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However, there are no criteria for initiating screening for CAD in this population. The current study investigated whether clinical and demographic characteristics can be used to predict significant CAD in patients with T2DM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Computed tomography coronary angiography (CTCA) and laboratory assessments were performed in 259 patients diagnosed with T2DM attending clinics in Northwest London, UK. Coronary artery calcium (CAC) was calculated during CTCA. Significant plaque was defined as one causing more than 50% luminal stenosis.\u00a0Associations between groups and variables were evaluated using Student\u2019s <jats:italic>t<\/jats:italic> test, Chi-square tests and univariate and multivariate regression analysis. P\u2009&lt;\u20090.05 was considered statistically significant.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among patients with a median duration of T2DM of 13\u00a0years and a mean age of 62.0\u00a0years, median CAC score was 105.91 Agatston Units. In a multivariate analyses, duration of diabetes, CAC score and the presence and number of coronary artery plaques and presence of significant plaque were significant predictors of cardiovascular adverse events. Systolic blood pressure (SBP) had borderline significance as a predictor of cardiovascular events (p\u2009=\u20090.05). In a receiver operating characteristic curve (ROC) analysis, duration of diabetes of\u2009&gt;\u200910.5\u00a0years predicted significant CAD (sensitivity, 75.3%; specificity 48.2%). Area under the ROC curve was 0.67 when combining duration of T2DM\u2009&gt;\u200910.5\u00a0years and SBP of\u2009&gt;\u2009139\u00a0mm Hg. Adverse cardiovascular events after a median follow-up of 22.8\u00a0months were also significantly higher in those with duration of T2DM\u2009&gt;\u200910.5\u00a0years and SBP\u2009&gt;\u2009140\u00a0mm Hg (log rank p\u2009=\u20090.02 and 0.009, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Routine screening for CAD using CTCA should be considered for patients with a diagnosis of T2DM for\u2009&gt;\u200910.5\u00a0years and SBP\u2009&gt;\u2009140\u00a0mm Hg.<\/jats:p>\n                <jats:p><jats:italic>Trial registration<\/jats:italic> Clinicaltrials.gov identifier: NCT02109835, 10 April 2014 (retrospectively registered)<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12933-019-0855-8","type":"journal-article","created":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T13:03:10Z","timestamp":1556024590000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Duration of type 2 diabetes mellitus and systolic blood pressure as determinants of severity of coronary stenosis and adverse events in an asymptomatic diabetic population: PROCEED study"],"prefix":"10.1186","volume":"18","clinical-trial-number":[{"clinical-trial-number":"nct02109835","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Shreenidhi M.","family":"Venuraju","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-2202","authenticated-orcid":false,"given":"Avijit","family":"Lahiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anand","family":"Jeevarethinam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Darko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devaki","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miranda","family":"Rosenthal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roby D.","family":"Rakhit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,23]]},"reference":[{"key":"855_CR1","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1136\/heartjnl-2011-301172","volume":"99","author":"G Pasterkamp","year":"2013","unstructured":"Pasterkamp G. 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