{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:19:11Z","timestamp":1793999951464,"version":"4.8.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No.H0517\/81560132"],"award-info":[{"award-number":["No.H0517\/81560132"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12933-017-0547-1","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T11:44:37Z","timestamp":1494935077000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["SGLT2 inhibitors: a novel choice for the combination therapy in diabetic kidney disease"],"prefix":"10.1186","volume":"16","author":[{"given":"Honghong","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoqin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaosi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"547_CR1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1007\/s00125-012-2534-0","volume":"55","author":"SE Inzucchi","year":"2012","unstructured":"Inzucchi SE, Bergenstal RM, Buse JB, Diamant M, Ferrannini E, Nauck M, et al. Management of hyperglycaemia in type 2 diabetes: a patient-centered approach. Position statement of the American Diabetes Association (ADA) and the European Association for the study of diabetes (EASD). Diabetologia. 2012;55:1577\u201396.","journal-title":"Diabetologia"},{"key":"547_CR2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.HYP.0000240331.32352.0c","volume":"48","author":"S Giunti","year":"2006","unstructured":"Giunti S, Barit D, Cooper ME. Mechanisms of diabetic nephropathy: role of hypertension. Hypertension. 2006;48:519\u201326.","journal-title":"Hypertension"},{"key":"547_CR3","doi-asserted-by":"crossref","first-page":"602","DOI":"10.7326\/0003-4819-154-9-201105030-00336","volume":"154","author":"WL Bennett","year":"2011","unstructured":"Bennett WL, Maruthur NM, Singh S, Segal JB, Wilson LM, Chatterjee R, et al. Comparative effectiveness and safety of medications for type 2 diabetes: an update including new drugs and 2-drug combinations. Ann Int Med. 2011;154:602\u201313.","journal-title":"Ann Int Med"},{"key":"547_CR4","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.tem.2016.07.002","volume":"27","author":"L Gnudi","year":"2016","unstructured":"Gnudi L, Coward RJ, Long DA. Diabetic nephropathy: perspective on novel molecular mechanisms. Trends Endocrinol Metab. 2016;27:820\u201330.","journal-title":"Trends Endocrinol Metab"},{"key":"547_CR5","doi-asserted-by":"publisher","DOI":"10.2174\/1381612823666170307103222","author":"M Elisaf","year":"2017","unstructured":"Elisaf M, Tzavela E, Karanatsis N, Tsimichodimos V. Antidiabetic drugs and the kidney. Curr Pharm Des. 2017. doi:\n                        10.2174\/1381612823666170307103222\n                        \n                    .","journal-title":"Curr Pharm Des."},{"key":"547_CR6","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12484","author":"W Yang","year":"2016","unstructured":"Yang W, Ji L, Zhou Z, Cain VA, Johnsson KM, Sjostrom CD. Efficacy and safety of dapagliflozin in Asian patients: a pooled analysis. J Diabetes. 2016. doi:\n                        10.1111\/1753-0407.12484\n                        \n                    .","journal-title":"J Diabetes"},{"key":"547_CR7","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1464-5491.2009.02894.x","volume":"27","author":"JE Gerich","year":"2010","unstructured":"Gerich JE. Role of the kidney in normal glucose homeostasis and in the hyperglycaemia of diabetes mellitus: therapeutic implications. Diabet Med. 2010;27:136\u201342.","journal-title":"Diabet Med"},{"key":"547_CR8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00424-003-1202-0","volume":"447","author":"EM Wright","year":"2004","unstructured":"Wright EM, Turk E. The sodium\/glucose cotransport family SLC5. Pflugers Arch. 2004;447:510\u20138.","journal-title":"Pflugers Arch"},{"key":"547_CR9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1463-1326.2011.01511.x","volume":"14","author":"RA DeFronzo","year":"2012","unstructured":"DeFronzo RA, Davidson JA, Del PS. The role of the kidneys in glucose homeostasis: a new path towards normalizing glycaemia. Diabetes Obes Metab. 2012;14:5\u201314.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2010.11.011","volume":"32","author":"CJ Bailey","year":"2011","unstructured":"Bailey CJ. Renal glucose reabsorption inhibitors to treat diabetes. Trends Pharmacol Sci. 2011;32:63\u201371.","journal-title":"Trends Pharmacol Sci"},{"key":"547_CR11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1210\/er.2010-0029","volume":"32","author":"MA Abdul-Ghani","year":"2011","unstructured":"Abdul-Ghani MA, Norton L, Defronzo RA. Role of Sodium\u2013glucose cotransporter 2 (SGLT 2) inhibitors in the treatment of type 2 diabetes. Endocr Rev. 2011;32:515\u201331.","journal-title":"Endocr Rev"},{"key":"547_CR12","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1172\/JCI70704","volume":"124","author":"A Merovci","year":"2014","unstructured":"Merovci A, Solis-Herrera C, Daniele G, Eldor R, Fiorentino TV, Tripathy D, et al. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production. J Clin Invest. 2014;124:509\u201314.","journal-title":"J Clin Invest"},{"key":"547_CR13","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2337\/diab.26.5.445","volume":"26","author":"RA DeFronzo","year":"1977","unstructured":"DeFronzo RA, Andres R, Bedsoe TA, Boden G, Faloona GA, Tobin JD. A test of the hypothesis that the rate of fall in glucose concentration triggers counterregulatory hormonal responses in man. Diabetes. 1977;26:445\u201352.","journal-title":"Diabetes"},{"key":"547_CR14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/dmr.5610030204","volume":"3","author":"RA DeFronzo","year":"1987","unstructured":"DeFronzo RA, Ferrannini E. Regulation of hepatic glucose metabolism in humans. Diabetes Metab Rev. 1987;3:415\u201359.","journal-title":"Diabetes Metab Rev"},{"issue":"48","key":"547_CR15","first-page":"1198","volume":"1999","author":"AD Cherrington","year":"1997","unstructured":"Cherrington AD, Lecture B. Control of glucose uptake and release by the liver in vivo. Diabetes. 1997;1999(48):1198\u2013214.","journal-title":"Diabetes"},{"key":"547_CR16","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1053\/meta.2002.34700","volume":"51","author":"M Matsuda","year":"2002","unstructured":"Matsuda M, Defronzo RA, Glass L, Consoli A, Giordano M, Bressler P, et al. Glucagon dose-response curve for hepatic glucose production and glucose disposal in type 2 diabetic patients and normal individuals. Metabolism. 2002;51:1111\u20139.","journal-title":"Metabolism"},{"key":"547_CR17","first-page":"e165703","volume":"11","author":"SJ Shin","year":"2016","unstructured":"Shin SJ, Chung S, Kim SJ, Lee EM, Yoo YH, Kim JW, et al. Effect of Sodium\u2013glucose co-transporter 2 inhibitor, dapagliflozin, on renal renin\u2013angiotensin system in an animal model of type 2 diabetes. PLoS ONE. 2016;11:e165703.","journal-title":"PLoS ONE"},{"key":"547_CR18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1161\/CIRCULATIONAHA.113.005081","volume":"129","author":"DZ Cherney","year":"2014","unstructured":"Cherney DZ, Perkins BA, Soleymanlou N, Maione M, Lai V, Lee A, et al. Renal hemodynamic effect of Sodium\u2013glucose cotransporter 2 inhibition in patients with type 1 diabetes mellitus. Circulation. 2014;129:587\u201397.","journal-title":"Circulation"},{"key":"547_CR19","doi-asserted-by":"crossref","first-page":"F194","DOI":"10.1152\/ajprenal.00520.2013","volume":"306","author":"V Vallon","year":"2014","unstructured":"Vallon V, Gerasimova M, Rose MA, Masuda T, Satriano J, Mayoux E, et al. SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice. Am J Physiol Renal Physiol. 2014;306:F194\u2013204.","journal-title":"Am J Physiol Renal Physiol"},{"key":"547_CR20","doi-asserted-by":"crossref","first-page":"R1009","DOI":"10.1152\/ajpregu.00809.2010","volume":"300","author":"V Vallon","year":"2011","unstructured":"Vallon V. The proximal tubule in the pathophysiology of the diabetic kidney. Am J Physiol Regul Integr Comp Physiol. 2011;300:R1009\u201322.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"547_CR21","doi-asserted-by":"crossref","first-page":"e54442","DOI":"10.1371\/journal.pone.0054442","volume":"8","author":"U Panchapakesan","year":"2013","unstructured":"Panchapakesan U, Pegg K, Gross S, Komala MG, Mudaliar H, Forbes J, et al. Effects of SGLT2 inhibition in human kidney proximal tubular cells\u2013renoprotection in diabetic nephropathy? PLoS ONE. 2013;8:e54442.","journal-title":"PLoS ONE"},{"key":"547_CR22","first-page":"e158810","volume":"11","author":"YK Chang","year":"2016","unstructured":"Chang YK, Choi H, Jeong JY, Na KR, Lee KW, Lim BJ, et al. Dapagliflozin, SGLT2 inhibitor, attenuates renal ischemia\u2013reperfusion injury. PLoS ONE. 2016;11:e158810.","journal-title":"PLoS ONE"},{"key":"547_CR23","first-page":"212262","volume":"3","author":"JJ Neumiller","year":"2014","unstructured":"Neumiller JJ. Empagliflozin: a new Sodium\u2013glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. Drugs Context. 2014;3:212262.","journal-title":"Drugs Context"},{"key":"547_CR24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/2042018816676239","volume":"7","author":"V Andrianesis","year":"2016","unstructured":"Andrianesis V, Glykofridi S, Doupis J. The renal effects of SGLT2 inhibitors and a mini-review of the literature. Ther Adv Endocrinol Metab. 2016;7:212\u201328.","journal-title":"Ther Adv Endocrinol Metab"},{"key":"547_CR25","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/s11906-015-0551-3","volume":"17","author":"JA Lovshin","year":"2015","unstructured":"Lovshin JA, Gilbert RE. Are SGLT2 inhibitors reasonable antihypertensive drugs and renoprotective? Curr Hypertens Rep. 2015;17:551.","journal-title":"Curr Hypertens Rep"},{"key":"547_CR26","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/j.ajkd.2014.02.010","volume":"64","author":"L Nicola De","year":"2014","unstructured":"De Nicola L, Gabbai FB, Liberti ME, Sagliocca A, Conte G, Minutolo R. Sodium\/glucose cotransporter 2 inhibitors and prevention of diabetic nephropathy: targeting the renal tubule in diabetes. Am J Kidney Dis. 2014;64:16\u201324.","journal-title":"Am J Kidney Dis"},{"key":"547_CR27","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/2042018814544153","volume":"5","author":"MC Thomas","year":"2014","unstructured":"Thomas MC. Renal effects of dapagliflozin in patients with type 2 diabetes. Ther Adv Endocrinol Metab. 2014;5:53\u201361.","journal-title":"Ther Adv Endocrinol Metab"},{"key":"547_CR28","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ki.2013.356","volume":"85","author":"DE Kohan","year":"2014","unstructured":"Kohan DE, Fioretto P, Tang W, List JF. Long-term study of patients with type 2 diabetes and moderate renal impairment shows that dapagliflozin reduces weight and blood pressure but does not improve glycemic control. Kidney Int. 2014;85:962\u201371.","journal-title":"Kidney Int"},{"key":"547_CR29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1111\/dom.12054","volume":"15","author":"K Stenlof","year":"2013","unstructured":"Stenlof K, Cefalu WT, Kim KA, Alba M, Usiskin K, Tong C, et al. Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exercise. Diabetes Obes Metab. 2013;15:372\u201382.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR30","doi-asserted-by":"crossref","first-page":"844","DOI":"10.14740\/jocmr2760w","volume":"8","author":"M Sano","year":"2016","unstructured":"Sano M, Takei M, Shiraishi Y, Suzuki Y. Increased hematocrit during Sodium\u2013glucose cotransporter 2 inhibitor therapy indicates recovery of tubulointerstitial function in diabetic kidneys. J Clin Med Res. 2016;8:844\u20137.","journal-title":"J Clin Med Res"},{"key":"547_CR31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/dom.12090","volume":"15","author":"JF Yale","year":"2013","unstructured":"Yale JF, Bakris G, Cariou B, Yue D, David-Neto E, Xi L, et al. Efficacy and safety of canagliflozin in subjects with type 2 diabetes and chronic kidney disease. Diabetes Obes Metab. 2013;15:463\u201373.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR32","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1097\/01.ASN.0000051700.07403.27","volume":"14","author":"V Vallon","year":"2003","unstructured":"Vallon V, Blantz RC, Thomson S. Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view. J Am Soc Nephrol. 2003;14:530\u20137.","journal-title":"J Am Soc Nephrol"},{"key":"547_CR33","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12933-015-0204-5","volume":"14","author":"SL Cea","year":"2015","unstructured":"Cea SL, Johansson S, Stefansson B, Rodriguez LA. Cardiovascular events and all-cause mortality in a cohort of 57,946 patients with type 2 diabetes: associations with renal function and cardiovascular risk factors. Cardiovasc Diabetol. 2015;14:38.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR34","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1093\/eurheartj\/ehv239","volume":"36","author":"E Ferrannini","year":"2015","unstructured":"Ferrannini E, DeFronzo RA. Impact of glucose-lowering drugs on cardiovascular disease in type 2 diabetes. Eur Heart J. 2015;36:2288\u201396.","journal-title":"Eur Heart J"},{"key":"547_CR35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12933-016-0431-4","volume":"15","author":"A Avogaro","year":"2016","unstructured":"Avogaro A, Fadini GP, Sesti G, Bonora E, Del PS. Continued efforts to translate diabetes cardiovascular outcome trials into clinical practice. Cardiovasc Diabetol. 2016;15:111.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR36","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","volume":"373","author":"B Zinman","year":"2015","unstructured":"Zinman B, Wanner C, Lachin JM, Fitchett D, Bluhmki E, Hantel S, et al. Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabetes. N Engl J Med. 2015;373:2117\u201328.","journal-title":"N Engl J Med"},{"key":"547_CR37","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1093\/eurheartj\/ehv728","volume":"37","author":"D Fitchett","year":"2016","unstructured":"Fitchett D, Zinman B, Wanner C, Lachin JM, Hantel S, Salsali A, et al. Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME(R) trial. Eur Heart J. 2016;37:1526\u201334.","journal-title":"Eur Heart J"},{"key":"547_CR38","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1056\/NEJMoa1515920","volume":"375","author":"C Wanner","year":"2016","unstructured":"Wanner C, Inzucchi SE, Lachin JM, Fitchett D, von Eynatten M, Mattheus M, et al. Empagliflozin and progression of kidney disease in type 2 diabetes. N Engl J Med. 2016;375:323\u201334.","journal-title":"N Engl J Med"},{"key":"547_CR39","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12933-016-0356-y","volume":"15","author":"C Sonesson","year":"2016","unstructured":"Sonesson C, Johansson PA, Johnsson E, Gause-Nilsson I. Cardiovascular effects of dapagliflozin in patients with type 2 diabetes and different risk categories: a meta-analysis. Cardiovasc Diabetol. 2016;15:37.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR40","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jdi.12266","volume":"6","author":"N Inagaki","year":"2015","unstructured":"Inagaki N, Kondo K, Yoshinari T, Kuki H. Efficacy and safety of canagliflozin alone or as add-on to other oral antihyperglycemic drugs in Japanese patients with type 2 diabetes: a 52-week open-label study. J Diabetes Investig. 2015;6:210\u20138.","journal-title":"J Diabetes Investig"},{"key":"547_CR41","first-page":"155","volume":"9","author":"KS Hershon","year":"2016","unstructured":"Hershon KS. Options for empagliflozin in combination therapy in type 2 diabetes mellitus. Int J Gen Med. 2016;9:155\u201372.","journal-title":"Int J Gen Med"},{"key":"547_CR42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1681\/ASN.2016060650","volume":"28","author":"IH Boer de","year":"2017","unstructured":"de Boer IH, Kahn SE. SGLT2 inhibitors-sweet success for diabetic kidney disease? J Am Soc Nephrol. 2017;28:7\u201310.","journal-title":"J Am Soc Nephrol"},{"key":"547_CR43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12933-016-0365-x","volume":"15","author":"LS Wu","year":"2016","unstructured":"Wu LS, Chang SH, Chang GJ, Liu JR, Chan YH, Lee HF, et al. A comparison between angiotensin converting enzyme inhibitors and angiotensin receptor blockers on end stage renal disease and major adverse cardiovascular events in diabetic patients: a population-based dynamic cohort study in Taiwan. Cardiovasc Diabetol. 2016;15:56.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.tem.2004.03.001","volume":"15","author":"LM Burrell","year":"2004","unstructured":"Burrell LM, Johnston CI, Tikellis C, Cooper ME. ACE2, a new regulator of the renin\u2013angiotensin system. Trends Endocrinol Metab. 2004;15:166\u20139.","journal-title":"Trends Endocrinol Metab"},{"key":"547_CR45","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/CIRCULATIONAHA.113.007071","volume":"129","author":"RC Stanton","year":"2014","unstructured":"Stanton RC. Sodium glucose transport 2 (SGLT2) inhibition decreases glomerular hyperfiltration: is there a role for SGLT2 inhibitors in diabetic kidney disease? Circulation. 2014;129:542\u20134.","journal-title":"Circulation"},{"key":"547_CR46","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1152\/ajprenal.00113.2003","volume":"286","author":"R Bautista","year":"2004","unstructured":"Bautista R, Manning R, Martinez F, Avila-Casado MC, Soto V, Medina A, et al. Angiotensin II-dependent increased expression of Na+-glucose cotransporter in hypertension. Am J Physiol Renal Physiol. 2004;286:F127\u201333.","journal-title":"Am J Physiol Renal Physiol"},{"key":"547_CR47","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1124\/jpet.113.203869","volume":"345","author":"N Kojima","year":"2013","unstructured":"Kojima N, Williams JM, Takahashi T, Miyata N, Roman RJ. Effects of a new SGLT2 inhibitor, luseogliflozin, on diabetic nephropathy in T2DN rats. J Pharmacol Exp Ther. 2013;345:464\u201372.","journal-title":"J Pharmacol Exp Ther"},{"key":"547_CR48","doi-asserted-by":"crossref","first-page":"E12436","DOI":"10.14814\/phy2.12436","volume":"3","author":"N Kojima","year":"2015","unstructured":"Kojima N, Williams JM, Slaughter TN, Kato S, Takahashi T, Miyata N, et al. Renoprotective effects of combined SGLT2 and ACE inhibitor therapy in diabetic Dahl S rats. Physiol Rep. 2015;3:E12436.","journal-title":"Physiol Rep"},{"key":"547_CR49","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/dom.12654","volume":"18","author":"HJ Heerspink","year":"2016","unstructured":"Heerspink HJ, Johnsson E, Gause-Nilsson I, Cain VA, Sjostrom CD. Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin\u2013angiotensin blockers. Diabetes Obes Metab. 2016;18:590\u20137.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR50","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3109\/08037051.2015.1116258","volume":"25","author":"MA Weber","year":"2016","unstructured":"Weber MA, Mansfield TA, Alessi F, Iqbal N, Parikh S, Ptaszynska A. Effects of dapagliflozin on blood pressure in hypertensive diabetic patients on renin\u2013angiotensin system blockade. Blood Press. 2016;25:93\u2013103.","journal-title":"Blood Press"},{"key":"547_CR51","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S2213-8587(15)00417-9","volume":"4","author":"MA Weber","year":"2016","unstructured":"Weber MA, Mansfield TA, Cain VA, Iqbal N, Parikh S, Ptaszynska A. Blood pressure and glycaemic effects of dapagliflozin versus placebo in patients with type 2 diabetes on combination antihypertensive therapy: a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Diabetes Endocrinol. 2016;4:211\u201320.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"547_CR52","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/dom.12322","volume":"16","author":"S Sha","year":"2014","unstructured":"Sha S, Polidori D, Heise T, Natarajan J, Farrell K, Wang SS, et al. Effect of the sodium glucose co-transporter 2 inhibitor canagliflozin on plasma volume in patients with type 2 diabetes mellitus. Diabetes Obes Metab. 2014;16:1087\u201395.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1517\/14740338.2015.1006625","volume":"14","author":"AJ Scheen","year":"2015","unstructured":"Scheen AJ. Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opin Drug Saf. 2015;14:505\u201324.","journal-title":"Expert Opin Drug Saf"},{"key":"547_CR54","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12933-016-0396-3","volume":"15","author":"M Sagara","year":"2016","unstructured":"Sagara M, Suzuki K, Aoki C, Tanaka S, Taguchi I, Inoue T, et al. Impact of teneligliptin on oxidative stress and endothelial function in type 2 diabetes patients with chronic kidney disease: a case-control study. Cardiovasc Diabetol. 2016;15:76.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR55","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2337\/diab.30.12.1000","volume":"30","author":"RA DeFronzo","year":"1981","unstructured":"DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes. 1981;30:1000\u20137.","journal-title":"Diabetes"},{"key":"547_CR56","doi-asserted-by":"crossref","first-page":"384","DOI":"10.2337\/dc14-2364","volume":"38","author":"RA DeFronzo","year":"2015","unstructured":"DeFronzo RA, Lewin A, Patel S, Liu D, Kaste R, Woerle HJ, et al. Combination of empagliflozin and linagliptin as second-line therapy in subjects with type 2 diabetes inadequately controlled on metformin. Diabetes Care. 2015;38:384\u201393.","journal-title":"Diabetes Care"},{"key":"547_CR57","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.4158\/EP14489.OR","volume":"20","author":"L Hansen","year":"2014","unstructured":"Hansen L, Iqbal N, Ekholm E, Cook W, Hirshberg B. Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy. Endocr Pract. 2014;20:1187\u201397.","journal-title":"Endocr Pract"},{"key":"547_CR58","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s12325-012-0055-3","volume":"29","author":"T Brand","year":"2012","unstructured":"Brand T, Macha S, Mattheus M, Pinnetti S, Woerle HJ. Pharmacokinetics of empagliflozin, a sodium glucose cotransporter-2 (SGLT-2) inhibitor, coadministered with sitagliptin in healthy volunteers. Adv Ther. 2012;29:889\u201399.","journal-title":"Adv Ther"},{"key":"547_CR59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1210\/jc.2011-1508","volume":"97","author":"A Chaudhuri","year":"2012","unstructured":"Chaudhuri A, Ghanim H, Vora M, Sia CL, Korzeniewski K, Dhindsa S, et al. Exenatide exerts a potent antiinflammatory effect. J Clin Endocrinol Metab. 2012;97:198\u2013207.","journal-title":"J Clin Endocrinol Metab"},{"key":"547_CR60","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1210\/jc.2008-2534","volume":"94","author":"RB Goldberg","year":"2009","unstructured":"Goldberg RB. Cytokine and cytokine-like inflammation markers, endothelial dysfunction, and imbalanced coagulation in development of diabetes and its complications. J Clin Endocrinol Metab. 2009;94:3171\u201382.","journal-title":"J Clin Endocrinol Metab"},{"key":"547_CR61","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s12933-015-0194-3","volume":"14","author":"X Zhou","year":"2015","unstructured":"Zhou X, Huang CH, Lao J, Pocai A, Forrest G, Price O, et al. Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats. Cardiovasc Diabetol. 2015;14:29.","journal-title":"Cardiovasc Diabetol"},{"key":"547_CR62","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.2337\/dc15-0355","volume":"38","author":"G Ferrannini","year":"2015","unstructured":"Ferrannini G, Hach T, Crowe S, Sanghvi A, Hall KD, Ferrannini E. Energy balance after Sodium\u2013glucose cotransporter 2 inhibition. Diabetes Care. 2015;38:1730\u20135.","journal-title":"Diabetes Care"},{"key":"547_CR63","first-page":"161","volume":"9","author":"S Bhavsar","year":"2013","unstructured":"Bhavsar S, Mudaliar S, Cherrington A. Evolution of exenatide as a diabetes therapeutic. Curr Diabetes Rev. 2013;9:161\u201393.","journal-title":"Curr Diabetes Rev"},{"key":"547_CR64","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/dom.12779","volume":"19","author":"P Lundkvist","year":"2017","unstructured":"Lundkvist P, Sjostrom CD, Amini S, Pereira MJ, Johnsson E, Eriksson JW. Dapagliflozin once-daily and exenatide once-weekly dual therapy: a 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes. Diabetes Obes Metab. 2017;19:49\u201360.","journal-title":"Diabetes Obes Metab"},{"key":"547_CR65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.numecd.2016.11.007","volume":"27","author":"JJ Gorgojo-Martinez","year":"2017","unstructured":"Gorgojo-Martinez JJ, Serrano-Moreno C, Sanz-Velasco A, Feo-Ortega G, Almodovar-Ruiz F. Real-world effectiveness and safety of dapagliflozin therapy added to a GLP1 receptor agonist in patients with type 2 diabetes. Nutr Metab Cardiovasc Dis. 2017;27:129\u201337.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"547_CR66","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejphar.2008.06.019","volume":"589","author":"M Taira","year":"2008","unstructured":"Taira M, Toba H, Murakami M, Iga I, Serizawa R, Murata S, et al. Spironolactone exhibits direct renoprotective effects and inhibits renal renin\u2013angiotensin\u2013aldosterone system in diabetic rats. Eur J Pharmacol. 2008;589:264\u201371.","journal-title":"Eur J Pharmacol"},{"key":"547_CR67","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.metabol.2016.06.001","volume":"65","author":"P Yang","year":"2016","unstructured":"Yang P, Huang T, Xu G. The novel mineralocorticoid receptor antagonist finerenone in diabetic kidney disease: progress and challenges. Metabolism. 2016;65:1342\u20139.","journal-title":"Metabolism"},{"key":"547_CR68","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s13300-015-0150-y","volume":"7","author":"Y Yavin","year":"2016","unstructured":"Yavin Y, Mansfield TA, Ptaszynska A, Johnsson K, Parikh S, Johnsson E. Effect of the SGLT2 inhibitor dapagliflozin on potassium levels in patients with type 2 diabetes mellitus: a pooled analysis. Diabetes Ther. 2016;7:125\u201337.","journal-title":"Diabetes Ther"},{"key":"547_CR69","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1111\/ijcp.12322","volume":"67","author":"JP Wilding","year":"2013","unstructured":"Wilding JP, Charpentier G, Hollander P, Gonzalez-Galvez G, Mathieu C, Vercruysse F, et al. Efficacy and safety of canagliflozin in patients with type 2 diabetes mellitus inadequately controlled with metformin and sulphonylurea: a randomised trial. Int J Clin Pract. 2013;67:1267\u201382.","journal-title":"Int J Clin Pract"},{"key":"547_CR70","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.2147\/DDDT.S50773","volume":"8","author":"MA Nauck","year":"2014","unstructured":"Nauck MA. Update on developments with SGLT2 inhibitors in the management of type 2 diabetes. Drug Des Devel Ther. 2014;8:1335\u201380.","journal-title":"Drug Des Devel Ther"}],"updated-by":[{"DOI":"10.1186\/s12933-018-0676-1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,3,9]],"date-time":"2018-03-09T00:00:00Z","timestamp":1520553600000}}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-017-0547-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T11:44:57Z","timestamp":1494935097000},"score":1,"resource":{"primary":{"URL":"http:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-017-0547-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,16]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["547"],"URL":"https:\/\/doi.org\/10.1186\/s12933-017-0547-1","relation":{"correction":[{"id-type":"doi","id":"10.1186\/s12933-018-0676-1","asserted-by":"object"}]},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,16]]},"article-number":"65"}}