{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:35:29Z","timestamp":1787020529644,"version":"build-2736575974"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100000265","name":"The UK Medical Research Council","doi-asserted-by":"crossref","award":["K013351"],"award-info":[{"award-number":["K013351"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"crossref"}]},{"name":"British Heart Foundation and the US National Institutes of Health","award":["R01HL36310"],"award-info":[{"award-number":["R01HL36310"]}]},{"name":"British Heart Foundation and the US National Institutes of Health","award":["R01AG013196"],"award-info":[{"award-number":["R01AG013196"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1186\/s12933-017-0634-3","type":"journal-article","created":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T05:36:34Z","timestamp":1512106594000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Adiponectin, biomarkers of inflammation and changes in cardiac autonomic function: Whitehall II study"],"prefix":"10.1186","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-3476","authenticated-orcid":false,"given":"Christian Stevns","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Vistisen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marit Eika","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Brunner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam G.","family":"Tab\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"Kivim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Herder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,1]]},"reference":[{"key":"634_CR1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2337\/dc16-2042","volume":"40","author":"R Pop-Busui","year":"2017","unstructured":"Pop-Busui R, Boulton AJ, Feldman EL, Bril V, Freeman R, Malik RA, Sosenko JM, Ziegler D. Diabetic Neuropathy: a position statement by the American Diabetes Association. Diabetes Care. 2017;40:136\u201354.","journal-title":"Diabetes Care"},{"key":"634_CR2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrendo.2011.113","volume":"7","author":"N Papanas","year":"2011","unstructured":"Papanas N, Vinik AI, Ziegler D. Neuropathy in prediabetes: does the clock start ticking early? Nat Rev Endocrinol. 2011;7:682\u201390.","journal-title":"Nat Rev Endocrinol"},{"key":"634_CR3","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","volume":"33","author":"S Tesfaye","year":"2010","unstructured":"Tesfaye S, Boulton AJ, Dyck PJ, Freeman R, Horowitz M, Kempler P, Lauria G, Malik RA, Spallone V, Vinik A, et al. Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments. Diabetes Care. 2010;33:2285\u201393.","journal-title":"Diabetes Care"},{"key":"634_CR4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0168-8227(02)00128-6","volume":"58","author":"SG Wheeler","year":"2002","unstructured":"Wheeler SG, Ahroni JH, Boyko EJ. Prospective study of autonomic neuropathy as a predictor of mortality in patients with diabetes. Diabetes Res Clin Pract. 2002;58:131\u20138.","journal-title":"Diabetes Res Clin Pract"},{"key":"634_CR5","doi-asserted-by":"crossref","first-page":"556","DOI":"10.2337\/dc07-1615","volume":"31","author":"D Ziegler","year":"2008","unstructured":"Ziegler D, Zentai CP, Perz S, Rathmann W, Haastert B, Doring A, Meisinger C. Prediction of mortality using measures of cardiac autonomic dysfunction in the diabetic and nondiabetic population: the MONICA\/KORA Augsburg Cohort Study. Diabetes Care. 2008;31:556\u201361.","journal-title":"Diabetes Care"},{"key":"634_CR6","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1007\/s00125-015-3534-7","volume":"58","author":"D Ziegler","year":"2015","unstructured":"Ziegler D, Voss A, Rathmann W, Strom A, Perz S, Roden M, Peters A, Meisinger C. Increased prevalence of cardiac autonomic dysfunction at different degrees of glucose intolerance in the general population: the KORA S4 survey. Diabetologia. 2015;58:1118\u201328.","journal-title":"Diabetologia"},{"key":"634_CR7","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/j.psyneuen.2008.08.007","volume":"33","author":"A Haensel","year":"2008","unstructured":"Haensel A, Mills PJ, Nelesen RA, Ziegler MG, Dimsdale JE. The relationship between heart rate variability and inflammatory markers in cardiovascular diseases. Psychoneuroendocrinology. 2008;33:1305\u201312.","journal-title":"Psychoneuroendocrinology"},{"key":"634_CR8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jdi.12042","volume":"4","author":"AI Vinik","year":"2013","unstructured":"Vinik AI, Erbas T, Casellini CM. Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. J Diabetes Investig. 2013;4:4\u201318.","journal-title":"J Diabetes Investig"},{"key":"634_CR9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molmet.2013.04.001","volume":"2","author":"R Ye","year":"2013","unstructured":"Ye R, Scherer PE. Adiponectin, driver or passenger on the road to insulin sensitivity? Mol Metab. 2013;2:133\u201341.","journal-title":"Mol Metab"},{"key":"634_CR10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1475-2840-11-24","volume":"11","author":"CH Jung","year":"2012","unstructured":"Jung CH, Kim BY, Kim CH, Kang SK, Jung SH, Mok JO. Association of serum adipocytokine levels with cardiac autonomic neuropathy in type 2 diabetic patients. Cardiovasc Diabetol. 2012;11:24.","journal-title":"Cardiovasc Diabetol"},{"key":"634_CR11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/heartjnl-2015-309181","volume":"103","author":"C Herder","year":"2017","unstructured":"Herder C, Schamarek I, Nowotny B, Carstensen-Kirberg M, Strassburger K, Nowotny P, Kannenberg JM, Strom A, Puttgen S, Mussig K, et al. Inflammatory markers are associated with cardiac autonomic dysfunction in recent-onset type 2 diabetes. Heart. 2017;103:63\u201370.","journal-title":"Heart"},{"key":"634_CR12","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1161\/CIRCULATIONAHA.117.028307","volume":"135","author":"N Sattar","year":"2017","unstructured":"Sattar N, Preiss D. Reverse causality in cardiovascular epidemiological research: more common than imagined? Circulation. 2017;135:2369\u201372.","journal-title":"Circulation"},{"key":"634_CR13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ije\/dyh372","volume":"34","author":"M Marmot","year":"2005","unstructured":"Marmot M, Brunner E. Cohort profile: the Whitehall II study. Int J Epidemiol. 2005;34:251\u20136.","journal-title":"Int J Epidemiol"},{"key":"634_CR14","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2337\/db09-1199","volume":"59","author":"M Carstensen","year":"2010","unstructured":"Carstensen M, Herder C, Kivimaki M, Jokela M, Roden M, Shipley MJ, Witte DR, Brunner EJ, Tabak AG. Accelerated increase in serum interleukin-1 receptor antagonist starts 6\u00a0years before diagnosis of type 2 diabetes: Whitehall II prospective cohort study. Diabetes. 2010;59:1222\u20137.","journal-title":"Diabetes"},{"key":"634_CR15","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.2337\/dc11-2263","volume":"35","author":"AG Tabak","year":"2012","unstructured":"Tabak AG, Carstensen M, Witte DR, Brunner EJ, Shipley MJ, Jokela M, Roden M, Kivimaki M, Herder C. Adiponectin trajectories before type 2 diabetes diagnosis: Whitehall II study. Diabetes Care. 2012;35:2540\u20137.","journal-title":"Diabetes Care"},{"key":"634_CR16","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2337\/dc12-1416","volume":"36","author":"B Schottker","year":"2013","unstructured":"Schottker B, Herder C, Rothenbacher D, Roden M, Kolb H, Muller H, Brenner H. Proinflammatory cytokines, adiponectin, and increased risk of primary cardiovascular events in diabetic patients with or without renal dysfunction: results from the ESTHER study. Diabetes Care. 2013;36:1703\u201311.","journal-title":"Diabetes Care"},{"key":"634_CR17","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1111\/joim.12295","volume":"276","author":"MN Jarczok","year":"2014","unstructured":"Jarczok MN, Koenig J, Mauss D, Fischer JE, Thayer JF. Lower heart rate variability predicts increased level of C-reactive protein 4\u00a0years later in healthy, non-smoking adults. J Intern Med. 2014;276:667\u201371.","journal-title":"J Intern Med"},{"key":"634_CR18","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s10286-009-0019-0","volume":"19","author":"P Singh","year":"2009","unstructured":"Singh P, Hawkley LC, McDade TW, Cacioppo JT, Masi CM. Autonomic tone and C-reactive protein: a prospective population-based study. Clin Auton Res. 2009;19:367\u201374.","journal-title":"Clin Auton Res"},{"key":"634_CR19","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.numecd.2017.04.004","volume":"27","author":"D Aune","year":"2017","unstructured":"Aune D, Sen A, o\u2019Hartaigh B, Janszky I, Romundstad PR, Tonstad S, Vatten LJ. Resting heart rate and the risk of cardiovascular disease, total cancer, and all-cause mortality\u2014a systematic review and dose-response meta-analysis of prospective studies. Nutr Metab Cardiovasc Dis. 2017;27:504\u201317.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"634_CR20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S2213-8587(15)00035-2","volume":"3","author":"C Herder","year":"2015","unstructured":"Herder C, Donath MY. Interleukin-1 receptor antagonist: friend or foe to the heart? Lancet Diabetes Endocrinol. 2015;3:228\u20139.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"634_CR21","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1161\/ATVBAHA.117.309307","volume":"37","author":"C Herder","year":"2017","unstructured":"Herder C, de Las Heras Gala T, Carstensen-Kirberg M, Huth C, Zierer A, Wahl S, Sudduth-Klinger J, Kuulasmaa K, Peretz D, Ligthart S, et al. Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease: meta-analysis of six population-based cohorts. Arterioscler Thromb Vasc Biol. 2017;37:1222\u20137.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"634_CR22","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tem.2015.08.001","volume":"26","author":"C Herder","year":"2015","unstructured":"Herder C, Dalmas E, Boni-Schnetzler M, Donath MY. The IL-1 pathway in type 2 diabetes and cardiovascular complications. Trends Endocrinol Metab. 2015;26:551\u201363.","journal-title":"Trends Endocrinol Metab"},{"key":"634_CR23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/SHK.0000000000000276","volume":"43","author":"GN Herlitz","year":"2015","unstructured":"Herlitz GN, Arlow RL, Cheung NH, Coyle SM, Griffel B, Macor MA, Lowry SF, Calvano SE, Gale SC. Physiologic variability at the verge of systemic inflammation: multiscale entropy of heart rate variability is affected by very low doses of endotoxin. Shock. 2015;43:133\u20139.","journal-title":"Shock"},{"key":"634_CR24","doi-asserted-by":"crossref","first-page":"e0159808","DOI":"10.1371\/journal.pone.0159808","volume":"11","author":"EH Aburawi","year":"2016","unstructured":"Aburawi EH, AlKaabi J, Zoubeidi T, Shehab A, Lessan N, Al Essa A, Yasin J, Saadi H, Souid AK. Subclinical inflammation and endothelial dysfunction in young patients with diabetes: a study from united arab emirates. PLoS ONE. 2016;11:e0159808.","journal-title":"PLoS ONE"},{"key":"634_CR25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12933-016-0364-y","volume":"15","author":"ML Meyer","year":"2016","unstructured":"Meyer ML, Gotman NM, Soliman EZ, Whitsel EA, Arens R, Cai J, Daviglus ML, Denes P, Gonzalez HM, Moreiras J, et al. Association of glucose homeostasis measures with heart rate variability among Hispanic\/Latino adults without diabetes: the Hispanic Community Health Study\/Study of Latinos (HCHS\/SOL). Cardiovasc Diabetol. 2016;15:45.","journal-title":"Cardiovasc Diabetol"},{"key":"634_CR26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12933-016-0411-8","volume":"15","author":"MK Svensson","year":"2016","unstructured":"Svensson MK, Lindmark S, Wiklund U, Rask P, Karlsson M, Myrin J, Kullberg J, Johansson L, Eriksson JW. Alterations in heart rate variability during everyday life are linked to insulin resistance. A role of dominating sympathetic over parasympathetic nerve activity? Cardiovasc Diabetol. 2016;15:91.","journal-title":"Cardiovasc Diabetol"},{"key":"634_CR27","doi-asserted-by":"crossref","first-page":"e3340","DOI":"10.1097\/MD.0000000000003340","volume":"95","author":"BI Tiftikcioglu","year":"2016","unstructured":"Tiftikcioglu BI, Bilgin S, Duksal T, Kose S, Zorlu Y. Autonomic neuropathy and endothelial dysfunction in patients with impaired glucose tolerance or type 2 diabetes mellitus. Medicine (Baltimore). 2016;95:e3340.","journal-title":"Medicine (Baltimore)"},{"key":"634_CR28","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.2337\/diacare.27.10.2392","volume":"27","author":"S Wakabayashi","year":"2004","unstructured":"Wakabayashi S, Aso Y. Adiponectin concentrations in sera from patients with type 2 diabetes are negatively associated with sympathovagal balance as evaluated by power spectral analysis of heart rate variation. Diabetes Care. 2004;27:2392\u20137.","journal-title":"Diabetes Care"},{"key":"634_CR29","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1002\/ajhb.22636","volume":"27","author":"LE Charles","year":"2014","unstructured":"Charles LE, Burchfiel CM, Sarkisian K, Li S, Miller DB, Gu JK, Fekedulegn D, Violanti JM, Andrew ME. Leptin, adiponectin, and heart rate variability among police officers. Am J Hum Biol. 2014;27:184\u201391.","journal-title":"Am J Hum Biol"},{"key":"634_CR30","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.metabol.2014.06.011","volume":"63","author":"JR Kizer","year":"2014","unstructured":"Kizer JR. Adiponectin, cardiovascular disease, and mortality: parsing the dual prognostic implications of a complex adipokine. Metabolism. 2014;63:1079\u201383.","journal-title":"Metabolism"},{"key":"634_CR31","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1161\/ATVBAHA.114.303828","volume":"34","author":"AS Antonopoulos","year":"2014","unstructured":"Antonopoulos AS, Margaritis M, Coutinho P, Digby J, Patel R, Psarros C, Ntusi N, Karamitsos TD, Lee R, De Silva R, et al. Reciprocal effects of systemic inflammation and brain natriuretic peptide on adiponectin biosynthesis in adipose tissue of patients with ischemic heart disease. Arterioscler Thromb Vasc Biol. 2014;34:2151\u20139.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"634_CR32","doi-asserted-by":"crossref","first-page":"569","DOI":"10.2337\/dc16-2259","volume":"40","author":"C Herder","year":"2017","unstructured":"Herder C, Kannenberg JM, Huth C, Carstensen-Kirberg M, Rathmann W, Koenig W, Heier M, Puttgen S, Thorand B, Peters A, et al. Proinflammatory cytokines predict the incidence and progression of distal sensorimotor polyneuropathy: KORA F4\/FF4 Study. Diabetes Care. 2017;40:569\u201379.","journal-title":"Diabetes Care"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-017-0634-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T05:36:50Z","timestamp":1512106610000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-017-0634-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["634"],"URL":"https:\/\/doi.org\/10.1186\/s12933-017-0634-3","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12]]},"article-number":"153"}}