{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:45:17Z","timestamp":1793108717925,"version":"4.5.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T00:00:00Z","timestamp":1637712000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes\u2014independently of confounding factors\u2014and whether it could predict this condition.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included asymptomatic patients with diabetes and no coronary history, who had undergone both a stress a myocardial scintigraphy to diagnose myocardial ischemia, and a computed tomography to measure their coronary artery calcium (CAC) score. EAT volume was retrospectively measured from computed tomography imaging. Determinants of EAT volume and asymptomatic myocardial ischemia were evaluated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study population comprised 274 individuals, including 153 men. Mean (\u00b1\u2009standard deviation) age was 62\u2009\u00b1\u20099\u00a0years, and 243, 23 and 8 had type 2, type 1, or another type of diabetes, respectively. Mean body mass index was 30\u2009\u00b1\u20096\u00a0kg\/m<jats:sup>2<\/jats:sup>, and mean EAT volume 96\u2009\u00b1\u200936\u00a0cm<jats:sup>3<\/jats:sup>. Myocardial ischemia was detected in 32 patients (11.7%). EAT volume was positively correlated with age, body mass index\u00a0and triglyceridemia, but negatively correlated with HbA1c, HDL- and LDL-cholesterol levels. Furthermore, EAT volume was lower in people with retinopathy, but higher in men, in current smokers, in patients with nephropathy, those with a CAC score\u2009&gt;\u2009100 Agatston units, and finally in individuals with myocardial ischemia (110\u2009\u00b1\u200937\u00a0cm<jats:sup>3<\/jats:sup> vs 94\u2009\u00b1\u200937\u00a0cm<jats:sup>3<\/jats:sup> in those without myocardial ischemia, p\u2009&lt;\u20090.05). The association between EAT volume and myocardial ischemia remained significant after adjustment for gender, diabetes duration, peripheral macrovascular disease and CAC score. We also found that area under the ROC curve analysis showed that EAT volume (AROC: 0.771 [95% confidence interval 0.683\u20130.858]) did not provide improved discrimination of myocardial ischemia over the following classic factors: gender, diabetes duration, peripheral macrovascular disease, retinopathy, nephropathy, smoking, atherogenic dyslipidemia, and CAC score (AROC 0.773 [0.683\u20130.862]).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes. However, considering EAT volume is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12933-021-01420-5","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T14:02:59Z","timestamp":1637762579000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study"],"prefix":"10.1186","volume":"20","author":[{"given":"Emmanuel","family":"Cosson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh Tuan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imen","family":"Rezgani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narimane","family":"Berkane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Bihan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sopio","family":"Tatulashvili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malak","family":"Taher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meriem","family":"Sal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Soussan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Yves","family":"Brillet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Valensi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,11,24]]},"reference":[{"key":"1420_CR1","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1056\/NEJMoa1310799","volume":"370","author":"EW Gregg","year":"2014","unstructured":"Gregg EW, Li Y, Wang J, Burrows NR, Ali MK, Rolka D, et al. Changes in diabetes-related complications in the United States, 1990\u20132010. N Engl J Med. 2014;370:1514\u201323.","journal-title":"N Engl J Med"},{"key":"1420_CR2","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.diabet.2020.09.001","volume":"46","author":"B Verg\u00e8s","year":"2020","unstructured":"Verg\u00e8s B. Cardiovascular disease in type 1 diabetes: a review of epidemiological data and underlying mechanisms. Diabetes Metab. 2020;46:442\u20139.","journal-title":"Diabetes Metab"},{"key":"1420_CR3","doi-asserted-by":"publisher","first-page":"204201882092882","DOI":"10.1177\/2042018820928824","volume":"11","author":"RH Christensen","year":"2020","unstructured":"Christensen RH, von Scholten BJ, Lehrskov LL, Rossing P, J\u00f8rgensen PG. Epicardial adipose tissue: an emerging biomarker of cardiovascular complications in type 2 diabetes? Ther Adv Endocrinol Metab. 2020;11:2042018820928824.","journal-title":"Ther Adv Endocrinol Metab"},{"key":"1420_CR4","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/s12933-019-0807-3","volume":"18","author":"Y Li","year":"2019","unstructured":"Li Y, Liu B, Li Y, Jing X, Deng S, Yan Y, et al. Epicardial fat tissue in patients with diabetes mellitus: a systematic review and meta-analysis. Cardiovasc Diabetol. 2019;18:3.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR5","doi-asserted-by":"publisher","first-page":"5989","DOI":"10.3390\/ijms20235989","volume":"20","author":"AC Villasante Fricke","year":"2019","unstructured":"Villasante Fricke AC, Iacobellis G. Epicardial adipose tissue: clinical biomarker of cardio-metabolic risk. Int J Mol Sci. 2019;20:5989.","journal-title":"Int J Mol Sci"},{"key":"1420_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nut.2018.07.002","volume":"59","author":"G Iacobellis","year":"2019","unstructured":"Iacobellis G, Barbaro G. Epicardial adipose tissue feeding and overfeeding the heart. Nutrition. 2019;59:1\u20136.","journal-title":"Nutrition"},{"key":"1420_CR7","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.jcmg.2010.07.014","volume":"3","author":"B Tamarappoo","year":"2010","unstructured":"Tamarappoo B, Dey D, Shmilovich H, Nakazato R, Gransar H, Cheng VY, et al. Increased pericardial fat volume measured from noncontrast CT predicts myocardial ischemia by SPECT. JACC Cardiovasc Imaging. 2010;3:1104\u201312.","journal-title":"JACC Cardiovasc Imaging"},{"key":"1420_CR8","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s12350-010-9235-1","volume":"17","author":"M Janik","year":"2010","unstructured":"Janik M, Hartlage G, Alexopoulos N, Mirzoyev Z, McLean DS, Arepalli CD, et al. Epicardial adipose tissue volume and coronary artery calcium to predict myocardial ischemia on positron emission tomography-computed tomography studies. J Nucl Cardiol. 2010;17:841\u20137.","journal-title":"J Nucl Cardiol"},{"key":"1420_CR9","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.atherosclerosis.2011.12.018","volume":"221","author":"R Nakazato","year":"2012","unstructured":"Nakazato R, Dey D, Cheng VY, Gransar H, Slomka PJ, Hayes SW, et al. Epicardial fat volume and concurrent presence of both myocardial ischemia and obstructive coronary artery disease. Atherosclerosis. 2012;221:422\u20136.","journal-title":"Atherosclerosis"},{"key":"1420_CR10","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s12350-014-0004-4","volume":"22","author":"T Khawaja","year":"2015","unstructured":"Khawaja T, Greer C, Thadani SR, Kato TS, Bhatia K, Shimbo D, et al. Increased regional epicardial fat volume associated with reversible myocardial ischemia in patients with suspected coronary artery disease. J Nucl Cardiol. 2015;22:325\u201333.","journal-title":"J Nucl Cardiol"},{"key":"1420_CR11","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jcct.2016.01.009","volume":"10","author":"MM Hell","year":"2016","unstructured":"Hell MM, Ding X, Rubeaux M, Slomka P, Gransar H, Terzopoulos D, et al. Epicardial adipose tissue volume but not density is an independent predictor for myocardial ischemia. J Cardiovasc Comput Tomogr. 2016;10:141\u20139.","journal-title":"J Cardiovasc Comput Tomogr"},{"key":"1420_CR12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1186\/1475-2840-11-83","volume":"11","author":"HM Kim","year":"2012","unstructured":"Kim HM, Kim KJ, Lee H-J, Yu HT, Moon JH, Kang ES, et al. Epicardial adipose tissue thickness is an indicator for coronary artery stenosis in asymptomatic type 2 diabetic patients: its assessment by cardiac magnetic resonance. Cardiovasc Diabetol. 2012;11:83.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/eurheartj\/ehz486","volume":"41","author":"F Cosentino","year":"2020","unstructured":"Cosentino F, Grant PJ, Aboyans V, Bailey CJ, Ceriello A, Delgado V, et al. 2019 ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. Eur Heart J. 2020;41:255\u2013323.","journal-title":"Eur Heart J"},{"key":"1420_CR14","doi-asserted-by":"publisher","first-page":"101185","DOI":"10.1016\/j.diabet.2020.08.002","volume":"47","author":"P Valensi","year":"2021","unstructured":"Valensi P, Henry P, Boccara F, Cosson E, Prevost G, Emmerich J, et al. Risk stratification and screening for coronary artery disease in asymptomatic patients with diabetes mellitus: Position paper of the French Society of Cardiology and the French-speaking Society of Diabetology. Diabetes Metab. 2021;47:101185.","journal-title":"Diabetes Metab"},{"key":"1420_CR15","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.diabet.2010.01.001","volume":"36","author":"P Valensi","year":"2010","unstructured":"Valensi P, Cosson E. It is not yet the time to stop screening diabetic patients for silent myocardial ischaemia. Diabetes Metab. 2010;36:91\u20136.","journal-title":"Diabetes Metab"},{"key":"1420_CR16","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1186\/s12933-016-0415-4","volume":"15","author":"P Valensi","year":"2016","unstructured":"Valensi P, Avignon A, Sultan A, Chanu B, Nguyen MT, Cosson E. Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. 2016;15:104.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR17","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.2337\/dc11-0480","volume":"34","author":"E Cosson","year":"2011","unstructured":"Cosson E, Nguyen MT, Chanu B, Banu I, Chiheb S, Balta C, et al. Cardiovascular risk prediction is improved by adding asymptomatic coronary status to routine risk assessment in type 2 diabetic patients. Diabetes Care. 2011;34:2101\u20137.","journal-title":"Diabetes Care"},{"key":"1420_CR18","doi-asserted-by":"publisher","first-page":"W54","DOI":"10.1097\/RTI.0000000000000287","volume":"32","author":"HS Hecht","year":"2017","unstructured":"Hecht HS, Cronin P, Blaha MJ, Budoff MJ, Kazerooni EA, Narula J, et al. 2016 SCCT\/STR guidelines for coronary artery calcium scoring of noncontrast noncardiac chest CT scans: a report of the Society of Cardiovascular Computed Tomography and Society of Thoracic Radiology. J Thorac Imaging. 2017;32:W54-66.","journal-title":"J Thorac Imaging"},{"key":"1420_CR19","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12933-021-01225-6","volume":"20","author":"E Cosson","year":"2021","unstructured":"Cosson E, Nguyen MT, Rezgani I, Tatulashvili S, Sal M, Berkane N, et al. Epicardial adipose tissue volume and coronary calcification among people living with diabetes: a cross-sectional study. Cardiovasc Diabetol. 2021;20:35.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR20","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s12933-021-01329-z","volume":"20","author":"H Bihan","year":"2021","unstructured":"Bihan H, Heidar R, Beloeuvre A, Allard L, Ouedraogo E, Tatulashvili S, et al. Epicardial adipose tissue and severe Coronavirus Disease 19. Cardiovasc Diabetol. 2021;20:147.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR21","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.jcmg.2015.11.023","volume":"9","author":"C Bavishi","year":"2016","unstructured":"Bavishi C, Argulian E, Chatterjee S, Rozanski A. CACS and the frequency of stress-induced myocardial ischemia during MPI: a meta-analysis. JACC Cardiovasc Imaging. 2016;9:580\u20139.","journal-title":"JACC Cardiovasc Imaging"},{"key":"1420_CR22","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S1262-3636(07)70187-8","volume":"31","author":"E Cosson","year":"2005","unstructured":"Cosson E, Attali JR, Valensi P. Markers for silent myocardial ischemia in diabetes. Are they helpful? Diabetes Metab. 2005;31:205\u201313.","journal-title":"Diabetes Metab"},{"key":"1420_CR23","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.numecd.2012.01.009","volume":"23","author":"E Cosson","year":"2013","unstructured":"Cosson E, Nguyen MT, Chanu B, Balta S, Takbou K, Valensi P. The report of male gender and retinopathy status improves the current consensus guidelines for the screening of myocardial ischemia in asymptomatic type 2 diabetic patients. Nutr Metab Cardiovasc Dis. 2013;23:557\u201365.","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"1420_CR24","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12872-018-0770-z","volume":"18","author":"S Al-Talabany","year":"2018","unstructured":"Al-Talabany S, Mordi I, Graeme Houston J, Colhoun HM, Weir-McCall JR, Matthew SZ, et al. Epicardial adipose tissue is related to arterial stiffness and inflammation in patients with cardiovascular disease and type 2 diabetes. BMC Cardiovasc Disord. 2018;18:31.","journal-title":"BMC Cardiovasc Disord"},{"key":"1420_CR25","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1016\/j.jacc.2012.11.062","volume":"61","author":"AA Mahabadi","year":"2013","unstructured":"Mahabadi AA, Berg MH, Lehmann N, K\u00e4lsch H, Bauer M, Kara K, et al. Association of epicardial fat with cardiovascular risk factors and incident myocardial infarction in the general population: the Heinz Nixdorf Recall Study. J Am Coll Cardiol. 2013;61:1388\u201395.","journal-title":"J Am Coll Cardiol"},{"key":"1420_CR26","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12933-019-0917-y","volume":"18","author":"RH Christensen","year":"2019","unstructured":"Christensen RH, von Scholten BJ, Hansen CS, Jensen MT, Vilsb\u00f8ll T, Rossing P, et al. Epicardial adipose tissue predicts incident cardiovascular disease and mortality in patients with type 2 diabetes. Cardiovasc Diabetol. 2019;18:114.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR27","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1177\/2047487317717820","volume":"24","author":"RH Christensen","year":"2017","unstructured":"Christensen RH, von Scholten BJ, Hansen CS, Heywood SE, Rosenmeier JB, Andersen UB, et al. Epicardial, pericardial and total cardiac fat and cardiovascular disease in type 2 diabetic patients with elevated urinary albumin excretion rate. Eur J Prev Cardiol. 2017;24:1517\u201324.","journal-title":"Eur J Prev Cardiol"},{"key":"1420_CR28","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1093\/ehjci\/jes024","volume":"13","author":"MO Versteylen","year":"2012","unstructured":"Versteylen MO, Takx RAP, Joosen IAPG, Nelemans PJ, Das M, Crijns HJGM, et al. Epicardial adipose tissue volume as a predictor for coronary artery disease in diabetic, impaired fasting glucose, and non-diabetic patients presenting with chest pain. Eur Heart J Cardiovasc Imaging. 2012;13:517\u201323.","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"1420_CR29","doi-asserted-by":"publisher","first-page":"e006379","DOI":"10.1161\/JAHA.117.006379","volume":"6","author":"N Nerlekar","year":"2017","unstructured":"Nerlekar N, Brown AJ, Muthalaly RG, Talman A, Hettige T, Cameron JD, et al. Association of epicardial adipose tissue and high-risk plaque characteristics: a systematic review and meta-analysis. J Am Heart Assoc. 2017;6:e006379.","journal-title":"J Am Heart Assoc"},{"key":"1420_CR30","doi-asserted-by":"publisher","first-page":"e0183514","DOI":"10.1371\/journal.pone.0183514","volume":"12","author":"AA Mahabadi","year":"2017","unstructured":"Mahabadi AA, Balcer B, Dykun I, Forsting M, Schlosser T, Heusch G, et al. Cardiac computed tomography-derived epicardial fat volume and attenuation independently distinguish patients with and without myocardial infarction. PLoS ONE. 2017;12:e0183514.","journal-title":"PLoS ONE"},{"key":"1420_CR31","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/1475-2840-13-20","volume":"13","author":"MT Nguyen","year":"2014","unstructured":"Nguyen MT, Pham I, Valensi P, Rousseau H, Vicaut E, Laguillier-Morizot C, et al. Flow-mediated-paradoxical vasoconstriction is independently associated with asymptomatic myocardial ischemia and coronary artery disease in type 2 diabetic patients. Cardiovasc Diabetol. 2014;13:20.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR32","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2337\/diacare.29.01.06.dc05-1422","volume":"29","author":"E Cosson","year":"2006","unstructured":"Cosson E, Pham I, Valensi P, Pari\u00e8s J, Attali J-R, Nitenberg A. Impaired coronary endothelium-dependent vasodilation is associated with microalbuminuria in patients with type 2 diabetes and angiographically normal coronary arteries. Diabetes Care. 2006;29:107\u201312.","journal-title":"Diabetes Care"},{"key":"1420_CR33","doi-asserted-by":"publisher","first-page":"208","DOI":"10.2337\/diacare.27.1.208","volume":"27","author":"A Nitenberg","year":"2004","unstructured":"Nitenberg A, Valensi P, Sachs R, Cosson E, Attali J-R, Antony I. Prognostic value of epicardial coronary artery constriction to the cold pressor test in type 2 diabetic patients with angiographically normal coronary arteries and no other major coronary risk factors. Diabetes Care. 2004;27:208\u201315.","journal-title":"Diabetes Care"},{"key":"1420_CR34","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12933-020-0995-x","volume":"19","author":"EH Zobel","year":"2020","unstructured":"Zobel EH, Christensen RH, Winther SA, Hasbak P, Hansen CS, von Scholten BJ, et al. Relation of cardiac adipose tissue to coronary calcification and myocardial microvascular function in type 1 and type 2 diabetes. Cardiovasc Diabetol. 2020;19:16.","journal-title":"Cardiovasc Diabetol"},{"key":"1420_CR35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.amjcard.2013.09.022","volume":"113","author":"WJY Chen","year":"2014","unstructured":"Chen WJY, Danad I, Raijmakers PG, Halbmeijer R, Harms HJ, Lammertsma AA, et al. Effect of type 2 diabetes mellitus on epicardial adipose tissue volume and coronary vasomotor function. Am J Cardiol. 2014;113:90\u20137.","journal-title":"Am J Cardiol"},{"key":"1420_CR36","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/cvr\/cvv208","volume":"108","author":"B Gaborit","year":"2015","unstructured":"Gaborit B, Venteclef N, Ancel P, Pelloux V, Gariboldi V, Leprince P, et al. Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location. Cardiovasc Res. 2015;108:62\u201373.","journal-title":"Cardiovasc Res"},{"key":"1420_CR37","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1002\/cphy.c160034","volume":"7","author":"B Gaborit","year":"2017","unstructured":"Gaborit B, Sengenes C, Ancel P, Jacquier A, Dutour A. Role of epicardial adipose tissue in health and disease: a matter of fat? Compr Physiol. 2017;7:1051\u201382.","journal-title":"Compr Physiol"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-021-01420-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12933-021-01420-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-021-01420-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T14:03:16Z","timestamp":1637762596000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-021-01420-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,24]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["1420"],"URL":"https:\/\/doi.org\/10.1186\/s12933-021-01420-5","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,24]]},"assertion":[{"value":"13 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 November 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"In Jean Verdier hospital, and in general in the various Public Assistance Hospitals in Paris, all patients are informed at admission that their medical records may be used for research, unless they indicate their opposition. For the present study, no patient indicated opposition.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"224"}}