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This study aims to evaluate the impact of periodontal therapy on lung function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sixty-two never-smoking patients with mild periodontitis and without other medical conditions participated in this single-blind, prospective trial. Patients underwent periodontal therapy following an infection control approach. Lung function was measured using forced oscillation technique, assessing airway resistance and reactance, and spirometry evaluating FEV\n                      <jats:sub>1<\/jats:sub>\n                      , FVC, and FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC. Lung function and fractional exhaled nitric oxide were assessed at baseline, three and six weeks, and every three months for a year. Periodontal parameters were recorded at baseline, six weeks, six and 12 months. Data were analysed using mixed-effects regression models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Patients (mean age 36 years, 58% female) showed significant improvements in periodontal parameters (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Oscillometry revealed a significant decrease in airway resistance at 11\u00a0Hz and 19\u00a0Hz after six weeks, with further significant decreases throughout the study. Resistance at 5\u00a0Hz (R\n                      <jats:sub>5<\/jats:sub>\n                      ) consistently declined, reaching significance at three months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001). By one year, R\n                      <jats:sub>5<\/jats:sub>\n                      , R\n                      <jats:sub>11<\/jats:sub>\n                      , R\n                      <jats:sub>19<\/jats:sub>\n                      , and R\n                      <jats:sub>5\u2009\u2212\u200920<\/jats:sub>\n                      showed significant reductions (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Airway reactance at 5\u00a0Hz became less negative at three months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002), while the reactance area (AX) decreased significantly at six months (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008). No significant changes were observed in spirometry or fractional exhaled nitric oxide.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A decrease in airway resistance was observed after periodontal therapy, underscoring its positive impact on small airway function. These findings suggest that oral infection control is valuable for respiratory health in young adults before chronic conditions establish.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>The trial was registered at ClinicalTrials.gov (NCT04781153) on February 19, 2021, prior to participant enrolment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12931-025-03246-1","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T08:53:53Z","timestamp":1746262433000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of periodontal therapy on lung function: a twelve-month follow-up intervention study"],"prefix":"10.1186","volume":"26","author":[{"given":"Anders","family":"R\u00f8sland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi J.","family":"Bertelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Heinrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stein Atle","family":"Lie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Malinovschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar F.","family":"Bun\u00e6s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"issue":"6","key":"3246_CR1","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/S2213-2600(20)30105-3","volume":"8","author":"JB Soriano","year":"2020","unstructured":"Soriano JB, Kendrick PJ, Paulson KR, et al. 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