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The present study was designed to identify the bacterial community characterized by 16S rRNA amplicon sequencing and determine the modulate affection of bacterial composition response western and Chinese medicine Qinghuayin (QHY) as well as antibiotic on model rats. The result shown the overall structure alteration of bacterial appeared under medicine intervened, antibiotic caused a marked depletion in bacterial diversity and richness. The enrichments of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    (85.1\u201390.7%) in antibiotic-free converts into\n                    <jats:italic>Bacteroidetes<\/jats:italic>\n                    (30.7\u201334.6%) in antibiotic-added model rat were demonstrated.\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    as the most dominant phylum in antibiotic-free treatments and significantly decreased till 21.9\u201368.5% in antibiotic-added treatments. Especially QHY-treated rats showed highest RA of\n                    <jats:italic>Firmicutes<\/jats:italic>\n                    (90.7%) and the amelioration of CAG using QHY attributed by beneficial bacterial enrichment, especially\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    and\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    . In addition, alpha and beta diversity analysis also demonstrated the clear dispersion and aggregation that revealed the alteration and steady of bacterial community structures. In summary, QHY has potential application value in the treatment of CAG, which attributed to close relation with the modulatory of internal bacterial communities.\n                  <\/jats:p>","DOI":"10.1186\/s12934-021-01525-2","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T08:02:56Z","timestamp":1612252976000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Modulation of gastrointestinal bacterial in chronic atrophic gastritis model rats by Chinese and west medicine intervention"],"prefix":"10.1186","volume":"20","author":[{"given":"Minghan","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-454X","authenticated-orcid":false,"given":"Sihan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youcheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuili","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"1525_CR1","doi-asserted-by":"publisher","first-page":"103774","DOI":"10.1016\/j.micpath.2019.103774","volume":"137","author":"I Aggeletopoulou","year":"2019","unstructured":"Aggeletopoulou I, Konstantakis C, Assimakopoulos SF, Triantos C. 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