{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T15:11:18Z","timestamp":1789830678212,"version":"4.0.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T00:00:00Z","timestamp":1718150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82070279"],"award-info":[{"award-number":["82070279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Key Laboratory of Precision Medicine in Cardio-Cerebrovascular Diseases Control and Prevention","award":["19-245-34"],"award-info":[{"award-number":["19-245-34"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]},{"name":"Guangxi Clinical Research Center for Cardio Cerebrovascular Diseases","award":["AD17129014"],"award-info":[{"award-number":["AD17129014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The specific pathophysiological pathways through which diabetes exacerbates myocardial ischemia\/reperfusion (I\/R) injury remain unclear; however, dysregulation of immune and inflammatory cells, potentially driven by abnormalities in their number and function due to diabetes, may play a significant role. In the present investigation, we simulated myocardial I\/R injury by inducing ischemia through ligation of the left anterior descending coronary artery in mice for 40\u00a0min, followed by reperfusion for 24\u00a0h. Previous studies have indicated that protein kinase C\u03b2 (PKC\u03b2) is upregulated under hyperglycemic conditions and is implicated in the development of various diabetic complications. The Y4 RNA fragment is identified as the predominant small RNA component present in the extracellular vesicles of cardio sphere-derived cells (CDCs), exhibiting notable anti-inflammatory properties in the contexts of myocardial infarction and cardiac hypertrophy. Our investigation revealed that the administration of Y4 RNA into the ventricular cavity of db\/db mice following myocardial I\/R injury markedly enhanced cardiac function. Furthermore, Y4 RNA was observed to facilitate M2 macrophage polarization and interleukin-10 secretion through the suppression of PKC\u03b2 activation. The mechanism by which Y4 RNA affects PKC\u03b2 by regulating macrophage activation within the inflammatory environment involves the inhibition of ERK1\/2 phosphorylation In our study, the role of PKC\u03b2 in regulating macrophage polarization during myocardial I\/R injury was investigated through the use of PKC\u03b2 knockout mice. Our findings indicate that PKC\u03b2 plays a crucial role in modulating the inflammatory response associated with macrophage activation in db\/db mice experiencing myocardial I\/R, with a notable exacerbation of this response observed upon significant upregulation of PKC\u03b2 expression. In vitro studies further elucidated the protective mechanism by which Y4 RNA modulates the PKC\u03b2\/ERK1\/2 signaling pathway to induce M2 macrophage activation. Overall, our findings suggest that Y4 RNA plays an anti-inflammatory role in diabetic I\/R injury, suggesting a novel therapeutic approach for managing myocardial I\/R injury in diabetic individuals.<\/jats:p>","DOI":"10.1186\/s12933-024-02247-6","type":"journal-article","created":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T18:01:52Z","timestamp":1718215312000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Y4 RNA fragments from cardiosphere-derived cells ameliorate diabetic myocardial ischemia\u2012reperfusion injury by inhibiting protein kinase C \u03b2-mediated macrophage polarization"],"prefix":"10.1186","volume":"23","author":[{"given":"De-Zhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Zhi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuang-Hong","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Yi","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,12]]},"reference":[{"issue":"2suppl","key":"2247_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1177\/2047487319878371","volume":"26","author":"E Dal Canto","year":"2019","unstructured":"Dal Canto E, Ceriello A, Ryd\u00e9n L, Ferrini M, Hansen TB, Schnell O, et al. Diabetes as a cardiovascular risk factor: an overview of global trends of macro and micro vascular complications. Eur J Prev Cardiol. 2019;26(2suppl):25\u201332.","journal-title":"Eur J Prev Cardiol"},{"key":"2247_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2018\/4059542","volume":"2018","author":"O Kurmus","year":"2018","unstructured":"Kurmus O, Aslan T, Ekici B, Baglan Uzunget S, Karaarslan S, Tanindi A, et al. Impact of admission blood glucose on coronary collateral Flow in patients with ST-Elevation myocardial infarction. Cardiol Res Pract. 2018;2018:1\u20135.","journal-title":"Cardiol Res Pract"},{"key":"2247_CR3","doi-asserted-by":"crossref","unstructured":"Ndumele CE, Matsushita K, Lazo M, Bello N, Blumenthal RS, Gerstenblith G et al. Obesity and subtypes of Incident Cardiovascular Disease. J Am Heart Association. 2016;5(8).","DOI":"10.1161\/JAHA.116.003921"},{"key":"2247_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.arr.2017.10.003","volume":"41","author":"F Prattichizzo","year":"2018","unstructured":"Prattichizzo F, De Nigris V, Spiga R, Mancuso E, La Sala L, Antonicelli R, et al. Inflammageing and metaflammation: the Yin and Yang of type 2 diabetes. Ageing Res Rev. 2018;41:1\u201317.","journal-title":"Ageing Res Rev"},{"key":"2247_CR5","first-page":"218","volume":"209","author":"J AR","year":"2012","unstructured":"AR J, JJ M. The inflammation highway:metabolism accelerates inflammatory traffic in obesity. Immunol Rev. 2012;209:218\u201338.","journal-title":"Immunol Rev"},{"issue":"1","key":"2247_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1097\/CRD.0000000000000173","volume":"26","author":"C Ashur","year":"2018","unstructured":"Ashur C, Frishman WH. Cardiosphere-Derived cells and ischemic heart failure. Cardiol Rev. 2018;26(1):8\u201321.","journal-title":"Cardiol Rev"},{"issue":"35","key":"2247_CR7","doi-asserted-by":"publisher","first-page":"3558","DOI":"10.1093\/eurheartj\/ehab419","volume":"42","author":"Y-N Lin","year":"2021","unstructured":"Lin Y-N, Mesquita T, Sanchez L, Chen Y-H, Liu W, Li C, et al. Extracellular vesicles from immortalized cardiosphere-derived cells attenuate arrhythmogenic cardiomyopathy in desmoglein-2 mutant mice. Eur Heart J. 2021;42(35):3558\u201371.","journal-title":"Eur Heart J"},{"key":"2247_CR8","doi-asserted-by":"crossref","unstructured":"Marb\u00e1n E, Liao K. On the cellular origin of cardiosphere-derived cells (CDCs). Basic Res Cardiol. 2022;117(1).","DOI":"10.1007\/s00395-022-00914-x"},{"issue":"1","key":"2247_CR9","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1080\/15476286.2022.2057725","volume":"19","author":"M Billmeier","year":"2022","unstructured":"Billmeier M, Green D, Hall AE, Turnbull C, Singh A, Xu P, et al. Mechanistic insights into non-coding Y RNA processing. RNA Biol. 2022;19(1):468\u201380.","journal-title":"RNA Biol"},{"key":"2247_CR10","doi-asserted-by":"crossref","unstructured":"Barile L, Moccetti T, Marb\u00e1n E, Vassalli G. Roles of exosomes in cardioprotection. Eur Heart J. 2016.","DOI":"10.1093\/eurheartj\/ehw304"},{"key":"2247_CR11","doi-asserted-by":"crossref","unstructured":"Gallet R, Dawkins J, Valle J, Simsolo E, de Couto G, Middleton R et al. Exosomes secreted by cardiosphere-derived cells reduce scarring, attenuate adverse remodelling, and improve function in acute and chronic porcine myocardial infarction. Eur Heart J. 2016.","DOI":"10.1093\/eurheartj\/ehw240"},{"issue":"1","key":"2247_CR12","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1146\/annurev-micro-020620-062812","volume":"74","author":"S Sim","year":"2020","unstructured":"Sim S, Hughes K, Chen X, Wolin SL. The bacterial Ro60 protein and its noncoding Y RNA regulators. Annu Rev Microbiol. 2020;74(1):387\u2013407.","journal-title":"Annu Rev Microbiol"},{"key":"2247_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cca.2021.02.003","volume":"517","author":"W Chen","year":"2021","unstructured":"Chen W, Li L, Wang J, Li Q, Zhang R, Wang S, et al. Extracellular vesicle YRNA in atherosclerosis. Clin Chim Acta. 2021;517:15\u201322.","journal-title":"Clin Chim Acta"},{"issue":"12","key":"2247_CR14","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1161\/CIRCRESAHA.119.316311","volume":"129","author":"D Soetkamp","year":"2021","unstructured":"Soetkamp D, Gallet R, Parker SJ, Holewinski R, Venkatraman V, Peck K, et al. Myofilament phosphorylation in stem cell treated Diastolic Heart failure. Circul Res. 2021;129(12):1125\u201340.","journal-title":"Circul Res"},{"key":"2247_CR15","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1016\/j.omtn.2021.04.014","volume":"24","author":"F Huang","year":"2021","unstructured":"Huang F, Na N, Ijichi T, Wu X, Miyamoto K, Ciullo A, et al. Exosomally derived Y RNA fragment alleviates hypertrophic cardiomyopathy in transgenic mice. Mol Therapy - Nucleic Acids. 2021;24:951\u201360.","journal-title":"Mol Therapy - Nucleic Acids"},{"issue":"3","key":"2247_CR16","doi-asserted-by":"publisher","first-page":"337","DOI":"10.15252\/emmm.201606924","volume":"9","author":"L Cambier","year":"2017","unstructured":"Cambier L, de Couto G, Ibrahim A, Echavez AK, Valle J, Liu W, et al. Y RNA fragment in extracellular vesicles confers cardioprotection via modulation of IL-10 expression and secretion. EMBO Mol Med. 2017;9(3):337\u201352.","journal-title":"EMBO Mol Med"},{"key":"2247_CR17","doi-asserted-by":"crossref","unstructured":"Mendoza R, Banerjee I, Manna D, Reghupaty SC, Yetirajam R, Sarkar D. Mouse Bone Marrow Cell Isolation and Macrophage Differentiation. Non-Alcoholic Steatohepatitis. Methods in Molecular Biology2022. pp. 85\u201391.","DOI":"10.1007\/978-1-0716-2128-8_8"},{"key":"2247_CR18","doi-asserted-by":"crossref","unstructured":"Ravi V, Jain A, Taneja A, Chatterjee K, Sundaresan NR. Isolation and culture of neonatal murine primary cardiomyocytes. Curr Protocols. 2021;1(7).","DOI":"10.1002\/cpz1.196"},{"issue":"3","key":"2247_CR19","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ejps.2012.04.018","volume":"47","author":"V Soetikno","year":"2012","unstructured":"Soetikno V, Sari FR, Sukumaran V, Lakshmanan AP, Mito S, Harima M, et al. Curcumin prevents diabetic cardiomyopathy in streptozotocin-induced diabetic rats: possible involvement of PKC\u2013MAPK signaling pathway. Eur J Pharm Sci. 2012;47(3):604\u201314.","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"2247_CR20","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1093\/cvr\/cvt091","volume":"99","author":"\u00d8 Sandanger","year":"2013","unstructured":"Sandanger \u00d8, Ranheim T, Vinge LE, Bliks\u00f8en M, Alfsnes K, Finsen AV, et al. The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia\u2013reperfusion injury. Cardiovascular Res. 2013;99(1):164\u201374.","journal-title":"Cardiovascular Res"},{"key":"2247_CR21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2014\/847827","volume":"2014","author":"J Fuentes-Antr\u00e1s","year":"2014","unstructured":"Fuentes-Antr\u00e1s J, Ioan AM, Tu\u00f1\u00f3n J, Egido J, Lorenzo \u00d3. Activation of toll-like receptors and Inflammasome Complexes in the Diabetic Cardiomyopathy-Associated inflammation. Int J Endocrinol. 2014;2014:1\u201310.","journal-title":"Int J Endocrinol"},{"key":"2247_CR22","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.yjmcc.2019.01.029","volume":"128","author":"V Marrocco","year":"2019","unstructured":"Marrocco V, Bogomolovas J, Ehler E, dos Remedios CG, Yu J, Gao C, et al. PKC and PKN in heart disease. J Mol Cell Cardiol. 2019;128:212\u201326.","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"2247_CR23","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.bbrc.2006.08.018","volume":"349","author":"H-T Ma","year":"2006","unstructured":"Ma H-T, Lin W-W, Zhao B, Wu W-T, Huang W, Li Y, et al. Protein kinase C \u03b2 and \u03b4 isoenzymes mediate cholesterol accumulation in PMA-activated macrophages. Biochem Biophys Res Commun. 2006;349(1):214\u201320.","journal-title":"Biochem Biophys Res Commun"},{"key":"2247_CR24","doi-asserted-by":"crossref","unstructured":"Zhao L, Li Y, Xu T, Lv Q, Bi X, Liu X et al. Dendritic cell-mediated chronic low-grade inflammation is regulated by the RAGE-TLR4-PKC\u03b21 signaling pathway in diabetic atherosclerosis. Mol Med. 2022;28(1).","DOI":"10.1186\/s10020-022-00431-6"},{"issue":"8","key":"2247_CR25","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.1172\/JCI81321","volume":"125","author":"G de Couto","year":"2015","unstructured":"de Couto G, Liu W, Tseliou E, Sun B, Makkar N, Kanazawa H, et al. Macrophages mediate cardioprotective cellular postconditioning in acute myocardial infarction. J Clin Invest. 2015;125(8):3147\u201362.","journal-title":"J Clin Invest"},{"issue":"2","key":"2247_CR26","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1161\/HYPERTENSIONAHA.118.11239","volume":"72","author":"L Cambier","year":"2018","unstructured":"Cambier L, Giani JF, Liu W, Ijichi T, Echavez AK, Valle J, et al. Angiotensin II\u2013Induced End-Organ damage in mice is attenuated by human exosomes and by an exosomal Y RNA fragment. Hypertension. 2018;72(2):370\u201380.","journal-title":"Hypertension"},{"key":"2247_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/6809703","volume":"2016","author":"AM Kay","year":"2016","unstructured":"Kay AM, Simpson CL, Stewart JA. The role of AGE\/RAGE signaling in diabetes-mediated vascular calcification. J Diabetes Res. 2016;2016:1\u20138.","journal-title":"J Diabetes Res"},{"issue":"3","key":"2247_CR28","doi-asserted-by":"publisher","first-page":"F585","DOI":"10.1152\/ajprenal.00186.2009","volume":"297","author":"J-K Chen","year":"2009","unstructured":"Chen J-K, Chen J, Thomas G, Kozma SC, Harris RC. S6 kinase 1 knockout inhibits uninephrectomy- or diabetes-induced renal hypertrophy. Am J Physiology-Renal Physiol. 2009;297(3):F585\u201393.","journal-title":"Am J Physiology-Renal Physiol"},{"key":"2247_CR29","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.metabol.2018.03.004","volume":"83","author":"X Chen","year":"2018","unstructured":"Chen X, Li X, Zhang W, He J, Xu B, Lei B, et al. Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-\u03baB pathway. Metabolism. 2018;83:256\u201370.","journal-title":"Metabolism"},{"issue":"8","key":"2247_CR30","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1038\/jid.2010.194","volume":"130","author":"MF Denning","year":"2010","unstructured":"Denning MF. Protein Kinase C\/Mitogen-Activated Protein Kinase Signaling in keratinocyte differentiation control. J Invest Dermatology. 2010;130(8):1968\u201370.","journal-title":"J Invest Dermatology"},{"key":"2247_CR31","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.atherosclerosis.2017.02.021","volume":"259","author":"MC Zuniga","year":"2017","unstructured":"Zuniga MC, Raghuraman G, Hitchner E, Weyand C, Robinson W, Zhou W. PKC-epsilon and TLR4 synergistically regulate resistin-mediated inflammation in human macrophages. Atherosclerosis. 2017;259:51\u20139.","journal-title":"Atherosclerosis"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-024-02247-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12933-024-02247-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-024-02247-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,12]],"date-time":"2024-06-12T18:02:05Z","timestamp":1718215325000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-024-02247-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,12]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["2247"],"URL":"https:\/\/doi.org\/10.1186\/s12933-024-02247-6","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,12]]},"assertion":[{"value":"24 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors of this study have no potential conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}],"article-number":"202"}}