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Magnesium deficiency is common among HT patients treated with calcineurin inhibitors and is a known risk factor for DM in non-HT patients. We therefore investigated the association between serum Mg (s-Mg) levels and new-onset diabetes after transplantation (NODAT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Between 2002 and 2017, 102 non-DM HT patients were assessed. In accordance with the mean value of all s-Mg levels recorded during the first year post-HT, patients were divided into high s-Mg (\u2265\u20091.8\u00a0mg\/dL) and low s-Mg (&lt;\u20091.8\u00a0mg\/dL) groups. The endpoint was NODAT, defined according to the diagnostic criteria of the American Diabetes Association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Baseline clinical and demographic characteristics for the high (n\u2009=\u200945) and low s-Mg (n\u2009=\u200957) groups were similar. Kaplan\u2013Meier survival analysis showed that 15-year freedom from NODAT was significantly higher among patients with high vs low s-Mg (85% vs 46% log-rank test, p\u2009&lt;\u20090.001). Consistently, multivariate analysis adjusted for age, gender, immunosuppression therapies, BMI and mean creatinine values in the first year post-HT, showed that low s-Mg was independently associated with a significant &gt;\u20098-fold increased risk for NODAT (95% CI 2.15\u201332.63, p\u2009=\u20090.003). Stroke rate was significantly higher in patients with low s-Mg levels vs high s-Mg (14% vs 0, p\u2009=\u20090.025), as well as long term mortality (HR 2.6, 95% CI 1.02\u20136.77, p\u2009=\u20090.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low s-Mg level post-HT is an independent risk factor for NODAT in HT patients. The implications of interventions, focusing on preventing or correcting low s-Mg, for the risk of NODAT and for clinical outcomes should be evaluated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12933-019-0939-5","type":"journal-article","created":{"date-parts":[[2019,10,11]],"date-time":"2019-10-11T06:03:23Z","timestamp":1570773803000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Hypomagnesemia is associated with new-onset diabetes mellitus following heart transplantation"],"prefix":"10.1186","volume":"18","author":[{"given":"Yael","family":"Peled","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eilon","family":"Ram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Lavee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Tenenbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique Z.","family":"Fisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dov","family":"Freimark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Klempfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonid","family":"Sternik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shechter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,10,11]]},"reference":[{"issue":"10","key":"939_CR1","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1016\/j.healun.2018.07.022","volume":"37","author":"KK Khush","year":"2018","unstructured":"Khush KK, Cherikh WS, Chambers DC, Goldfarb S, Hayes D Jr, Kucheryavaya AY, Levvey BJ, Meiser B, Rossano JW, Stehlik J, et al. 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