{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:08:45Z","timestamp":1784092125835,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T00:00:00Z","timestamp":1778889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":60,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation of China","doi-asserted-by":"crossref","award":["2022JJ40792"],"award-info":[{"award-number":["2022JJ40792"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 202103115"],"award-info":[{"award-number":["No. 202103115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Respir Res"],"DOI":"10.1186\/s12931-026-03720-4","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:35:31Z","timestamp":1778931331000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["OGDH primes macrophage for M1-like polarization and ferroptosis in sepsis associated acute lung injury"],"prefix":"10.1186","volume":"27","author":[{"given":"Lingli","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,16]]},"reference":[{"key":"3720_CR1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","volume":"395","author":"KE Rudd","year":"2020","unstructured":"Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, Colombara DV, Ikuta KS, Kissoon N, Finfer S, et al. Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study. Lancet. 2020;395:200\u201311.","journal-title":"Lancet"},{"key":"3720_CR2","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1038\/s41572-019-0069-0","volume":"5","author":"MA Matthay","year":"2019","unstructured":"Matthay MA, Zemans RL, Zimmerman GA, Arabi YM, Beitler JR, Mercat A, Herridge M, Randolph AG, Calfee CS. Acute respiratory distress syndrome. Nat Rev Dis Primers. 2019;5:18.","journal-title":"Nat Rev Dis Primers"},{"key":"3720_CR3","doi-asserted-by":"publisher","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","volume":"2","author":"RS Hotchkiss","year":"2016","unstructured":"Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Sepsis and septic shock. Nat Rev Dis Primers. 2016;2:16045.","journal-title":"Nat Rev Dis Primers"},{"key":"3720_CR4","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","volume":"400","author":"LDJ Bos","year":"2022","unstructured":"Bos LDJ, Ware LB. Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes. Lancet. 2022;400:1145\u201356.","journal-title":"Lancet"},{"key":"3720_CR5","doi-asserted-by":"publisher","first-page":"L709","DOI":"10.1152\/ajplung.00341.2013","volume":"306","author":"NR Aggarwal","year":"2014","unstructured":"Aggarwal NR, King LS, D\u2019Alessio FR. Diverse macrophage populations mediate acute lung inflammation and resolution. Am J Physiol Lung Cell Mol Physiol. 2014;306:L709\u2013725.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3720_CR6","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1056\/NEJMra2026131","volume":"383","author":"DC Fajgenbaum","year":"2020","unstructured":"Fajgenbaum DC, June CH. Cytokine Storm. N Engl J Med. 2020;383:2255\u201373.","journal-title":"N Engl J Med"},{"key":"3720_CR7","doi-asserted-by":"publisher","first-page":"884362","DOI":"10.3389\/fimmu.2022.884362","volume":"13","author":"J Zhang","year":"2022","unstructured":"Zhang J, Zheng Y, Wang Y, Wang J, Sang A, Song X, Li X. YAP1 alleviates sepsis-induced acute lung injury via inhibiting ferritinophagy-mediated ferroptosis. Front Immunol. 2022;13:884362.","journal-title":"Front Immunol"},{"key":"3720_CR8","doi-asserted-by":"publisher","first-page":"e1389","DOI":"10.1002\/ctm2.1389","volume":"13","author":"H Zhang","year":"2023","unstructured":"Zhang H, Wu D, Wang Y, Guo K, Spencer CB, Ortoga L, Qu M, Shi Y, Shao Y, Wang Z, et al. METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury. Clin Transl Med. 2023;13:e1389.","journal-title":"Clin Transl Med"},{"key":"3720_CR9","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS, et al. Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 2012;149:1060\u201372.","journal-title":"Cell"},{"key":"3720_CR10","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","volume":"22","author":"X Jiang","year":"2021","unstructured":"Jiang X, Stockwell BR, Conrad M. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 2021;22:266\u201382.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"3720_CR11","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1146\/annurev-immunol-081619-104850","volume":"38","author":"DG Ryan","year":"2020","unstructured":"Ryan DG, O\u2019Neill LAJ. Krebs Cycle Reborn in Macrophage Immunometabolism. Annu Rev Immunol. 2020;38:289\u2013313.","journal-title":"Annu Rev Immunol"},{"key":"3720_CR12","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/j.celrep.2018.07.065","volume":"24","author":"DS Koenis","year":"2018","unstructured":"Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Evers-van Gogh IJ, Van den Bossche J, Speijer D, Kim Y, et al. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Cell Rep. 2018;24:2127\u2013e21402127.","journal-title":"Cell Rep"},{"key":"3720_CR13","doi-asserted-by":"publisher","first-page":"eabm8161","DOI":"10.1126\/sciimmunol.abm8161","volume":"7","author":"X Chen","year":"2022","unstructured":"Chen X, Sunkel B, Wang M, Kang S, Wang T, Gnanaprakasam JNR, Liu L, Cassel TA, Scott DA, Mu\u00f1oz-Cabello AM, et al. Succinate dehydrogenase\/complex II is critical for metabolic and epigenetic regulation of T cell proliferation and inflammation. Sci Immunol. 2022;7:eabm8161.","journal-title":"Sci Immunol"},{"key":"3720_CR14","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.tcb.2013.11.008","volume":"24","author":"E Mills","year":"2014","unstructured":"Mills E, O\u2019Neill LA. Succinate: a metabolic signal in inflammation. Trends Cell Biol. 2014;24:313\u201320.","journal-title":"Trends Cell Biol"},{"key":"3720_CR15","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","volume":"167","author":"EL Mills","year":"2016","unstructured":"Mills EL, Kelly B, Logan A, Costa ASH, Varma M, Bryant CE, Tourlomousis P, D\u00e4britz JHM, Gottlieb E, Latorre I, et al. Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages. Cell. 2016;167:457\u2013e470413.","journal-title":"Cell"},{"key":"3720_CR16","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1038\/ni.3796","volume":"18","author":"PS Liu","year":"2017","unstructured":"Liu PS, Wang H, Li X, Chao T, Teav T, Christen S, Di Conza G, Cheng WC, Chou CH, Vavakova M, et al. \u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. Nat Immunol. 2017;18:985\u201394.","journal-title":"Nat Immunol"},{"key":"3720_CR17","doi-asserted-by":"publisher","first-page":"5042","DOI":"10.21037\/jtd-21-948","volume":"13","author":"Y Hao","year":"2021","unstructured":"Hao Y, Wang Z, Wang X, Zhan W, Wu D. OGDH is involved in sepsis induced acute lung injury through the MAPK pathway. J Thorac Dis. 2021;13:5042\u201354.","journal-title":"J Thorac Dis"},{"key":"3720_CR18","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41586-019-1577-5","volume":"573","author":"JJ Morris JPt, Yashinskie","year":"2019","unstructured":"Morris JPt, Yashinskie JJ, Koche R, Chandwani R, Tian S, Chen CC, Baslan T, Marinkovic ZS, S\u00e1nchez-Rivera FJ, Leach SD, et al. \u03b1-Ketoglutarate links p53 to cell fate during tumour suppression. Nature. 2019;573:595\u20139.","journal-title":"Nature"},{"key":"3720_CR19","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/s41419-018-0802-8","volume":"9","author":"S Atlante","year":"2018","unstructured":"Atlante S, Visintin A, Marini E, Savoia M, Dianzani C, Giorgis M, S\u00fcr\u00fcn D, Maione F, Schn\u00fctgen F, Farsetti A, et al. \u03b1-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis. Cell Death Dis. 2018;9:756.","journal-title":"Cell Death Dis"},{"key":"3720_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/2049-3002-2-4","volume":"2","author":"SD Stuart","year":"2014","unstructured":"Stuart SD, Schauble A, Gupta S, Kennedy AD, Keppler BR, Bingham PM, Zachar Z. A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process. Cancer Metab. 2014;2:4.","journal-title":"Cancer Metab"},{"key":"3720_CR21","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/S1470-2045(17)30314-5","volume":"18","author":"A Alistar","year":"2017","unstructured":"Alistar A, Morris BB, Desnoyer R, Klepin HD, Hosseinzadeh K, Clark C, Cameron A, Leyendecker J, D\u2019Agostino R Jr., Topaloglu U, et al. Safety and tolerability of the first-in-class agent CPI-613 in combination with modified FOLFIRINOX in patients with metastatic pancreatic cancer: a single-centre, open-label, dose-escalation, phase 1 trial. Lancet Oncol. 2017;18:770\u20138.","journal-title":"Lancet Oncol"},{"key":"3720_CR22","doi-asserted-by":"publisher","first-page":"2060","DOI":"10.1158\/1078-0432.CCR-17-2282","volume":"24","author":"TS Pardee","year":"2018","unstructured":"Pardee TS, Anderson RG, Pladna KM, Isom S, Ghiraldeli LP, Miller LD, Chou JW, Jin G, Zhang W, Ellis LR, et al. A Phase I Study of CPI-613 in Combination with High-Dose Cytarabine and Mitoxantrone for Relapsed or Refractory Acute Myeloid Leukemia. Clin Cancer Res. 2018;24:2060\u201373.","journal-title":"Clin Cancer Res"},{"key":"3720_CR23","doi-asserted-by":"publisher","first-page":"2426","DOI":"10.1002\/1873-3468.12777","volume":"591","author":"A Young","year":"2017","unstructured":"Young A, Gardiner D, Brosnan ME, Brosnan JT, Mailloux RJ. Physiological levels of formate activate mitochondrial superoxide\/hydrogen peroxide release from mouse liver mitochondria. FEBS Lett. 2017;591:2426\u201338.","journal-title":"FEBS Lett"},{"key":"3720_CR24","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.freeradbiomed.2016.06.014","volume":"97","author":"RJ Mailloux","year":"2016","unstructured":"Mailloux RJ, Gardiner D, O\u2019Brien M. 2-Oxoglutarate dehydrogenase is a more significant source of O2(\u00b7-)\/H2O2 than pyruvate dehydrogenase in cardiac and liver tissue. Free Radic Biol Med. 2016;97:501\u201312.","journal-title":"Free Radic Biol Med"},{"key":"3720_CR25","doi-asserted-by":"publisher","unstructured":"Lai K, Song C, Gao M, Deng Y, Lu Z, Li N, et al. Uridine alleviates Sepsis-induced acute lung injury by inhibiting Ferroptosis of macrophage. Int J Mol Sci. 2023;24 (6):5093. https:\/\/doi.org\/10.3390\/ijms24065093.","DOI":"10.3390\/ijms24065093"},{"key":"3720_CR26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1038\/s41420-021-00807-3","volume":"8","author":"R He","year":"2022","unstructured":"He R, Liu B, Xiong R, Geng B, Meng H, Lin W, Hao B, Zhang L, Wang W, Jiang W, et al. Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. Cell Death Discov. 2022;8:43.","journal-title":"Cell Death Discov"},{"key":"3720_CR27","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","volume":"59","author":"M Gao","year":"2015","unstructured":"Gao M, Monian P, Quadri N, Ramasamy R, Jiang X. Glutaminolysis and Transferrin Regulate Ferroptosis. Mol Cell. 2015;59:298\u2013308.","journal-title":"Mol Cell"},{"key":"3720_CR28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","volume":"392","author":"M Cecconi","year":"2018","unstructured":"Cecconi M, Evans L, Levy M, Rhodes A. Sepsis and septic shock. Lancet. 2018;392:75\u201387.","journal-title":"Lancet"},{"key":"3720_CR29","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1164\/rccm.202303-0558WS","volume":"209","author":"MA Matthay","year":"2024","unstructured":"Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, et al. A New Global Definition of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2024;209:37\u201347.","journal-title":"Am J Respir Crit Care Med"},{"key":"3720_CR30","doi-asserted-by":"publisher","first-page":"37252","DOI":"10.1038\/srep37252","volume":"6","author":"S Liu","year":"2016","unstructured":"Liu S, Su X, Pan P, Zhang L, Hu Y, Tan H, Wu D, Liu B, Li H, Li H, et al. Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury. Sci Rep. 2016;6:37252.","journal-title":"Sci Rep"},{"key":"3720_CR31","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.aca.2013.01.015","volume":"768","author":"T Barri","year":"2013","unstructured":"Barri T, Dragsted LO. UPLC-ESI-QTOF\/MS and multivariate data analysis for blood plasma and serum metabolomics: effect of experimental artefacts and anticoagulant. Anal Chim Acta. 2013;768:118\u201328.","journal-title":"Anal Chim Acta"},{"key":"3720_CR32","doi-asserted-by":"publisher","first-page":"e944","DOI":"10.1097\/SLA.0000000000004644","volume":"276","author":"GR Nunns","year":"2022","unstructured":"Nunns GR, Vigneshwar N, Kelher MR, Stettler GR, Gera L, Reisz JA, D\u2019Alessandro A, Ryon J, Hansen KC, Gamboni F, et al. Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS. Ann Surg. 2022;276:e944\u201354.","journal-title":"Ann Surg"},{"key":"3720_CR33","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1097\/SHK.0000000000001333","volume":"53","author":"M Liu","year":"2020","unstructured":"Liu M, Chen Y, Wang S, Zhou H, Feng D, Wei J, Shi X, Wu L, Zhang P, Yang H. Lv X: \u03b1-Ketoglutarate Modulates Macrophage Polarization Through Regulation of PPAR\u03b3 Transcription and mTORC1\/p70S6K Pathway to Ameliorate ALI\/ARDS. Shock. 2020;53:103\u201313.","journal-title":"Shock"},{"key":"3720_CR34","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41556-018-0217-x","volume":"21","author":"J Jung","year":"2019","unstructured":"Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity. Nat Cell Biol. 2019;21:85\u201393.","journal-title":"Nat Cell Biol"},{"key":"3720_CR35","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nature11986","volume":"496","author":"GM Tannahill","year":"2013","unstructured":"Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, et al. Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1. Nature. 2013;496:238\u201342.","journal-title":"Nature"},{"key":"3720_CR36","doi-asserted-by":"publisher","unstructured":"Liu Z, Gan L, Zhang T, Ren Q, Sun C. Melatonin alleviates adipose inflammation through elevating \u03b1-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. J Pineal Res. 2018;64(1). https:\/\/doi.org\/10.1111\/jpi.12455.","DOI":"10.1111\/jpi.12455"},{"key":"3720_CR37","doi-asserted-by":"publisher","first-page":"4373","DOI":"10.1093\/eurheartj\/ehab605","volume":"42","author":"H Cui","year":"2021","unstructured":"Cui H, Chen Y, Li K, Zhan R, Zhao M, Xu Y, Lin Z, Fu Y, He Q, Tang PC, et al. Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection. Eur Heart J. 2021;42:4373\u201385.","journal-title":"Eur Heart J"},{"key":"3720_CR38","doi-asserted-by":"publisher","first-page":"103194","DOI":"10.1016\/j.redox.2024.103194","volume":"74","author":"D Wu","year":"2024","unstructured":"Wu D, Spencer CB, Ortoga L, Zhang H, Miao C. Histone lactylation-regulated METTL3 promotes ferroptosis via m6A-modification on ACSL4 in sepsis-associated lung injury. Redox Biol. 2024;74:103194.","journal-title":"Redox Biol"},{"key":"3720_CR39","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1038\/s41589-019-0462-8","volume":"16","author":"AA Kapralov","year":"2020","unstructured":"Kapralov AA, Yang Q, Dar HH, Tyurina YY, Anthonymuthu TS, Kim R, St Croix CM, Mikulska-Ruminska K, Liu B, Shrivastava IH, et al. Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death. Nat Chem Biol. 2020;16:278\u201390.","journal-title":"Nat Chem Biol"},{"key":"3720_CR40","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","volume":"34","author":"M de la Rojo","year":"2018","unstructured":"de la Rojo M, Chapman E, Zhang DD. NRF2 and the Hallmarks of Cancer. Cancer Cell. 2018;34:21\u201343.","journal-title":"Cancer Cell"},{"key":"3720_CR41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccell.2020.06.001","volume":"38","author":"JD Hayes","year":"2020","unstructured":"Hayes JD, Dinkova-Kostova AT, Tew KD. Oxidative Stress in Cancer. Cancer Cell. 2020;38:167\u201397.","journal-title":"Cancer Cell"},{"key":"3720_CR42","doi-asserted-by":"publisher","first-page":"101107","DOI":"10.1016\/j.redox.2019.101107","volume":"23","author":"M Dodson","year":"2019","unstructured":"Dodson M, Castro-Portuguez R, Zhang DD. NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis. Redox Biol. 2019;23:101107.","journal-title":"Redox Biol"},{"key":"3720_CR43","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1016\/j.molcel.2014.09.025","volume":"56","author":"C Yang","year":"2014","unstructured":"Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, et al. Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport. Mol Cell. 2014;56:414\u201324.","journal-title":"Mol Cell"},{"key":"3720_CR44","doi-asserted-by":"publisher","first-page":"19345","DOI":"10.1073\/pnas.0709747104","volume":"104","author":"RJ DeBerardinis","year":"2007","unstructured":"DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A. 2007;104:19345\u201350.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3720_CR45","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1016\/j.jhep.2019.12.015","volume":"72","author":"W Dai","year":"2020","unstructured":"Dai W, Xu L, Yu X, Zhang G, Guo H, Liu H, Song G, Weng S, Dong L, Zhu J, et al. OGDHL silencing promotes hepatocellular carcinoma by reprogramming glutamine metabolism. J Hepatol. 2020;72:909\u201323.","journal-title":"J Hepatol"},{"key":"3720_CR46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s11658-024-00558-w","volume":"29","author":"S Wu","year":"2024","unstructured":"Wu S, Tang W, Liu L, Wei K, Tang Y, Ma J, Li H, Ao Y. Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation. Cell Mol Biol Lett. 2024;29:36.","journal-title":"Cell Mol Biol Lett"},{"key":"3720_CR47","doi-asserted-by":"publisher","first-page":"10604","DOI":"10.1111\/jcmm.15679","volume":"24","author":"Y Ye","year":"2020","unstructured":"Ye Y, Zhang HW, Mei HX, Xu HR, Xiang SY, Yang Q, Zheng SX, Gao Smith F, Jin SW, Wang Q. PDX regulates inflammatory cell infiltration via resident macrophage in LPS-induced lung injury. J Cell Mol Med. 2020;24:10604\u201314.","journal-title":"J Cell Mol Med"},{"key":"3720_CR48","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/1465-9921-6-61","volume":"6","author":"B Beck-Schimmer","year":"2005","unstructured":"Beck-Schimmer B, Schwendener R, Pasch T, Reyes L, Booy C, Schimmer RC. Alveolar macrophages regulate neutrophil recruitment in endotoxin-induced lung injury. Respir Res. 2005;6:61.","journal-title":"Respir Res"}],"container-title":["Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12931-026-03720-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-026-03720-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12931-026-03720-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:01:31Z","timestamp":1784091691000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12931-026-03720-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,16]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3720"],"URL":"https:\/\/doi.org\/10.1186\/s12931-026-03720-4","relation":{},"ISSN":["1465-993X"],"issn-type":[{"value":"1465-993X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,16]]},"assertion":[{"value":"11 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 May 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All animal experimental procedures were carried out in accordance with the Institutional Ethics and Animal Use Committee of Central South University (CSU-2023-0307). Patients\u2019 written informed consent for publication were obtained and was approved by the Institutional Review Board of Xiangya Hospital (202103115).","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"286"}}