X, Wang X, Jiao N, Chen J, Sun D. Association of VEGFA polymorphisms with chronic obstructive pulmonary disease in Chinese Han and Mongolian populations. Exp Physiol. 2021;106(8):1839\u201348.","journal-title":"Exp Physiol"},{"issue":"21","key":"3079_CR8","doi-asserted-by":"publisher","first-page":"7822","DOI":"10.3390\/ijms21217822","volume":"21","author":"D Rozmus","year":"2020","unstructured":"Rozmus D, Ciesielska A, P\u0142omi\u0144ski J, Grzybowski R, Fiedorowicz E, Kordulewska N, Savelkoul H, Kostyra E, Cie\u015bli\u0144ska A. Vitamin D binding protein (VDBP) and its gene polymorphisms-the risk of malignant tumors and other diseases. Int J Mol Sci. 2020;21(21):7822.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"3079_CR9","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.3390\/diagnostics11081412","volume":"11","author":"I Hlap\u010di\u0107","year":"2021","unstructured":"Hlap\u010di\u0107 I, Grdi\u0107 Rajkovi\u0107 M, \u010ceri A, Dabeli\u0107 S, Popovi\u0107-Grle S, Radi\u0107 Antolic M, Kne\u017eevi\u0107 J, F\u00f6rsti A, Rumora L. Increased HSP70 and TLR2 gene expression and association of HSP70 rs6457452 single nucleotide polymorphism with the risk of chronic obstructive pulmonary disease in the Croatian population. Diagnostics. 2021;11(8):1412.","journal-title":"Diagnostics"},{"key":"3079_CR10","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.2147\/COPD.S321150","volume":"16","author":"Z Abudureheman","year":"2021","unstructured":"Abudureheman Z, Li L, Zhong X, Xu J, Gong H, Yilamujiang S, Ren J, Xie C, Zheng A, Tuerxun D, Abudukadeer A, Aini P, Xu A, Zou X. The rs74794265 SNP of the SREK1 Gene is associated with COPD in Kashi, China. Int J Chron Obstruct Pulmon Dis. 2021;16:2631\u20136.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"4","key":"3079_CR11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.arbres.2020.07.022","volume":"57","author":"R D\u00edaz-Pe\u00f1a","year":"2021","unstructured":"D\u00edaz-Pe\u00f1a R, Silva RS, Hosgood HD 3rd, Jaime S, Miravitlles M, Olloquequi J. HLA-DRB1 alleles are associated with COPD in a Latin American admixed population. Arch Bronconeumol. 2021;57(4):291\u20137.","journal-title":"Arch Bronconeumol"},{"issue":"12","key":"3079_CR12","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1016\/j.jacc.2007.06.012","volume":"50","author":"FG Hage","year":"2007","unstructured":"Hage FG, Szalai AJ. C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk. J Am Coll Cardiol. 2007;50(12):1115\u201322.","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"3079_CR13","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1086\/431366","volume":"77","author":"CS Carlson","year":"2005","unstructured":"Carlson CS, Aldred SF, Lee PK, et al. Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Am J Hum Genet. 2005;77(1):64\u201377.","journal-title":"Am J Hum Genet"},{"key":"3079_CR14","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1084\/jem.172.6.1665","volume":"172","author":"CR Maliszewski","year":"1990","unstructured":"Maliszewski CR, March CJ, Schoenborn MA, Gimpel S, Shen L. Expression cloning of a human Fc receptor for IgA. J Exp Med. 1990;172:1665\u201372. https:\/\/doi.org\/10.1084\/jem.172.6.1665.","journal-title":"J Exp Med"},{"issue":"5","key":"3079_CR15","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1038\/gene.2009.35","volume":"10","author":"X Li","year":"2009","unstructured":"Li X, Ptacek TS, Brown EE, Edberg JC. Fcgamma receptors: structure, function and role as genetic risk factors in SLE. Genes Immun. 2009;10(5):380\u20139.","journal-title":"Genes Immun"},{"issue":"12","key":"3079_CR16","doi-asserted-by":"publisher","first-page":"4974","DOI":"10.1073\/pnas.1018369108","volume":"108","author":"J Lu","year":"2011","unstructured":"Lu J, Marjon KD, Marnell LL, et al. Recognition and functional activation of the human IgA receptor (FcalphaRI) by C-reactive protein. Proc Natl Acad Sci U S A. 2011;108(12):4974\u20139.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"3079_CR17","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1038\/hr.2012.89","volume":"35","author":"H Kong","year":"2012","unstructured":"Kong H, Qian YS, Tang XF, et al. C-reactive protein (CRP) gene polymorphisms, CRP levels and risk of incident essential hypertension: findings from an observational cohort of Han Chinese. Hypertens Res. 2012;35(10):1019\u201323.","journal-title":"Hypertens Res"},{"issue":"6","key":"3079_CR18","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.1016\/j.clnu.2019.08.016","volume":"39","author":"AB Arouca","year":"2020","unstructured":"Arouca AB, Meirhaeghe A, Dallongeville J, et al. Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents. Clin Nutr. 2020;39(6):1919\u201326.","journal-title":"Clin Nutr"},{"issue":"8","key":"3079_CR19","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1042\/CS20100504","volume":"120","author":"CE Bolton","year":"2011","unstructured":"Bolton CE, Schumacher W, Cockcroft JR, et al. The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study. Clin Sci. 2011;120(8):347\u201355.","journal-title":"Clin Sci"},{"key":"3079_CR20","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1755-8794-5-64","volume":"5","author":"Y Guo","year":"2012","unstructured":"Guo Y, Gong Y, Pan C, et al. Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study. BMC Med Genom. 2012;5:64.","journal-title":"BMC Med Genom"},{"issue":"4","key":"3079_CR21","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1111\/ane.12180","volume":"129","author":"J Guo","year":"2014","unstructured":"Guo J, Yu L, Zhang J, Chen N, et al. CRP gene polymorphism predicts post-stroke functional outcome in Han Chinese. Acta Neurol Scand. 2014;129(4):263\u20138.","journal-title":"Acta Neurol Scand"},{"issue":"5","key":"3079_CR22","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1002\/ijc.29086","volume":"136","author":"K Nimptsch","year":"2015","unstructured":"Nimptsch K, Aleksandrova K, Boeing H, et al. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk. Int J Cancer. 2015;136(5):1181\u201392.","journal-title":"Int J Cancer"},{"issue":"6","key":"3079_CR23","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.4049\/jimmunol.178.6.3973","volume":"178","author":"J Wu","year":"2007","unstructured":"Wu J, Ji C, Xie F, et al. FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. J Immunol. 2007;178(6):3973\u201382.","journal-title":"J Immunol"},{"key":"3079_CR24","doi-asserted-by":"publisher","first-page":"4828","DOI":"10.4049\/jimmunol.174.8.4828","volume":"174","author":"YT Huang","year":"2005","unstructured":"Huang YT, Wright A, et al. Intraepithelial cell neutralization of HIV-1 replication by IgA. J Immunol. 2005;174:4828\u201335.","journal-title":"J Immunol"},{"key":"3079_CR25","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/ng.81","volume":"40","author":"JB Harley","year":"2008","unstructured":"Harley JB, Alarcon-Riquelme ME, Criswell LA, et al. Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet. 2008;40:204\u201310.","journal-title":"Nat Genet"},{"key":"3079_CR26","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1093\/hmg\/ddm194","volume":"16","author":"BZ Alizadeh","year":"2007","unstructured":"Alizadeh BZ, Valdigem G, Coenen MJ, et al. Association analysis of functional variants of the FcgRIIa and FcgRIIIa genes with type 1 diabetes, celiac disease and rheumatoid arthritis. Hum Mol Genet. 2007;16:2552\u20139.","journal-title":"Hum Mol Genet"},{"key":"3079_CR27","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/nri856","volume":"2","author":"T Takai","year":"2002","unstructured":"Takai T. Roles of Fc receptors in autoimmunity. Nat Rev Immunol. 2002;2:580\u201392.","journal-title":"Nat Rev Immunol"},{"key":"3079_CR28","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1038\/ng.549","volume":"42","author":"DP McGovern","year":"2010","unstructured":"McGovern DP, Gardet A, T\u00f6rkvist L, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet. 2010;42:332\u20137.","journal-title":"Nat Genet"},{"key":"3079_CR29","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1038\/ng.482","volume":"41","author":"K Asano","year":"2009","unstructured":"Asano K, Matsushita T, Umeno J, et al. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet. 2009;41:1325\u20139.","journal-title":"Nat Genet"},{"issue":"10","key":"3079_CR30","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1089\/gtmb.2018.0042","volume":"22","author":"SL Xia","year":"2018","unstructured":"Xia SL, Lin DP, Lin QR, et al. A case-control study on association of ulcerative colitis with FCGR2A gene polymorphisms in Chinese patients. Genet Test Mol Biomarkers. 2018;22(10):607\u201314.","journal-title":"Genet Test Mol Biomarkers"},{"issue":"10","key":"3079_CR31","doi-asserted-by":"publisher","first-page":"17239","DOI":"10.18632\/oncotarget.12738","volume":"8","author":"S Chen","year":"2017","unstructured":"Chen S, Wen X, Li J, et al. Association of FCGR2A\/FCGR3A variant rs2099684 with Takayasu arteritis in the Han Chinese population. Oncotarget. 2017;8(10):17239\u201345.","journal-title":"Oncotarget"},{"key":"3079_CR32","doi-asserted-by":"publisher","first-page":"R109","DOI":"10.1186\/ar1996","volume":"8","author":"AW Morgan","year":"2006","unstructured":"Morgan AW, Robinson JI, Barrett JH, et al. Association of FCGR2A and FCGR2A-FCGR3A haplotypes with susceptibility to giant cell arteritis. Arthritis Res Ther. 2006;8:R109.","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"3079_CR33","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1002\/ijc.29086","volume":"136","author":"KAK Nimptsch","year":"2015","unstructured":"Nimptsch KAK, Boeing H, Janke J, et al. Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk. Int J Cancer. 2015;136(5):1181\u201392.","journal-title":"Int J Cancer"},{"key":"3079_CR34","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.cyto.2016.09.007","volume":"88","author":"PFPL Todendi","year":"2016","unstructured":"Todendi PFPL, Klinger EI, Reuter CP, et al. Low-grade inflammation markers in children and adolescents: influence of anthropometric characteristics and CRP and IL6 polymorphisms. Cytokine. 2016;88:177\u201383.","journal-title":"Cytokine"},{"issue":"01","key":"3079_CR35","first-page":"19","volume":"16","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Tian Y, Dong J, Li LQ, Deng XX. Studies of CRP levels and CRP gene polymorphism rs1205 in type 2 diabetes mellitus patients. Label Immunoass Clin Med. 2009;16(01):19\u201322.","journal-title":"Label Immunoass Clin Med"},{"issue":"5","key":"3079_CR36","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1093\/rheumatology\/kev433","volume":"55","author":"MWNS Tsang-A-Sjoe","year":"2016","unstructured":"Tsang-A-Sjoe MWNS, Bultink IE, Geissler J, et al. Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis. Rheumatology. 2016;55(5):939\u201348.","journal-title":"Rheumatology"},{"issue":"5","key":"3079_CR37","doi-asserted-by":"publisher","first-page":"3272","DOI":"10.4049\/jimmunol.178.5.3272","volume":"178","author":"KYH Su","year":"2007","unstructured":"Su KYH, Li X, Li X, et al. Expression profile of FcgammaRIIb on leukocytes and its dysregulation in systemic lupus erythematosus. J Immunol. 2007;178(5):3272\u201380.","journal-title":"J Immunol"},{"issue":"3","key":"3079_CR38","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.4049\/jimmunol.1003945","volume":"188","author":"JBW Van der Heijden","year":"2012","unstructured":"Van der Heijden JBW, Geissler J, de Boer M, et al. Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles. J Immunol. 2012;188(3):1318\u201324.","journal-title":"J Immunol"},{"issue":"1","key":"3079_CR39","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1186\/s12879-017-2390-0","volume":"17","author":"EOOW Munde","year":"2017","unstructured":"Munde EOOW, Raballah E, Anyona SB, et al. Association between Fc\u03b3 receptor IIA, IIIA and IIIB genetic polymorphisms and susceptibility to severe malaria anemia in children in western Kenya. BMC Infect Dis. 2017;17(1):289.","journal-title":"BMC Infect Dis"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-03079-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-024-03079-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-024-03079-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T21:29:20Z","timestamp":1736371760000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-024-03079-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3079"],"URL":"https:\/\/doi.org\/10.1186\/s12931-024-03079-4","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"9 August 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was conducted according to the guidelines of the Declaration of Helsinki and was approved in June 2018 by Harbin Medical University (research project: hrbmuecdc20180601). All participants provided informed consent prior to starting the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"5"}}