{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T00:18:43Z","timestamp":1778285923562,"version":"3.51.4"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea","award":["(HI14C0018)"],"award-info":[{"award-number":["(HI14C0018)"]}]},{"name":"Dong-A Pharmaceutical Company","award":["Dong-A 2014"],"award-info":[{"award-number":["Dong-A 2014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Cell Int"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12935-015-0274-1","type":"journal-article","created":{"date-parts":[[2015,12,18]],"date-time":"2015-12-18T04:55:47Z","timestamp":1450414547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The effects of MOTILIPERM on cisplatin induced testicular toxicity in Sprague\u2013Dawley rats"],"prefix":"10.1186","volume":"15","author":[{"given":"Kiran Kumar","family":"Soni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyung","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan Shou","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Jung","family":"Chae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Kwan","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,12,18]]},"reference":[{"issue":"1","key":"274_CR1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jlac.18440510102","volume":"51","author":"M Peyrone","year":"1844","unstructured":"Peyrone M. Ueber die Einwirkung des Ammoniaks auf Platinchlor\u00fcr. Ann Chemie Pharm. 1844;51(1):1\u201329.","journal-title":"Ann Chemie Pharm"},{"issue":"9\u201310","key":"274_CR2","first-page":"1493","volume":"63","author":"JH Burchenal","year":"1979","unstructured":"Burchenal JH, Kalaher K, Dew K, Lokys L. Rationale for development of platinum analogs. Cancer Treat Rep. 1979;63(9\u201310):1493\u20138.","journal-title":"Cancer Treat Rep"},{"issue":"10","key":"274_CR3","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/S0959-8049(98)00224-X","volume":"34","author":"D Lebwohl","year":"1998","unstructured":"Lebwohl D, Canetta R. Clinical development of platinum complexes in cancer therapy: an historical perspective and an update. Eur J Cancer. 1998;34(10):1522\u201334.","journal-title":"Eur J Cancer"},{"issue":"8","key":"274_CR4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrc2167","volume":"7","author":"L Kelland","year":"2007","unstructured":"Kelland L. The resurgence of platinum-based cancer chemotherapy. Nat Rev Cancer. 2007;7(8):573\u201384.","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"274_CR5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0305-7372(79)80057-2","volume":"6","author":"AW Prestayko","year":"1979","unstructured":"Prestayko AW, D\u2019Aoust JC, Issell BF, Crooke ST. Cisplatin (cis-diamminedichloroplatinum II). Cancer Treat Rev. 1979;6(1):17\u201339.","journal-title":"Cancer Treat Rev"},{"key":"274_CR6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1093\/jncimonographs\/lgi006","volume":"34","author":"K Boekelheide","year":"2005","unstructured":"Boekelheide K. Mechanisms of toxic damage to spermatogenesis. J Natl Cancer Inst Monogr. 2005;34:6\u20138.","journal-title":"J Natl Cancer Inst Monogr"},{"issue":"2","key":"274_CR7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.mrgentox.2004.08.010","volume":"564","author":"SM Cherry","year":"2004","unstructured":"Cherry SM, Hunt PA, Hassold TJ. Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation. Mutat Res. 2004;564(2):115\u20131128.","journal-title":"Mutat Res"},{"issue":"5","key":"274_CR8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1745-7262.2006.00179.x","volume":"8","author":"A Amin","year":"2006","unstructured":"Amin A, Hamza A. Effects of ginger and roselle on cisplatininduced reproductive toxicity in rats. Asian J Androl. 2006;8(5):607\u201312.","journal-title":"Asian J Androl"},{"issue":"6","key":"274_CR9","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1095\/biolreprod59.6.1371","volume":"59","author":"L Franca","year":"1998","unstructured":"Franca L, Ogawa T, Avarbock M, Brinster R, Russell L. Germ cell genotype controls cell cycle during spermatogenesis in the rat. Biol Reprod. 1998;59(6):1371\u20137.","journal-title":"Biol Reprod"},{"issue":"3","key":"274_CR10","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-7992(90)90087-Z","volume":"243","author":"ID Adler","year":"1990","unstructured":"Adler ID, El Tarras A. Clastogenic effects of cis-diamminedichloroplatinum II. Induction of chromosomal aberrations in primary spermatocytes and spermatogonial stem cell of mice. Mutat Res. 1990;243(3):173\u20138.","journal-title":"Mutat Res"},{"issue":"1","key":"274_CR11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/01485019408987767","volume":"32","author":"AI Vawda","year":"1994","unstructured":"Vawda AI. Effect of testosterone on cisplatin-induced testicular damage. Arch Androl. 1994;32(1):53\u20137.","journal-title":"Arch Androl"},{"issue":"4","key":"274_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1368-7646(98)80005-8","volume":"1","author":"SW Johnson","year":"1998","unstructured":"Johnson SW, Ferry KV, Hamilton TC. Recent insights into platinum drug resistance in cancer. Drug Resist Updat. 1998;1(4):243\u201354.","journal-title":"Drug Resist Updat"},{"issue":"2","key":"274_CR13","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1745-7262.2008.00379.x","volume":"10","author":"A Amin","year":"2008","unstructured":"Amin A, Hamza AA, Kmbal A, Daoud S. Herbal extracts counteract cisplatin-mediated cell death in rat testis. Asian J Androl. 2008;10(2):291\u20137.","journal-title":"Asian J Androl"},{"issue":"1","key":"274_CR14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1600-079X.2006.00327.x","volume":"41","author":"A Atessahin","year":"2006","unstructured":"Atessahin A, Sahna E, Turk G, Ceriba\u015fi AO, Yilmaz S, Y\u00fcce A, et al. Chemoprotective effect of melatonin against cisplatin-induced testicular toxicity in rats. J Pineal Res. 2006;41(1):21\u20137.","journal-title":"J Pineal Res"},{"issue":"3","key":"274_CR15","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/j.1939-4640.1992.tb00306.x","volume":"13","author":"JG Alvarez","year":"1992","unstructured":"Alvarez JG, Storey BT. Evidence for increased lipid peroxidase damage and loss of superoxid dismutase activity as a mode of sublethal cryodamage of humans sperm during cryopreservation. J Androl. 1992;13(3):232\u201341.","journal-title":"J Androl"},{"issue":"3","key":"274_CR16","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10600-008-9083-2","volume":"44","author":"GT Mavlonov","year":"2008","unstructured":"Mavlonov GT, Ubaidullaeva KA, Kadryaeva GV, Kuznetsova NN. Cytotoxic components of Cuscuta. Chem Nat Compd. 2008;44(3):409\u201310.","journal-title":"Chem Nat Compd"},{"issue":"1","key":"274_CR17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jep.2008.06.027","volume":"119","author":"JX Yang","year":"2008","unstructured":"Yang JX, Wang YL, Bao Y, Guo J. The total flavones from Semen cuscutae reverse the reduction of testosterone level and the expression of androgen receptor gene in kidney-yang deficient mice. J Ethnopharmacol. 2008;119(1):166\u201371.","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"274_CR18","first-page":"145","volume":"17","author":"SJ Peng","year":"1997","unstructured":"Peng SJ, Lu RK, Yu LH. Effect of Semen cuacutae, Rhizoma curculiginis, Radix morindae, Officinalis on human spermatozoa\u2019s motility and membrane function in vitro. Chinese Journal of integrated traditional and Western Medicine. 1997;17(3):145\u20137.","journal-title":"Chinese Journal of integrated traditional and Western Medicine"},{"issue":"1","key":"274_CR19","first-page":"45","volume":"8","author":"A Khaki","year":"2009","unstructured":"Khaki A, Fathiazad F, Nouri M, Khaki AA, Khamenehi HJ, Hamadeh M. Evaluation of androgenic activity of allium cepa on spermatogenesis in the rat. Folia Morphol (Warsz). 2009;8(1):45\u201351.","journal-title":"Folia Morphol (Warsz)"},{"issue":"3","key":"274_CR20","doi-asserted-by":"crossref","first-page":"445","DOI":"10.3346\/jkms.2006.21.3.445","volume":"21","author":"HS Yang","year":"2006","unstructured":"Yang HS, Han DK, Kim JR, Sim JC. Effects of alpha- tocopherol on cadmium-induced toxicity in rat testis and spermatogenesis. J Korean Med Sci. 2006;21(3):445\u201351.","journal-title":"J Korean Med Sci"},{"issue":"7173","key":"274_CR21","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1136\/bmj.317.7173.1636","volume":"317","author":"JH Cummings","year":"1998","unstructured":"Cummings JH, Bingham SA. Fortnightly review diet and the prevention of cancer. BMJ. 1998;317(7173):1636\u201340.","journal-title":"BMJ"},{"key":"274_CR22","first-page":"337","volume":"3","author":"L Endre","year":"1990","unstructured":"Endre L, Beck F, Prasad A. The role of zinc in human health. J Trace Elem Exp Med. 1990;3:337\u201375.","journal-title":"J Trace Elem Exp Med"},{"issue":"1","key":"274_CR23","first-page":"122","volume":"42","author":"ML Meistrich","year":"1982","unstructured":"Meistrich ML, Finch M, Da Cunha MF, Hacker U, Au WW. Damaging effects of fourteen chemotherapeutic drugs on mouse testis cells. Cancer Res. 1982;42(1):122\u201331.","journal-title":"Cancer Res"},{"issue":"2","key":"274_CR24","first-page":"84","volume":"3","author":"OO Azu","year":"2010","unstructured":"Azu OO, Duru FIO, Osinubi AA, Noronha CC, Elesha SO, Okanlawon AO. Protective agent, Kigelia Africana fruit extract, against cisplatin-induced kidney oxidant injury in Sprague\u2013Dawley rats. Asian J Pharma Clin Res. 2010;3(2):84\u20138.","journal-title":"Asian J Pharma Clin Res"},{"issue":"9","key":"274_CR25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-4682-9-1","volume":"24","author":"A Amin","year":"2012","unstructured":"Amin A, Mahmoud-Ghoneim D, Syam MI, Daoud S. Neural network assessment of herbal protection against chemotherapeutic-induced reproductive toxicity. Theor Biol Med Model. 2012;24(9):1.","journal-title":"Theor Biol Med Model"},{"issue":"6","key":"274_CR26","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/S0090-4295(96)00313-5","volume":"48","author":"RK Sharma","year":"1996","unstructured":"Sharma RK, Agarwal A. Role of reactive oxygen species in male infertility. Urology. 1996;48(6):835\u201350.","journal-title":"Urology"},{"issue":"7","key":"274_CR27","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/ar.20693","volume":"291","author":"LC Lirdi","year":"2008","unstructured":"Lirdi LC, Stumpp T, Sasso-Cerri E, Miraglia SM. Amifostine protective effect on cisplatin-treated rat testis. Anat Rec (Hoboken). 2008;291(7):797\u2013808.","journal-title":"Anat Rec (Hoboken)"},{"issue":"3","key":"274_CR28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/S0015-0282(97)00239-2","volume":"68","author":"A Yoshida","year":"1997","unstructured":"Yoshida A, Miura K, Shirai M. Evaluation of seminiferous tubule scores obtained through testicular biopsy examinations of nonobstructive azoospermic men. Fertil Steril. 1997;68(3):514\u20138.","journal-title":"Fertil Steril"},{"issue":"45","key":"274_CR29","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1016\/S0021-9258(18)46930-X","volume":"269","author":"BJ Clark","year":"1994","unstructured":"Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells\u2014characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994;269(45):28314\u201322.","journal-title":"J Biol Chem"},{"issue":"7","key":"274_CR30","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/humrep\/dep058","volume":"24","author":"YO Ilbey","year":"2009","unstructured":"Ilbey YO, Ozbek E, Cekmen M. Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod. 2009;24(7):1717\u201325.","journal-title":"Hum Reprod"},{"issue":"3","key":"274_CR31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3390\/genes4030306","volume":"4","author":"H Kadowaki","year":"2013","unstructured":"Kadowaki H, Nishitoh H. Signaling Pathways from the Endoplasmic Reticulum and Their Roles in Disease. Genes (Basel). 2013;4(3):306\u201333.","journal-title":"Genes (Basel)"},{"issue":"5453","key":"274_CR32","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.287.5453.664","volume":"287","author":"F Urano","year":"2000","unstructured":"Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP, Ron D. Coupling of stress in the ER to activation of jnk protein kinases by transmembrane protein kinase IRE1. Science. 2000;287(5453):664\u20136.","journal-title":"Science"},{"issue":"11","key":"274_CR33","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1101\/gad.992302","volume":"16","author":"H Nishitoh","year":"2002","unstructured":"Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. Ask1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002;16(11):1345\u201355.","journal-title":"Genes Dev"}],"container-title":["Cancer Cell International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-015-0274-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T05:23:52Z","timestamp":1718256232000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.cancerci.com\/content\/15\/1\/121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["274"],"URL":"https:\/\/doi.org\/10.1186\/s12935-015-0274-1","relation":{},"ISSN":["1475-2867"],"issn-type":[{"value":"1475-2867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12]]},"article-number":"121"}}