{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T05:19:45Z","timestamp":1781846385003,"version":"3.54.5"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T00:00:00Z","timestamp":1759708800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011735","name":"Bioenergy Technologies Office","doi-asserted-by":"publisher","award":["DE-AC02-05CH11231"],"award-info":[{"award-number":["DE-AC02-05CH11231"]}],"id":[{"id":"10.13039\/100011735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microb Cell Fact"],"DOI":"10.1186\/s12934-025-02841-7","type":"journal-article","created":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:16:35Z","timestamp":1759756595000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Production of triacetic acid lactone from oleic acid by engineering the yeast Candida viswanathii"],"prefix":"10.1186","volume":"24","author":[{"given":"Saptarshi","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Hutagalung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier E.","family":"Flores","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yichao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonhoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan C.","family":"Burnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Mo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,6]]},"reference":[{"key":"2841_CR1","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1021\/jacsau.2c00344","volume":"2","author":"JS Cho","year":"2022","unstructured":"Cho JS, Kim GB, Eun H, Moon CW, Lee SY. Designing microbial cell factories for the production of chemicals. JACS Au. 2022;2:1781\u201399.","journal-title":"JACS Au"},{"key":"2841_CR2","doi-asserted-by":"publisher","DOI":"10.1093\/jimb\/kuab056","author":"BC Lad","year":"2022","unstructured":"Lad BC, Coleman SM, Alper HS. Microbial valorization of underutilized and nonconventional waste streams. J Ind Microbiol Biotechnol. 2022. https:\/\/doi.org\/10.1093\/jimb\/kuab056.","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2841_CR3","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ese3.9","volume":"1","author":"RAD Arancon","year":"2013","unstructured":"Arancon RAD, Lin CSK, Chan KM, Kwan TH, Luque R. Advances on waste valorization: new horizons for a more sustainable society. Energy Sci Eng. 2013;1:53\u201371.","journal-title":"Energy Sci Eng"},{"key":"2841_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.124457","volume":"321","author":"A Patel","year":"2021","unstructured":"Patel A, Sarkar O, Rova U, Christakopoulos P, Matsakas L. Valorization of volatile fatty acids derived from low-cost organic waste for lipogenesis in oleaginous microorganisms-a review. Bioresour Technol. 2021;321:124457.","journal-title":"Bioresour Technol"},{"key":"2841_CR5","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tifs.2020.02.017","volume":"99","author":"T Ahmad","year":"2020","unstructured":"Ahmad T, Belwal T, Li L, Ramola S, Aadil RM, Abdullah, et al. Utilization of wastewater from edible oil industry, turning waste into valuable products: A review. Trends Food Sci Technol. 2020;99:21\u201333.","journal-title":"Trends Food Sci Technol"},{"key":"2841_CR6","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s12649-013-9202-6","volume":"4","author":"M-P Zacharof","year":"2013","unstructured":"Zacharof M-P, Lovitt RW. Complex effluent streams as a potential source of volatile fatty acids. Waste Biomass Valor. 2013;4:557\u201381.","journal-title":"Waste Biomass Valor"},{"key":"2841_CR7","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/s12934-021-01712-1","volume":"20","author":"F Abeln","year":"2021","unstructured":"Abeln F, Chuck CJ. The history, state of the art and future prospects for oleaginous yeast research. Microb Cell Fact. 2021;20:221.","journal-title":"Microb Cell Fact"},{"key":"2841_CR8","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040526","author":"Z Hilmi Ibrahim","year":"2020","unstructured":"Hilmi Ibrahim Z, Bae JH, Lee SH, Sung BH, Ab Rashid AH, Sohn JH. Genetic manipulation of a lipolytic yeast Candida aaseri SH14 using CRISPR-Cas9 system. Microorganisms. 2020. https:\/\/doi.org\/10.3390\/microorganisms8040526.","journal-title":"Microorganisms"},{"key":"2841_CR9","first-page":"1","volume":"3","author":"D Xie","year":"2017","unstructured":"Xie D, Soong Y-H, Na L, Qin J, Chen S, Keats J, et al. A new biomanufacturing platform for bioconversion of plant oils into High-Value products. Adv Biochem Biotechnol. 2017;3:1\u201310.","journal-title":"Adv Biochem Biotechnol"},{"key":"2841_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108128","volume":"65","author":"Y-HV Soong","year":"2023","unstructured":"Soong Y-HV, Coleman SM, Liu N, Qin J, Lawton C, Alper HS, et al. Using oils and fats to replace sugars as feedstocks for biomanufacturing: challenges and opportunities for the yeast Yarrowia lipolytica. Biotechnol Adv. 2023;65:108128.","journal-title":"Biotechnol Adv"},{"key":"2841_CR11","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.1128\/AEM.69.10.5983-5991.2003","volume":"69","author":"DL Craft","year":"2003","unstructured":"Craft DL, Madduri KM, Eshoo M, Wilson CR. Identification and characterization of the CYP52 family of Candida tropicalis ATCC 20336, important for the conversion of fatty acids and alkanes to alpha,omega-dicarboxylic acids. Appl Environ Microbiol. 2003;69:5983\u201391.","journal-title":"Appl Environ Microbiol"},{"key":"2841_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s13068-022-02160-8","volume":"15","author":"L Zhang","year":"2022","unstructured":"Zhang L, Yang H, Xia Y, Shen W, Liu L, Li Q, et al. Engineering the oleaginous yeast Candida tropicalis for \u03b1-humulene overproduction. Biotechnol Biofuels Bioprod. 2022;15:59.","journal-title":"Biotechnol Biofuels Bioprod"},{"key":"2841_CR13","doi-asserted-by":"publisher","first-page":"e202212440","DOI":"10.1002\/anie.202212440","volume":"62","author":"Y Zhou","year":"2023","unstructured":"Zhou Y, Mirts EN, Yook S, Waugh M, Martini R, Jin Y-S, et al. Reshaping the 2-Pyrone synthase active site for chemoselective biosynthesis of polyketides. Angew Chem Int Ed. 2023;62:e202212440.","journal-title":"Angew Chem Int Ed"},{"key":"2841_CR14","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1039\/c2gc35343a","volume":"14","author":"M Chia","year":"2012","unstructured":"Chia M, Schwartz TJ, Shanks BH, Dumesic JA. Triacetic acid lactone as a potential biorenewable platform chemical. Green Chem. 2012;14:1850\u20133.","journal-title":"Green Chem"},{"key":"2841_CR15","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1002\/bit.20759","volume":"93","author":"D Xie","year":"2006","unstructured":"Xie D, Shao Z, Achkar J, Zha W, Frost JW, Zhao H. Microbial synthesis of triacetic acid lactone. Biotechnol Bioeng. 2006;93:727\u201336.","journal-title":"Biotechnol Bioeng"},{"key":"2841_CR16","doi-asserted-by":"publisher","first-page":"3177","DOI":"10.1039\/C7GC00296C","volume":"19","author":"BH Shanks","year":"2017","unstructured":"Shanks BH, Keeling PL. Bioprivileged molecules: creating value from biomass. Green Chem. 2017;19:3177\u201385.","journal-title":"Green Chem"},{"key":"2841_CR17","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s10295-018-2062-0","volume":"45","author":"Y Li","year":"2018","unstructured":"Li Y, Qian S, Dunn R, Cirino PC. Engineering Escherichia coli to increase triacetic acid lactone (TAL) production using an optimized TAL sensor-reporter system. J Ind Microbiol Biotechnol. 2018;45:789\u201393.","journal-title":"J Ind Microbiol Biotechnol"},{"key":"2841_CR18","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.jbiosc.2023.07.006","volume":"136","author":"Y Matsuoka","year":"2023","unstructured":"Matsuoka Y, Fujie N, Nakano M, Koshiba A, Kondo A, Tanaka T. Triacetic acid lactone production using 2-pyrone synthase expressing Yarrowia lipolytica via targeted gene deletion. J Biosci Bioeng. 2023;136:320\u20136.","journal-title":"J Biosci Bioeng"},{"key":"2841_CR19","doi-asserted-by":"publisher","first-page":"2529","DOI":"10.1002\/bit.28159","volume":"119","author":"M Cao","year":"2022","unstructured":"Cao M, Tran VG, Qin J, Olson A, Mishra S, Schultz JC, et al. Metabolic engineering of oleaginous yeast Rhodotorula toruloides for overproduction of triacetic acid lactone. Biotechnol Bioeng. 2022;119:2529\u201340.","journal-title":"Biotechnol Bioeng"},{"key":"2841_CR20","doi-asserted-by":"crossref","unstructured":"Feng L, Xu J, Ye C, Gao J, Huang L, Xu Z, et al. Metabolic engineering of Pichia pastoris for the production of triacetic acid lactone. J Fungi (Basel). 2023;9.","DOI":"10.3390\/jof9040494"},{"key":"2841_CR21","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.ymben.2019.08.017","volume":"56","author":"H Liu","year":"2019","unstructured":"Liu H, Marsafari M, Wang F, Deng L, Xu P. Engineering acetyl-CoA metabolic shortcut for eco-friendly production of polyketides triacetic acid lactone in Yarrowia lipolytica. Metab Eng. 2019;56:60\u20138.","journal-title":"Metab Eng"},{"key":"2841_CR22","doi-asserted-by":"publisher","first-page":"2096","DOI":"10.1073\/pnas.1721203115","volume":"115","author":"KA Markham","year":"2018","unstructured":"Markham KA, Palmer CM, Chwatko M, Wagner JM, Murray C, Vazquez S, et al. Rewiring Yarrowia lipolytica toward triacetic acid lactone for materials generation. Proc Natl Acad Sci USA. 2018;115:2096\u2013101.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"50","key":"2841_CR23","doi-asserted-by":"publisher","first-page":"33635","DOI":"10.1074\/jbc.273.50.33635","volume":"273","author":"G Lametschwandtner","year":"1998","unstructured":"Lametschwandtner G, Brocard C, Fransen M, Van Veldhoven P, Berger J, Hartig A. The difference in recognition of terminal tripeptides as peroxisomal targeting signal 1 between yeast and human is due to different affinities of their receptor Pex5p to the cognate signal and to residues adjacent to it. J Biol Chem. 1998;273(50):33635\u201343.","journal-title":"J Biol Chem"},{"key":"2841_CR24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jmb.2004.05.064","volume":"341","author":"OI Petriv","year":"2004","unstructured":"Petriv OI, Tang L, Titorenko VI, Rachubinski RA. A new definition for the consensus sequence of the peroxisome targeting signal type 2. J Mol Biol. 2004;341:119\u201334.","journal-title":"J Mol Biol"},{"key":"2841_CR25","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1038\/s41596-020-0351-3","volume":"15","author":"Z Li","year":"2020","unstructured":"Li Z, Wang H, Cai C, Wong AH-H, Wang J, Gao J, et al. Genome-wide piggybac transposon-based mutagenesis and quantitative insertion-site analysis in haploid Candida species. Nat Protoc. 2020;15:2705\u201327.","journal-title":"Nat Protoc"},{"key":"2841_CR26","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1021\/acssynbio.0c00123","volume":"9","author":"Y Zhao","year":"2020","unstructured":"Zhao Y, Yao Z, Ploessl D, Ghosh S, Monti M, Schindler D, et al. Leveraging the Hermes transposon to accelerate the development of nonconventional Yeast-based microbial cell factories. ACS Synth Biol. 2020;9:1736\u201352.","journal-title":"ACS Synth Biol"},{"key":"2841_CR27","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.ymben.2023.03.007","volume":"77","author":"NN Pham","year":"2023","unstructured":"Pham NN, Chang C-W, Chang Y-H, Tu Y, Chou J-Y, Wang H-Y, et al. Rational genome and metabolic engineering of Candida viswanathii by split CRISPR to produce hundred grams of Dodecanedioic acid. Metab Eng. 2023;77:76\u201388.","journal-title":"Metab Eng"},{"key":"2841_CR28","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1186\/s12934-022-01977-0","volume":"21","author":"PB Otoupal","year":"2022","unstructured":"Otoupal PB, Geiselman GM, Oka AM, Barcelos CA, Choudhary H, Dinh D, et al. Advanced one-pot deconstruction and valorization of lignocellulosic biomass into triacetic acid lactone using Rhodosporidium toruloides. Microb Cell Fact. 2022;21:254.","journal-title":"Microb Cell Fact"},{"key":"2841_CR29","doi-asserted-by":"crossref","unstructured":"Nakayasu ES, Nicora CD, Sims AC, Burnum-Johnson KE, Kim Y-M, Kyle JE, et al. MPLEx: a robust and universal protocol for single-sample integrative proteomic, metabolomic, and lipidomic analyses. mSystems. 2016;1.","DOI":"10.1128\/mSystems.00043-16"},{"key":"2841_CR30","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1093\/bioinformatics\/btq054","volume":"26","author":"B MacLean","year":"2010","unstructured":"MacLean B, Tomazela DM, Shulman N, Chambers M, Finney GL, Frewen B, et al. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics. 2010;26:966\u20138.","journal-title":"Bioinformatics"},{"key":"2841_CR31","doi-asserted-by":"publisher","first-page":"5277","DOI":"10.1038\/ncomms6277","volume":"5","author":"S Kim","year":"2014","unstructured":"Kim S, Pevzner PA. MS-GF\u2009+\u2009makes progress towards a universal database search tool for proteomics. Nat Commun. 2014;5:5277.","journal-title":"Nat Commun"},{"key":"2841_CR32","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.compbiolchem.2008.02.006","volume":"32","author":"ME Monroe","year":"2008","unstructured":"Monroe ME, Shaw JL, Daly DS, Adkins JN, Smith RD. MASIC: a software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC-MS(\/MS) features. Comput Biol Chem. 2008;32:215\u20137.","journal-title":"Comput Biol Chem"},{"key":"2841_CR33","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1021\/acs.jproteome.2c00610","volume":"22","author":"DJ Degnan","year":"2023","unstructured":"Degnan DJ, Stratton KG, Richardson R, Claborne D, Martin EA, Johnson NA, et al. PmartR 2.0: a quality control, visualization, and statistics pipeline for multiple omics datatypes. J Proteome Res. 2023;22:570\u20136.","journal-title":"J Proteome Res"},{"key":"2841_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2015.00209","volume":"6","author":"Y-M Kim","year":"2015","unstructured":"Kim Y-M, Nowack S, Olsen MT, Becraft ED, Wood JM, Thiel V, et al. Diel metabolomics analysis of a hot spring chlorophototrophic microbial mat leads to new hypotheses of community member metabolisms. Front Microbiol. 2015;6:209.","journal-title":"Front Microbiol"},{"key":"2841_CR35","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1038\/s41467-024-48009-6","volume":"15","author":"Z Pang","year":"2024","unstructured":"Pang Z, Xu L, Viau C, Lu Y, Salavati R, Basu N, et al. Metaboanalystr 4.0: a unified LC-MS workflow for global metabolomics. Nat Commun. 2024;15:3675.","journal-title":"Nat Commun"},{"key":"2841_CR36","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1128\/EC.00017-08","volume":"7","author":"K Strijbis","year":"2008","unstructured":"Strijbis K, van Roermund CWT, Visser WF, Mol EC, van den Burg J, MacCallum DM, et al. Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation. Eukaryot Cell. 2008;7:610\u20138.","journal-title":"Eukaryot Cell"},{"key":"2841_CR37","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0021-9258(18)81297-2","volume":"238","author":"HG Wood","year":"1963","unstructured":"Wood HG, Allen SH, Stjernholm R, Jacobson B. Transcarboxylase. III. Purification and properties of methylmalonyl-oxaloacetic transcarboxylase containing tritiated biotin. J Biol Chem. 1963;238:547\u201356.","journal-title":"J Biol Chem"},{"key":"2841_CR38","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms11010092","author":"T Hirasawa","year":"2022","unstructured":"Hirasawa T, Maeda T. Adaptive laboratory evolution of microorganisms: methodology and application for bioproduction. Microorganisms. 2022. https:\/\/doi.org\/10.3390\/microorganisms11010092.","journal-title":"Microorganisms"},{"key":"2841_CR39","doi-asserted-by":"publisher","first-page":"15451","DOI":"10.1021\/ja107707v","volume":"132","author":"W Lu","year":"2010","unstructured":"Lu W, Ness JE, Xie W, Zhang X, Minshull J, Gross RA. Biosynthesis of monomers for plastics from renewable oils. J Am Chem Soc. 2010;132:15451\u20135.","journal-title":"J Am Chem Soc"},{"key":"2841_CR40","doi-asserted-by":"publisher","first-page":"5992","DOI":"10.1128\/AEM.69.10.5992-5999.2003","volume":"69","author":"WH Eschenfeldt","year":"2003","unstructured":"Eschenfeldt WH, Zhang Y, Samaha H, Stols L, Eirich LD, Wilson CR, et al. Transformation of fatty acids catalyzed by cytochrome P450 monooxygenase enzymes of Candida tropicalis. Appl Environ Microbiol. 2003;69:5992\u20139.","journal-title":"Appl Environ Microbiol"},{"key":"2841_CR41","doi-asserted-by":"crossref","unstructured":"Schrevens S, Sanglard D. Hijacking transposable elements for saturation mutagenesis in fungi. Front Fungal Biol. 2021;2.","DOI":"10.3389\/ffunb.2021.633876"},{"key":"2841_CR42","doi-asserted-by":"publisher","DOI":"10.1002\/biot.202300590","author":"Y-K Ding","year":"2024","unstructured":"Ding Y-K, Ning Y, Fu Y-J. Dual cytoplasmic-peroxisomal compartmentalization engineering and multiple metabolic engineering strategies for high yield non-psychoactive cannabinoid in Saccharomyces cerevisiae. Biotechnol J. 2024. https:\/\/doi.org\/10.1002\/biot.202300590.","journal-title":"Biotechnol J"},{"key":"2841_CR43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.ymben.2019.11.001","volume":"57","author":"G-S Liu","year":"2020","unstructured":"Liu G-S, Li T, Zhou W, Jiang M, Tao X-Y, Liu M, et al. The yeast peroxisome: a dynamic storage depot and subcellular factory for squalene overproduction. Metab Eng. 2020;57:151\u201361.","journal-title":"Metab Eng"},{"key":"2841_CR44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-25241-y","volume":"12","author":"L Sun","year":"2021","unstructured":"Sun L, Lee JW, Yook S, Lane S, Sun Z, Kim SR, et al. Complete and efficient conversion of plant cell wall hemicellulose into high-value bioproducts by engineered yeast. Nat Commun. 2021;12:4975.","journal-title":"Nat Commun"}],"container-title":["Microbial Cell Factories"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12934-025-02841-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12934-025-02841-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12934-025-02841-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T13:16:37Z","timestamp":1759756597000},"score":1,"resource":{"primary":{"URL":"https:\/\/microbialcellfactories.biomedcentral.com\/articles\/10.1186\/s12934-025-02841-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,6]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["2841"],"URL":"https:\/\/doi.org\/10.1186\/s12934-025-02841-7","relation":{},"ISSN":["1475-2859"],"issn-type":[{"value":"1475-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,6]]},"assertion":[{"value":"29 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"A.H. has a financial interest in Pyrone Systems Inc. The other authors declare they have no outside financial interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"215"}}