{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:03:29Z","timestamp":1792652609532,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T00:00:00Z","timestamp":1491264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["a Grant-in-Aid (C) for Scientific Research (KAKENHI Grant no. 25462429)"],"award-info":[{"award-number":["a Grant-in-Aid (C) for Scientific Research (KAKENHI Grant no. 25462429)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12933-017-0527-5","type":"journal-article","created":{"date-parts":[[2017,4,4]],"date-time":"2017-04-04T19:01:36Z","timestamp":1491332496000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Glycemia and the cardioprotective effects of insulin pre-conditioning in the isolated rat heart"],"prefix":"10.1186","volume":"16","author":[{"given":"Yosuke","family":"Nakadate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Oguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamaki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadahiko","family":"Ishiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schricker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,4,4]]},"reference":[{"key":"527_CR1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.atherosclerosis.2008.10.029","volume":"204","author":"DJ Hausenloy","year":"2009","unstructured":"Hausenloy DJ, Yellon DM. Preconditioning and postconditioning: underlying mechanisms and clinical application. Atherosclerosis. 2009;204:334\u201341.","journal-title":"Atherosclerosis"},{"key":"527_CR2","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1051\/ject\/200638168","volume":"38","author":"S Najmaii","year":"2006","unstructured":"Najmaii S, Redford D, Larson DF. Hyperglycemia as an effect of cardiopulmonary bypass: intra-operative glucose management. J Extra Corpor Technol. 2006;38:168\u201373.","journal-title":"J Extra Corpor Technol"},{"key":"527_CR3","doi-asserted-by":"publisher","first-page":"536510","DOI":"10.1155\/2014\/536510","volume":"2014","author":"T Sato","year":"2014","unstructured":"Sato T, Sato H, Oguchi T, Fukushima H, Carvalho G, Lattermann R, et al. Insulin preconditioning elevates p-Akt and cardiac contractility after reperfusion in the isolated ischemic rat heart. Biomed Res Int. 2014;2014:536510.","journal-title":"Biomed Res Int"},{"key":"527_CR4","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1097\/ALN.0b013e3181d3d4b4","volume":"112","author":"AE Duncan","year":"2010","unstructured":"Duncan AE, Abd-Elsayed A, Maheshwari A, Xu M, Soltesz E, Koch CG. Role of intraoperative and postoperative blood glucose concentrations in predicting outcomes after cardiac surgery. Anesthesiology. 2010;112:860\u201371.","journal-title":"Anesthesiology"},{"key":"527_CR5","doi-asserted-by":"publisher","first-page":"H601","DOI":"10.1152\/ajpheart.00122.2004","volume":"287","author":"JF LaDisa Jr","year":"2004","unstructured":"LaDisa JF Jr, Krolikowski JG, Pagel PS, Warltier DC, Kersten JR. Cardioprotection by glucose-insulin-potassium: dependence on KATP channel opening and blood glucose concentration before ischemia. Am J Physiol Heart Circ Physiol. 2004;287:H601\u20137.","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"527_CR6","doi-asserted-by":"publisher","first-page":"2067","DOI":"10.1161\/01.CIR.0000034509.14906.AE","volume":"106","author":"K Esposito","year":"2002","unstructured":"Esposito K, Nappo F, Marfella R, Giugliano G, Giugliano F, Ciotola M, et al. Inflammatory cytokine concentrations are acutely increased by hyperglycemia in humans: role of oxidative stress. Circulation. 2002;106:2067\u201372.","journal-title":"Circulation"},{"key":"527_CR7","doi-asserted-by":"publisher","first-page":"1187","DOI":"10.1172\/JCI23506","volume":"114","author":"G Van den Berghe","year":"2004","unstructured":"Van den Berghe G. How does blood glucose control with insulin save lives in intensive care? J Clin Invest. 2004;114:1187\u201395.","journal-title":"J Clin Invest"},{"key":"527_CR8","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1161\/01.CIR.74.5.1124","volume":"74","author":"CE Murry","year":"1986","unstructured":"Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124\u201336.","journal-title":"Circulation"},{"key":"527_CR9","doi-asserted-by":"publisher","first-page":"S86","DOI":"10.1016\/S0168-8227(11)70019-5","volume":"93","author":"F Iliadis","year":"2011","unstructured":"Iliadis F, Kadoglou N, Didangelos T. Insulin and the heart. Diabetes Res Clin Pract. 2011;93:S86\u201391.","journal-title":"Diabetes Res Clin Pract"},{"key":"527_CR10","first-page":"H721","volume":"275","author":"JR Kersten","year":"1998","unstructured":"Kersten JR, Schmeling TJ, Orth KG, Pagel PS, Warltier DC. Acute hyperglycemia abolishes ischemic preconditioning in vivo. Am J Physiol. 1998;275:H721\u20135.","journal-title":"Am J Physiol"},{"key":"527_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1097\/00000542-200201000-00032","volume":"96","author":"F Kehl","year":"2002","unstructured":"Kehl F, Krolikowski JG, Mraovic B, Pagel PS, Warltier DC, Kersten JR. Hyperglycemia prevents isoflurane-induced preconditioning against myocardial infarction. Anesthesiology. 2002;96:183\u20138.","journal-title":"Anesthesiology"},{"key":"527_CR12","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12933-015-0313-1","volume":"14","author":"T Baranyai","year":"2015","unstructured":"Baranyai T, Nagy CT, Koncsos G, On\u00f3di Z, K\u00e1rolyi-Szab\u00f3 M, Makkos A, et al. Acute hyperglycemia abolishes cardioprotection by remote ischemic perconditioning. Cardiovasc Diabetol. 2015;14:151.","journal-title":"Cardiovasc Diabetol"},{"key":"527_CR13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/cvr\/cvu132","volume":"103","author":"Q Yu","year":"2014","unstructured":"Yu Q, Zhou N, Nan Y, Zhang L, Li Y, Hao X, et al. Effective glycaemic control critically determines insulin cardioprotection against ischaemia\/reperfusion injury in anaesthetized dogs. Cardiovasc Res. 2014;103:238\u201347.","journal-title":"Cardiovasc Res"},{"key":"527_CR14","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1161\/01.CIR.104.3.330","volume":"104","author":"T Matsui","year":"2001","unstructured":"Matsui T, Tao J, del Monte F, Lee KH, Li L, Picard M, et al. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001;104:330\u20135.","journal-title":"Circulation"},{"key":"527_CR15","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1093\/cvr\/cvn093","volume":"79","author":"L Bertrand","year":"2008","unstructured":"Bertrand L, Horman S, Beauloye C, Vanoverschelde JL. Insulin signaling in the heart. Cardiovasc Res. 2008;79:238\u201348.","journal-title":"Cardiovasc Res"},{"key":"527_CR16","doi-asserted-by":"publisher","first-page":"E629","DOI":"10.1152\/ajpendo.00221.2007","volume":"293","author":"H Su","year":"2007","unstructured":"Su H, Sun X, Ma H, Zhang HF, Yu QJ, Huang C, et al. Acute hyperglycemia exacerbates myocardial ischemia\/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab. 2007;293:E629\u201335.","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"527_CR17","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1016\/S0140-6736(09)60553-5","volume":"373","author":"KM Dungan","year":"2009","unstructured":"Dungan KM, Braithwaite SS, Preiser JC. Stress hyperglycaemia. Lancet. 2009;373:1798\u2013807.","journal-title":"Lancet"},{"key":"527_CR18","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.bpa.2009.08.005","volume":"23","author":"SJ Van Cromphaut","year":"2009","unstructured":"Van Cromphaut SJ. Hyperglycaemia as part of the stress response: the underlying mechanisms. Best Pract Res Clin Anaesthesiol. 2009;23:375\u201386.","journal-title":"Best Pract Res Clin Anaesthesiol"},{"key":"527_CR19","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s10741-010-9180-8","volume":"16","author":"P Kleinbongard","year":"2011","unstructured":"Kleinbongard P, Schulz R, Heusch G. TNFalpha in myocardial ischemia\/reperfusion, remodeling and heart failure. Heart Fail Rev. 2011;16:49\u201369.","journal-title":"Heart Fail Rev"},{"key":"527_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ijcard.2013.11.035","volume":"171","author":"JA Povlsen","year":"2014","unstructured":"Povlsen JA, Lofgren B, Dalgas C, Jespersen NR, Johnsen J, Botker HE. Frequent biomarker analysis in the isolated perfused heart reveals two distinct phases of reperfusion injury. Int J Cardiol. 2014;171:9\u201314.","journal-title":"Int J Cardiol"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-017-0527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12933-017-0527-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-017-0527-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:21:24Z","timestamp":1692750084000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-017-0527-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,4]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["527"],"URL":"https:\/\/doi.org\/10.1186\/s12933-017-0527-5","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,4]]},"assertion":[{"value":"12 August 2016","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 March 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"43"}}