{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T23:12:30Z","timestamp":1780528350803,"version":"3.54.1"},"reference-count":101,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":44,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1S28622N"],"award-info":[{"award-number":["1S28622N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1158725N"],"award-info":[{"award-number":["1158725N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G049022N"],"award-info":[{"award-number":["G049022N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007660","name":"Universiteit Antwerpen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007660","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["852600"],"award-info":[{"award-number":["852600"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Microb Cell Fact"],"DOI":"10.1186\/s12934-026-03008-8","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:36:53Z","timestamp":1776778613000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Modular biosynthesis of microbiome-derived polyketides and nonribosomal peptides: insights and opportunities for Lactobacillaceae"],"prefix":"10.1186","volume":"25","author":[{"given":"Jelle","family":"Dillen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Eilers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E.M.K.","family":"Dricot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matisse","family":"Van Hee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Vandenheuvel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joleen","family":"Masschelein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Lebeer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,4,21]]},"reference":[{"issue":"4","key":"3008_CR1","doi-asserted-by":"publisher","first-page":"2782","DOI":"10.1099\/ijsem.0","volume":"70","author":"J Zheng","year":"2020","unstructured":"Zheng J, Wittouck S, Salvetti E, Franz CMAP, Harris HMB, Mattarelli P, et al. A taxonomic note on the genus Lactobacillus: Description of 23 novel genera, emended description of the genus Lactobacillus beijerinck 1901, and union of Lactobacillaceae and Leuconostocaceae. Int J Syst Evol Microbiol. 2020;70(4):2782\u2013858. https:\/\/doi.org\/10.1099\/ijsem.0. .004107 PubMed PMID: 32293557.","journal-title":"Int J Syst Evol Microbiol"},{"issue":"1","key":"3008_CR2","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.1093\/femsre\/fux030","volume":"41","author":"RM Duar","year":"2017","unstructured":"Duar RM, Lin XB, Zheng J, Martino ME, Grenier T, P\u00e9rez-Mu\u00f1oz ME, et al. Lifestyles in transition: evolution and natural history of the genus Lactobacillus. FEMS Microbiol Rev. 2017;41(1):S27\u201348. https:\/\/doi.org\/10.1093\/femsre\/fux030. PubMed PMID: 28673043.","journal-title":"FEMS Microbiol Rev"},{"issue":"3","key":"3008_CR3","first-page":"e771","volume":"4","author":"S Condori","year":"2022","unstructured":"Condori S, Ahannach S, Vander Donck L, Oerlemans E, Dillen J, Dricot C, et al. Recent insights into the vaginal microbiome. Microbiota Health Disease. 2022;4(3):e771.","journal-title":"Microbiota Health Disease"},{"issue":"12","key":"3008_CR4","doi-asserted-by":"publisher","first-page":"e00134","DOI":"10.1128\/AEM.00134-18","volume":"84","author":"S Wuyts","year":"2018","unstructured":"Wuyts S, Van Beeck W, Oerlemans EFM, Wittouck S, Claes IJJ, De Boeck I, et al. Carrot Juice Fermentations as Man-Made Microbial Ecosystems Dominated by Lactic Acid Bacteria. Appl Environ Microbiol. 2018;84(12):e00134\u201318. https:\/\/doi.org\/10.1128\/AEM.00134-18. PubMed PMID: 29654180.","journal-title":"Appl Environ Microbiol"},{"issue":"8","key":"3008_CR5","doi-asserted-by":"publisher","first-page":"107674","DOI":"10.1016\/j.celrep.2020.107674","volume":"31","author":"I De Boeck","year":"2020","unstructured":"De Boeck I, van den Broek MFL, Allonsius CN, Spacova I, Wittouck S, Martens K, et al. Lactobacilli Have a Niche in the Human Nose. Cell Rep. 2020;31(8):107674. https:\/\/doi.org\/10.1016\/j.celrep.2020.107674. PubMed PMID: 32460009.","journal-title":"Cell Rep"},{"key":"3008_CR6","volume-title":"The Prolongation of Life: Optimistic Studies","author":"II Metchnikoff","year":"1908","unstructured":"Metchnikoff II. The Prolongation of Life: Optimistic Studies. New York: Putnam; 1908."},{"key":"3008_CR7","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.copbio.2019.09.023","volume":"61","author":"S Wuyts","year":"2020","unstructured":"Wuyts S, Van Beeck W, Allonsius CN, van den Broek MF, Lebeer S. Applications of plant-based fermented foods and their microbes. Curr Opin Biotechnol. 2020;61:45\u201352. https:\/\/doi.org\/10.1016\/j.copbio.2019.09.023.","journal-title":"Curr Opin Biotechnol"},{"key":"3008_CR8","doi-asserted-by":"publisher","unstructured":"Vieco-Saiz N, Belguesmia Y, Raspoet R, Auclair E, Gancel F, Kempf I, et al. Benefits and inputs from lactic acid bacteria and their bacteriocins as alternatives to antibiotic growth promoters during food-animal production. Front Microbiol. 2019;10. https:\/\/doi.org\/10.3389\/fmicb.2019.00057.","DOI":"10.3389\/fmicb.2019.00057"},{"issue":"16","key":"3008_CR9","doi-asserted-by":"publisher","first-page":"4985","DOI":"10.1128\/AEM.00753-08","volume":"74","author":"J Walter","year":"2008","unstructured":"Walter J. Ecological role of lactobacilli in the gastrointestinal tract: Implications for fundamental and biomedical research. Appl Environ Microbiol. 2008;74(16):4985\u201396. https:\/\/doi.org\/10.1128\/AEM.00753-08.","journal-title":"Appl Environ Microbiol"},{"key":"3008_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3389\/fphys.2015.00081","volume":"6","author":"MI Petrova","year":"2015","unstructured":"Petrova MI, Lievens E, Malik S, Imholz N, Lebeer S. Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health. Front Physiol. 2015;6:81. https:\/\/doi.org\/10.3389\/fphys.2015.00081.","journal-title":"Front Physiol"},{"issue":"8","key":"3008_CR11","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, et al. Expert consensus document: The international scientific association for probiotics and prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506\u201314. https:\/\/doi.org\/10.1038\/nrgastro.2014.66. PubMed PMID: 24912386.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"3008_CR12","unstructured":"U.S. Department of Health and Human Services, Food and, Administration D, Center for Biologics Evaluation and Research. Early Clinical Trials with Live Biotherapeutic Products: Chemistry, Manufacturing, and Control Information [Internet]. 2016. Report. Available from: http:\/\/www.fda.gov\/BiologicsBloodVaccines\/GuidanceComplianceRegulatoryInformation\/Guida"},{"key":"3008_CR13","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/j.lwt.2016.06.066","volume":"73","author":"S \u00d6zcelik","year":"2016","unstructured":"\u00d6zcelik S, Kuley E, \u00d6zogul F. Formation of lactic, acetic, succinic, propionic, formic and butyric acid by lactic acid bacteria. LWT. 2016;73:536\u201342. https:\/\/doi.org\/10.1016\/j.lwt.2016.06.066.","journal-title":"LWT"},{"issue":"9","key":"3008_CR14","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1093\/jac\/dkt156","volume":"68","author":"M Aldunate","year":"2013","unstructured":"Aldunate M, Tyssen D, Johnson A, Zakir T, Sonza S, Moench T, et al. Vaginal concentrations of lactic acid potently inactivate HIV. J Antimicrob Chemother. 2013;68(9):2015\u201325. https:\/\/doi.org\/10.1093\/jac\/dkt156.","journal-title":"J Antimicrob Chemother"},{"key":"3008_CR15","doi-asserted-by":"publisher","DOI":"10.1128\/mmbr.00317-25","author":"J Dillen","year":"2026","unstructured":"Dillen J, Maeyens LT, Hill C, Lebeer S. Updated scheme for classification of bacteriocins in Gram-positive bacteria and comprehensive overview for Lactobacillaceae. Microbiol Mol Biol Rev. 2026. https:\/\/doi.org\/10.1128\/mmbr.00317-25.","journal-title":"Microbiol Mol Biol Rev"},{"key":"3008_CR16","doi-asserted-by":"publisher","first-page":"2587","DOI":"10.12688\/f1000research.9615.1","volume":"5","author":"JW Hegarty","year":"2016","unstructured":"Hegarty JW, Guinane CM, Ross RP, Hill C, Cotter PD. Bacteriocin production: A relatively unharnessed probiotic trait? F1000Res. 2016;5:2587. https:\/\/doi.org\/10.12688\/f1000research.9615.1.","journal-title":"F1000Res"},{"issue":"25","key":"3008_CR17","doi-asserted-by":"publisher","first-page":"9259","DOI":"10.1073\/pnas.1401734111","volume":"111","author":"H Wang","year":"2014","unstructured":"Wang H, Fewer DP, Holm L, Rouhiainen L, Sivonen K. Atlas of nonribosomal peptide and polyketide biosynthetic pathways reveals common occurrence of nonmodular enzymes. PNAS. 2014;111(25):9259\u201364. https:\/\/doi.org\/10.1073\/pnas.1401734111. PubMed PMID: 24927540.","journal-title":"PNAS"},{"key":"3008_CR18","doi-asserted-by":"publisher","first-page":"3770","DOI":"10.1002\/anie.201609079","volume":"56","author":"RD S\u00fcssmuth","year":"2017","unstructured":"S\u00fcssmuth RD, Mainz A. Nonribosomal Peptide Synthesis - Principles and Prospects. Angew Chem. 2017;56:3770\u2013821.","journal-title":"Angew Chem"},{"issue":"3","key":"3008_CR19","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1128\/aem.42.3.408","volume":"42","author":"DG Cooper","year":"1981","unstructured":"Cooper DG, Macdonald CR, Duff SJB, Kosaric N. Enhanced production of surfactin from Bacillus subtilis by continuous product removal and metal cation additions. Appl Environ Microbiol. 1981;42(3):408\u201312. https:\/\/doi.org\/10.1128\/aem.42.3.408. -412.1981 PubMed PMID: 16345840.","journal-title":"Appl Environ Microbiol"},{"key":"3008_CR20","doi-asserted-by":"publisher","first-page":"11525","DOI":"10.1039\/d0sc03627g","volume":"11","author":"Y Hai","year":"2020","unstructured":"Hai Y, Jenner M, Tang Y. Fungal siderophore biosynthesis catalysed by an iterative nonribosomal peptide synthetase. Chem Sci. 2020;11:11525\u201330. https:\/\/doi.org\/10.1039\/d0sc03627g.","journal-title":"Chem Sci"},{"issue":"4","key":"3008_CR21","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3844\/ajabssp.2017.148.156","volume":"13","author":"JA Priyanto","year":"2017","unstructured":"Priyanto JA, Astuti RI, Nomura J, Wahyudi AT. Bioactive Compounds from Sponge Associated Bacteria: Anticancer Activity and NRPS-PKS Gene Expression in Different Carbon Sources. Am J Biochem Biotechnol. 2017;13(4):148\u201356. https:\/\/doi.org\/10.3844\/ajabssp.2017.148.156.","journal-title":"Am J Biochem Biotechnol"},{"key":"3008_CR22","doi-asserted-by":"publisher","unstructured":"Felnagle EA, Jackson EE, Chan YA, Podevels AM, Berti AD, McMahon MD, et al. Nonribosomal peptide synthetases involved in the production of medically relevant natural products. Mol Pharm. 2008;191\u2013211. https:\/\/doi.org\/10.1021\/mp700137g.","DOI":"10.1021\/mp700137g"},{"key":"3008_CR23","unstructured":"U.S. Food & Drug Administration. Generally Recognized as Safe (GRAS); 2023. https:\/\/www.fda.gov\/food\/food-ingredients-packaging\/generally-recognized-safe-gras."},{"key":"3008_CR24","unstructured":"European Food Safety Authority. https:\/\/www.efsa.europa.eu\/en\/topics\/topic\/qualified-presumption-safety-qps. 2025. Qualified presumption of safety (QPS)."},{"issue":"6","key":"3008_CR25","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1128\/AEM.03691-14","volume":"81","author":"XB Lin","year":"2015","unstructured":"Lin XB, Lohans CT, Duar R, Zheng J, Vederas JC, Walter J, et al. Genetic determinants of reutericyclin biosynthesis in Lactobacillus reuteri. Appl Environ Microbiol. 2015;81(6):2032\u201341. https:\/\/doi.org\/10.1128\/AEM.03691-14. PubMed PMID: 25576609.","journal-title":"Appl Environ Microbiol"},{"issue":"9","key":"3008_CR26","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1016\/j.cell","volume":"185","author":"JR Patel","year":"2022","unstructured":"Patel JR, Oh J, Wang S, Crawford JM, Isaacs FJ. Cross-kingdom expression of synthetic genetic elements promotes discovery of metabolites in the human microbiome. Cell. 2022;185(9):1487\u2013e150514. https:\/\/doi.org\/10.1016\/j.cell. 2022.03.008 PubMed PMID: 35366417.","journal-title":"Cell"},{"issue":"4","key":"3008_CR27","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1073\/pnas.0337704100","volume":"100","author":"M Kleerebezem","year":"2003","unstructured":"Kleerebezem M, Boekhorst J, Van Kranenburg R, Molenaar D, Kuipers OP, Leer R, et al. Complete genome sequence of Lactobacillus plantarum WCFS1. Proc Natl Acad Sci U S A. 2003;100(4):1990\u20135. https:\/\/doi.org\/10.1073\/pnas.0337704100. PubMed PMID: 12566566.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3008_CR28","doi-asserted-by":"publisher","first-page":"e60521","DOI":"10.1371\/journal.pone.0060521","volume":"8","author":"M Fukao","year":"2013","unstructured":"Fukao M, Oshima K, Morita H, Toh H, Suda W, Kim SW, et al. Genomic Analysis by Deep Sequencing of the Probiotic Lactobacillus brevis KB290 Harboring Nine Plasmids Reveals Genomic Stability. PLoS ONE. 2013;8(3):e60521. https:\/\/doi.org\/10.1371\/journal.pone.0060521.","journal-title":"PLoS ONE"},{"issue":"10","key":"3008_CR29","doi-asserted-by":"publisher","first-page":"e01661","DOI":"10.1128\/AEM.01661-18","volume":"85","author":"M \u00d6z\u00e7am","year":"2019","unstructured":"\u00d6z\u00e7am M, Tocmo R, Oh JH, Afrazi A, Mezrich JD, Roos S, et al. Gut symbionts Lactobacillus reuteri R2lc and 2010 encode a polyketide synthase cluster that activates the mammalian aryl hydrocarbon receptor. Appl Environ Microbiol. 2019;85(10):e01661\u201318. https:\/\/doi.org\/10.1128\/AEM.01661-18. PubMed PMID: 30389766.","journal-title":"Appl Environ Microbiol"},{"issue":"4","key":"3008_CR30","doi-asserted-by":"publisher","first-page":"e0056222","DOI":"10.1128\/msphere.00562-22","volume":"8","author":"A Ene","year":"2023","unstructured":"Ene A, Banerjee S, Wolfe AJ, Putonti C. Exploring the genotypic and phenotypic differences distinguishing Lactobacillus jensenii and Lactobacillus mulieris. mSphere. 2023;8(4):e0056222. https:\/\/doi.org\/10.1128\/msphere.00562-22. PubMed PMID: 37366621.","journal-title":"mSphere"},{"issue":"12","key":"3008_CR31","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1080\/09168451.2017.1391687","volume":"81","author":"A Miyanaga","year":"2017","unstructured":"Miyanaga A. Structure and function of polyketide biosynthetic enzymes: various strategies for production of structurally diverse polyketides. Biosci Biotechnol Biochem. 2017;81(12):2227\u201336. https:\/\/doi.org\/10.1080\/09168451.2017.1391687. PubMed PMID: 29090652.","journal-title":"Biosci Biotechnol Biochem"},{"key":"3008_CR32","doi-asserted-by":"publisher","unstructured":"Moolhuijzen PM, Muria-gonzalez MJ, Syme R, Rawlinson C, See PT, Mo CS et al. Expansion and Conservation of Biosynthetic Gene Clusters in Pathogenic Pyrenophora spp. 12. 2020;12(4):242. https:\/\/doi.org\/10.3390\/toxins12040242","DOI":"10.3390\/toxins12040242"},{"issue":"8","key":"3008_CR33","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/S1074-5521(99)80082-9","volume":"6","author":"T Stachelhaus","year":"1999","unstructured":"Stachelhaus T, Mootz HD, Marahiel MA. The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases. Chem Biol. 1999;6(8):493\u2013505.","journal-title":"Chem Biol"},{"issue":"3","key":"3008_CR34","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S1074-5521(00)00091-0","volume":"7","author":"GL Challis","year":"2000","unstructured":"Challis GL, Ravel J, Townsend CA. Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains. Chem Biol. 2000;7(3):211\u201324. https:\/\/doi.org\/10.1016\/S1074-5521(00)00091-0.","journal-title":"Chem Biol"},{"issue":"D1","key":"3008_CR35","doi-asserted-by":"publisher","first-page":"D465","DOI":"10.1093\/nar\/gkz1000","volume":"48","author":"A Flissi","year":"2019","unstructured":"Flissi A, Ricart E, Campart C, Chevalier M, Dufresne Y, Michalik J, et al. Norine: Update of the nonribsosomal peptide resource. Nucleic Acids Res. 2019;48(D1):D465\u20139. https:\/\/doi.org\/10.1093\/nar\/gkz1000.","journal-title":"Nucleic Acids Res"},{"key":"3008_CR36","doi-asserted-by":"publisher","unstructured":"Flissi A, Duban M, Jacques P, Lecl\u00e8re V, Pupin M, Norine. Bioinformatics Methods and Tools for the Characterization of Newly Discovered Nonribosomal Peptides. In. 2023. pp. 303\u201318. https:\/\/doi.org\/10.1007\/978-1-0716-3214-7_16","DOI":"10.1007\/978-1-0716-3214-7_16"},{"key":"3008_CR37","doi-asserted-by":"publisher","unstructured":"Terlouw BR, Huang C, Meijer D, Cediel-Becerra JDD, Rothe ML, Jenner M, et al. PARAS: high-accuracy machine-learning of substrate specificities in nonribosomal peptide synthetases. JACS Au. 2026;6. https:\/\/doi.org\/10.1021\/jacsau.5c01636.","DOI":"10.1021\/jacsau.5c01636"},{"issue":"85","key":"3008_CR38","doi-asserted-by":"publisher","first-page":"20130297","DOI":"10.1098\/rsif.2013.0297","volume":"10","author":"BJ Dunn","year":"2013","unstructured":"Dunn BJ, Khosla C. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. J R Soc Interface. 2013;10(85):20130297. https:\/\/doi.org\/10.1098\/rsif.2013.0297. PubMed PMID: 23720536.","journal-title":"J R Soc Interface"},{"issue":"2","key":"3008_CR39","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1367-5931(03)00016-4","volume":"7","author":"G Liou","year":"2003","unstructured":"Liou G. Building-block selectivity of polyketide synthases. Curr Opin Chem Biol. 2003;7(2):279\u201384. https:\/\/doi.org\/10.1016\/S1367-5931(03)00016-4.","journal-title":"Curr Opin Chem Biol"},{"issue":"13","key":"3008_CR40","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1016\/S0021-9258(19)34183-3","volume":"243","author":"J Elovson","year":"1968","unstructured":"Elovson J, Vagelos PR. Acyl Carrier Protein. J Biol Chem. 1968;243(13):3603\u201311. https:\/\/doi.org\/10.1016\/S0021-9258(19)34183-3.","journal-title":"J Biol Chem"},{"issue":"18","key":"3008_CR41","doi-asserted-by":"publisher","first-page":"7735","DOI":"10.1007\/s00253-014-5952-8","volume":"98","author":"M Kotowska","year":"2014","unstructured":"Kotowska M, Pawlik K. Roles of type II thioesterases and their application for secondary metabolite yield improvement. Appl Microbiol Biotechnol. 2014;98(18):7735\u201346. https:\/\/doi.org\/10.1007\/s00253-014-5952-8.","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"3008_CR42","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1039\/d1np00035g","volume":"39","author":"RF Little","year":"2022","unstructured":"Little RF, Hertweck C. Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis. Nat Prod Rep. 2022;39(1):163\u2013205. https:\/\/doi.org\/10.1039\/d1np00035g. PubMed PMID: 34622896.","journal-title":"Nat Prod Rep"},{"issue":"13","key":"3008_CR43","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1021\/ol501568t","volume":"16","author":"A Nakayama","year":"2014","unstructured":"Nakayama A, Okano A, Feng Y, Collins JC, Collins KC, Walsh CT, et al. Enzymatic Glycosylation of Vancomycin Aglycon: Completion of a Total Synthesis of Vancomycin and N- and C-Terminus Substituent Effects of the Aglycon Substrate. Org Lett. 2014;16(13):3572\u20135. https:\/\/doi.org\/10.1021\/ol501568t.","journal-title":"Org Lett"},{"issue":"1","key":"3008_CR44","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.fgb.2010.06.012","volume":"48","author":"BS Evans","year":"2011","unstructured":"Evans BS, Robinson SJ, Kelleher NL. Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo. Fungal Genet Biol. 2011;48(1):49\u201361. .012 PubMed PMID: 20601041.","journal-title":"Fungal Genet Biol"},{"issue":"1","key":"3008_CR45","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/s42003-024-06467-0","volume":"7","author":"Z Li","year":"2024","unstructured":"Li Z, Jiao Y, Ling J, Zhao J, Yang Y, Mao Z, et al. Characterization of a methyltransferase for iterative N-methylation at the leucinostatin termini in Purpureocillium lilacinum. Commun Biol. 2024;7(1):757. https:\/\/doi.org\/10.1038\/s42003-024-06467-0.","journal-title":"Commun Biol"},{"issue":"4","key":"3008_CR46","doi-asserted-by":"publisher","first-page":"2514","DOI":"10.1128\/AEM.72.4.2514-2519.2006","volume":"72","author":"O Volokhan","year":"2006","unstructured":"Volokhan O, Sletta H, Ellingsen TE, Zotchev SB. Characterization of the P450 monooxygenase NysL, responsible for C-10 hydroxylation during biosynthesis of the polyene macrolide antibiotic nystatin in Streptomyces noursei. Appl Environ Microbiol. 2006;72(4):2514\u20139. https:\/\/doi.org\/10.1128\/AEM.72.4.2514-2519.2006.","journal-title":"Appl Environ Microbiol"},{"issue":"10","key":"3008_CR47","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1039\/c2np20025b","volume":"29","author":"GH Hur","year":"2012","unstructured":"Hur GH, Vickery CR, Burkart MD. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology. Nat Prod Rep. 2012;29(10):1074\u201398. https:\/\/doi.org\/10.1039\/c2np20025b.","journal-title":"Nat Prod Rep"},{"issue":"W1","key":"3008_CR48","doi-asserted-by":"publisher","first-page":"W32","DOI":"10.1093\/nar\/gkaf334","volume":"53","author":"K Blin","year":"2025","unstructured":"Blin K, Shaw S, Vader L, Szenei J, Reitz ZL, Augustijn HE, et al. antiSMASH 8.0: extended gene cluster detection capabilities and analyses of chemistry, enzymology, and regulation. Nucleic Acids Res. 2025;53(W1):W32\u20138. https:\/\/doi.org\/10.1093\/nar\/gkaf334.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3008_CR49","doi-asserted-by":"publisher","first-page":"6058","DOI":"10.1038\/s41467-020-19986-1","volume":"11","author":"MA Skinnider","year":"2020","unstructured":"Skinnider MA, Johnston CW, Gunabalasingam M, Merwin NJ, Kieliszek AM, MacLellan RJ, et al. Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences. Nat Commun. 2020;11(1):6058. https:\/\/doi.org\/10.1038\/s41467-020-19986-1.","journal-title":"Nat Commun"},{"issue":"D1","key":"3008_CR50","doi-asserted-by":"publisher","first-page":"D678","DOI":"10.1093\/nar\/gkae1115","volume":"53","author":"MM Zdouc","year":"2025","unstructured":"Zdouc MM, Blin K, Louwen NLL, Navarro J, Loureiro C, Bader CD, et al. MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration. Nucleic Acids Res. 2025;53(D1):D678\u201390. https:\/\/doi.org\/10.1093\/nar\/gkae1115.","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"3008_CR51","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/s41589-019-0400-9","volume":"16","author":"JC Navarro-Mu\u00f1oz","year":"2020","unstructured":"Navarro-Mu\u00f1oz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, et al. A computational framework to explore large-scale biosynthetic diversity. Nat Chem Biol. 2020;16(1):60\u20138. https:\/\/doi.org\/10.1038\/s41589-019-0400-9.","journal-title":"Nat Chem Biol"},{"issue":"18","key":"3008_CR52","doi-asserted-by":"publisher","first-page":"e110","DOI":"10.1093\/nar\/gkz654","volume":"47","author":"GD Hannigan","year":"2019","unstructured":"Hannigan GD, Prihoda D, Palicka A, Soukup J, Klempir O, Rampula L, et al. A deep learning genome-mining strategy for biosynthetic gene cluster prediction. Nucleic Acids Res. 2019;47(18):e110\u2013110. https:\/\/doi.org\/10.1093\/nar\/gkz654.","journal-title":"Nucleic Acids Res"},{"key":"3008_CR53","doi-asserted-by":"publisher","DOI":"10.1101\/2021.05.03.442509","author":"LM Carroll","year":"2021","unstructured":"Carroll LM, Larralde M, Fleck JS, Ponnudurai R, Milanese A, Cappio E, et al. Accurate de novo identification of biosynthetic gene clusters with GECCO. BioRxiv preprint. 2021. https:\/\/doi.org\/10.1101\/2021.05.03.442509.","journal-title":"BioRxiv preprint"},{"issue":"3","key":"3008_CR54","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3390\/molecules28030927","volume":"28","author":"S Iqbal","year":"2023","unstructured":"Iqbal S, Begum F, Rabaan AA, Aljeldah M, Al Shammari BR, Alawfi A, et al. Classification and Multifaceted Potential of Secondary Metabolites Produced by Bacillus subtilis Group: A Comprehensive Review. Molecules. 2023;28(3):927. https:\/\/doi.org\/10.3390\/molecules28030927.","journal-title":"Molecules"},{"issue":"8","key":"3008_CR55","doi-asserted-by":"publisher","first-page":"3468","DOI":"10.1021\/cr0503097","volume":"106","author":"MA Fischbach","year":"2006","unstructured":"Fischbach MA, Walsh CT. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: Logic machinery, and mechanisms. Chem Rev. 2006;106(8):3468\u201396. https:\/\/doi.org\/10.1021\/cr0503097. PubMed PMID: 16895337.","journal-title":"Chem Rev"},{"issue":"B","key":"3008_CR56","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0076-6879(","volume":"459","author":"YQ Cheng","year":"2009","unstructured":"Cheng YQ, Coughlin JM, Lim SK, Shen B. Chapter 8 Type I Polyketide Synthases That Require Discrete Acyltransferases. Methods Enzymol. 2009;459(B):165\u201386. https:\/\/doi.org\/10.1016\/S0076-6879(. 09)04608-4 PubMed PMID: 19362640.","journal-title":"Methods Enzymol"},{"issue":"2","key":"3008_CR57","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S1074-5521(00)00076-4","volume":"7","author":"B Wilkinson","year":"2000","unstructured":"Wilkinson B, Foster G, Rudd BA, Taylor NL, Blackaby AP, Sidebottom PJ, et al. Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase. Chem Biol. 2000;7(2):111\u20137. https:\/\/doi.org\/10.1016\/S1074-5521(00)00076-4.","journal-title":"Chem Biol"},{"key":"3008_CR58","doi-asserted-by":"publisher","first-page":"104334","DOI":"10.1016\/j.fm.2023.104334","volume":"115","author":"A Rajput","year":"2023","unstructured":"Rajput A, Chauhan SM, Mohite OS, Hyun JC, Ardalani O, Jahn LJ, et al. Pangenome analysis reveals the genetic basis for taxonomic classification of the Lactobacillaceae family. Food Microbiol. 2023;115:104334. https:\/\/doi.org\/10.1016\/j.fm.2023.104334.","journal-title":"Food Microbiol"},{"issue":"6471","key":"3008_CR59","doi-asserted-by":"publisher","first-page":"eaax9176","DOI":"10.1126\/science.aax9176","volume":"366","author":"Y Sugimoto","year":"2019","unstructured":"Sugimoto Y, Camacho FR, Wang S, Chankhamjon P, Odabas A, Biswas A, et al. A metagenomic strategy for harnessing the chemical repertoire of the human microbiome. Sci (1979). 2019;366(6471):eaax9176. https:\/\/doi.org\/10.1126\/science.aax9176.","journal-title":"Sci (1979)"},{"issue":"W1","key":"3008_CR60","doi-asserted-by":"publisher","first-page":"W46","DOI":"10.1093\/nar\/gkad344","volume":"51","author":"K Blin","year":"2023","unstructured":"Blin K, Shaw S, Augustijn HE, Reitz ZL, Biermann F, Alanjary M, et al. antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation. Nucleic Acids Res. 2023;51(W1):W46\u201350. https:\/\/doi.org\/10.1093\/nar\/gkad344. PubMed PMID: 37140036.","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"3008_CR61","doi-asserted-by":"publisher","first-page":"4325","DOI":"10.1128\/AEM.66.10.4325-4333.2000","volume":"66","author":"MG Ganzle","year":"2000","unstructured":"Ganzle MG, Holtzel A, Walter J, Jung G, Hammes WP. Characterization of reutericyclin produced by Lactobacillus reuteri LTH2584. Appl Environ Microbiol. 2000;66(10):4325\u201333. https:\/\/doi.org\/10.1128\/AEM.66.10.4325-4333.2000. PubMed PMID: 11010877.","journal-title":"Appl Environ Microbiol"},{"issue":"15","key":"3008_CR62","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1002\/1521-3773(20000804)39:15<2766","volume":"39","author":"A H\u00f6ltzel","year":"2000","unstructured":"H\u00f6ltzel A, G\u00e4nzle MG, Nicholson GJ, Hammes WP, Jung G. The first low molecular weight antibiotic from lactic acid bacteria: Reutericyclin, a new tetramic acid. Angew Chem Int Ed. 2000;39(15):2766\u20138. https:\/\/doi.org\/10.1002\/1521-3773(20000804)39:15%3C2766::AID-ANIE2766%3E3.0.CO;2-G.","journal-title":"Angew Chem Int Ed"},{"issue":"1","key":"3008_CR100","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10930-019-09879-8","volume":"39","author":"AS Pavlova","year":"2020","unstructured":"Pavlova AS, Ozhegov GD, Arapidi GP, Butenko IO, Fomin ES, Alemasov NA, et al. Identification of antimicrobial peptides from novel lactobacillus fermentum strain. Protein J. 2020;39(1):73\u201384. https:\/\/doi.org\/10.1007\/s10930-019-09879-8","journal-title":"Protein J"},{"key":"3008_CR101","doi-asserted-by":"publisher","unstructured":"Kumar MM, Dhanasekaran D. Chapter 7 - Biosynthetic Gene Cluster Analysis in Lactobacillus Species Using antiSMASH. In: Dhanasekaran D, Sankaranarayanan A, editors. Advances in Probiotics. Academic Press; 2021. p. 113\u2013120. https:\/\/doi.org\/10.1016\/B978-0-12-822909-5.00007-1.","DOI":"10.1016\/B978-0-12-822909-5.00007-1"},{"issue":"4","key":"3008_CR63","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1021\/acsinfecdis.9b00365","volume":"6","author":"X Tang","year":"2020","unstructured":"Tang X, Kudo Y, Baker JL, Labonte S, Jordan PA, McKinnie SMK, et al. Cariogenic Streptococcus mutans Produces Tetramic Acid Strain-Specific Antibiotics That Impair Commensal Colonization. ACS Infect Dis. 2020;6(4):563\u201371. https:\/\/doi.org\/10.1021\/acsinfecdis.9b00365.","journal-title":"ACS Infect Dis"},{"issue":"2","key":"3008_CR64","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1584\/jpestics.2.345","volume":"69","author":"MG G\u00e4nzle","year":"2003","unstructured":"G\u00e4nzle MG, Vogel RF. Studies on the Mode of Action of Reutericyclin. Appl Environ Microbiol. 2003;69(2):1305\u20137. https:\/\/doi.org\/10.1584\/jpestics.2.345.","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"3008_CR65","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1271\/bbb.110860","volume":"76","author":"A Hayashi","year":"2012","unstructured":"Hayashi A, Saitou H, Mori T, Matano I, Sugisaki H, Maruyama K. Molecular and catalytic properties of monoacetylphloroglucinol acetyltransferase from pseudomonas sp. YGJ3. Biosci Biotechnol Biochem. 2012;76(3):559\u201366. https:\/\/doi.org\/10.1271\/bbb.110860. PubMed PMID: 22451400.","journal-title":"Biosci Biotechnol Biochem"},{"key":"3008_CR66","doi-asserted-by":"publisher","unstructured":"Biotechnol AM. Reutericyclin: biological activity, mode of action, and potential applications. 2004;326\u201332. https:\/\/doi.org\/10.1007\/s00253-003-1536-8","DOI":"10.1007\/s00253-003-1536-8"},{"key":"3008_CR67","doi-asserted-by":"publisher","first-page":"103507","DOI":"10.1016\/j.fm.2020.103507","volume":"91","author":"Z Li","year":"2020","unstructured":"Li Z, Siepmann FB, Rojas Tovar LE, Chen X, G\u00e4nzle MG. Effect of copy number of the spoVA2mob operon, sourdough and reutericyclin on ropy bread spoilage caused by Bacillus spp. Food Microbiol. 2020;91:103507. https:\/\/doi.org\/10.1016\/j.fm.2020.103507.","journal-title":"Food Microbiol"},{"key":"3008_CR68","doi-asserted-by":"publisher","unstructured":"Mulani MS, Kamble EE, Kumkar SN, Tawre MS. Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review. 10. 2019;10(April). https:\/\/doi.org\/10.3389\/fmicb.2019.00539","DOI":"10.3389\/fmicb.2019.00539"},{"issue":"9","key":"3008_CR69","doi-asserted-by":"publisher","first-page":"4028","DOI":"10.1128\/AAC.00457-09","volume":"53","author":"JG Hurdle","year":"2009","unstructured":"Hurdle JG, Yendapally R, Sun D, Lee RE. Evaluation of analogs of reutericyclin as prospective candidates for treatment of staphylococcal skin infections. Antimicrob Agents Chemother. 2009;53(9):4028\u201331. https:\/\/doi.org\/10.1128\/AAC.00457-09.","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"3008_CR70","doi-asserted-by":"publisher","first-page":"557","DOI":"10.3390\/antibiotics12030557","volume":"12","author":"MS Linz","year":"2023","unstructured":"Linz MS, Mattappallil A, Finkel D, Parker D. Clinical Impact of Staphylococcus aureus Skin and Soft Tissue Infections. Antibiotics. 2023;12(3):557. https:\/\/doi.org\/10.3390\/antibiotics12030557.","journal-title":"Antibiotics"},{"issue":"2","key":"3008_CR71","doi-asserted-by":"publisher","first-page":"100521","DOI":"10.1016\/j.xcrm.2022.100521","volume":"3","author":"S Lebeer","year":"2022","unstructured":"Lebeer S, Oerlemans EFM, Claes I, Henkens T, Delanghe L, Wuyts S, et al. Selective targeting of skin pathobionts and inflammation with topically applied lactobacilli. Cell Rep Med. 2022;3(2):100521. https:\/\/doi.org\/10.1016\/j.xcrm.2022.100521.","journal-title":"Cell Rep Med"},{"key":"3008_CR72","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep04721","volume":"4","author":"PT Cherian","year":"2014","unstructured":"Cherian PT, Wu X, Maddox MM, Singh AP, Lee RE, Hurdle JG. Chemical modulation of the biological activity of reutericyclin: A membrane-active antibiotic from lactobacillus reuteri. Sci Rep. 2014;4:1\u20139. https:\/\/doi.org\/10.1038\/srep04721.","journal-title":"Sci Rep"},{"issue":"2","key":"3008_CR73","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.immuni.2013.08.003","volume":"39","author":"T Zelante","year":"2013","unstructured":"Zelante T, Iannitti RG, Cunha C, Luca A, De, Giovannini G, Pieraccini G, et al. Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22. Immunity. 2013;39(2):372\u201385. https:\/\/doi.org\/10.1016\/j.immuni.2013.08.003.","journal-title":"Immunity"},{"key":"3008_CR74","first-page":"806","volume":"810","author":"L Cervantes-barragan","year":"2017","unstructured":"Cervantes-barragan L, Chai JN, Tianero MD, Luccia B, Di, Ahern PP, Merriman J, et al. Lactobacillus reuteri induces gut intraepithelial CD4\u2009+\u2009CD8aa\u2009+\u2009T-cells. 810. 2017;810:806\u201310.","journal-title":"810"},{"key":"3008_CR75","doi-asserted-by":"crossref","unstructured":"\u00d6z\u00e7am M, Tocmo R, Oh Jhwan, Afrazi A, Mezrich JD, Roos S et al. crossm Gut Symbionts Lactobacillus reuteri R2lc and 2010 Encode a Polyketide Synthase Cluster That Activates the Mammalian Aryl Hydrocarbon Receptor. 85. 2019;85(10):1\u201317.","DOI":"10.1128\/AEM.01661-18"},{"issue":"6","key":"3008_CR76","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.chom.2022.03.033","volume":"30","author":"M \u00d6z\u00e7am","year":"2022","unstructured":"\u00d6z\u00e7am M, Oh JH, Tocmo R, Acharya D, Zhang S, Astmann TJ, et al. A secondary metabolite drives intraspecies antagonism in a gut symbiont that is inhibited by cell-wall acetylation. Cell Host Microbe. 2022;30(6):824\u2013e8356. https:\/\/doi.org\/10.1016\/j.chom.2022.03.033. PubMed PMID: 35443156.","journal-title":"Cell Host Microbe"},{"key":"3008_CR77","doi-asserted-by":"publisher","unstructured":"Jusuf S, Dong P, ting, Hui J, Ulloa ER, Liu GY, Jolla L. Granadaene Photobleaching Reduces the Virulence and Increases Antimicrobial Susceptibility of Streptococcus agalactiae. 97. 2021;97(4):816\u201325. https:\/\/doi.org\/10.1111\/php.13389.Granadaene","DOI":"10.1111\/php.13389.Granadaene"},{"issue":"6","key":"3008_CR78","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.chom.2022.05.012","volume":"30","author":"SP Claus","year":"2022","unstructured":"Claus SP. The kiss of death: Limosilactobacillus reuteri PKS drives intraspecies competition. Cell Host Microbe. 2022;30(6):757\u20139. https:\/\/doi.org\/10.1016\/j.chom.2022.05.012.","journal-title":"Cell Host Microbe"},{"key":"3008_CR79","doi-asserted-by":"publisher","first-page":"1095555","DOI":"10.3389\/fmicb.2023.1095555","volume":"14","author":"Z Yu","year":"2023","unstructured":"Yu Z, Chen J, Liu Y, Meng Q, Liu H, Yao Q, et al. The role of potential probiotic strains Lactobacillus reuteri in various intestinal diseases: New roles for an old player. Front Microbiol. 2023;14:1095555. https:\/\/doi.org\/10.3389\/fmicb.2023.1095555.","journal-title":"Front Microbiol"},{"key":"3008_CR80","doi-asserted-by":"publisher","unstructured":"Chen Y, Wang Y, Fu Y, Yin Y, Xu K. Modulating AHR function offers exciting therapeutic potential in gut immunity and inflammation. Cell Biosci. 2023;1\u201326. https:\/\/doi.org\/10.1186\/s13578-023-01046-y.","DOI":"10.1186\/s13578-023-01046-y"},{"issue":"9","key":"3008_CR81","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.1074\/jbc.M309658200","volume":"279","author":"N Kessler","year":"2004","unstructured":"Kessler N, Schuhmann H, Morneweg S, Linne U, Marahiel MA. The Linear Pentadecapeptide Gramicidin Is Assembled by Four Multimodular Nonribosomal Peptide Synthetases That Comprise 16 Modules with 56 Catalytic Domains. J Biol Chem. 2004;279(9):7413\u20139. https:\/\/doi.org\/10.1074\/jbc.M309658200.","journal-title":"J Biol Chem"},{"issue":"11","key":"3008_CR82","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1038\/s41564-023-01500-0","volume":"8","author":"S Lebeer","year":"2023","unstructured":"Lebeer S, Ahannach S, Gehrmann T, Wittouck S, Eilers T, Oerlemans E, et al. A citizen-science-enabled catalogue of the vaginal microbiome and associated factors. Nat Microbiol. 2023;8(11):2183\u201395. https:\/\/doi.org\/10.1038\/s41564-023-01500-0. PubMed PMID: 37884815.","journal-title":"Nat Microbiol"},{"issue":"3","key":"3008_CR83","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1099\/mic.0.000238","volume":"162","author":"AA Abdelmaksoud","year":"2016","unstructured":"Abdelmaksoud AA, Koparde VN, Sheth NU, Serrano MG, Glascock AL, Fettweis JM, et al. Comparison of Lactobacillus crispatus isolates from Lactobacillus-dominated vaginal microbiomes with isolates from microbiomes containing bacterial vaginosis-associated bacteria. Microbiol (United Kingdom). 2016;162(3):466\u201375. https:\/\/doi.org\/10.1099\/mic.0.000238. PubMed PMID: 26747455.","journal-title":"Microbiol (United Kingdom)"},{"key":"3008_CR84","first-page":"287","volume":"147","author":"T Takatsugu","year":"1997","unstructured":"Takatsugu T, Kanatani K. Isolation and partial characterization of crispacin A, a cell-associated bacteriocin produced by Lactobacillus crispatus JCM 2009. 147. 1997;147:287\u201390.","journal-title":"147"},{"key":"3008_CR85","doi-asserted-by":"publisher","first-page":"615","DOI":"10.3389\/fphys.2017.00615","volume":"8","author":"GP Stafford","year":"2017","unstructured":"Stafford GP, Parker JL, Amabebe E, Kistler J, Reynolds S, Stern V, et al. Spontaneous preterm birth is associated with differential expression of vaginal metabolites by lactobacilli-dominated microflora. Front Physiol. 2017;8:615. https:\/\/doi.org\/10.3389\/fphys.2017.00615.","journal-title":"Front Physiol"},{"issue":"1","key":"3008_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-019-44579-4","volume":"9","author":"SJ Jang","year":"2019","unstructured":"Jang SJ, Lee K, Kwon B, You HJ, Ko GP. Vaginal lactobacilli inhibit growth and hyphae formation of Candida albicans. Sci Rep. 2019;9(1):1\u20139. https:\/\/doi.org\/10.1038\/s41598-019-44579-4. PubMed PMID: 31148560.","journal-title":"Sci Rep"},{"issue":"3","key":"3008_CR87","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.tim.2016.11.007","volume":"25","author":"MI Petrova","year":"2017","unstructured":"Petrova MI, Reid G, Vaneechoutte M, Lebeer S. Lactobacillus iners: Friend or Foe ? Trends Microbiol. 2017;25(3):182\u201391. https:\/\/doi.org\/10.1016\/j.tim.2016.11.007.","journal-title":"Trends Microbiol"},{"key":"3008_CR88","doi-asserted-by":"publisher","unstructured":"Holm JB, Carter KA, Ravel J, Brotman RM. Lactobacillus iners and Genital Health: Molecular Clues to an Enigmatic Vaginal Species. Current Infectious Disease Reports. Springer; 2023. pp. 67\u201375. https:\/\/doi.org\/10.1007\/s11908-023-00798-5","DOI":"10.1007\/s11908-023-00798-5"},{"issue":"1","key":"3008_CR89","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/s41522-025-00731-9","volume":"11","author":"X Wang","year":"2025","unstructured":"Wang X, Jiang Q, Tian X, Chen W, Mai J, Lin G, et al. Metagenomic analysis reveals the novel role of vaginal Lactobacillus iners in Chinese healthy pregnant women. NPJ Biofilms Microbiomes. 2025;11(1):92. https:\/\/doi.org\/10.1038\/s41522-025-00731-9.","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"6","key":"3008_CR90","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1016\/j.cell.2014.08.032","volume":"158","author":"MS Donia","year":"2014","unstructured":"Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, et al. A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics. Cell. 2014;158(6):1402\u201314. https:\/\/doi.org\/10.1016\/j.cell.2014.08.032.","journal-title":"Cell"},{"issue":"1","key":"3008_CR91","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41564-023-01544-2","volume":"9","author":"BO Torres Salazar","year":"2023","unstructured":"Torres Salazar BO, Dema T, Schilling NA, Janek D, Bornikoel J, Berscheid A, et al. Commensal production of a broad-spectrum and short-lived antimicrobial peptide polyene eliminates nasal Staphylococcus aureus. Nat Microbiol. 2023;9(1):200\u201313. https:\/\/doi.org\/10.1038\/s41564-023-01544-2.","journal-title":"Nat Microbiol"},{"issue":"3","key":"3008_CR92","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.cell.2016.12.021","volume":"168","author":"CJ Guo","year":"2017","unstructured":"Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, et al. Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases. Cell. 2017;168(3):517\u2013e52618. https:\/\/doi.org\/10.1016\/j.cell.2016.12.021.","journal-title":"Cell"},{"issue":"3","key":"3008_CR93","doi-asserted-by":"publisher","first-page":"380","DOI":"10.4103\/epj.epj_46_23","volume":"22","author":"AMA Elmasry","year":"2023","unstructured":"Elmasry AMA, Hussein W, Abdelmoteleb A. New molecule of nonribosomal peptide synthesis mechanism from Lactiplantibacillus plantarum LMG100 probiotic bacteria. Egypt Pharm J. 2023;22(3):380\u201390. https:\/\/doi.org\/10.4103\/epj.epj_46_23.","journal-title":"Egypt Pharm J"},{"issue":"1","key":"3008_CR94","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1039\/c4mb00406j","volume":"11","author":"R Zvanych","year":"2015","unstructured":"Zvanych R, Lukenda N, Li X, Kim JJ, Tharmarajah S, MaGarvey NA. Systems biosynthesis of secondary metabolic pathways within the oral human microbiome member Streptococcus mutans. Mol Biosyst. 2015;11(1):97\u2013104. https:\/\/doi.org\/10.1039\/c4mb00406j.","journal-title":"Mol Biosyst"},{"key":"3008_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep37479","volume":"6","author":"L Liu","year":"2016","unstructured":"Liu L, Hao T, Xie Z, Horsman GP, Chen Y. Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans. Sci Rep. 2016;6:1\u201310. https:\/\/doi.org\/10.1038\/srep37479.","journal-title":"Sci Rep"},{"key":"3008_CR96","doi-asserted-by":"publisher","unstructured":"Chait YA, Gunenc A, Hosseinian F, Bendali F. Antipathogenic and probiotic potential of Lactobacillus brevis strains newly isolated from Algerian artisanal cheeses. Folia Microbiol (Praha). 2021;429\u201340. https:\/\/doi.org\/10.1007\/s12223-021-00857-1.","DOI":"10.1007\/s12223-021-00857-1"},{"issue":"1","key":"3008_CR97","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/s00284-018-1581-2","volume":"76","author":"ME Fraunhofer","year":"2019","unstructured":"Fraunhofer ME, Gei\u00dfler AJ, Behr J, Vogel RF. Comparative Genomics of Lactobacillus brevis Reveals a Significant Plasmidome Overlap of Brewery and Insect Isolates. Curr Microbiol. 2019;76(1):37\u201347. https:\/\/doi.org\/10.1007\/s00284-018-1581-2. PubMed PMID: 30341451.","journal-title":"Curr Microbiol"},{"key":"3008_CR98","doi-asserted-by":"publisher","unstructured":"Zhang D, Zhang J, Kalimuthu S, Liu J, Song ZM, He B, bei, et al. A systematically biosynthetic investigation of lactic acid bacteria reveals diverse antagonistic bacteriocins that potentially shape the human microbiome. Microbiome. 2023;11(91). https:\/\/doi.org\/10.1186\/s40168-023-01540-y. PubMed PMID: 37101246.","DOI":"10.1186\/s40168-023-01540-y"},{"key":"3008_CR99","doi-asserted-by":"publisher","first-page":"100065","DOI":"10.1016\/j.medmic.2022.100065","volume":"14","author":"Y Huo","year":"2022","unstructured":"Huo Y, Jiang Q, Zhao W. Meta-analysis of metagenomics reveals the signatures of vaginal microbiome in preterm birth. Med Microecology. 2022;14:100065. https:\/\/doi.org\/10.1016\/j.medmic.2022.100065.","journal-title":"Med Microecology"}],"container-title":["Microbial Cell Factories"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12934-026-03008-8","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12934-026-03008-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12934-026-03008-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:51:46Z","timestamp":1780527106000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12934-026-03008-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,21]]},"references-count":101,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["3008"],"URL":"https:\/\/doi.org\/10.1186\/s12934-026-03008-8","relation":{},"ISSN":["1475-2859"],"issn-type":[{"value":"1475-2859","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,21]]},"assertion":[{"value":"15 October 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"S.L. declares to be a voluntary academic board member of the International Scientific Association on Probiotics and Prebiotics (ISAPP, www.isappscience.org), cofounder of YUN and scientific advisor for Freya Biosciences. She declares research funding from YUN, BioOrg, Puratos, DSM I-Health and Lesaffre\/Gnosis. None of these organizations or companies were involved in the design, communication or data analysis. T.E. is partially funded by a VLAIO-project not related to this research. The other authors declare no competing interests related to this review manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"140"}}