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The current study aimed to isolate and identify oleaginous yeasts having superior ability to accumulate high quantities of lipids; and enhancing lipid production using response surface methodology and repeated-batch fermentation. Results revealed that, twenty marine oleaginous yeasts were isolated, and the most potent lipid producer isolate was <jats:italic>Candida parapsilosis<\/jats:italic> Y19 according to qualitative screening test using Nile-red dye. Orange peels was used as substrate where <jats:italic>C. parapsilosis<\/jats:italic> Y19 produced 1.14\u00a0g\/l lipids at 23.0% in batch fermentation. To enhance the lipid production, statistical optimization using Taguchi design through Response surface methodology was carried out. Total lipids were increased to 2.46\u00a0g\/l and lipid content increased to 30.7% under optimal conditions of: orange peel 75\u00a0g\/l, peptone 7\u00a0g\/l, yeast extract 5\u00a0g\/l, inoculum size 2%\u00a0(<jats:italic>v\/v<\/jats:italic>), pH 5 and incubation period 6 d. Furthermore, repeated-batch fermentation of <jats:italic>C. parapsilosis<\/jats:italic> Y19 enhanced lipid production where total lipids increased at 4.19 folds (4.78\u00a0g\/l) compared to batch culture (before optimization). Also, the lipid content was increased at 1.7 folds (39.1%) compared to batch culture (before optimization). Fatty acid profile of the produced lipid using repeated-batch fermentation includes unsaturated fatty acids (USFAs) at 74.8% and saturated fatty acids (SFAs) at 25.1%. Additionally, in repeated-batch fermentation, the major fatty acid was oleic acid at 45.0%; followed by linoleic acid at 26.0%. In conclusion, <jats:italic>C. parapsilosis<\/jats:italic> Y19 is considered a promising strain for lipid production. Also, both statistical optimizations using RSM and repeated-batch fermentation are efficient methods for lipid production from <jats:italic>C. parapsilosis<\/jats:italic> Y19.<\/jats:p>","DOI":"10.1186\/s12934-024-02635-3","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T13:23:06Z","timestamp":1736515386000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Response surface methodology and repeated-batch fermentation strategies for enhancing lipid production from marine oleaginous Candida parapsilosis Y19 using orange peel waste"],"prefix":"10.1186","volume":"24","author":[{"given":"AbdAllah M.","family":"Matouk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadallah M.","family":"Abu-Elreesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Ali","family":"Abdel-Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Said E.","family":"Desouky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr H.","family":"Hashem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"issue":"5","key":"2635_CR1","first-page":"409","volume":"5","author":"A Akpinar-Bayizit","year":"2014","unstructured":"Akpinar-Bayizit A. 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