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We investigated the association between the\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    and the\n                    <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                    at the end of the second decade of life and indirect pathways from social vulnerability, alcohol consumption, and body fat mass. It is a population-based study in the RPS cohort of 18\u201319\u00a0years (n\u2009=\u20092,515), S\u00e3o Lu\u00eds, Brazil. The theoretical model analyzed the association between\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    and\n                    <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                    by sex, using structural equation modeling (SEM). The\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    was a latent variable deduced from the correlations of Triglyceride to HDL ratio, Triglyceride Glycemic index, and VLDL; the Vascular Risk Phenotype was deduced from Systolic Blood Pressure, Diastolic Blood Pressure, and Pulse Wave Velocity. The\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    was directly associated with the\n                    <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                    in males (standardized coefficient SC\u2009=\u20090.183; p\u2009&lt;\u20090.001) and females (SC\u2009=\u20090.152; p\u2009&lt;\u20090.001). The\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    was an indirect pathway in the association of alcohol consumption and higher values of fat mass index with the\u00a0\n                    <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                    . VLDL presented the highest factor loading, appearing as a marker of insulin resistance linked to cardiovascular risk in young people. Lower values of socioeconomic status, harmful use of alcohol, and high body fat values were also associated with higher values of the two phenotypes. The association of the\n                    <jats:italic>Insulin Resistance Phenotype<\/jats:italic>\n                    with the\n                    <jats:italic>Vascular Risk Phenotype<\/jats:italic>\n                    suggests common pathophysiological mechanisms present in early events in the continuums of diabetes and cardiovascular disease in adolescence.\n                  <\/jats:p>","DOI":"10.1186\/s12933-022-01724-0","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T14:38:48Z","timestamp":1671460728000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Insulin resistance phenotype is associated with vascular risk phenotype at the end of the second decade of life: a population-based study"],"prefix":"10.1186","volume":"21","author":[{"given":"Janaina Maiana Abreu","family":"Barbosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio Augusto Moura","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosangela Fernandes Lucena","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernadete Jorge Leal","family":"Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelma Ximenes Prado Teixeira","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanda Maria Ferreira","family":"Sim\u00f5es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jacqueline Silva","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Antonio","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Archanjo","family":"Ferraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Claudia Costa","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"1724_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"FJ Lin","year":"2017","unstructured":"Lin FJ, Tseng WK, Yin WH, et al. 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