{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:34:50Z","timestamp":1787020490723,"version":"build-2736575974"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T00:00:00Z","timestamp":1737158400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cardiovasc Diabetol"],"DOI":"10.1186\/s12933-025-02573-3","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T06:11:59Z","timestamp":1737180719000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["ICAM1 blockade improves ischemic muscle reperfusion in diabetic mice"],"prefix":"10.1186","volume":"24","author":[{"given":"Ninon","family":"Foussard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Bourguignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Grouthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Caradu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Chapouly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain-Pierre","family":"Gadeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Couffinhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Ange","family":"Renault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,18]]},"reference":[{"key":"2573_CR1","doi-asserted-by":"publisher","unstructured":"Criqui MH, Matsushita K, Aboyans V, Hess CN, Hicks CW, Kwan TW, McDermott MM, Misra S, Ujueta F, on behalf of the American Heart Association Council on Epidemiology and Prevention; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular Radiology and Intervention; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; and Stroke Council. Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association. Circulation [Internet]; 144, (2021). Accessed 24 Jul 2022. https:\/\/doi.org\/10.1161\/CIR.0000000000001005","DOI":"10.1161\/CIR.0000000000001005"},{"key":"2573_CR2","doi-asserted-by":"publisher","first-page":"868370","DOI":"10.3389\/fcvm.2022.868370","volume":"9","author":"J Lin","year":"2022","unstructured":"Lin J, Chen Y, Jiang N, Li Z, Xu S. Burden of peripheral artery disease and its attributable risk factors in 204 countries and territories from 1990 to 2019. Front Cardiovasc Med. 2022;9:868370.","journal-title":"Front Cardiovasc Med"},{"key":"2573_CR3","doi-asserted-by":"publisher","first-page":"e1020","DOI":"10.1016\/S2214-109X(19)30255-4","volume":"7","author":"P Song","year":"2019","unstructured":"Song P, Rudan D, Zhu Y, Fowkes FJI, Rahimi K, Fowkes FGR, Rudan I. Global, regional, and national prevalence and risk factors for peripheral artery disease in 2015: an updated systematic review and analysis. Lancet Global Health. 2019;7:e1020\u201330.","journal-title":"Lancet Global Health"},{"key":"2573_CR4","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","volume":"76","author":"GA Roth","year":"2020","unstructured":"Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP, Bonny A, Brauer M, Brodmann M, Cahill TJ, Carapetis J, Catapano AL, Chugh SS, Cooper LT, Coresh J, Criqui M, DeCleene N, Eagle KA, Emmons-Bell S, Feigin VL, Fern\u00e1ndez-Sol\u00e0 J, Fowkes G, Gakidou E, Grundy SM, He FJ, Howard G, Hu F, Inker L, Karthikeyan G, Kassebaum N, Koroshetz W, Lavie C, Lloyd-Jones D, Lu HS, Mirijello A, Temesgen AM, Mokdad A, Moran AE, Muntner P, Narula J, Neal B, Ntsekhe M, Moraes de Oliveira G, Otto C, Owolabi M, Pratt M, Rajagopalan S, Reitsma M, Ribeiro ALP, Rigotti N, Rodgers A, Sable C, Shakil S, Sliwa-Hahnle K, Stark B, Sundstr\u00f6m J, Timpel P, Tleyjeh IM, Valgimigli M, Vos T, Whelton PK, Yacoub M, Zuhlke L, Murray C, Fuster V, Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton A, Benjamin EJ, Benziger CP, Bonny A, Brauer M, Brodmann M, Cahill TJ, Carapetis JR, Catapano AL, Chugh S, Cooper LT, Coresh J, Criqui MH, DeCleene NK, Eagle KA, Emmons-Bell S, Feigin VL, Fern\u00e1ndez-Sola J, Fowkes FGR, Gakidou E, Grundy SM, He FJ et al. Global Burden of cardiovascular diseases and risk factors. J Am Coll Cardiol. 2020;76:2982\u20133021.","journal-title":"J Am Coll Cardiol"},{"key":"2573_CR5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s00125-006-0491-1","volume":"50","author":"L Prompers","year":"2007","unstructured":"Prompers L, Huijberts M, Apelqvist J, Jude E, Piaggesi A, Bakker K, Edmonds M, Holstein P, Jirkovska A, Mauricio D, Ragnarson Tennvall G, Reike H, Spraul M, Uccioli L, Urbancic V, Van Acker K, van Baal J, van Merode F, Schaper N. High prevalence of ischaemia, infection and serious comorbidity in patients with diabetic foot disease in Europe. Baseline results from the Eurodiale study. Diabetologia. 2007;50:18\u201325.","journal-title":"Diabetologia"},{"key":"2573_CR6","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.avsg.2022.04.051","volume":"86","author":"K Satam","year":"2022","unstructured":"Satam K, Aboian E, Huttler J, Zhuo H, Zhang Y, Tonnessen B, Cardella J, Guzman RJ, Ochoa Chaar CI. Eligibility of patients with chronic limb threatening ischemia for deep venous arterialization. Ann Vasc Surg. 2022;86:260\u20137.","journal-title":"Ann Vasc Surg"},{"key":"2573_CR7","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1016\/j.jvs.2015.07.065","volume":"62","author":"AM Abu Dabrh","year":"2015","unstructured":"Abu Dabrh AM, Steffen MW, Undavalli C, Asi N, Wang Z, Elamin MB, Conte MS, Murad MH. The natural history of untreated severe or critical limb ischemia. J Vasc Surg. 2015;62:1642\u2013e16513.","journal-title":"J Vasc Surg"},{"key":"2573_CR8","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1067\/mva.2003.142","volume":"37","author":"MR Nehler","year":"2003","unstructured":"Nehler MR, Hiatt WR, Taylor LM. Is revascularization and limb salvage always the best treatment for critical limb ischemia? J Vasc Surg. 2003;37:704\u20138.","journal-title":"J Vasc Surg"},{"key":"2573_CR9","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1016\/j.jvs.2014.03.290","volume":"60","author":"MR Nehler","year":"2014","unstructured":"Nehler MR, Duval S, Diao L, Annex BH, Hiatt WR, Rogers K, Zakharyan A, Hirsch AT. Epidemiology of peripheral arterial disease and critical limb ischemia in an insured national population. J Vasc Surg. 2014;60:686\u2013e6952.","journal-title":"J Vasc Surg"},{"key":"2573_CR10","doi-asserted-by":"publisher","first-page":"3188","DOI":"10.1161\/01.CIR.99.24.3188","volume":"99","author":"T Couffinhal","year":"1999","unstructured":"Couffinhal T, Silver M, Kearney M, Sullivan A, Witzenbichler B, Magner M, Annex B, Peters K, Isner JM. Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-\/- mice. Circulation. 1999;99:3188\u201398.","journal-title":"Circulation"},{"key":"2573_CR11","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1172\/JCI117018","volume":"93","author":"S Takeshita","year":"1994","unstructured":"Takeshita S, Zheng LP, Brogi E, Kearney M, Pu LQ, Bunting S, Ferrara N, Symes JF, Isner JM. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic Hind limb model. J Clin Invest. 1994;93:662\u201370.","journal-title":"J Clin Invest"},{"key":"2573_CR12","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1161\/ATVBAHA.120.315028","volume":"40","author":"JJ Lee","year":"2020","unstructured":"Lee JJ, Arpino J-M, Yin H, Nong Z, Szpakowski A, Hashi AA, Chevalier J, O\u2019Neil C, Pickering JG. Systematic interrogation of angiogenesis in the ischemic mouse Hind limb: vulnerabilities and Quality Assurance. Arterioscler Thromb Vasc Biol. 2020;40:2454\u201367.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2573_CR13","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1177\/1358863X9600100114","volume":"1","author":"JM Isner","year":"1996","unstructured":"Isner JM. Therapeutic angiogenesis: a new frontier for vascular therapy. Vasc Med. 1996;1:79\u201387.","journal-title":"Vasc Med"},{"key":"2573_CR14","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/S0140-6736(96)03361-2","volume":"348","author":"JM Isner","year":"1996","unstructured":"Isner JM, Pieczek A, Schainfeld R, Blair R, Haley L, Asahara T, Rosenfield K, Razvi S, Walsh K, Symes JF. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet. 1996;348:370\u20134.","journal-title":"Lancet"},{"key":"2573_CR15","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1161\/CIRCRESAHA.115.303565","volume":"116","author":"JP Cooke","year":"2015","unstructured":"Cooke JP, Losordo DW. Modulating the vascular response to limb ischemia: angiogenic and cell therapies. Circ Res. 2015;116:1561\u201378.","journal-title":"Circ Res"},{"key":"2573_CR16","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.ejvs.2015.08.018","volume":"50","author":"SMO Peeters Weem","year":"2015","unstructured":"Peeters Weem SMO, Teraa M, de Borst GJ, Verhaar MC, Moll FL. Bone marrow derived cell therapy in critical limb ischemia: a Meta-analysis of Randomized Placebo controlled trials. Eur J Vasc Endovasc Surg. 2015;50:775\u201383.","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"2573_CR17","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.jvs.2015.07.069","volume":"62","author":"AM Abu Dabrh","year":"2015","unstructured":"Abu Dabrh AM, Steffen MW, Asi N, Undavalli C, Wang Z, Elamin MB, Conte MS, Murad MH. Nonrevascularization-based treatments in patients with severe or critical limb ischemia. J Vasc Surg. 2015;62:1330\u2013e133913.","journal-title":"J Vasc Surg"},{"key":"2573_CR18","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1161\/CIRCRESAHA.118.313177","volume":"123","author":"C Caradu","year":"2018","unstructured":"Caradu C, Couffinhal T, Chapouly C, Guimbal S, Hollier PL, Ducasse E, Bura-Riviere A, Dubois M, Gadeau AP, Renault MA. Restoring endothelial function by targeting desert hedgehog downstream of Klf2 improves critical limb ischemia in adults. Circul Res. 2018;123:1053\u201365.","journal-title":"Circul Res"},{"key":"2573_CR19","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1002\/path.1833","volume":"207","author":"J Favier","year":"2005","unstructured":"Favier J, Germain S, Emmerich J, Corvol P, Gasc JM. Critical overexpression of thrombospondin 1 in chronic leg ischaemia. J Pathol. 2005;207:358\u201366.","journal-title":"J Pathol"},{"key":"2573_CR20","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1002\/bjs.5496","volume":"93","author":"TK Ho","year":"2006","unstructured":"Ho TK, Rajkumar V, Black CM, Abraham DJ, Baker DM. Increased angiogenic response but deficient arteriolization and abnormal microvessel ultrastructure in critical leg ischaemia. Br J Surg. 2006;93:1368\u201376.","journal-title":"Br J Surg"},{"key":"2573_CR21","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.jvs.2015.06.139","volume":"64","author":"JM McClung","year":"2016","unstructured":"McClung JM, McCord TJ, Southerland K, Schmidt CA, Padgett ME, Ryan TE, Kontos CD. Subacute limb ischemia induces skeletal muscle injury in genetically susceptible mice independent of vascular density. J Vasc Surg. 2016;64:1101\u2013e11112.","journal-title":"J Vasc Surg"},{"key":"2573_CR22","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1161\/CIRCRESAHA.116.310535","volume":"120","author":"JM Arpino","year":"2017","unstructured":"Arpino JM, Nong Z, Li F, Yin H, Ghonaim N, Milkovich S, Balint B, O\u2019Neil C, Fraser GM, Goldman D, Ellis CG, Pickering JG. Four-dimensional microvascular analysis reveals that regenerative angiogenesis in ischemic muscle produces a flawed microcirculation. Circ Res. 2017;120:1453\u201365.","journal-title":"Circ Res"},{"key":"2573_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/eurheartj\/ehad562","volume":"45","author":"S Tarvainen","year":"2024","unstructured":"Tarvainen S, Wirth G, Juusola G, Hautero O, Kalliokoski K, Sj\u00f6ros T, Nikulainen V, Taavitsainen J, Hyt\u00f6nen J, Frimodig C, Happonen K, Selander T, Laitinen T, Hakovirta HH, Knuuti J, Laham-Karam N, Hartikainen J, M\u00e4kinen K, Yl\u00e4-Herttuala S, Korpisalo P. Critical limb-threatening ischaemia and microvascular transformation: clinical implications. Eur Heart J. 2024;45:255\u201364.","journal-title":"Eur Heart J"},{"key":"2573_CR24","doi-asserted-by":"crossref","unstructured":"Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM. Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight. 2018;3:e123235, 123235.","DOI":"10.1172\/jci.insight.123235"},{"key":"2573_CR25","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1186\/s13073-023-01250-y","volume":"15","author":"KW Southerland","year":"2023","unstructured":"Southerland KW, Xu Y, Peters DT, Lin X, Wei X, Xiang Y, Fei K, Olivere LA, Morowitz JM, Otto J, Dai Q, Kontos CD, Diao Y. Skeletal muscle regeneration failure in ischemic-damaged limbs is associated with pro-inflammatory macrophages and premature differentiation of satellite cells. Genome Med. 2023;15:95.","journal-title":"Genome Med"},{"key":"2573_CR26","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1161\/CIRCRESAHA.122.322033","volume":"132","author":"N Foussard","year":"2023","unstructured":"Foussard N, Rouault P, Cornuault L, Reynaud A, Buys ES, Chapouly C, Gadeau A-P, Couffinhal T, Mohammedi K, Renault M-A. Praliciguat promotes ischemic leg reperfusion in leptin receptor-deficient mice. Circ Res. 2023;132:34\u201348.","journal-title":"Circ Res"},{"key":"2573_CR27","first-page":"1667","volume":"152","author":"T Couffinhal","year":"1998","unstructured":"Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol. 1998;152:1667\u201379.","journal-title":"Am J Pathol"},{"key":"2573_CR28","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1161\/CIRCRESAHA.107.153346","volume":"101","author":"M Bosch-Marce","year":"2007","unstructured":"Bosch-Marce M, Okuyama H, Wesley JB, Sarkar K, Kimura H, Liu YV, Zhang H, Strazza M, Rey S, Savino L, Zhou YF, McDonald KR, Na Y, Vandiver S, Rabi A, Shaked Y, Kerbel R, Lavallee T, Semenza GL. Effects of aging and hypoxia-inducible factor-1 activity on angiogenic cell mobilization and recovery of perfusion after limb ischemia. Circ Res. 2007;101:1310\u20138.","journal-title":"Circ Res"},{"key":"2573_CR29","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.vascn.2016.10.007","volume":"84","author":"S Nath","year":"2017","unstructured":"Nath S, Ghosh SK, Choudhury Y. A murine model of type 2 diabetes mellitus developed using a combination of high fat diet and multiple low doses of streptozotocin treatment mimics the metabolic characteristics of type 2 diabetes mellitus in humans. J Pharmacol Toxicol Methods. 2017;84:20\u201330.","journal-title":"J Pharmacol Toxicol Methods"},{"key":"2573_CR30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1023\/A:1023403928385","volume":"246","author":"D Scholz","year":"2003","unstructured":"Scholz D, Thomas S, Sass S, Podzuweit T. Angiogenesis and myogenesis as two facets of inflammatory post-ischemic tissue regeneration. Mol Cell Biochem. 2003;246:57\u201367.","journal-title":"Mol Cell Biochem"},{"key":"2573_CR31","first-page":"673","volume":"141","author":"C Page","year":"1992","unstructured":"Page C, Rose M, Yacoub M, Pigott R. Antigenic heterogeneity of vascular endothelium. Am J Pathol. 1992;141:673\u201383.","journal-title":"Am J Pathol"},{"key":"2573_CR32","doi-asserted-by":"publisher","first-page":"R943","DOI":"10.1152\/ajpregu.00480.2015","volume":"310","author":"O Baum","year":"2016","unstructured":"Baum O, Torchetti E, Malik C, Hoier B, Walker M, Walker PJ, Odriozola A, Graber F, Tschanz SA, Bangsbo J, Hoppeler H, Askew CD, Hellsten Y. Capillary ultrastructure and mitochondrial volume density in skeletal muscle in relation to reduced exercise capacity of patients with intermittent claudication. Am J Physiol Regul Integr Comp Physiol. 2016;310:R943\u201351.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2573_CR33","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1111\/apm.12586","volume":"124","author":"S Roos","year":"2016","unstructured":"Roos S, Fyhr I-M, Sunnerhagen KS, Moslemi A-R, Oldfors A, Ullman M. Histopathological changes in skeletal muscle associated with chronic ischaemia. APMIS. 2016;124:935\u201341.","journal-title":"APMIS"},{"key":"2573_CR34","doi-asserted-by":"publisher","first-page":"2575","DOI":"10.3390\/jcm9082575","volume":"9","author":"CJ Mietus","year":"2020","unstructured":"Mietus CJ, Lackner TJ, Karvelis PS, Willcockson GT, Shields CM, Lambert NG, Koutakis P, Fuglestad MA, Hernandez H, Haynatzki GR, Kim JKS, DeSpiegelaere HK, Pipinos II, Casale GP. Abnormal microvascular architecture, fibrosis, and pericyte characteristics in the calf muscle of peripheral artery disease patients with claudication and critical limb ischemia. J Clin Med. 2020;9:2575.","journal-title":"J Clin Med"},{"key":"2573_CR35","doi-asserted-by":"publisher","first-page":"100133","DOI":"10.1016\/j.jvssci.2023.100133","volume":"5","author":"CI Ochoa Chaar","year":"2024","unstructured":"Ochoa Chaar CI, Kim T, Alameddine D, DeWan A, Guzman R, Dardik A, Grossetta Nardini HK, Wallach JD, Kullo I, Murray M. Systematic review and meta-analysis of the genetics of peripheral arterial disease. JVS Vasc Sci. 2024;5:100133.","journal-title":"JVS Vasc Sci"},{"key":"2573_CR36","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1369\/0022155415569348","volume":"63","author":"P Koutakis","year":"2015","unstructured":"Koutakis P, Miserlis D, Myers SA, Kim JK, Zhu Z, Papoutsi E, Swanson SA, Haynatzki G, Ha DM, Carpenter LA, McComb RD, Johanning JM, Casale GP. Pipinos. Abnormal accumulation of desmin in gastrocnemius myofibers of patients with peripheral artery disease: associations with altered myofiber morphology and density, mitochondrial dysfunction and impaired limb function. J Histochem Cytochem. 2015;63:256\u201369.","journal-title":"J Histochem Cytochem"},{"key":"2573_CR37","doi-asserted-by":"publisher","first-page":"R291","DOI":"10.1152\/ajpregu.00525.2012","volume":"305","author":"K Cluff","year":"2013","unstructured":"Cluff K, Miserlis D, Naganathan GK, Pipinos II, Koutakis P, Samal A, McComb RD, Subbiah J, Casale GP. Morphometric analysis of gastrocnemius muscle biopsies from patients with peripheral arterial disease: objective grading of muscle degeneration. Am J Physiol Regul Integr Comp Physiol. 2013;305:R291\u20139.","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2573_CR38","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.avsg.2023.09.094","volume":"99","author":"J Ferreira","year":"2024","unstructured":"Ferreira J, Afonso J, Longatto-Filho A, Roque S, Carneiro A, Vila I, Silva C, Cunha C, Mesquita A, Cotter J, Correia-Neves M, Mansilha A, Cunha P. Inflammation is a histological characteristic of skeletal muscle in chronic limb threatening ischemia. Ann Vasc Surg. 2024;99:10\u20138.","journal-title":"Ann Vasc Surg"},{"key":"2573_CR39","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.jvssci.2022.03.003","volume":"3","author":"ZR Salyers","year":"2022","unstructured":"Salyers ZR, Mariani V, Balestrieri N, Kumar RA, Vugman NA, Thome T, Villani KR, Berceli SA, Scali ST, Vasilakos G, Ryan TE. S100A8 and S100A9 are elevated in chronically threatened ischemic limb muscle and induce ischemic mitochondrial pathology in mice. JVS Vasc Sci. 2022;3:232\u201345.","journal-title":"JVS Vasc Sci"},{"key":"2573_CR40","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.jvs.2009.10.044","volume":"51","author":"TK Ho","year":"2010","unstructured":"Ho TK, Tsui J, Xu S, Leoni P, Abraham DJ, Baker DM. Angiogenic effects of stromal cell-derived factor-1 (SDF-1\/CXCL12) variants in vitro and the in vivo expressions of CXCL12 variants and CXCR4 in human critical leg ischemia. J Vasc Surg. 2010;51:689\u201399.","journal-title":"J Vasc Surg"},{"key":"2573_CR41","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1161\/CIRCRESAHA.113.301546","volume":"113","author":"MA Renault","year":"2013","unstructured":"Renault MA, Vandierdonck S, Chapouly C, Yu Y, Qin G, Metras A, Couffinhal T, Losordo DW, Yao Q, Reynaud A, Jaspard-Vinassa B, Belloc I, Desgranges C, Gadeau AP. Gli3 regulation of myogenesis is necessary for ischemia-induced angiogenesis. Circ Res. 2013;113:1148\u201358.","journal-title":"Circ Res"},{"key":"2573_CR42","doi-asserted-by":"crossref","unstructured":"Caradu C, Guy A, James C, Reynaud A, Gadeau AP, Renault MA. Endogenous sonic hedgehog limits inflammation and angiogenesis in the ischemic skeletal muscle of mice. Cardiovascular Res. 2018;114:759\u201370.","DOI":"10.1093\/cvr\/cvy017"},{"key":"2573_CR43","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/j.redox.2014.07.002","volume":"2","author":"P Koutakis","year":"2014","unstructured":"Koutakis P, Weiss DJ, Miserlis D, Shostrom VK, Papoutsi E, Ha DM, Carpenter LA, McComb RD, Casale GP, Pipinos II. Oxidative damage in the gastrocnemius of patients with peripheral artery disease is myofiber type selective. Redox Biol. 2014;2:921\u20138.","journal-title":"Redox Biol"},{"key":"2573_CR44","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1161\/CIRCRESAHA.123.323161","volume":"133","author":"CG Pass","year":"2023","unstructured":"Pass CG, Palzkill V, Tan J, Kim K, Thome T, Yang Q, Fazzone B, Robinson ST, O\u2019Malley KA, Yue F, Scali ST, Berceli SA, Ryan TE. Single-nuclei RNA-sequencing of the gastrocnemius muscle in peripheral artery disease. Circ Res. 2023;133:791\u2013809.","journal-title":"Circ Res"}],"container-title":["Cardiovascular Diabetology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-025-02573-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12933-025-02573-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12933-025-02573-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T06:58:59Z","timestamp":1737183539000},"score":1,"resource":{"primary":{"URL":"https:\/\/cardiab.biomedcentral.com\/articles\/10.1186\/s12933-025-02573-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,18]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2573"],"URL":"https:\/\/doi.org\/10.1186\/s12933-025-02573-3","relation":{},"ISSN":["1475-2840"],"issn-type":[{"value":"1475-2840","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,18]]},"assertion":[{"value":"23 October 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 January 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"20"}}