{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:56:43Z","timestamp":1790423803736,"version":"4.1.0"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88881.062224\/2014-01"],"award-info":[{"award-number":["88881.062224\/2014-01"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["2252\/2011"],"award-info":[{"award-number":["2252\/2011"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ23197"],"award-info":[{"award-number":["APQ23197"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["311743\/2013-7"],"award-info":[{"award-number":["311743\/2013-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microb Cell Fact"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12934-016-0548-x","type":"journal-article","created":{"date-parts":[[2016,8,30]],"date-time":"2016-08-30T10:53:17Z","timestamp":1472554397000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Lactococcus lactis carrying the pValac eukaryotic expression vector coding for IL-4 reduces chemically-induced intestinal inflammation by increasing the levels of IL-10-producing regulatory cells"],"prefix":"10.1186","volume":"15","author":[{"given":"Bianca Mendes","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Melo","family":"Preisser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Bastos","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Zurita-Turk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Pr\u00f3speri","family":"de Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa Pecini","family":"da Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Pires","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cristina","family":"Gomes-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Caetano","family":"de Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Carmona Cara","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Chatel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco Ariston de Carvalho","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Langella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0480-8993","authenticated-orcid":false,"given":"Anderson","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,8,30]]},"reference":[{"key":"548_CR1","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/medicina44010005","volume":"44","author":"J Sventoraityte","year":"2008","unstructured":"Sventoraityte J, Zvirbliene A, Kiudelis G, et al. Immune system alterations in patients with inflammatory bowel disease during remission. Medicina (Kaunas). 2008;44:27\u201333.","journal-title":"Medicina (Kaunas)"},{"key":"548_CR2","first-page":"309","volume":"13","author":"MG Neuman","year":"2004","unstructured":"Neuman MG. Signaling for inflammation and repair in inflammatory bowel disease. Rom J Gastroenterol. 2004;13:309\u201316.","journal-title":"Rom J Gastroenterol"},{"key":"548_CR3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ijmm.2009.08.004","volume":"300","author":"C Reiff","year":"2010","unstructured":"Reiff C, Kelly D. Inflammatory bowel disease, gut bacteria and probiotic therapy. Int J Med Microbiol. 2010;300:25\u201333.","journal-title":"Int J Med Microbiol"},{"key":"548_CR4","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.anaerobe.2013.04.006","volume":"24","author":"JM Peloquin","year":"2013","unstructured":"Peloquin JM, Nguyen DD. The microbiota and inflammatory bowel disease: insights from animal models. Anaerobe. 2013;24:102\u20136.","journal-title":"Anaerobe"},{"key":"548_CR5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/MOG.0b013e32835b9a40","volume":"29","author":"T Yamamoto","year":"2013","unstructured":"Yamamoto T. Nutrition and diet in inflammatory bowel disease. Curr Opin Gastroenterol. 2013;29:216\u201321.","journal-title":"Curr Opin Gastroenterol"},{"key":"548_CR6","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1203\/PDR.0b013e318163a897","volume":"63","author":"N Holland","year":"2008","unstructured":"Holland N, Dong J, Garnett E, et al. Reduced intracellular T-helper 1 interferon-gamma in blood of newly diagnosed children with Crohn\u2019s disease and age-related changes in Th1\/Th2 cytokine profiles. Pedriatr Res. 2008;63:257\u201362.","journal-title":"Pedriatr Res"},{"key":"548_CR7","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1089\/10430340050111386","volume":"11","author":"MA Rogy","year":"2000","unstructured":"Rogy MA, Beinhauer BG, Reinisch W, et al. Transfer of interleukin-4 and interleukin-10 in patients with severe inflammatory bowel disease of the rectum. Hum Gene Ther. 2000;11:1731\u201341.","journal-title":"Hum Gene Ther"},{"key":"548_CR8","first-page":"73","volume":"4","author":"JPF Schoffen","year":"2011","unstructured":"Schoffen JPF, Prado IMM. Aspectos epidemiol\u00f3gicos e etiol\u00f3gicos da doen\u00e7a de Crohn. Revista Sa\u00fade e Pesquisa. 2011;4:73\u201380.","journal-title":"Revista Sa\u00fade e Pesquisa"},{"key":"548_CR9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4292\/wjgpt.v4.i3.41","volume":"4","author":"GC Actis","year":"2013","unstructured":"Actis GC, Rosina F. Inflammatory bowel disease: an archetype disorder of outer environment sensor systems. World J Gastrointest Pharmacol Ther. 2013;4:41\u20136.","journal-title":"World J Gastrointest Pharmacol Ther"},{"key":"548_CR10","doi-asserted-by":"crossref","first-page":"e0011","DOI":"10.5041\/RMMJ.10111","volume":"4","author":"Y Chowers","year":"2013","unstructured":"Chowers Y. Taking Crohn\u2019s disease personally. Rambam Maimonides Med J. 2013;4:e0011.","journal-title":"Rambam Maimonides Med J."},{"key":"548_CR11","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1172\/JCI30587","volume":"117","author":"W Strober","year":"2007","unstructured":"Strober W, Fuss I, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117:514\u201321.","journal-title":"J Clin Invest."},{"key":"548_CR12","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1182\/blood.V77.9.1859.1859","volume":"77","author":"WE Paul","year":"1991","unstructured":"Paul WE. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood. 1991;77:1859\u201370.","journal-title":"Blood"},{"issue":"753","key":"548_CR13","first-page":"64","volume":"92","author":"IG Luzina","year":"2012","unstructured":"Luzina IG, Keegan AD, Heller NM, et al. Regulation of inflammation by interleukin-4: a review of \u201calternatives\u201d. J Leukoc Biol. 2012;92(753):64.","journal-title":"J Leukoc Biol"},{"key":"548_CR14","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1067\/mai.2001.114989","volume":"107","author":"FD Finkelman","year":"2001","unstructured":"Finkelman FD, Urban JF Jr. The other side of the coin: the protective role of the TH2 cytokines. J Allergy Clin Immunol. 2001;107:772\u201380.","journal-title":"J Allergy Clin Immunol"},{"key":"548_CR15","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1365-2567.2011.03499.x","volume":"134","author":"CJ Oliphant","year":"2011","unstructured":"Oliphant CJ, Barlow JL, McKenzie AN. Insights into the initiation of type 2 immune responses. Immunology. 2011;134:378\u201385.","journal-title":"Immunology"},{"key":"548_CR16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","volume":"32","author":"S Gordon","year":"2010","unstructured":"Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity. 2010;32:593\u2013604.","journal-title":"Immunity"},{"key":"548_CR17","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1007\/s13238-011-1083-5","volume":"2","author":"Z Li","year":"2011","unstructured":"Li Z, Zhang Y, Sun B. Current understanding of Th2 cell differentiation and function. Protein Cell. 2011;2:604\u201311.","journal-title":"Protein Cell"},{"key":"548_CR18","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1172\/JCI119823","volume":"100","author":"CM Hogaboam","year":"1997","unstructured":"Hogaboam CM, Vallance BA, Kumar A, et al. Therapeutic effects of interleukin-4 gene transfer in experimental inflammatory bowel disease. J Clin Invest. 1997;100:2766\u201376.","journal-title":"J Clin Invest."},{"key":"548_CR19","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1378\/chest.117.4.1162","volume":"117","author":"SM Opal","year":"2000","unstructured":"Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest. 2000;117:1162\u201372.","journal-title":"Chest"},{"key":"548_CR20","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.3748\/wjg.14.4280","volume":"14","author":"F Sanchez-Munoz","year":"2008","unstructured":"Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK. Role of cytokines in inflammatory bowel disease. World J Gastroenterol. 2008;14:4280\u20138.","journal-title":"World J Gastroenterol"},{"key":"548_CR21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/1471-230X-13-165","volume":"13","author":"J Xiong","year":"2013","unstructured":"Xiong J, Lin YH, Bi LH, et al. Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis. BMC Gastroenterol. 2013;13:165.","journal-title":"BMC Gastroenterol"},{"key":"548_CR22","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1128\/AEM.00825-09","volume":"75","author":"S Innocentin","year":"2009","unstructured":"Innocentin S, Guimar\u00e3es V, Miyoshi A, et al. Lactococcus lactis expressing either Staphylococcus aureus fibronectin-binding protein A or Listeria monocytogenes internalin A can efficiently internalize and deliver DNA in human epithelial cells. Appl Environ Microbiol. 2009;75:4870\u20138.","journal-title":"Appl Environ Microbiol"},{"key":"548_CR23","doi-asserted-by":"crossref","first-page":"e44892","DOI":"10.1371\/journal.pone.0044892","volume":"7","author":"D Pontes","year":"2012","unstructured":"Pontes D, Innocentin S, Del Carmen S, et al. Production of fibronectin binding protein A at the surface of Lactococcus lactis increases plasmid transfer in vitro and in vivo. PLoS One. 2012;7:e44892.","journal-title":"PLoS One"},{"key":"548_CR24","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/1721727X1301100308","volume":"11","author":"S Carmen Del","year":"2013","unstructured":"Del Carmen S, Zurita-Turk M, Lima FA, et al. A novel interleukin-10 DNA mucosal delivery system attenuates intestinal inflammation in a mouse model. Eur J Inflamm. 2013;11:641\u201354.","journal-title":"Eur J Inflamm"},{"key":"548_CR25","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1479-0556-7-4","volume":"7","author":"V Guimar\u00e3es","year":"2009","unstructured":"Guimar\u00e3es V, Innocentin S, Chatel JM, et al. A new plasmid vector for DNA delivery using lactococci. Genet Vaccines Ther. 2009;7:4.","journal-title":"Genet Vaccines Ther"},{"key":"548_CR26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1006\/excr.1996.3427","volume":"230","author":"DA Dean","year":"1997","unstructured":"Dean DA. Import of plasmid DNA into the nucleus is sequence specific. Exp Cell Res. 1997;230:293\u2013302.","journal-title":"Exp Cell Res"},{"key":"548_CR27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/sj.gt.3300924","volume":"6","author":"J Vacik","year":"1999","unstructured":"Vacik J, Dean BS, Zimmer WE, et al. Cell-specific nuclear import of plasmid DNA. Gene Ther. 1999;6:1006\u201314.","journal-title":"Gene Ther"},{"key":"548_CR28","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1128\/IAI.69.10.6296-6302.2001","volume":"69","author":"YA Que","year":"2001","unstructured":"Que YA, Francois P, Haefliger JA, et al. Reassessing the role of Staphylococcus aureus clumping factor and fibronecting-binding protein by expression in Lactococcus lactis. Infect Immun. 2001;69:6296\u2013302.","journal-title":"Infect Immun"},{"key":"548_CR29","first-page":"177","volume-title":"Molecular cloning: a laboratory manual","author":"JS Reece-Hoyes","year":"2012","unstructured":"Reece-Hoyes JS, Walhout AJM. Cloning and transformation with plasmid vectors. In: Green MR, Sambrook J, editors. Molecular cloning: a laboratory manual. Cold Spring Harbor: Cold Spring Harbor Laboratory; 2012. p. 177\u201382."},{"key":"548_CR30","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/jb.175.18.5806-5813.1993","volume":"175","author":"P Langella","year":"1993","unstructured":"Langella P, Le Loir Y, Ehrlich SD, et al. Efficient plasmid mobilization by pIP501 in Lactococcus lactis subsp. lactis. J Bacteriol. 1993;175:5806\u201313.","journal-title":"J Bacteriol"},{"key":"548_CR31","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0002-9440(10)64466-5","volume":"161","author":"N Cenac","year":"2002","unstructured":"Cenac N, Coelho AM, Nguyen C, et al. Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2. Am J Pathol. 2002;161:1903\u201315.","journal-title":"Am J Pathol"},{"key":"548_CR32","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1136\/gut.41.4.487","volume":"41","author":"CK Ameho","year":"1997","unstructured":"Ameho CK, Adjei AA, Harrison EK, et al. Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor \u03b1 production in trinitrobenzene sulphonic acid induced colitis. Gut. 1997;41:487\u201393.","journal-title":"Gut"},{"key":"548_CR33","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/75068","volume":"6","author":"R Atreya","year":"2000","unstructured":"Atreya R, Mudter J, Finotto S, et al. Blockade of interleukin 6 trans signaling suppresses T-cell resistance against apoptosis in chronic intestinal inflammation: evidence in crohn disease and experimental colitis in vivo. Nat Med. 2000;6:583\u20138.","journal-title":"Nat Med"},{"key":"548_CR34","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.pathophys.2014.05.002","volume":"21","author":"YL Jones-Hall","year":"2014","unstructured":"Jones-Hall YL, Grisham MB. Immunopathological characterization of selected mouse models of inflammatory bowel disease: comparison to human disease. Pathophysiology. 2014;21:267\u201388.","journal-title":"Pathophysiology"},{"key":"548_CR35","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1074-7613(01)00151-0","volume":"14","author":"SM Hurst","year":"2001","unstructured":"Hurst SM, Wilkinson TS, McLoughlin RM, et al. IL-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. Immunity. 2001;14:705\u201314.","journal-title":"Immunity"},{"issue":"25","key":"548_CR36","first-page":"9","volume":"24","author":"G Kaplasnki","year":"2003","unstructured":"Kaplasnki G, Marin V, Montero-Julian F, et al. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol. 2003;24(25):9.","journal-title":"Trends Immunol"},{"key":"548_CR37","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/01.MIB.0000218764.06959.91","volume":"12","author":"Z Zhang","year":"2006","unstructured":"Zhang Z, Zheng M, Bindas J, et al. Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis. 2006;12:382\u20138.","journal-title":"Inflamm Bowel Dis"},{"key":"548_CR38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.smim.2013.12.003","volume":"26","author":"MJ Waldner","year":"2014","unstructured":"Waldner MJ, Neurath MF. Master regulator of intestinal disease: iL-6 in chronic inflammation and cancer development. Semin Immunol. 2014;26:75\u20139.","journal-title":"Semin Immunol"},{"key":"548_CR39","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1136\/gut.2009.182170","volume":"58","author":"L Rovedatti","year":"2009","unstructured":"Rovedatti L, Kudo T, Biancheri P, et al. Differential regulation of interleukin 17 and interferon gamma production in inflammatory bowel disease. Gut. 2009;58:1629\u201336.","journal-title":"Gut"},{"key":"548_CR40","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.192.1.41","volume":"192","author":"A Kitani","year":"2000","unstructured":"Kitani A, Fuss IJ, Nakamura K, et al. Treatment of experimental (trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-\u03b21 plasmid: TGF-\u03b21-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and IL-12 receptor \u03b22 chain downregulation. J Exp Med. 2000;192:41\u201352.","journal-title":"J Exp Med"},{"key":"548_CR41","doi-asserted-by":"crossref","first-page":"900","DOI":"10.4049\/jimmunol.168.2.900","volume":"168","author":"IJ Fuss","year":"2002","unstructured":"Fuss IJ, Boirivant M, Lacy B, et al. The interrelated roles of TGF-\u03b2 and IL-10 in the regulation of experimental colitis. J Immunol. 2002;168:900\u20138.","journal-title":"J Immunol"},{"key":"548_CR42","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nri2322","volume":"8","author":"A Cerutti","year":"2008","unstructured":"Cerutti A. The regulation of IgA class switching. Nat Rev Immunol. 2008;8:421\u201334.","journal-title":"Nat Rev Immunol"},{"key":"548_CR43","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/imr.12180","volume":"260","author":"KL Alexander","year":"2014","unstructured":"Alexander KL, Targan SR, Elson CO. Microbiota activation and regulation of innate and adaptive immunity. Immunol Rev. 2014;260:206\u201320.","journal-title":"Immunol Rev"},{"key":"548_CR44","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.4049\/jimmunol.162.9.5224","volume":"162","author":"MK Levings","year":"1999","unstructured":"Levings MK, Schrader JW. IL-4 inhibits the production of TNF-\u03b1 and IL-12 by STAT6-dependent and -independent mechanisms. J Immunol. 1999;162:5224\u20139.","journal-title":"J Immunol"},{"key":"548_CR45","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1084\/jem.20011956","volume":"195","author":"MF Neurath","year":"2002","unstructured":"Neurath MF, Weigmann B, Finotto F, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn\u2019s disease. J Exp Med. 2002;195:1129\u201343.","journal-title":"J Exp Med"},{"key":"548_CR46","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1126\/science.1059835","volume":"292","author":"AC Mullen","year":"2001","unstructured":"Mullen AC, High FA, Hutchins AS, et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science. 2001;292:1907\u201310.","journal-title":"Science"},{"key":"548_CR47","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nm0602-567","volume":"8","author":"MG Neurath","year":"2002","unstructured":"Neurath MG, Finotto F, Glimcher LH. The role of Th1\/Th2 polarization in mucosal immunity. Nat Med. 2002;8:567\u201373.","journal-title":"Nat Med"},{"key":"548_CR48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1097\/01.mib.0000227817.54969.5e","volume":"12","author":"AA Velde te","year":"2006","unstructured":"te Velde AA, Verstege MI, Hommes DW. Critical appraisal of the current practice in murine TNBS-induced colitis. Inflamm Bowel Dis. 2006;12:995\u20139.","journal-title":"Inflamm Bowel Dis"},{"key":"548_CR49","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.4049\/jimmunol.164.9.4878","volume":"164","author":"M Yamamoto","year":"2000","unstructured":"Yamamoto M, Yoshizaki K, Kishimoto T, et al. IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol. 2000;164:4878\u201382.","journal-title":"J Immunol"},{"key":"548_CR50","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1089\/jir.2012.0030","volume":"32","author":"Y Jin","year":"2012","unstructured":"Jin Y, Lin Y, Lin L, et al. IL-17\/INF-\u03b3 interactions regulate intestinal inflammation in TNBS-induced acute colitis. J Interferon Cytokine Res. 2012;32:548\u201356.","journal-title":"J Interferon Cytokine Res"},{"key":"548_CR51","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature04754","volume":"441","author":"PR Magan","year":"2006","unstructured":"Magan PR, Harrington LE, O\u2019Quinn DB, et al. Transforming growth factor-\u03b2 induces development of the T(H)17 lineage. Nature. 2006;441:231\u20134.","journal-title":"Nature"},{"key":"548_CR52","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.20.100301.064816","volume":"20","author":"W Strober","year":"2002","unstructured":"Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20:495\u2013549.","journal-title":"Annu Rev Immunol"},{"key":"548_CR53","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1472-6750-14-73","volume":"14","author":"M Zurita-Turk","year":"2014","unstructured":"Zurita-Turk M, Del Carmen S, Santos AC, et al. Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis. BMC Biotechnol. 2014;14:73.","journal-title":"BMC Biotechnol"},{"key":"548_CR54","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1159\/000329099","volume":"3","author":"AM Mowat","year":"2011","unstructured":"Mowat AM, Bain CC. Mucosal macrophages in intestinal homeostasis and inflammation. J Innate Immun. 2011;3:550\u201364.","journal-title":"J Innate Immun"},{"key":"548_CR55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.cellimm.2014.03.012","volume":"291","author":"CC Bain","year":"2014","unstructured":"Bain CC, Mowat AM. The monocyte-macrophage axis in the intestine. Cell Immunol. 2014;291:41\u20138.","journal-title":"Cell Immunol"},{"key":"548_CR56","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/imr.12192","volume":"260","author":"CC Bain","year":"2014","unstructured":"Bain CC, Mowat AM. Macrophages in intestinal homeostasis and inflammation. Immunol Rev. 2014;260:102\u201317.","journal-title":"Immunol Rev"},{"key":"548_CR57","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/nri2448","volume":"8","author":"MD Mosser","year":"2008","unstructured":"Mosser MD, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008;8:958\u201369.","journal-title":"Nat Rev Immunol"},{"key":"548_CR58","doi-asserted-by":"crossref","first-page":"848","DOI":"10.7326\/0003-4819-128-10-199805150-00009","volume":"128","author":"W Strober","year":"1998","unstructured":"Strober W, L\u00fadv\u00edksson BR, Fuss IJ. The pathogenesis of mucosal inflammation in murine models of inflammatory bowel disease and Crohn disease. Ann Intern Med. 1998;128:848\u201356.","journal-title":"Ann Intern Med"},{"key":"548_CR59","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pep.2011.06.005","volume":"79","author":"DS Pontes","year":"2011","unstructured":"Pontes DS, de Azevedo MS, Chatel JM, et al. Lactococcus lactis as a live vector: heterologous protein production and DNA delivery systems. Protein Expr Purif. 2011;79:165\u201375.","journal-title":"Protein Expr Purif"},{"key":"548_CR60","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s10517-012-1572-4","volume":"152","author":"SV Lyamina","year":"2012","unstructured":"Lyamina SV, Kruglov SV, Vedenikin TY, et al. Alternative reprogramming of M1\/M2 phenotype of mouse peritoneal macrophages in vitro with interferon-\u03b3 and interleukin-4. Bull Exp Biol Med. 2012;152:548\u201351.","journal-title":"Bull Exp Biol Med"},{"key":"548_CR61","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1182\/blood-2006-05-019430","volume":"108","author":"A Mantovani","year":"2006","unstructured":"Mantovani A. Macrophage diversity and polarization: in vivo veritas. Blood. 2006;108:408\u20139.","journal-title":"Blood"}],"container-title":["Microbial Cell Factories"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12934-016-0548-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T22:11:04Z","timestamp":1692483064000},"score":1,"resource":{"primary":{"URL":"http:\/\/microbialcellfactories.biomedcentral.com\/articles\/10.1186\/s12934-016-0548-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8,30]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["548"],"URL":"https:\/\/doi.org\/10.1186\/s12934-016-0548-x","relation":{},"ISSN":["1475-2859"],"issn-type":[{"value":"1475-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,30]]},"article-number":"150"}}