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Animal procedures were revised and approved by the Institutional Animal Care & Use Committee (IACUC) from the Center of Biomedical Research of La Rioja (CIBIR, Spain) (refs. 03\/12 and 13\/12), in accordance to the present legislation and recommendations on animal welfare and ethical principles. All animals were bred and maintained under specific pathogen-free (SPF) conditions in laminar flow caging at the CIBIR animal facility.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"292"}}