{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:36:31Z","timestamp":1790962591730,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T00:00:00Z","timestamp":1741737600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"Applied research project unit of geriatric medicine clinical technology in Jiangsu Province","award":["LD2022001"],"award-info":[{"award-number":["LD2022001"]}]},{"name":"Jiangsu Province Elderly Health Scientific Research Project","award":["LKM2024021"],"award-info":[{"award-number":["LKM2024021"]}]},{"name":"The Major Natural Science Research Projects in Colleges and Universities of Jiangsu Province","award":["No. 22KJA320003"],"award-info":[{"award-number":["No. 22KJA320003"]}]},{"name":"Jiangsu Province Capability Improvement Project through Science, Technology and Education","award":["No. CXZX202228"],"award-info":[{"award-number":["No. CXZX202228"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82471605, 82171576"],"award-info":[{"award-number":["82471605, 82171576"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-025-03170-4","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:30:35Z","timestamp":1741793435000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["YAP\/TAZ-mediated nuclear membrane rupture in promoting senescence of skeletal muscle associated with COPD"],"prefix":"10.1186","volume":"26","author":[{"given":"Ge","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuping","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoran","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianping","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,3,12]]},"reference":[{"key":"3170_CR1","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1016\/S2213-2600(21)00555-5","volume":"10","author":"A Agust\u00ed","year":"2022","unstructured":"Agust\u00ed A, Mel\u00e9n E, DeMeo D, Breyer-Kohansal R, Faner R. Pathogenesis of chronic obstructive pulmonary disease: Understanding the contributions of gene-environment interactions across the lifespan. Lancet Respiratory Med. 2022;10:512\u201324.","journal-title":"Lancet Respiratory Med"},{"key":"3170_CR2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S2213-2600(23)00461-7","volume":"12","author":"P Venkatesan","year":"2024","unstructured":"Venkatesan P. GOLD COPD report: 2024 update. Lancet Respiratory Med. 2024;12:15\u20136.","journal-title":"Lancet Respiratory Med"},{"key":"3170_CR3","unstructured":"Liang-Kung C, Jean W, Prasert A, Tung-Wai A, Ming-Yueh C, Katsuya I, Hak Chul J, Lin K, Miji K, Sunyoung K et al. Asian working group for sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment. J Am Med Dir Assoc, 21."},{"key":"3170_CR4","doi-asserted-by":"crossref","unstructured":"Leonardo MF, Bartolome RC, Alvar A, Gerard JC, Mark TD, Miguel D, Jamuna KK, Lies L, Maria MO, Sundeep SS et al. COPD and Multimorbidity: recognising and addressing a syndemic occurrence. Lancet Respir Med 2023, 11.","DOI":"10.1016\/S2213-2600(23)00261-8"},{"key":"3170_CR5","unstructured":"Yusheng C, Wei S, Jiaming L, Ying J, Chuqian L, Liyuan Z, Xia Z, Wenhui Z, Beibei L, Yongpan A et al. The landscape of aging. Sci China Life Sci 2022, 65."},{"key":"3170_CR6","doi-asserted-by":"publisher","first-page":"133741","DOI":"10.1016\/j.ijbiomac.2024.133741","volume":"275","author":"L Liao","year":"2024","unstructured":"Liao L, Deng M, Gao Q, Zhang Q, Bian Y, Wang Z, Li J, Xu W, Li C, Wang K, et al. Predictive and therapeutic value of lipoprotein-associated phospholipaseA2 in sarcopenia in chronic obstructive pulmonary disease. Int J Biol Macromol. 2024;275:133741.","journal-title":"Int J Biol Macromol"},{"key":"3170_CR7","doi-asserted-by":"crossref","unstructured":"Pauline H, Isabelle D, Pierre S, Pauline E, L\u00e9o B, Ma\u00e9va Z, Fares G, Maurice H, Pascal P, Patrick B. Main pathogenic mechanisms and recent advances in COPD peripheral skeletal muscle wasting. Int J Mol Sci 2023, 24.","DOI":"10.3390\/ijms24076454"},{"key":"3170_CR8","unstructured":"Sophie IJ, vB, Harry RG, Ramon CL, Annemie MWJS. Towards personalized management of sarcopenia in COPD. Int J Chron Obstruct Pulmon Dis 2021, 16."},{"key":"3170_CR9","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1152\/physrev.00061.2017","volume":"99","author":"L Larsson","year":"2019","unstructured":"Larsson L, Degens H, Li M, Salviati L, Lee Y, Thompson W, Kirkland J, Sandri M. Sarcopenia: Aging-Related loss of muscle mass and function. Physiol Rev. 2019;99:427\u2013511.","journal-title":"Physiol Rev"},{"key":"3170_CR10","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.lfs.2018.10.062","volume":"214","author":"H Xie","year":"2018","unstructured":"Xie H, Wu L, Deng Z, Huo Y, Cheng Y. Emerging roles of YAP\/TAZ in lung physiology and diseases. Life Sci. 2018;214:176\u201383.","journal-title":"Life Sci"},{"key":"3170_CR11","doi-asserted-by":"crossref","unstructured":"Iwan S, Ardo S, Ronny L, Paul MY, Hanna G. Hippo pathway effectors YAP and TAZ and their association with skeletal muscle ageing. J Physiol Biochem 2021, 77.","DOI":"10.1007\/s13105-021-00787-z"},{"key":"3170_CR12","unstructured":"Minyang F, Yuan H, Tianxia L, Kun-Liang G, Ting L, Min L. The Hippo signalling pathway and its implications in human health and diseases. Signal Transduct Target Ther, 7."},{"key":"3170_CR13","doi-asserted-by":"publisher","first-page":"6048","DOI":"10.1038\/ncomms7048","volume":"6","author":"KI Watt","year":"2015","unstructured":"Watt KI, Turner BJ, Hagg A, Zhang X, Davey JR, Qian H, Beyer C, Winbanks CE, Harvey KF, Gregorevic P. The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size. Nat Commun. 2015;6:6048.","journal-title":"Nat Commun"},{"key":"3170_CR14","doi-asserted-by":"publisher","first-page":"190","DOI":"10.3389\/fphys.2017.00190","volume":"8","author":"O Gnimassou","year":"2017","unstructured":"Gnimassou O, Francaux M, Deldicque L. Hippo pathway and skeletal muscle mass regulation in mammals: A controversial relationship. Front Physiol. 2017;8:190.","journal-title":"Front Physiol"},{"key":"3170_CR15","doi-asserted-by":"crossref","unstructured":"Felipe SG, Adriana C-C, Alexia B-P, Daniela LR, Andrea R, Juan Carlos C, Enrique B. Denervation drives YAP\/TAZ activation in muscular fibro\/adipogenic progenitors. Int J Mol Sci 2023, 24.","DOI":"10.3390\/ijms24065585"},{"key":"3170_CR16","unstructured":"Lidan Z, Yu-Taro N, Hiroyuki N, Takayuki K, Kazutake T, Madoka I-U, Akiyoshi U, Yoshiaki O, Takefumi D, Shuichi W et al. The CalcR-PKA-Yap1 Axis is critical for maintaining quiescence in muscle stem cells. Cell Rep 2019, 29."},{"key":"3170_CR17","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1002\/jcsm.13213","volume":"14","author":"M Deng","year":"2023","unstructured":"Deng M, Zhang Q, Yan L, Bian Y, Li R, Gao J, Wang Y, Miao J, Li J, Zhou X, Hou G. Glycyl-l-histidyl-l-lysine-Cu(2+) rescues cigarette smoking-induced skeletal muscle dysfunction via a Sirtuin 1-dependent pathway. J Cachexia Sarcopenia Muscle. 2023;14:1365\u201380.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3170_CR18","doi-asserted-by":"publisher","first-page":"929926","DOI":"10.3389\/fphys.2022.929926","volume":"13","author":"L Zhang","year":"2022","unstructured":"Zhang L, Li C, Xiong J, Chang C, Sun Y. Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smoke-induced model of chronic obstructive pulmonary disease. Front Physiol. 2022;13:929926.","journal-title":"Front Physiol"},{"key":"3170_CR19","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.2147\/COPD.S314640","volume":"16","author":"C Li","year":"2021","unstructured":"Li C, Deng Z, Zheng G, Xie T, Wei X, Huo Z, Bai J. Histone deacetylase 2 suppresses skeletal muscle atrophy and senescence via NF-\u03baB signaling pathway in cigarette Smoke-Induced mice with emphysema. Int J Chron Obstruct Pulmon Dis. 2021;16:1661\u201375.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"3170_CR20","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1002\/jcsm.13194","volume":"14","author":"E Alcalde-Est\u00e9vez","year":"2023","unstructured":"Alcalde-Est\u00e9vez E, Sosa P, Asenjo-Bueno A, Plaza P, Valenzuela PL, Naves-D\u00edaz M, Olmos G, L\u00f3pez-Ongil S, Ruiz-Torres MP. Dietary phosphate restriction prevents the appearance of sarcopenia signs in old mice. J Cachexia Sarcopenia Muscle. 2023;14:1060\u201374.","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"3170_CR21","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/COPD.S234634","volume":"15","author":"L Chen","year":"2020","unstructured":"Chen L, Luo L, Kang N, He X, Li T, Chen Y. The protective effect of HBO1 on cigarette smoke Extract-Induced apoptosis in airway epithelial cells. Int J Chron Obstruct Pulmon Dis. 2020;15:15\u201324.","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"3170_CR22","doi-asserted-by":"publisher","first-page":"121539","DOI":"10.1016\/j.lfs.2023.121539","volume":"320","author":"HK Ko","year":"2023","unstructured":"Ko HK, Hsiao YH, Jeng MJ, Yang DM, Chen PK, Su KC, Chou KT, Perng DW. The role of transforming growth factor-\u03b22 in cigarette smoke-induced lung inflammation and injury. Life Sci. 2023;320:121539.","journal-title":"Life Sci"},{"key":"3170_CR23","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.2147\/COPD.S377226","volume":"17","author":"L Zhang","year":"2022","unstructured":"Zhang L, Li D, Chang C, Sun Y. Myostatin\/HIF2\u03b1-Mediated ferroptosis is involved in skeletal muscle dysfunction in chronic obstructive pulmonary disease. Int J Chronic Obstr Pulm Dis. 2022;17:2383\u201399.","journal-title":"Int J Chronic Obstr Pulm Dis"},{"key":"3170_CR24","doi-asserted-by":"crossref","unstructured":"Wang C, Yue F, Kuang S. Muscle histology characterization using H&E staining and muscle Fiber type classification using Immunofluorescence staining. Bio Protoc 2017, 7.","DOI":"10.21769\/BioProtoc.2279"},{"key":"3170_CR25","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1002\/jcsm.12600","volume":"11","author":"W Sep\u00falveda-Loyola","year":"2020","unstructured":"Sep\u00falveda-Loyola W, Osadnik C, Phu S, Morita A, Duque G, Probst V. Diagnosis, prevalence, and clinical impact of sarcopenia in COPD: a systematic review and meta-analysis. J cachexia Sarcopenia Muscle. 2020;11:1164\u201376.","journal-title":"J cachexia Sarcopenia Muscle"},{"key":"3170_CR26","doi-asserted-by":"crossref","unstructured":"Benz E, Trajanoska K, Lahousse L, Schoufour JD, Terzikhan N, De Roos E, de Jonge GB, Williams R, Franco OH, Brusselle G, Rivadeneira F. Sarcopenia in COPD: a systematic review and meta-analysis. Eur Respir Rev 2019, 28.","DOI":"10.1183\/16000617.0049-2019"},{"key":"3170_CR27","doi-asserted-by":"crossref","unstructured":"Li Y, Eugenie N, Marian V, Qinghua W, Kamil K. Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression. Arch Toxicol 2022, 97.","DOI":"10.1007\/s00204-022-03423-x"},{"key":"3170_CR28","doi-asserted-by":"crossref","unstructured":"Nor Shaheera MK, Sabreena S, Shaharum S, Parisa F. Aging of the cells: insight into cellular senescence and detection methods. Eur J Cell Biol 2020, 99.","DOI":"10.1016\/j.ejcb.2020.151108"},{"key":"3170_CR29","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1038\/s41586-022-04924-6","volume":"607","author":"H Sladitschek-Martens","year":"2022","unstructured":"Sladitschek-Martens H, Guarnieri A, Brumana G, Zanconato F, Battilana G, Xiccato R, Panciera T, Forcato M, Bicciato S, Guzzardo V, et al. YAP\/TAZ activity in stromal cells prevents ageing by controlling cGAS-STING. Nature. 2022;607:790\u20138.","journal-title":"Nature"},{"key":"3170_CR30","doi-asserted-by":"publisher","first-page":"130037","DOI":"10.1016\/j.ijbiomac.2024.130037","volume":"262","author":"Y Jiang","year":"2024","unstructured":"Jiang Y, Fu L, Liu B, Li F. YAP induces FAK phosphorylation to inhibit gastric cancer cell proliferation via upregulation of HMGB1. Int J Biol Macromol. 2024;262:130037.","journal-title":"Int J Biol Macromol"},{"key":"3170_CR31","doi-asserted-by":"publisher","first-page":"2396","DOI":"10.1016\/j.celrep.2017.05.054","volume":"19","author":"M Murgia","year":"2017","unstructured":"Murgia M, Toniolo L, Nagaraj N, Ciciliot S, Vindigni V, Schiaffino S, Reggiani C, Mann M. Single muscle Fiber proteomics reveals Fiber-Type-Specific features of human muscle aging. Cell Rep. 2017;19:2396\u2013409.","journal-title":"Cell Rep"},{"key":"3170_CR32","doi-asserted-by":"crossref","unstructured":"Victoria M, Andr\u00e9s C, Valentina S, Oleg D, Yiwei L, Sascha J, Eva A, Juan A, Jessica S, Laura O et al. Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration. Nature 2022, 613.","DOI":"10.1038\/s41586-022-05535-x"},{"key":"3170_CR33","doi-asserted-by":"crossref","unstructured":"Alexiane D, Jason DK, Shankar V, Andrea A. The cGAS-STING pathway as a therapeutic target in inflammatory diseases. Nat Rev Immunol 2021, 21.","DOI":"10.1038\/s41577-021-00524-z"},{"key":"3170_CR34","doi-asserted-by":"crossref","unstructured":"Chenyu S, Zhuoyi H, Dingjun X, Huihui B, Juan L, Xuanxuan Z, Qiang Z, Li S, Heng Y, Tong L, Yinghua L. STING signaling in inflammaging: a new target against musculoskeletal diseases. Front Immunol 2023, 14.","DOI":"10.3389\/fimmu.2023.1227364"},{"key":"3170_CR35","doi-asserted-by":"publisher","first-page":"e1010045","DOI":"10.1371\/journal.pgen.1010045","volume":"19","author":"E Haarer","year":"2023","unstructured":"Haarer E, Theodore C, Guo S, Frier R, Campellone K. Genomic instability caused by Arp2\/3 complex inactivation results in micronucleus biogenesis and cellular senescence. PLoS Genet. 2023;19:e1010045.","journal-title":"PLoS Genet"},{"key":"3170_CR36","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.ceb.2020.08.012","volume":"68","author":"V Papalazarou","year":"2021","unstructured":"Papalazarou V, Machesky L. The cell pushes back: the Arp2\/3 complex is a key orchestrator of cellular responses to environmental forces. Curr Opin Cell Biol. 2021;68:37\u201344.","journal-title":"Curr Opin Cell Biol"},{"key":"3170_CR37","unstructured":"Ting X, Xinyue B, Xingyi W, Lezheng W, Fei L, Hui S, Yue S. Exercise rehabilitation and chronic respiratory diseases: effects, mechanisms, and therapeutic benefits. Int J Chron Obstruct Pulmon Dis 2023, 18."},{"key":"3170_CR38","unstructured":"Alfonso JC-J, G\u03cblistan B, J\u03cbrgen B, Yves B, Olivier B, Tommy C, Cyrus C, Francesco L, Yves R, Avan Aihie S et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 2019, 48."}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-025-03170-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T15:30:53Z","timestamp":1741793453000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-025-03170-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,12]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3170"],"URL":"https:\/\/doi.org\/10.1186\/s12931-025-03170-4","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,12]]},"assertion":[{"value":"11 December 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 March 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University (approved protocol number: 2023-SR-530). The manuscript does not contain human subjects.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"98"}}