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This research sought to isolate and determine the safety and inhibitory capabilities of a\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      culture taken from the human body\n                      <jats:italic>.<\/jats:italic>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One organism was isolated, named \u201c\n                      <jats:italic>L. gasseri<\/jats:italic>\n                      HHuMIN D\u201d, and evaluated for safety. A 5% dilution of\n                      <jats:italic>L. gasseri<\/jats:italic>\n                      HHuMIN D culture supernatant exhibited 88.8% inhibition against halitosis-producing anaerobic microorganisms and the organism itself exhibited powerful inhibitory effects on the growth of 11 oral bacteria. Hydrogen peroxide production reached 802\u00a0\u03bcmol\/L after 12\u00a0h and gradually diminished until 24\u00a0h, it efficiently aggregated with\n                      <jats:italic>P. catoniae<\/jats:italic>\n                      and\n                      <jats:italic>S. sanguinis<\/jats:italic>\n                      , and it completely suppressed\n                      <jats:italic>S. mutans<\/jats:italic>\n                      -manufactured artificial dental plaque.\n                      <jats:italic>L. gasseri<\/jats:italic>\n                      HHuMIN D\u2019s KB cell adhesion capacity was 4.41\u00a0cells\u00a0per\u00a0cell, and the cell adhesion of\n                      <jats:italic>F. nucleatum<\/jats:italic>\n                      and\n                      <jats:italic>S. mutans<\/jats:italic>\n                      diminished strongly in protection and displacement assays.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      These results suggest that\n                      <jats:italic>L. gasseri<\/jats:italic>\n                      HHuMIN D is a safe, bioactive, lactobacterial food ingredient, starter culture, and\/or probiotic microorganism for human oral health.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12934-021-01563-w","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T07:03:04Z","timestamp":1616482984000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Oral probiotic activities and biosafety of Lactobacillus gasseri HHuMIN D"],"prefix":"10.1186","volume":"20","author":[{"given":"Soyon","family":"Mann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong Soo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony V.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun Eog","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keum Taek","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2661-5073","authenticated-orcid":false,"given":"Seockmo","family":"Ku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"1563_CR1","unstructured":"CDC. 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