{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:23:45Z","timestamp":1793643825947,"version":"4.5.1"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Shenzhen Science Technology and Innovative Commission","award":["JCYJ20220530152800001"],"award-info":[{"award-number":["JCYJ20220530152800001"]}]},{"name":"Shenzhen Science Technology and Innovative Commission","award":["JCYJ20210324114400002"],"award-info":[{"award-number":["JCYJ20210324114400002"]}]},{"name":"Shenzhen Science Technology and Innovative Commission","award":["KCXFZ202002011008256"],"award-info":[{"award-number":["KCXFZ202002011008256"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32100734"],"award-info":[{"award-number":["32100734"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["32100914"],"award-info":[{"award-number":["32100914"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82170042"],"award-info":[{"award-number":["82170042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Natural Science Foundation of Guangdong province, China","award":["2021A1515010478"],"award-info":[{"award-number":["2021A1515010478"]}]},{"name":"Natural Science Foundation of Guangdong province, China","award":["2214050008970"],"award-info":[{"award-number":["2214050008970"]}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2022YFF0710800"],"award-info":[{"award-number":["2022YFF0710800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-025-03120-0","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:36:36Z","timestamp":1738337796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Targeting BRD4 ameliorates experimental emphysema by disrupting super-enhancer in polarized alveolar macrophage"],"prefix":"10.1186","volume":"26","author":[{"given":"Difei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqiong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanxi","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danna","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haizhao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongchang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanze","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,31]]},"reference":[{"key":"3120_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.00239-2023","volume":"61","author":"A Agusti","year":"2023","unstructured":"Agusti A, Celli BR, Criner GJ, Halpin D, Anzueto A, Barnes P, Bourbeau J, Han MK, Martinez FJ, de Oca MM, et al. Global initiative for chronic obstructive lung disease 2023 report: GOLD executive summary. Eur Respir J. 2023;61:1.","journal-title":"Eur Respir J"},{"key":"3120_CR2","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/nri2254","volume":"8","author":"PJ Barnes","year":"2008","unstructured":"Barnes PJ. Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 2008;8:183\u201392.","journal-title":"Nat Rev Immunol"},{"key":"3120_CR3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.imbio.2017.11.001","volume":"223","author":"S Arora","year":"2018","unstructured":"Arora S, Dev K, Agarwal B, Das P, Syed MA. Macrophages: their role, activation and polarization in pulmonary diseases. Immunobiology. 2018;223:383\u201396.","journal-title":"Immunobiology"},{"key":"3120_CR4","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nature12034","volume":"496","author":"TA Wynn","year":"2013","unstructured":"Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013;496:445\u201355.","journal-title":"Nature"},{"key":"3120_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1172\/JCI88876","volume":"127","author":"T McLaughlin","year":"2017","unstructured":"McLaughlin T, Ackerman SE, Shen L, Engleman E. Role of innate and adaptive immunity in obesity-associated metabolic disease. J Clin Invest. 2017;127:5\u201313.","journal-title":"J Clin Invest"},{"key":"3120_CR6","doi-asserted-by":"publisher","first-page":"292","DOI":"10.14348\/molcells.2021.0058","volume":"44","author":"YD Woo","year":"2021","unstructured":"Woo YD, Jeong D, Chung DH. Development and functions of alveolar macrophages. Mol Cells. 2021;44:292\u2013300.","journal-title":"Mol Cells"},{"key":"3120_CR7","doi-asserted-by":"publisher","first-page":"106469","DOI":"10.1016\/j.phrs.2022.106469","volume":"184","author":"D Mei","year":"2022","unstructured":"Mei D, Liao W, Gan P, Tran Q, Chan C, Heng C, Wong WJ. Angiotensin II type-2 receptor activation in alveolar macrophages mediates protection against cigarette smoke-induced chronic obstructive pulmonary disease. Pharmacol Res. 2022;184:106469.","journal-title":"Pharmacol Res"},{"key":"3120_CR8","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3389\/fimmu.2014.00435","volume":"5","author":"R Vlahos","year":"2014","unstructured":"Vlahos R, Bozinovski S. Role of alveolar macrophages in chronic obstructive pulmonary disease. Front Immunol. 2014;5:435.","journal-title":"Front Immunol"},{"key":"3120_CR9","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/s41467-021-27860-x","volume":"13","author":"B Spix","year":"2022","unstructured":"Spix B, Butz ES, Chen C-C, Rosato AS, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, et al. Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice. Nat Commun. 2022;13:318.","journal-title":"Nat Commun"},{"key":"3120_CR10","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1165\/rcmb.2013-0407OC","volume":"51","author":"JB Trojanek","year":"2014","unstructured":"Trojanek JB, Cobos-Correa A, Diemer S, Kormann M, Schubert SC, Zhou-Suckow Z, Agrawal R, Duerr J, Wagner CJ, Schatterny J, et al. Airway mucus obstruction triggers macrophage activation and matrix metalloproteinase 12-dependent emphysema. Am J Respir Cell Mol Biol. 2014;51:709\u201320.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3120_CR11","doi-asserted-by":"publisher","first-page":"24922","DOI":"10.1074\/jbc.M116.756791","volume":"291","author":"KJ Warren","year":"2016","unstructured":"Warren KJ, Fang X, Gowda NM, Thompson JJ, Heller NM. The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Receptor Substrate-2. J Biol Chem. 2016;291:24922\u201330.","journal-title":"J Biol Chem"},{"key":"3120_CR12","doi-asserted-by":"publisher","first-page":"897","DOI":"10.3390\/cells10040897","volume":"10","author":"JW Lee","year":"2021","unstructured":"Lee JW, Chun W, Lee HJ, Min JH, Kim SM, Seo JY, Ahn KS, Oh SR. The role of macrophages in the development of acute and chronic inflammatory lung diseases. Cells. 2021;10:897.","journal-title":"Cells"},{"key":"3120_CR13","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/s41564-022-01196-8","volume":"7","author":"Z Yan","year":"2022","unstructured":"Yan Z, Chen B, Yang Y, Yi X, Wei M, Ecklu-Mensah G, Buschmann MM, Liu H, Gao J, Liang W, et al. Multi-omics analyses of airway host-microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions. Nat Microbiol. 2022;7:1361\u201375.","journal-title":"Nat Microbiol"},{"key":"3120_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.03406-2020","volume":"57","author":"G Benincasa","year":"2021","unstructured":"Benincasa G, DeMeo DL, Glass K, Silverman EK, Napoli C. Epigenetics and pulmonary diseases in the horizon of precision medicine: a review. Eur Respir J. 2021;57:1.","journal-title":"Eur Respir J"},{"key":"3120_CR15","doi-asserted-by":"publisher","first-page":"2217","DOI":"10.1038\/s41467-017-02403-5","volume":"8","author":"JE Lee","year":"2017","unstructured":"Lee JE, Park YK, Park S, Jang Y, Waring N, Dey A, Ozato K, Lai B, Peng W, Ge K. Brd4 binds to active enhancers to control cell identity gene induction in adipogenesis and myogenesis. Nat Commun. 2017;8:2217.","journal-title":"Nat Commun"},{"key":"3120_CR16","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1038\/s41467-020-17205-5","volume":"11","author":"J Wilflingseder","year":"2020","unstructured":"Wilflingseder J, Willi M, Lee HK, Olauson H, Jankowski J, Ichimura T, Erben R, Valerius MT, Hennighausen L, Bonventre JV. Enhancer and super-enhancer dynamics in repair after ischemic acute kidney injury. Nat Commun. 2020;11:3383.","journal-title":"Nat Commun"},{"key":"3120_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.837977","volume":"13","author":"T Hua","year":"2022","unstructured":"Hua T, Wang H, Fan X, An N, Li J, Song H, Kong E, Li Y, Yuan H. BRD4 inhibition attenuates inflammatory pain by ameliorating NLRP3 inflammasome-induced pyroptosis. Front Immunol. 2022;13: 837977.","journal-title":"Front Immunol"},{"key":"3120_CR18","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1161\/CIRCRESAHA.119.315125","volume":"125","author":"MS Stratton","year":"2019","unstructured":"Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, et al. Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation. Circ Res. 2019;125:662\u201377.","journal-title":"Circ Res"},{"key":"3120_CR19","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1136\/thoraxjnl-2020-215092","volume":"76","author":"R Zakarya","year":"2021","unstructured":"Zakarya R, Chan YL, Rutting S, Reddy K, Bozier J, Woldhuis RR, Xenaki D, Van Ly D, Chen H, Brandsma CA, et al. BET proteins are associated with the induction of small airway fibrosis in COPD. Thorax. 2021;76:647\u201355.","journal-title":"Thorax"},{"key":"3120_CR20","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1038\/s41419-019-1564-7","volume":"10","author":"S Sui","year":"2019","unstructured":"Sui S, Zhang J, Xu S, Wang Q, Wang P, Pang D. Ferritinophagy is required for the induction of ferroptosis by the bromodomain protein BRD4 inhibitor (+)-JQ1 in cancer cells. Cell Death Dis. 2019;10:331.","journal-title":"Cell Death Dis"},{"key":"3120_CR21","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1186\/s12964-023-01319-6","volume":"21","author":"SL Kim","year":"2023","unstructured":"Kim SL, Choi HS, Lee DS. BRD4\/nuclear PD-L1\/RelB circuit is involved in the stemness of breast cancer cells. Cell Commun Signal. 2023;21:315.","journal-title":"Cell Commun Signal"},{"key":"3120_CR22","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1038\/s41467-019-09257-z","volume":"10","author":"Y Chen","year":"2019","unstructured":"Chen Y, Xu L, Mayakonda A, Huang ML, Kanojia D, Tan TZ, Dakle P, Lin RY, Ke XY, Said JW, et al. Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma. Nat Commun. 2019;10:1353.","journal-title":"Nat Commun"},{"key":"3120_CR23","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.jcmgh.2023.10.001","volume":"17","author":"N Modi","year":"2023","unstructured":"Modi N, Chen Y, Dong X, Hu X, Lau GW, Wilson KT, Peek RM Jr, Chen LF. BRD4 regulates glycolysis-dependent Nos2 expression in macrophages upon H pylori infection. Cell Mol Gastroenterol Hepatol. 2023;17:292\u2013308.","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"3120_CR24","doi-asserted-by":"publisher","first-page":"6020","DOI":"10.1093\/nar\/gkad300","volume":"51","author":"Y Li","year":"2023","unstructured":"Li Y, Yi Y, Lv J, Gao X, Yu Y, Babu SS, Bruno I, Zhao D, Xia B, Peng W, et al. Low RNA stability signifies increased post-transcriptional regulation of cell identity genes. Nucleic Acids Res. 2023;51:6020\u201338.","journal-title":"Nucleic Acids Res"},{"key":"3120_CR25","doi-asserted-by":"publisher","first-page":"2658","DOI":"10.1016\/j.apsb.2022.02.009","volume":"12","author":"T Yang","year":"2022","unstructured":"Yang T, Hu Y, Miao J, Chen J, Liu J, Cheng Y, Gao X. A BRD4 PROTAC nanodrug for glioma therapy via the intervention of tumor cells proliferation, apoptosis and M2 macrophages polarization. Acta Pharm Sin B. 2022;12:2658\u201371.","journal-title":"Acta Pharm Sin B"},{"key":"3120_CR26","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1164\/rccm.201504-0779OC","volume":"193","author":"K Yadava","year":"2016","unstructured":"Yadava K, Pattaroni C, Sichelstiel AK, Trompette A, Gollwitzer ES, Salami O, von Garnier C, Nicod LP, Marsland BJ. Microbiota promotes chronic pulmonary inflammation by enhancing IL-17A and autoantibodies. Am J Respir Crit Care Med. 2016;193:975\u201387.","journal-title":"Am J Respir Crit Care Med"},{"key":"3120_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1183\/13993003.01510-2018","volume":"53","author":"R Chen","year":"2019","unstructured":"Chen R, Zhang Q, Chen S, Tang H, Huang P, Wei S, Liang Z, Chen X, Tao A, Yao L. IL-17F, rather than IL-17A, underlies airway inflammation in a steroid-insensitive toluene diisocyanate-induced asthma model. Eur Respir J. 2019;53:1.","journal-title":"Eur Respir J"},{"key":"3120_CR28","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B. Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics. 2014;30:2114\u201320.","journal-title":"Bioinformatics"},{"key":"3120_CR29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL. Fast gapped-read alignment with Bowtie 2. Nat Methods. 2012;9:357\u20139.","journal-title":"Nat Methods"},{"key":"3120_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1038\/nmeth.4197","volume":"14","author":"R Patro","year":"2017","unstructured":"Patro R, Duggal G, Love MI, Irizarry RA, Kingsford C. Salmon provides fast and bias-aware quantification of transcript expression. Nat Methods. 2017;14:417\u20139.","journal-title":"Nat Methods"},{"key":"3120_CR31","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","volume":"26","author":"MD Robinson","year":"2010","unstructured":"Robinson MD, McCarthy DJ, Smyth GK. edgeR: a Bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26:139\u201340.","journal-title":"Bioinformatics"},{"key":"3120_CR32","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS. 2012;16:284\u20137.","journal-title":"OMICS"},{"key":"3120_CR33","doi-asserted-by":"publisher","first-page":"btac757","DOI":"10.1093\/bioinformatics\/btac757","volume":"39","author":"Z Fang","year":"2023","unstructured":"Fang Z, Liu X, Peltz G. GSEApy: a comprehensive package for performing gene set enrichment analysis in Python. Bioinformatics. 2023;39:btac757.","journal-title":"Bioinformatics"},{"key":"3120_CR34","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13072-019-0287-4","volume":"12","author":"MP Meers","year":"2019","unstructured":"Meers MP, Tenenbaum D, Henikoff S. Peak calling by sparse enrichment analysis for CUT&RUN chromatin profiling. Epigenetics Chromatin. 2019;12:42.","journal-title":"Epigenetics Chromatin"},{"key":"3120_CR35","unstructured":"\u2217 RS, \u2020 GB: DiffBind: Differential binding analysis of ChIP-Seq peak data."},{"key":"3120_CR36","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.585","volume":"2","author":"Q Wang","year":"2022","unstructured":"Wang Q, Li M, Wu T, Zhan L, Li L, Chen M, Xie W, Xie Z, Hu E, Xu S, Yu G. Exploring epigenomic datasets by ChIPseeker. Curr Protoc. 2022;2: e585.","journal-title":"Curr Protoc"},{"key":"3120_CR37","doi-asserted-by":"publisher","first-page":"W160","DOI":"10.1093\/nar\/gkw257","volume":"44","author":"F Ramirez","year":"2016","unstructured":"Ramirez F, Ryan DP, Gruning B, Bhardwaj V, Kilpert F, Richter AS, Heyne S, Dundar F, Manke T. deepTools2: a next generation web server for deep-sequencing data analysis. Nucleic Acids Res. 2016;44:W160-165.","journal-title":"Nucleic Acids Res"},{"key":"3120_CR38","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12864-018-4625-x","volume":"19","author":"Z Gu","year":"2018","unstructured":"Gu Z, Eils R, Schlesner M, Ishaque N. EnrichedHeatmap: an R\/Bioconductor package for comprehensive visualization of genomic signal associations. BMC Genomics. 2018;19:234.","journal-title":"BMC Genomics"},{"key":"3120_CR39","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1186\/1471-2164-15-284","volume":"15","author":"L Shen","year":"2014","unstructured":"Shen L, Shao N, Liu X, Nestler E. ngs.plot: quick mining and visualization of next-generation sequencing data by integrating genomic databases. BMC Genomics. 2014;15:284.","journal-title":"BMC Genomics"},{"key":"3120_CR40","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM. BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics. 2010;26:841\u20132.","journal-title":"Bioinformatics"},{"key":"3120_CR41","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.cell.2013.03.036","volume":"153","author":"J Loven","year":"2013","unstructured":"Loven J, Hoke HA, Lin CY, Lau A, Orlando DA, Vakoc CR, Bradner JE, Lee TI, Young RA. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell. 2013;153:320\u201334.","journal-title":"Cell"},{"key":"3120_CR42","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1093\/bib\/bbs017","volume":"14","author":"H Thorvaldsdottir","year":"2013","unstructured":"Thorvaldsdottir H, Robinson JT, Mesirov JP. Integrative genomics viewer (IGV): high-performance genomics data visualization and exploration. Brief Bioinform. 2013;14:178\u201392.","journal-title":"Brief Bioinform"},{"key":"3120_CR43","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2018100293","volume":"38","author":"A Dey","year":"2019","unstructured":"Dey A, Yang W, Gegonne A, Nishiyama A, Pan R, Yagi R, Grinberg A, Finkelman FD, Pfeifer K, Zhu J, et al. BRD4 directs hematopoietic stem cell development and modulates macrophage inflammatory responses. EMBO J. 2019;38: e100293.","journal-title":"EMBO J"},{"key":"3120_CR44","doi-asserted-by":"publisher","first-page":"13392","DOI":"10.1038\/s41598-017-13888-x","volume":"7","author":"MS Eapen","year":"2017","unstructured":"Eapen MS, Hansbro PM, McAlinden K, Kim RY, Ward C, Hackett TL, Walters EH, Sohal SS. Abnormal M1\/M2 macrophage phenotype profiles in the small airway wall and lumen in smokers and chronic obstructive pulmonary disease (COPD). Sci Rep. 2017;7:13392.","journal-title":"Sci Rep"},{"issue":"Suppl","key":"3120_CR45","doi-asserted-by":"publisher","first-page":"S180","DOI":"10.1513\/AnnalsATS.201305-123AW","volume":"10","author":"PS Hiemstra","year":"2013","unstructured":"Hiemstra PS. Altered macrophage function in chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2013;10(Suppl):S180-185.","journal-title":"Ann Am Thorac Soc"},{"key":"3120_CR46","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.7150\/ijbs.46153","volume":"16","author":"K Hao","year":"2020","unstructured":"Hao K, Jiang W, Zhou M, Li H, Chen Y, Jiang F, Hu Q. Targeting BRD4 prevents acute gouty arthritis by regulating pyroptosis. Int J Biol Sci. 2020;16:3163\u201373.","journal-title":"Int J Biol Sci"},{"key":"3120_CR47","doi-asserted-by":"publisher","first-page":"E3993","DOI":"10.1073\/pnas.1700109114","volume":"114","author":"Y Bao","year":"2017","unstructured":"Bao Y, Wu X, Chen J, Hu X, Zeng F, Cheng J, Jin H, Lin X, Chen LJ. Brd4 modulates the innate immune response through Mnk2-eIF4E pathway-dependent translational control of I\u03baB\u03b1. Proc Natl Acad Sci. 2017;114:E3993\u20134001.","journal-title":"Proc Natl Acad Sci"},{"key":"3120_CR48","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1080\/15592294.2015.1034416","volume":"10","author":"D Sengupta","year":"2015","unstructured":"Sengupta D, Kannan A, Kern M, Moreno MA, Vural E, Stack B Jr, Suen JY, Tackett AJ, Gao L. Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma. Epigenetics. 2015;10:460\u20136.","journal-title":"Epigenetics"},{"key":"3120_CR49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009343","volume":"17","author":"S Das","year":"2021","unstructured":"Das S, Mukherjee S, Ali N. Super enhancer-mediated transcription of miR146a-5p drives M2 polarization during Leishmania donovani infection. PLoS Pathog. 2021;17: e1009343.","journal-title":"PLoS Pathog"},{"key":"3120_CR50","doi-asserted-by":"publisher","first-page":"13057","DOI":"10.1073\/pnas.1813927115","volume":"115","author":"S Shibata","year":"2018","unstructured":"Shibata S, Miyake K, Tateishi T, Yoshikawa S, Yamanishi Y, Miyazaki Y, Inase N, Karasuyama H. Basophils trigger emphysema development in a murine model of COPD through IL-4-mediated generation of MMP-12-producing macrophages. Proc Natl Acad Sci U S A. 2018;115:13057\u201362.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3120_CR51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s12931-023-02348-y","volume":"24","author":"Y Duan","year":"2023","unstructured":"Duan Y, Zhou S, Wang J. BRD4 is involved in viral exacerbation of chronic obstructive pulmonary disease. Respir Res. 2023;24:37.","journal-title":"Respir Res"},{"key":"3120_CR52","doi-asserted-by":"publisher","first-page":"L621","DOI":"10.1152\/ajplung.00436.2018","volume":"316","author":"K Tang","year":"2019","unstructured":"Tang K, Zhao J, Xie J, Wang J. Decreased miR-29b expression is associated with airway inflammation in chronic obstructive pulmonary disease. Am J Physiol Lung Cell Mol Physiol. 2019;316:L621\u20139.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3120_CR53","first-page":"101","volume":"36","author":"Y Liu","year":"2021","unstructured":"Liu Y, Huang ZZ, Min L, Li ZF, Chen K. The BRD4 inhibitor JQ1 protects against chronic obstructive pulmonary disease in mice by suppressing NF-kappaB activation. Histol Histopathol. 2021;36:101\u201312.","journal-title":"Histol Histopathol"},{"key":"3120_CR54","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1038\/nature09504","volume":"468","author":"P Filippakopoulos","year":"2010","unstructured":"Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, et al. Selective inhibition of BET bromodomains. Nature. 2010;468:1067\u201373.","journal-title":"Nature"},{"key":"3120_CR55","doi-asserted-by":"publisher","first-page":"3670","DOI":"10.4049\/jimmunol.1202838","volume":"190","author":"AC Belkina","year":"2013","unstructured":"Belkina AC, Nikolajczyk BS, Denis GV. BET protein function is required for inflammation: Brd2 genetic disruption and BET inhibitor JQ1 impair mouse macrophage inflammatory responses. J Immunol. 2013;190:3670\u20138.","journal-title":"J Immunol"},{"key":"3120_CR56","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.chembiol.2015.05.009","volume":"22","author":"J Lu","year":"2015","unstructured":"Lu J, Qian Y, Altieri M, Dong H, Wang J, Raina K, Hines J, Winkler JD, Crew AP, Coleman K, Crews CM. Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4. Chem Biol. 2015;22:755\u201363.","journal-title":"Chem Biol"},{"key":"3120_CR57","doi-asserted-by":"publisher","first-page":"11428","DOI":"10.7150\/thno.47432","volume":"10","author":"G Deng","year":"2020","unstructured":"Deng G, Zeng F, Su J, Zhao S, Hu R, Zhu W, Hu S, Chen X, Yin M. BET inhibitor suppresses melanoma progression via the noncanonical NF-kappaB\/SPP1 pathway. Theranostics. 2020;10:11428\u201343.","journal-title":"Theranostics"},{"key":"3120_CR58","doi-asserted-by":"crossref","unstructured":"Xu L, Jiao J, Liu M, Qin Y, Zhang M, Yan D, Xu K, Sang W. A combination of CPI-0610 and SAHA induces apoptosis through STAT3 and p38 signalling pathways in diffuse large B-cell lymphoma cells. Curr Med Chem. 2023.","DOI":"10.2174\/0109298673244868231017043517"},{"key":"3120_CR59","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.cell.2013.03.035","volume":"153","author":"WA Whyte","year":"2013","unstructured":"Whyte WA, Orlando DA, Hnisz D, Abraham BJ, Lin CY, Kagey MH, Rahl PB, Lee TI, Young RA. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell. 2013;153:307\u201319.","journal-title":"Cell"},{"key":"3120_CR60","doi-asserted-by":"publisher","first-page":"Inad019","DOI":"10.1093\/lifemedi\/lnad019","volume":"2","author":"ME Carelock","year":"2023","unstructured":"Carelock ME, Master RP, Kim M-C, Jin Z, Wang L, Maharjan CK, Hua N, De U, Kolb R, Xiao Y. Targeting intracellular proteins with cell type-specific functions for cancer immunotherapy. Life Med. 2023;2:Inad019.","journal-title":"Life Med"},{"key":"3120_CR61","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3390\/pharmaceutics13071005","volume":"13","author":"Y Fu","year":"2021","unstructured":"Fu Y, Saraswat A, Wei Z, Agrawal MY, Dukhande VV, Reznik SE, Patel K. Development of Dual ARV-825 and Nintedanib-Loaded PEGylated Nano-Liposomes for Synergistic Efficacy in Vemurafnib-Resistant Melanoma. Pharmaceutics. 2021;13:1005.","journal-title":"Pharmaceutics"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03120-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-025-03120-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03120-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T15:36:47Z","timestamp":1738337807000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-025-03120-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,31]]},"references-count":61,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3120"],"URL":"https:\/\/doi.org\/10.1186\/s12931-025-03120-0","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,31]]},"assertion":[{"value":"1 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Cohort study was approved by the Medical Ethics Committee of First Affiliated Hospital of Guangzhou Medical University and the Medical Ethics Committee of Shenzhen People\u2019s Hospital (reference No. 2017-22 and KY-LL-2020294-01) []. Written informed consent was obtained from all participants. All animal experiments conducted in this study were approved by the Animal Care and Use Committee of Shenzhen People\u2019s Hospital (AUP-220714-CRC-0599-01).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not Applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"46"}}