{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:58:35Z","timestamp":1792511915785,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T00:00:00Z","timestamp":1614384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304069\/2019-1"],"award-info":[{"award-number":["304069\/2019-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["303492\/2019-8"],"award-info":[{"award-number":["303492\/2019-8"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/202.807\/2017"],"award-info":[{"award-number":["E-26\/202.807\/2017"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E-26\/202.535\/2019"],"award-info":[{"award-number":["E-26\/202.535\/2019"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The prognostic importance of non-traditional risk factors for peripheral artery disease (PAD) development\/progression is scarcely studied in diabetes. We investigated if carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) added prognostic information beyond traditional cardiovascular risk markers for PAD outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ankle-brachial index (ABI) was measured at baseline and after a median of 91\u00a0months of follow-up in 681 individuals with type 2 diabetes. Multivariate Cox regressions examined the associations between the candidate variables and the outcome. PAD development\/progression was defined by a reduction in ABI\u2009\u2265\u20090.15 (to a level\u2009&lt;\u20090.9) or limb revascularization procedures, lower-extremity amputations or death due to PAD. The improvement in risk discrimination was assessed by increases in C-statistics of the models.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Seventy-seven patients developed\/progressed PAD: 50 reduced ABI to\u2009&lt;\u20090.9, seven had lower-limb revascularizations, and 20 had amputations or death. Age, male sex, diabetes duration, presence of microvascular complications (peripheral neuropathy and diabetic kidney disease), baseline HbA<jats:sub>1c<\/jats:sub>, 24-h systolic BP (SBP) and mean cumulative office SBP and LDL-cholesterol were associated with PAD development\/progression in several models. CIMT and cf-PWV were additionally associated with PAD outcomes, and their inclusion further improved risk discrimination (with C-statistic increases between 0.025 and 0.030). The inclusion of ambulatory 24-h SBP, instead of office SBP, also improved PAD risk discrimination.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Increased CIMT and aortic stiffness are associated with greater risks of developing\/progressing PAD, beyond traditional risk factors, in type 2 diabetes.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12933-021-01249-y","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T12:02:56Z","timestamp":1614427376000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Traditional and non-traditional risk factors for peripheral artery disease development\/progression in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study"],"prefix":"10.1186","volume":"20","author":[{"given":"Claudia R. L.","family":"Cardoso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana V.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thain\u00e1 R. M.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie C.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6318-7077","authenticated-orcid":false,"given":"Gil F.","family":"Salles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,27]]},"reference":[{"key":"1249_CR1","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1161\/CIRCRESAHA.116.303849","volume":"116","author":"MH Criqui","year":"2015","unstructured":"Criqui MH, Aboyans V. Epidemiology of peripheral artery disease. Circ Res. 2015;116:1509\u201326.","journal-title":"Circ Res"},{"key":"1249_CR2","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.2337\/diacare.24.8.1433","volume":"24","author":"EB Jude","year":"2001","unstructured":"Jude EB, Oyibo SO, Chalmers N, Boulton AJ. Peripheral arterial disease in diabetic and nondiabetic patients: a comparison of severity and outcome. Diabetes Care. 2001;24:1433\u20137.","journal-title":"Diabetes Care"},{"key":"1249_CR3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ahj.2012.06.017","volume":"164","author":"JD Dawn Abbott","year":"2012","unstructured":"Dawn Abbott JD, Lombardero MS, Barsness GW, Pena-Sing I, Buitr\u00f3n LV, Singh P, et al. Ankle-brachial index and cardiovascular outcomes in the bypass angioplasty revascularization investigation 2 diabetes trial. Am Heart J. 2012;164:585\u201390.","journal-title":"Am Heart J"},{"key":"1249_CR4","doi-asserted-by":"publisher","first-page":"2266","DOI":"10.1007\/s00125-018-4709-9","volume":"61","author":"CRL Cardoso","year":"2018","unstructured":"Cardoso CRL, Melo JV, Salles GC, Leite NC, Salles GF. Prognostic impact of the ankle-brachial index on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Diabetologia. 2018;61:2266\u201376.","journal-title":"Diabetologia"},{"issue":"2-suppl","key":"1249_CR5","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1177\/2047487319880044","volume":"26","author":"G Buso","year":"2019","unstructured":"Buso G, Aboyans V, Mazzolai L. Lower extremity artery disease in patients with type 2 diabetes. Eur J Prev Cardiol. 2019;26(2-suppl):114\u201324.","journal-title":"Eur J Prev Cardiol"},{"key":"1249_CR6","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/nrcardio.2016.179","volume":"14","author":"FG Fowkes","year":"2017","unstructured":"Fowkes FG, Aboyans V, Fowkes FJ, McDermott MM, Sampson UK, Criqui MH. Peripheral artery disease: epidemiology and global perspectives. Nat Rev Cardiol. 2017;14:156\u201370.","journal-title":"Nat Rev Cardiol"},{"key":"1249_CR7","doi-asserted-by":"publisher","first-page":"894","DOI":"10.2337\/diacare.25.5.894","volume":"25","author":"AI Adler","year":"2002","unstructured":"Adler AI, Stevens RJ, Neil A, Stratton IM, Boulton AJ, Holman RR. UKPDS 59: hyperglycemia and other potentially modifiable risk factors for peripheral vascular disease in type 2 diabetes. Diabetes Care. 2002;25:894\u20139.","journal-title":"Diabetes Care"},{"key":"1249_CR8","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.2337\/diacare.26.4.1241","volume":"26","author":"M Kallio","year":"2003","unstructured":"Kallio M, Forsblom C, Groop PH, Groop L, Lep\u00e4ntalo M. Development of new peripheral arterial occlusive disease in patients with type 2 diabetes during a mean follow-up of 11 years. Diabetes Care. 2003;26:1241\u20135.","journal-title":"Diabetes Care"},{"key":"1249_CR9","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.atherosclerosis.2004.11.024","volume":"180","author":"K Wattanakit","year":"2005","unstructured":"Wattanakit K, Folsom AR, Selvin E, Weatherley BD, Pankow JS, Brancati FL, Hirsch AT. Risk factors for peripheral arterial disease incidence in persons with diabetes: the atherosclerosis risk in communities (ARIC) study. Atherosclerosis. 2005;180:389\u201397.","journal-title":"Atherosclerosis"},{"key":"1249_CR10","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2337\/diacare.29.03.06.dc05-1567","volume":"29","author":"PE Norman","year":"2006","unstructured":"Norman PE, Davis WA, Bruce DG, Davis TM. Peripheral arterial disease and risk of cardiac death in type 2 diabetes: the Fremantle diabetes study. Diabetes Care. 2006;29:575\u201380.","journal-title":"Diabetes Care"},{"key":"1249_CR11","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.diabres.2007.10.002","volume":"79","author":"IT Lee","year":"2008","unstructured":"Lee IT, Huang CN, Lee WJ, Lee HS, Sheu WH. High total-to-HDL cholesterol ratio predicting deterioration of ankle brachial index in Asian type 2 diabetic subjects. Diabetes Res Clin Pract. 2008;79:419\u201326.","journal-title":"Diabetes Res Clin Pract"},{"key":"1249_CR12","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1016\/j.jdiacomp.2014.04.013","volume":"28","author":"J Eshcol","year":"2014","unstructured":"Eshcol J, Jebarani S, Anjana RM, Mohan V, Pradeepa R. Prevalence, incidence and progression of peripheral arterial disease in Asian Indian type 2 diabetic patients. J Diabetes Complicat. 2014;28:627\u201331.","journal-title":"J Diabetes Complicat"},{"key":"1249_CR13","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.2337\/dc13-2303","volume":"37","author":"RC Thurston","year":"2014","unstructured":"Thurston RC, Mulukutla S, Aboyans V, Brooks MM, BARI 2D Study Group. Risk factors for incident peripheral arterial disease in type 2 diabetes: results from the bypass angioplasty revascularization investigation in type 2 diabetes (BARI 2D) trial. Diabetes Care. 2014;37:1346\u201352.","journal-title":"Diabetes Care"},{"key":"1249_CR14","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.2337\/dc16-0588","volume":"39","author":"K Mohammedi","year":"2016","unstructured":"Mohammedi K, Woodward M, Hirakawa Y, Zoungas S, Colagiuri S, Hamet P, ADVANCE Collaborative Group, et al. Microvascular and macrovascular disease and risk for major peripheral arterial disease in patients with type 2 diabetes. Diabetes Care. 2016;39:1796\u2013803.","journal-title":"Diabetes Care"},{"key":"1249_CR15","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1097\/HJH.0b013e32834fa8b0","volume":"30","author":"LM Van Bortel","year":"2012","unstructured":"Van Bortel LM, Laurent S, Boutouyrie P, Chowienczyk P, Cruickshank JK, De Backer T, Artery Society, European Society of Hypertension Working Group on Vascular Structure and Function, European Network for Noninvasive Investigation of Large Arteries, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens. 2012;30:445\u20138.","journal-title":"J Hypertens"},{"key":"1249_CR16","doi-asserted-by":"publisher","first-page":"3772","DOI":"10.2337\/dc13-0506","volume":"36","author":"CR Cardoso","year":"2013","unstructured":"Cardoso CR, Ferreira MT, Leite NC, Salles GF. Prognostic impact of aortic stiffness in high-risk type 2 diabetic patients: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care. 2013;36:3772\u20138.","journal-title":"Diabetes Care"},{"key":"1249_CR17","doi-asserted-by":"publisher","first-page":"1223","DOI":"10.1016\/j.jdiacomp.2016.06.008","volume":"30","author":"M Wijkman","year":"2016","unstructured":"Wijkman M, L\u00e4nne T, \u00d6stgren CJ, Nystrom FH. Aortic pulse wave velocity predicts incident cardiovascular events in patients with type 2 diabetes treated in primary care. J Diabetes Complicat. 2016;30:1223\u20138.","journal-title":"J Diabetes Complicat"},{"issue":"1","key":"1249_CR18","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12933-019-0809-1","volume":"18","author":"CRL Cardoso","year":"2019","unstructured":"Cardoso CRL, Salles GC, Leite NC, Salles GF. Prognostic impact of carotid intima-media thickness and carotid plaques on the development of micro- and macrovascular complications in individuals with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Cardiovasc Diabetol. 2019;18(1):2.","journal-title":"Cardiovasc Diabetol"},{"key":"1249_CR19","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.1007\/s00125-015-3658-9","volume":"58","author":"CR Cardoso","year":"2015","unstructured":"Cardoso CR, Moran CB, Marinho FS, Ferreira MT, Salles GF. Increased aortic stiffness predicts future development and progression of peripheral neuropathy in patients with type 2 diabetes: the Rio de Janeiro type 2 diabetes cohort study. Diabetologia. 2015;58:2161\u20138.","journal-title":"Diabetologia"},{"key":"1249_CR20","doi-asserted-by":"publisher","first-page":"4867","DOI":"10.1038\/s41598-017-05159-6","volume":"7","author":"CRL Cardoso","year":"2017","unstructured":"Cardoso CRL, Leite NC, Dib E, Salles GF. Predictors of development and progression of retinopathy in patients with type 2 diabetes: importance of blood pressure parameters. Sci Rep. 2017;7:4867.","journal-title":"Sci Rep"},{"key":"1249_CR21","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1038\/hr.2012.83","volume":"35","author":"WJ Verberk","year":"2012","unstructured":"Verberk WJ, Kollias A, Stergiou GS. Automated oscillometric determination of the ankle-brachial index: a systematic review and meta-analysis. Hypertens Res. 2012;35:883\u201391.","journal-title":"Hypertens Res"},{"key":"1249_CR22","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1161\/CIRCULATIONAHA.107.763227","volume":"118","author":"C Espinola-Klein","year":"2008","unstructured":"Espinola-Klein C, Rupprecht HJ, Bickel C, Lackner K, Savvidis S, Messow CM, Munzel T, Blankenberg S, AtheroGene Investigators. Different calculations of ankle-brachial index and their impact on cardiovascular risk prediction. Circulation. 2008;118:961\u20137.","journal-title":"Circulation"},{"key":"1249_CR23","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1016\/j.amjcard.2014.07.023","volume":"114","author":"V Jeevanantham","year":"2014","unstructured":"Jeevanantham V, Chehab B, Austria E, Shrivastava R, Wiley M, Tadros P, Dawn B, Vacek JL, Gupta K. Comparison of accuracy of two different methods to determine ankle-brachial index to predict peripheral arterial disease severity confirmed by angiography. Am J Cardiol. 2014;114:1105\u201310.","journal-title":"Am J Cardiol"},{"key":"1249_CR24","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1161\/01.HYP.26.3.485","volume":"26","author":"R Asmar","year":"1995","unstructured":"Asmar R, Benetos A, Topouchian J, Laurent P, Pannier B, Brisac AM, et al. Assessment of arterial distensibility by automatic pulse wave velocity: validation and clinical application studies. Hypertension. 1995;26:485\u201390.","journal-title":"Hypertension"},{"key":"1249_CR25","doi-asserted-by":"publisher","first-page":"897","DOI":"10.2337\/dc14-2791","volume":"38","author":"MT Ferreira","year":"2015","unstructured":"Ferreira MT, Leite NC, Cardoso CR, Salles GF. Correlates of aortic stiffness progression in patients with type 2 diabetes: importance of glycemic control: the Rio de Janeiro type 2 diabetes cohort study. Diabetes Care. 2015;38:897\u2013904.","journal-title":"Diabetes Care"},{"key":"1249_CR26","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000097034","volume":"23","author":"PJ Touboul","year":"2007","unstructured":"Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Bornstein N, et al. Mannheim carotid intima-media thickness consensus (2004\u20132006). An update on behalf of the Advisory Board of the 3rd and 4th Watching the Risk Symposium, 13th and 15th European Stroke Conferences, Mannheim, Germany, 2004, and Brussels, Belgium, 2006. Cerebrovasc Dis. 2007;23:75\u201380.","journal-title":"Cerebrovasc Dis"},{"key":"1249_CR27","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.echo.2007.11.011","volume":"21","author":"JH Stein","year":"2008","unstructured":"Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, American Society of Echocardiography Carotid Intima-Media Thickness Task Force, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr. 2008;21:93\u2013111.","journal-title":"J Am Soc Echocardiogr"},{"key":"1249_CR28","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1097\/HJH.0b013e328352aba6","volume":"30","author":"CR Cardoso","year":"2012","unstructured":"Cardoso CR, Marques CE, Leite NC, Salles GF. Factors associated with carotid intima-media thickness and carotid plaques in type 2 diabetic patients. J Hypertens. 2012;30:940\u20137.","journal-title":"J Hypertens"},{"key":"1249_CR29","doi-asserted-by":"publisher","first-page":"837","DOI":"10.2307\/2531595","volume":"44","author":"ER DeLong","year":"1988","unstructured":"DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837\u201345.","journal-title":"Biometrics"},{"key":"1249_CR30","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/S2213-8587(17)30183-3","volume":"5","author":"K Matsushita","year":"2017","unstructured":"Matsushita K, Ballew SH, Coresh J, Arima H, \u00c4rnl\u00f6v J, Cirillo M, Chronic Kidney Disease Prognosis Consortium, et al. Measures of chronic kidney disease and risk of incident peripheral artery disease: a collaborative meta-analysis of individual participant data. Lancet Diabetes Endocrinol. 2017;5:718\u201328.","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1249_CR31","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1161\/CIRCULATIONAHA.106.678342","volume":"116","author":"EL Schiffrin","year":"2007","unstructured":"Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116:85\u201397.","journal-title":"Circulation"},{"key":"1249_CR32","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/1477-5956-9-25","volume":"9","author":"M Luczak","year":"2011","unstructured":"Luczak M, Formanowicz D, Pawliczak E, Wanic-Kossowska M, Wykretowicz A, Figlerowicz M. Chronic kidney disease-related atherosclerosis\u2014proteomic studies of blood plasma. Proteome Sci. 2011;9:25.","journal-title":"Proteome Sci"},{"key":"1249_CR33","doi-asserted-by":"publisher","first-page":"2751","DOI":"10.2337\/dc20-1085","volume":"43","author":"N Foussard","year":"2020","unstructured":"Foussard N, Saulnier PJ, Potier L, Ragot S, Schneider F, Gand E, SURDIAGENE Study Group, et al. Relationship between diabetic retinopathy stages and risk of major lower-extremity arterial disease in patients with type 2 diabetes. Diabetes Care. 2020;43:2751\u20139.","journal-title":"Diabetes Care"},{"key":"1249_CR34","doi-asserted-by":"publisher","first-page":"2634","DOI":"10.1007\/s00125-006-0431-0","volume":"49","author":"WA Davis","year":"2006","unstructured":"Davis WA, Norman PE, Bruce DG, Davis TM. Predictors, consequences and costs of diabetes-related lower extremity amputation complicating type 2 diabetes: the Fremantle diabetes study. Diabetologia. 2006;49:2634\u201341.","journal-title":"Diabetologia"},{"key":"1249_CR35","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.jdiacomp.2015.06.014","volume":"29","author":"L Salvotelli","year":"2015","unstructured":"Salvotelli L, Stoico V, Perrone F, Cacciatori V, Negri C, Brangani C, et al. Prevalence of neuropathy in type 2 diabetic patients and its association with other diabetes complications: the Verona Diabetic Foot Screening Program. J Diabetes Complicat. 2015;29:1066\u201370.","journal-title":"J Diabetes Complicat"},{"key":"1249_CR36","doi-asserted-by":"publisher","first-page":"4343","DOI":"10.1210\/jc.2017-01922","volume":"102","author":"EJ Barrett","year":"2017","unstructured":"Barrett EJ, Liu Z, Khamaisi M, King GL, Klein R, Klein BEK, et al. Diabetic microvascular disease: an Endocrine Society scientific statement. J Clin Endocrinol Metab. 2017;102:4343\u2013410.","journal-title":"J Clin Endocrinol Metab"},{"key":"1249_CR37","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1177\/1358863X19835925","volume":"24","author":"JF Polak","year":"2019","unstructured":"Polak JF, Herrington D, O\u2019Leary DH. Associations of edge-detected and manual-traced common carotid artery intima-media thickness with incident peripheral artery disease: the multi-ethnic study of atherosclerosis. Vasc Med. 2019;24:306\u201312.","journal-title":"Vasc Med"},{"key":"1249_CR38","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.5551\/jat.43141","volume":"25","author":"N Katakami","year":"2018","unstructured":"Katakami N, Mita T, Gosho M, Takahara M, Irie Y, Yasuda T, et al. Clinical utility of carotid ultrasonography in the prediction of cardiovascular events in patients with diabetes: a combined analysis of data obtained in five longitudinal studies. J Atheroscler Thromb. 2018;25:1053\u201366.","journal-title":"J Atheroscler Thromb"},{"key":"1249_CR39","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1001\/jama.2012.9630","volume":"308","author":"HM Den Ruijter","year":"2012","unstructured":"Den Ruijter HM, Peters SA, Anderson TJ, Britton AR, Dekker JM, Eijkemans MJ, et al. Common carotid intima-media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012;308:796\u2013803.","journal-title":"JAMA"},{"key":"1249_CR40","doi-asserted-by":"publisher","first-page":"1518","DOI":"10.1016\/j.jvs.2017.06.068","volume":"66","author":"GJ Zahner","year":"2017","unstructured":"Zahner GJ, Gruendl MA, Spaulding KA, Schaller MS, Hills NK, Gasper WJ, Grenon SM. Association between arterial stiffness and peripheral artery disease as measured by radial artery tonometry. J Vasc Surg. 2017;66:1518\u201326.","journal-title":"J Vasc Surg"},{"key":"1249_CR41","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1111\/jch.12167","volume":"15","author":"M Catalano","year":"2013","unstructured":"Catalano M, Scandale G, Carzaniga G, Cinquini M, Minola M, Dimitrov G, Carotta M. Increased aortic stiffness and related factors in patients with peripheral arterial disease. J Clin Hypertens. 2013;15:712\u20136.","journal-title":"J Clin Hypertens"},{"key":"1249_CR42","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1016\/j.jacc.2009.10.061","volume":"55","author":"C Vlachopoulos","year":"2010","unstructured":"Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318\u201327.","journal-title":"J Am Coll Cardiol"},{"key":"1249_CR43","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1016\/j.jacc.2013.09.063","volume":"63","author":"Y Ben-Shlomo","year":"2014","unstructured":"Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63:636\u201346.","journal-title":"J Am Coll Cardiol"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-021-01249-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12933-021-01249-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-021-01249-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T12:11:19Z","timestamp":1614427879000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-021-01249-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,27]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1249"],"URL":"https:\/\/doi.org\/10.1186\/s12933-021-01249-y","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,27]]},"assertion":[{"value":"13 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 February 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the Research Ethics Committee of School of Medicine and University Hospital, Federal University of Rio de Janeiro (Number 124\/2004), and all participants gave written informed consent.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"54"}}