{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:22:17Z","timestamp":1787980937018,"version":"build-2784847793"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T00:00:00Z","timestamp":1753833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"name":"the Stichting Astma Bestrijding","award":["SAB, Project 2021-021"],"award-info":[{"award-number":["SAB, Project 2021-021"]}]},{"name":"the Noordelijke Cara Stichting","award":["NCS, Project 2019\/02"],"award-info":[{"award-number":["NCS, Project 2019\/02"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-025-03330-6","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T21:28:06Z","timestamp":1753910886000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Extracellular vesicles from bronchoalveolar lavage fluid provide insights into the inhaled corticosteroids treatment response in COPD"],"prefix":"10.1186","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-4028","authenticated-orcid":false,"given":"Jiahua","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0066-3720","authenticated-orcid":false,"given":"Justina C.","family":"Wolters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2418-0061","authenticated-orcid":false,"given":"Karim","family":"Rafie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshuo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Bartel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9336-7340","authenticated-orcid":false,"given":"Maarten","family":"van den Berge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6732-8903","authenticated-orcid":false,"given":"Machteld N.","family":"Hylkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,30]]},"reference":[{"key":"3330_CR1","unstructured":"Chronic obstructive pulmonary. disease (COPD) fact sheet. Available from: https:\/\/www.who.int"},{"key":"3330_CR2","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1016\/S0140-6736(22)00470-6","volume":"399","author":"SA Christenson","year":"2022","unstructured":"Christenson SA, Smith BM, Bafadhel M, Putcha N. Chronic obstructive pulmonary disease. Lancet. 2022;399:2227\u201342.","journal-title":"Lancet"},{"key":"3330_CR3","unstructured":"COMMITTEE GS: Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: 2025 report. Available from: https:\/\/goldcopd.org"},{"key":"3330_CR4","doi-asserted-by":"publisher","first-page":"1801219","DOI":"10.1183\/13993003.01219-2018","volume":"52","author":"A Agusti","year":"2018","unstructured":"Agusti A, Fabbri LM, Singh D, Vestbo J, Celli B, Franssen FME, Rabe KF, Papi A. Inhaled corticosteroids in COPD: friend or foe? Eur Respir J. 2018;52:1801219.","journal-title":"Eur Respir J"},{"key":"3330_CR5","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1056\/NEJMoa1713901","volume":"378","author":"DA Lipson","year":"2018","unstructured":"Lipson DA, Barnhart F, Brealey N, Brooks J, Criner GJ, Day NC, Dransfield MT, Halpin DMG, Han MK, Jones CE, et al. Once-Daily Single-Inhaler triple versus dual therapy in patients with COPD. N Engl J Med. 2018;378:1671\u201380.","journal-title":"N Engl J Med"},{"key":"3330_CR6","doi-asserted-by":"publisher","first-page":"230084","DOI":"10.1183\/16000617.0084-2023","volume":"32","author":"S Lea","year":"2023","unstructured":"Lea S, Higham A, Beech A, Singh D. How inhaled corticosteroids target inflammation in COPD. Eur Respiratory Rev. 2023;32:230084.","journal-title":"Eur Respiratory Rev"},{"key":"3330_CR7","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1186\/s12890-015-0155-3","volume":"15","author":"BG Cos\u00edo","year":"2015","unstructured":"Cos\u00edo BG, Jahn A, Iglesias A, Shafiek H, Busquets X, Agust\u00ed A. Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD. BMC Pulm Med. 2015;15:157.","journal-title":"BMC Pulm Med"},{"key":"3330_CR8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s12931-017-0539-4","volume":"18","author":"RM Khalaf","year":"2017","unstructured":"Khalaf RM, Lea SR, Metcalfe HJ, Singh D. Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi. Respir Res. 2017;18:61.","journal-title":"Respir Res"},{"key":"3330_CR9","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1742-7843.2011.00707.x","volume":"109","author":"J Knobloch","year":"2011","unstructured":"Knobloch J, Hag H, Jungck D, Urban K, Koch A. Resveratrol impairs the release of steroid-resistant cytokines from bacterial endotoxin-exposed alveolar macrophages in chronic obstructive pulmonary disease. Basic Clin Pharmacol Toxicol. 2011;109:138\u201343.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"3330_CR10","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1164\/ajrccm.153.2.8564092","volume":"153","author":"VM Keatings","year":"1996","unstructured":"Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med. 1996;153:530\u20134.","journal-title":"Am J Respir Crit Care Med"},{"key":"3330_CR11","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.intimp.2011.10.006","volume":"12","author":"J Plumb","year":"2012","unstructured":"Plumb J, Gaffey K, Kane B, Malia-Milanes B, Shah R, Bentley A, Ray D, Singh D. Reduced glucocorticoid receptor expression and function in airway neutrophils. Int Immunopharmacol. 2012;12:26\u201333.","journal-title":"Int Immunopharmacol"},{"key":"3330_CR12","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1164\/rccm.201408-1458OC","volume":"191","author":"SA Christenson","year":"2015","unstructured":"Christenson SA, Steiling K, van den Berge M, Hijazi K, Hiemstra PS, Postma DS, Lenburg ME, Spira A, Woodruff PG. Asthma\u2013COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015;191:758\u201366.","journal-title":"Am J Respir Crit Care Med"},{"key":"3330_CR13","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1136\/thorax-2021-217736","volume":"78","author":"A Faiz","year":"2023","unstructured":"Faiz A, Pavlidis S, Kuo C-H, Rowe A, Hiemstra PS, Timens W, Berg M, Wisman M, Guo Y-K, Djukanovi\u0107 R, et al. Th2 high and mast cell gene signatures are associated with corticosteroid sensitivity in COPD. Thorax. 2023;78:335.","journal-title":"Thorax"},{"key":"3330_CR14","first-page":"1405","volume":"7","author":"A Yousuf","year":"2019","unstructured":"Yousuf A, Ibrahim W, Greening NJ, Brightling CE. T2 biologics for chronic obstructive pulmonary disease. J Allergy Clin Immunology: Pract. 2019;7:1405\u201316.","journal-title":"J Allergy Clin Immunology: Pract"},{"key":"3330_CR15","doi-asserted-by":"publisher","first-page":"2222","DOI":"10.1056\/NEJMoa1516385","volume":"374","author":"JA Wedzicha","year":"2016","unstructured":"Wedzicha JA, Banerji D, Chapman KR, Vestbo J, Roche N, Ayers RT, Thach C, Fogel R, Patalano F, Vogelmeier CF. Indacaterol\u2013Glycopyrronium versus Salmeterol\u2013Fluticasone for COPD. N Engl J Med. 2016;374:2222\u201334.","journal-title":"N Engl J Med"},{"key":"3330_CR16","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1136\/thx.2006.071068","volume":"62","author":"J Bourbeau","year":"2007","unstructured":"Bourbeau J, Christodoulopoulos P, Maltais F, Yamauchi Y, Olivenstein R, Hamid Q. Effect of salmeterol\/fluticasone propionate on airway inflammation in COPD: a randomised controlled trial. Thorax. 2007;62:938.","journal-title":"Thorax"},{"key":"3330_CR17","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/j.bcp.2009.10.001","volume":"79","author":"H Sarir","year":"2010","unstructured":"Sarir H, Mortaz E, Janse WT, Givi ME, Nijkamp FP, Folkerts G. IL-8 production by macrophages is synergistically enhanced when cigarette smoke is combined with TNF-\u03b1. Biochem Pharmacol. 2010;79:698\u2013705.","journal-title":"Biochem Pharmacol"},{"key":"3330_CR18","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1164\/ajrccm.155.4.9105097","volume":"155","author":"K Kurashima","year":"1997","unstructured":"Kurashima K, Mukaida N, Fujimura M, Yasui M, Nakazumi Y, Matsuda T, Matsushima K. Elevated chemokine levels in Bronchoalveolar lavage fluid of tuberculosis patients. Am J Respir Crit Care Med. 1997;155:1474\u20137.","journal-title":"Am J Respir Crit Care Med"},{"key":"3330_CR19","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.21037\/tlcr.2019.12.16","volume":"8","author":"JY Hur","year":"2019","unstructured":"Hur JY, Lee JS, Kim IA, Kim HJ, Kim WS, Lee KY. Extracellular vesicle-based EGFR genotyping in Bronchoalveolar lavage fluid from treatment-naive non-small cell lung cancer patients. Transl Lung Cancer Res. 2019;8:1051\u201360.","journal-title":"Transl Lung Cancer Res"},{"key":"3330_CR20","doi-asserted-by":"publisher","first-page":"620","DOI":"10.3390\/diagnostics11040620","volume":"11","author":"E-S Choi","year":"2021","unstructured":"Choi E-S, Faruque HA, Kim J-H, Kim KJ, Choi JE, Kim BA, Kim B, Kim YJ, Woo MH, Park JY, et al. CD5L as an extracellular Vesicle-Derived biomarker for liquid biopsy of lung Cancer. Diagnostics. 2021;11:620.","journal-title":"Diagnostics"},{"key":"3330_CR21","doi-asserted-by":"publisher","first-page":"621","DOI":"10.7150\/thno.72297","volume":"13","author":"WL Thuya","year":"2023","unstructured":"Thuya WL, Kong LR, Syn NL, Ding L-W, Cheow ESH, Wong RTX, Wang T, Goh RMW-J, Song H, Jayasinghe MK, et al. FAM3C in Circulating tumor-derived extracellular vesicles promotes non-small cell lung cancer growth in secondary sites. Theranostics. 2023;13:621\u201338.","journal-title":"Theranostics"},{"key":"3330_CR22","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1002\/cncr.34576","volume":"129","author":"D de Miguel-Perez","year":"2023","unstructured":"de Miguel-Perez D, Russo A, Gunasekaran M, Buemi F, Hester L, Fan X, Carter-Cooper BA, Lapidus RG, Peleg A, Arroyo-Hern\u00e1ndez M, et al. Baseline extracellular vesicle TGF-\u03b2 is a predictive biomarker for response to immune checkpoint inhibitors and survival in non\u2013small cell lung cancer. Cancer. 2023;129:521\u201330.","journal-title":"Cancer"},{"key":"3330_CR23","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1093\/brain\/awad341","volume":"147","author":"T Xue","year":"2024","unstructured":"Xue T, Liu W, Wang L, Shi Y, Hu Y, Yang J, Li G, Huang H, Cui D. Extracellular vesicle biomarkers for complement dysfunction in schizophrenia. Brain. 2024;147:1075\u201386.","journal-title":"Brain"},{"key":"3330_CR24","doi-asserted-by":"publisher","first-page":"105800","DOI":"10.1016\/j.nbd.2022.105800","volume":"171","author":"Y Li","year":"2022","unstructured":"Li Y, Xia M, Meng S, Wu D, Ling S, Chen X, Liu C. MicroRNA-29c-3p in dual-labeled exosome is a potential diagnostic marker of subjective cognitive decline. Neurobiol Dis. 2022;171:105800.","journal-title":"Neurobiol Dis"},{"key":"3330_CR25","doi-asserted-by":"publisher","first-page":"21639","DOI":"10.1021\/acsnano.3c06803","volume":"17","author":"MK Jayasinghe","year":"2023","unstructured":"Jayasinghe MK, Gao C, Yap G, Yeo BZJ, Vu LT, Tay DJW, Loh WX, Aw ZQ, Chen H, Phung DC, et al. Red blood Cell-Derived extracellular vesicles display endogenous antiviral effects and enhance the efficacy of antiviral oligonucleotide therapy. ACS Nano. 2023;17:21639\u201361.","journal-title":"ACS Nano"},{"key":"3330_CR26","doi-asserted-by":"publisher","first-page":"e0290046","DOI":"10.1371\/journal.pone.0290046","volume":"18","author":"M Cacciottolo","year":"2023","unstructured":"Cacciottolo M, Li Y, Nice JB, LeClaire MJ, Twaddle R, Mora CL, Adachi SY, Young M, Angeles J, Elliott K, Sun M. Nanograms of SARS-CoV-2 Spike protein delivered by exosomes induce potent neutralization of both delta and Omicron variants. PLoS ONE. 2023;18:e0290046.","journal-title":"PLoS ONE"},{"key":"3330_CR27","doi-asserted-by":"crossref","unstructured":"Bartel S, Wolters JC, Noor H, Rafie K, Fang J, Kirchner B, Nolte-\u2032t Hoen E, Pfaffl MW, Rutgers S, Timens W et al. Altered Extracellular Vesicle-Derived Protein and microRNA Signatures in Bronchoalveolar Lavage Fluid from Patients with Chronic Obstructive Pulmonary Disease. In Cells. 2024;13.","DOI":"10.3390\/cells13110945"},{"key":"3330_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1164\/rccm.200401-112OC","volume":"170","author":"TS Lapperre","year":"2004","unstructured":"Lapperre TS, Snoeck-Stroband JB, Gosman MME, Stolk J, Sont JK, Jansen DF, Kerstjens HAM, Postma DS, Sterk PJ. Dissociation of lung function and airway inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170:499\u2013504.","journal-title":"Am J Respir Crit Care Med"},{"key":"3330_CR29","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/resp.13312","volume":"23","author":"FJ Hartjes","year":"2018","unstructured":"Hartjes FJ, Vonk JM, Faiz A, Hiemstra PS, Lapperre TS, Kerstjens HAM, Postma DS, van den Berge M. Leiden universities corticosteroids in obstructive lung disease study G: predictive value of eosinophils and neutrophils on clinical effects of ICS in COPD. Respirology. 2018;23:1023\u201331.","journal-title":"Respirology"},{"key":"3330_CR30","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1074\/mcp.M114.044305","volume":"14","author":"R Bruderer","year":"2015","unstructured":"Bruderer R, Bernhardt OM, Gandhi T, Miladinovi\u0107 SM, Cheng L-Y, Messner S, Ehrenberger T, Zanotelli V, Butscheid Y, Escher C, et al. Extending the limits of quantitative proteome profiling with Data-Independent acquisition and application to Acetaminophen-Treated Three-Dimensional liver microtissues. Mol Cell Proteom. 2015;14:1400\u201310.","journal-title":"Mol Cell Proteom"},{"key":"3330_CR31","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1016\/j.jaci.2023.02.005","volume":"151","author":"B Yan","year":"2023","unstructured":"Yan B, Ren Y, Liu C, Shu L, Wang C, Zhang L. Cystatin SN in type 2 inflammatory airway diseases. J Allergy Clin Immunol. 2023;151:1191\u2013e12031193.","journal-title":"J Allergy Clin Immunol"},{"key":"3330_CR32","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.jaci.2022.10.029","volume":"151","author":"B Jakiela","year":"2023","unstructured":"Jakiela B, Soja J, Sladek K, Przybyszowski M, Plutecka H, Gielicz A, Licholai S, Aab A, Rebane A, Bochenek G. Bronchial epithelial cell transcriptome shows endotype heterogeneity of asthma in patients with NSAID-exacerbated respiratory disease. J Allergy Clin Immunol. 2023;151:953\u201365.","journal-title":"J Allergy Clin Immunol"},{"key":"3330_CR33","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1136\/thorax-2023-221230","volume":"79","author":"T Karp","year":"2024","unstructured":"Karp T, Faiz A, van Nijnatten J, Kerstjens HAM, Boudewijn I, Kraft M, Vonk JM, Nawijn MC, Heijink IH, Begh\u00e9 B, et al. Nasal epithelial gene expression identifies relevant asthma endotypes in the ATLANTIS study. Thorax. 2024;79:905.","journal-title":"Thorax"},{"key":"3330_CR34","doi-asserted-by":"publisher","first-page":"374","DOI":"10.4168\/aair.2023.15.3.374","volume":"15","author":"L Du","year":"2023","unstructured":"Du L, Xu C, Tang K, Shi J, Tang L, Lisha X, Lei C, Liu H, Liang Y, Guo Y. Epithelial CST1 promotes airway eosinophilic inflammation in asthma via the AKT signaling pathway. Allergy Asthma Immunol Res. 2023;15:374\u201394.","journal-title":"Allergy Asthma Immunol Res"},{"key":"3330_CR35","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.jaci.2022.04.034","volume":"150","author":"AL Nocera","year":"2022","unstructured":"Nocera AL, Mueller SK, Workman AD, Wu D, McDonnell K, Sadow PM, Amiji MM, Bleier BS. Cystatin SN is a potent upstream initiator of epithelial-derived type 2 inflammation in chronic rhinosinusitis. J Allergy Clin Immunol. 2022;150:872\u201381.","journal-title":"J Allergy Clin Immunol"},{"key":"3330_CR36","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1111\/all.14016","volume":"75","author":"L George","year":"2020","unstructured":"George L, Taylor AR, Esteve-Codina A, Soler Artigas M, Thun GA, Bates S, Pavlidis S, Wagers S, Boland A, Prasse A, et al. Blood eosinophil count and airway epithelial transcriptome relationships in COPD versus asthma. Allergy. 2020;75:370\u201380.","journal-title":"Allergy"},{"key":"3330_CR37","doi-asserted-by":"crossref","unstructured":"Wang Z, He Y, Li Q, Zhao Y, Zhang G, Luo Z. Network analyses of upper and lower airway transcriptomes identify shared mechanisms among children with recurrent wheezing and school-age asthma. Front Immunol 2023;14.","DOI":"10.3389\/fimmu.2023.1087551"},{"key":"3330_CR38","doi-asserted-by":"crossref","unstructured":"Russo P, Tomino C, Santoro A, Prinzi G, Proietti S, Kisialiou A, Cardaci V, Fini M, Magnani M, Collacchi F et al. FKBP5 rs4713916: A Potential Genetic Predictor of Interindividual Different Response to Inhaled Corticosteroids in Patients with Chronic Obstructive Pulmonary Disease in a Real-Life Setting. International Journal of Molecular Sciences 2019, 20:2024.","DOI":"10.3390\/ijms20082024"},{"key":"3330_CR39","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/npp.2015.235","volume":"41","author":"AS Zannas","year":"2016","unstructured":"Zannas AS, Wiechmann T, Gassen NC, Binder EB. Gene\u2013Stress\u2013Epigenetic regulation of FKBP5: clinical and translational implications. Neuropsychopharmacology. 2016;41:261\u201374.","journal-title":"Neuropsychopharmacology"},{"key":"3330_CR40","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1007\/s00408-020-00376-9","volume":"198","author":"S-J Huang","year":"2020","unstructured":"Huang S-J, Ding Z-N, Xiang H-X, Fu L, Fei J. Association between serum S100A8\/S100A9 heterodimer and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease. Lung. 2020;198:645\u201352.","journal-title":"Lung"},{"key":"3330_CR41","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1183\/09031936.00158414","volume":"45","author":"SD Pouwels","year":"2015","unstructured":"Pouwels SD, Nawijn MC, Bathoorn E, Riezebos-Brilman A, van Oosterhout AJM, Kerstjens HAM, Heijink IH. Increased serum levels of LL37, HMGB1 and S100A9 during exacerbation in COPD patients. Eur Respir J. 2015;45:1482\u20135.","journal-title":"Eur Respir J"},{"key":"3330_CR42","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1189\/jlb.1008647","volume":"86","author":"JM Ehrchen","year":"2009","unstructured":"Ehrchen JM, Sunderk\u00f6tter C, Foell D, Vogl T, Roth J. The endogenous Toll\u2013like receptor 4 agonist S100A8\/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol. 2009;86:557\u201366.","journal-title":"J Leukoc Biol"},{"key":"3330_CR43","doi-asserted-by":"crossref","unstructured":"Heizmann CW, Ackermann GE, Galichet A. Pathologies Involving the S100 Proteins and Rage. In Calcium Signalling and Disease: Molecular Pathology of Calcium.Edited by Carafoli E, Brini M. Dordrecht: Springer Netherlands; 2007:93\u2013138.","DOI":"10.1007\/978-1-4020-6191-2_5"},{"key":"3330_CR44","doi-asserted-by":"crossref","unstructured":"Kelly-Robinson GA, Reihill JA, Lundy FT, McGarvey LP, Lockhart JC, Litherland GJ, Thornbury KD, Martin SL. The Serpin superfamily and their role in the regulation and dysfunction of Serine protease activity in COPD and other chronic lung diseases. Int J Mol Sci. 2021;22.","DOI":"10.3390\/ijms22126351"},{"key":"3330_CR45","doi-asserted-by":"publisher","first-page":"L245","DOI":"10.1152\/ajplung.00362.2017","volume":"316","author":"Y Mo","year":"2018","unstructured":"Mo Y, Zhang K, Feng Y, Yi L, Liang Y, Wu W, Zhao J, Zhang Z, Xu Y, Hu Q, et al. Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation. Am J Physiology-Lung Cell Mol Physiol. 2018;316:L245\u201354.","journal-title":"Am J Physiology-Lung Cell Mol Physiol"},{"key":"3330_CR46","doi-asserted-by":"crossref","unstructured":"Knyazeva A, Li S, Corkery DP, Shankar K, Herzog LK, Zhang X, Singh B, Niggemeyer G, Grill D, Gilthorpe JD et al. A chemical inhibitor of IST1-CHMP1B interaction impairs endosomal recycling and induces noncanonical LC3 lipidation. Proceedings of the National Academy of Sciences. 2024;121:e2317680121.","DOI":"10.1073\/pnas.2317680121"},{"key":"3330_CR47","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1038\/nsmb.1621","volume":"16","author":"M Bajorek","year":"2009","unstructured":"Bajorek M, Schubert HL, McCullough J, Langelier C, Eckert DM, Stubblefield W-MB, Uter NT, Myszka DG, Hill CP, Sundquist WI. Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol. 2009;16:754\u201362.","journal-title":"Nat Struct Mol Biol"},{"key":"3330_CR48","doi-asserted-by":"publisher","first-page":"e1144","DOI":"10.1371\/journal.pone.0001144","volume":"2","author":"M Felberbaum-Corti","year":"2007","unstructured":"Felberbaum-Corti M, Morel E, Cavalli V, Vilbois F, Gruenberg J. The redox sensor TXNL1 plays a regulatory role in fluid phase endocytosis. PLoS ONE. 2007;2:e1144.","journal-title":"PLoS ONE"},{"key":"3330_CR49","doi-asserted-by":"crossref","unstructured":"Baudot AD, Wang VMY, Leach JD, O\u2019Prey J, Long JS, Paulus-Hock V, Lilla S, Thomson DM, Greenhorn J, Ghaffar F et al. Glycan degradation promotes macroautophagy. Proceedings of the National Academy of Sciences 2022;119:e2111506119.","DOI":"10.1073\/pnas.2111506119"},{"key":"3330_CR50","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1165\/rcmb.2015-0122TR","volume":"53","author":"Y Takeda","year":"2015","unstructured":"Takeda Y, Suzuki M, Jin Y, Tachibana I. Preventive role of tetraspanin CD9 in systemic inflammation of chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol. 2015;53:751\u201360.","journal-title":"Am J Respir Cell Mol Biol"},{"key":"3330_CR51","doi-asserted-by":"publisher","first-page":"26089","DOI":"10.1074\/jbc.M801902200","volume":"283","author":"Y Takeda","year":"2008","unstructured":"Takeda Y, He P, Tachibana I, Zhou B, Miyado K, Kaneko H, Suzuki M, Minami S, Iwasaki T, Goya S, et al. Double deficiency of tetraspanins CD9 and CD81 alters cell motility and protease production of macrophages and causes chronic obstructive pulmonary Disease-like phenotype in mice. J Biol Chem. 2008;283:26089\u201397.","journal-title":"J Biol Chem"},{"key":"3330_CR52","doi-asserted-by":"publisher","first-page":"3619","DOI":"10.3892\/ol.2015.3737","volume":"10","author":"C Cai","year":"2015","unstructured":"Cai C, Shi R, Gao Y, Zeng J, Wei M, Wang H, Zheng W, Ma W. Reduced expression of Sushi domain containing 2 is associated with progression of non-small cell lung cancer. Oncol Lett. 2015;10:3619\u201324.","journal-title":"Oncol Lett"},{"key":"3330_CR53","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.7150\/jca.39319","volume":"11","author":"W Guo","year":"2020","unstructured":"Guo W, Shao F, Sun S, Song P, Guo L, Xue X, Zhang G, Zhang H, Gao Y, Qiu B, et al. Loss of SUSD2 expression correlates with poor prognosis in patients with surgically resected lung adenocarcinoma. J Cancer. 2020;11:1648\u201356.","journal-title":"J Cancer"},{"key":"3330_CR54","doi-asserted-by":"publisher","first-page":"517","DOI":"10.7326\/0003-4819-151-8-200910200-00004","volume":"151","author":"TS Lapperre","year":"2009","unstructured":"Lapperre TS, Snoeck-Stroband JB, Gosman MME, Jansen DF, van Schadewijk A, Thiadens HA, Vonk JM, Boezen HM, ten Hacken NHT, Sont JK, et al. Effect of fluticasone with and without Salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease. Ann Intern Med. 2009;151:517\u201327.","journal-title":"Ann Intern Med"},{"key":"3330_CR55","doi-asserted-by":"publisher","first-page":"1600839","DOI":"10.1183\/13993003.00839-2016","volume":"49","author":"LIZ Kunz","year":"2017","unstructured":"Kunz LIZ, ten Hacken NHT, Lapperre TS, Timens W, Kerstjens HAM, van Schadewijk A, Vonk JM, Sont JK, Snoeck-Stroband JB, Postma DS, et al. Airway inflammation in COPD after long-term withdrawal of inhaled corticosteroids. Eur Respir J. 2017;49:1600839.","journal-title":"Eur Respir J"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-025-03330-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-025-03330-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:45:48Z","timestamp":1757328348000},"score":1,"resource":{"primary":{"URL":"https:\/\/respiratory-research.biomedcentral.com\/articles\/10.1186\/s12931-025-03330-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,30]]},"references-count":55,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3330"],"URL":"https:\/\/doi.org\/10.1186\/s12931-025-03330-6","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,30]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 July 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the ethics committees of the University Medical Center Groningen (UMCG) as part of the GLUCOLD study (ClinicalTrials.gov: NCT00158847, preregistered April 2000). All procedures involving human participants were conducted in accordance with the Declaration of Helsinki. Informed consent was obtained from all participants prior to enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"254"}}