{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:24:18Z","timestamp":1793751858433,"version":"4.6.1"},"reference-count":106,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:00:00Z","timestamp":1759449600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Cell Int"],"DOI":"10.1186\/s12935-025-03979-5","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:20:04Z","timestamp":1759490404000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["GRP-based vaccines as a novel approach in cancer immunotherapy: mechanisms, challenges, and prospects"],"prefix":"10.1186","volume":"25","author":[{"given":"Razieh Malekian","family":"Shahreza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Zare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Rastegar-Pouyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Aria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Hakim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Arefnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamid","family":"Bakherad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,10,3]]},"reference":[{"issue":"1","key":"3979_CR1","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s10103-024-03977-5","volume":"39","author":"F Javani Jouni","year":"2024","unstructured":"Javani Jouni F, Rastegar-Pouyani N, Najjar N, Nasirpour M, Payez A, Kashi G, et al. Evaluation of the effects of photodynamic therapy consisted of the blue laser and zinc oxide QDs on MDA-MB-231 cancer cells by inhibiting cancer markers and inducing apoptosis. Lasers Med Sci. 2024;39(1):28.","journal-title":"Lasers Med Sci"},{"issue":"9","key":"3979_CR2","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1007\/s10529-023-03383-x","volume":"45","author":"M Danaeifar","year":"2023","unstructured":"Danaeifar M, Negahdari B, Eslam HM, Zare H, Ghanaat M, Koushali SS, et al. Polymeric nanoparticles for DNA vaccine-based cancer immunotherapy: a review. Biotechnol Lett. 2023;45(9):1053\u201372.","journal-title":"Biotechnol Lett"},{"issue":"1","key":"3979_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/CritRevEukarGeneExpr.v4.i1.10","volume":"4","author":"E Little","year":"1994","unstructured":"Little E, Ramakrishnan M, Roy B, Gazit G, Lee AS. The glucose-regulated proteins (GRP78 and GRP94): functions, gene regulation, and applications. Crit Rev Eukaryot Gene Expr. 1994;4(1):1\u201318.","journal-title":"Crit Rev Eukaryot Gene Expr"},{"issue":"8","key":"3979_CR4","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1158\/0008-5472.CAN-07-0325","volume":"67","author":"AS Lee","year":"2007","unstructured":"Lee AS. GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007;67(8):3496\u20139.","journal-title":"Cancer Res"},{"issue":"2","key":"3979_CR5","doi-asserted-by":"publisher","first-page":"169","DOI":"10.5301\/jbm.5000063","volume":"29","author":"H Zare","year":"2014","unstructured":"Zare H, Rajabibazl M, Rasooli I, Ebrahimizadeh W, Bakherad H, Ardakani LS, et al. Production of nanobodies against Prostate-Specific membrane antigen (PSMA) recognizing LnCaP cells. Int J Biol Markers. 2014;29(2):169\u201379.","journal-title":"Int J Biol Markers"},{"issue":"1","key":"3979_CR6","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1146\/annurev.biochem.73.011303.074134","volume":"74","author":"M Schr\u00f6der","year":"2005","unstructured":"Schr\u00f6der M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem. 2005;74(1):739\u201389.","journal-title":"Annu Rev Biochem"},{"key":"3979_CR7","doi-asserted-by":"crossref","unstructured":"Fribley A, Zhang K, Kaufman RJ. Regulation of apoptosis by the unfolded protein response. In Apoptosis: Methods and Protocols, Second Edition. 2009. pp. 191\u2013204.","DOI":"10.1007\/978-1-60327-017-5_14"},{"issue":"14","key":"3979_CR8","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.2174\/1389557523666230119110744","volume":"23","author":"P Amini","year":"2023","unstructured":"Amini P, Moazamiyanfar R, Dakkali MS, Jafarzadeh E, Ganjizadeh M, Rastegar-Pouyani N, et al. Induction of cancer cell death by apigenin: a review on different cell death pathways. Mini-Rev Med Chem. 2023;23(14):1461\u201378.","journal-title":"Mini-Rev Med Chem"},{"issue":"18","key":"3979_CR9","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184588","volume":"20","author":"EA Taha","year":"2019","unstructured":"Taha EA, Ono K, Eguchi T. Roles of extracellular HSPs as biomarkers in immune surveillance and immune evasion. Int J Mol Sci. 2019;20(18):4588.","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3979_CR10","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1007\/s00018-021-03764-3","volume":"78","author":"L Secl\u00ec","year":"2021","unstructured":"Secl\u00ec L, Fusella F, Avalle L, Brancaccio M. The dark-side of the outside: how extracellular heat shock proteins promote cancer. Cell Mol Life Sci. 2021;78(9):4069\u201383.","journal-title":"Cell Mol Life Sci"},{"key":"3979_CR11","doi-asserted-by":"crossref","unstructured":"Calderwood SK, Gong J, Murshid A. Extracellular hsps: the complicated roles of extracellular HSPs in immunity. Front Immunol. 2016;7.","DOI":"10.3389\/fimmu.2016.00159"},{"issue":"2","key":"3979_CR12","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","volume":"13","author":"C Hetz","year":"2012","unstructured":"Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012;13(2):89\u2013102.","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"3979_CR13","doi-asserted-by":"publisher","first-page":"364","DOI":"10.3109\/02656736.2013.803607","volume":"29","author":"XY Wang","year":"2013","unstructured":"Wang XY, Subjeck JR. High molecular weight stress proteins: identification, cloning and utilisation in cancer immunotherapy. Int J Hyperthermia. 2013;29(5):364\u201375.","journal-title":"Int J Hyperthermia"},{"issue":"7","key":"3979_CR14","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/onc.2012.130","volume":"32","author":"B Luo","year":"2013","unstructured":"Luo B, Lee AS. The critical roles of endoplasmic reticulum chaperones and unfolded protein response in tumorigenesis and anticancer therapies. Oncogene. 2013;32(7):805\u201318.","journal-title":"Oncogene"},{"issue":"1","key":"3979_CR15","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01950-w","volume":"9","author":"X Chen","year":"2024","unstructured":"Chen X, Wu Q, Gong W, Ju S, Fan J, Gao X, et al. GRP75 triggers white adipose tissue browning to promote cancer-associated cachexia. Signal Transduct Target Ther. 2024;9(1):253.","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"3979_CR16","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/s10020-023-00706-6","volume":"29","author":"AO Akinyemi","year":"2023","unstructured":"Akinyemi AO, Simpson KE, Oyelere SF, Nur M, Ngule CM, Owoyemi BCD, et al. Unveiling the dark side of glucose-regulated protein 78 (GRP78) in cancers and other human pathology: a systematic review. Mol Med. 2023;29(1):112.","journal-title":"Mol Med"},{"issue":"5","key":"3979_CR17","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.jinf.2020.02.026","volume":"80","author":"IM Ibrahim","year":"2020","unstructured":"Ibrahim IM, Abdelmalek DH, Elshahat ME, Elfiky AA. COVID-19 spike-host cell receptor GRP78 binding site prediction. J Infect. 2020;80(5):554\u201362.","journal-title":"J Infect"},{"issue":"12","key":"3979_CR18","doi-asserted-by":"publisher","first-page":"3759","DOI":"10.1002\/jmv.25737","volume":"92","author":"AA Elfiky","year":"2020","unstructured":"Elfiky AA. Human papillomavirus E6: host cell receptor, GRP78, binding site prediction. J Med Virol. 2020;92(12):3759\u201365.","journal-title":"J Med Virol"},{"issue":"3","key":"3979_CR19","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1007\/s12192-020-01106-z","volume":"25","author":"AA Elfiky","year":"2020","unstructured":"Elfiky AA. Ebola virus glycoprotein GP1\u2014host cell-surface HSPA5 binding site prediction. Cell Stress Chaperones. 2020;25(3):541\u20138.","journal-title":"Cell Stress Chaperones"},{"issue":"14","key":"3979_CR20","doi-asserted-by":"publisher","first-page":"5248","DOI":"10.1080\/07391102.2020.1784794","volume":"39","author":"AA Elfiky","year":"2021","unstructured":"Elfiky AA, Ibrahim IM. Zika virus envelope \u2013 heat shock protein A5 (GRP78) binding site prediction. J Biomol Struct Dyn. 2021;39(14):5248\u201360.","journal-title":"J Biomol Struct Dyn"},{"issue":"2","key":"3979_CR21","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.immuni.2006.12.005","volume":"26","author":"Y Yang","year":"2007","unstructured":"Yang Y, Liu B, Dai J, Srivastava PK, Zammit DJ, Lefran\u00e7ois L, et al. Heat shock protein gp96 is a master chaperone for Toll-like receptors and is important in the innate function of macrophages. Immunity. 2007;26(2):215\u201326.","journal-title":"Immunity"},{"issue":"6","key":"3979_CR22","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","volume":"140","author":"GS Hotamisligil","year":"2010","unstructured":"Hotamisligil GS. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell. 2010;140(6):900\u201317.","journal-title":"Cell"},{"issue":"1","key":"3979_CR23","doi-asserted-by":"publisher","first-page":"19730","DOI":"10.1038\/s41598-020-76839-z","volume":"10","author":"Y Kawaguchi","year":"2020","unstructured":"Kawaguchi Y, Hagiwara D, Miyata T, Hodai Y, Kurimoto J, Takagi H, et al. Endoplasmic reticulum chaperone BiP\/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice. Sci Rep. 2020;10(1):19730.","journal-title":"Sci Rep"},{"issue":"2","key":"3979_CR24","doi-asserted-by":"publisher","first-page":"382","DOI":"10.3390\/biomedicines13020382","volume":"13","author":"Y Yang","year":"2025","unstructured":"Yang Y, Li W, Zhao Y, Sun M, Xing F, Yang J, et al. Grp78 in glioma progression and therapy: implications for targeted approaches. Biomedicines. 2025;13(2):382.","journal-title":"Biomedicines"},{"issue":"1","key":"3979_CR25","doi-asserted-by":"publisher","first-page":"490","DOI":"10.4049\/jimmunol.166.1.490","volume":"166","author":"XY Wang","year":"2001","unstructured":"Wang XY, Kazim L, Repasky EA, Subjeck JR. Characterization of heat shock protein 110 and glucose-regulated protein 170 as cancer vaccines and the effect of fever-range hyperthermia on vaccine activity. J Immunol. 2001;166(1):490\u20137.","journal-title":"J Immunol"},{"issue":"2","key":"3979_CR26","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1002\/bab.1916","volume":"68","author":"H Aghamollaei","year":"2021","unstructured":"Aghamollaei H, Ghanei M, Rasaee MJ, Latifi AM, Bakherad H, Fasihi-Ramandi M, et al. Isolation and characterization of a novel nanobody for detection of GRP78 expressing cancer cells. Biotechnol Appl Biochem. 2021;68(2):239\u201346.","journal-title":"Biotechnol Appl Biochem"},{"issue":"1","key":"3979_CR27","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/bab.1455","volume":"64","author":"H Aghamollaei","year":"2017","unstructured":"Aghamollaei H, Mousavi Gargari SL, Ghanei M, Rasaee MJ, Amani J, Bakherad H, et al. Structure prediction, expression, and antigenicity of c-terminal of GRP78. Biotechnol Appl Biochem. 2017;64(1):117\u201325.","journal-title":"Biotechnol Appl Biochem"},{"issue":"4","key":"3979_CR28","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nrc3701","volume":"14","author":"AS Lee","year":"2014","unstructured":"Lee AS. Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential. Nat Rev Cancer. 2014;14(4):263\u201376.","journal-title":"Nat Rev Cancer"},{"issue":"5","key":"3979_CR29","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1074\/jbc.M113.507491","volume":"289","author":"J Behnke","year":"2014","unstructured":"Behnke J, Hendershot LM. The large Hsp70 Grp170 binds to unfolded protein substrates in vivo with a regulation distinct from conventional Hsp70s. J Biol Chem. 2014;289(5):2899\u2013907.","journal-title":"J Biol Chem"},{"issue":"5","key":"3979_CR30","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/j.semcdb.2010.03.004","volume":"21","author":"D Eletto","year":"2010","unstructured":"Eletto D, Dersh D, Argon Y. GRP94 in ER quality control and stress responses. Semin Cell Dev Biol. 2010;21(5):479\u201385.","journal-title":"Semin Cell Dev Biol"},{"issue":"6","key":"3979_CR31","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/35014014","volume":"2","author":"A Bertolotti","year":"2000","unstructured":"Bertolotti A, Zhang Y, Hendershot LM, Harding HP, Ron D. Dynamic interaction of bip and ER stress transducers in the unfolded-protein response. Nat Cell Biol. 2000;2(6):326\u201332.","journal-title":"Nat Cell Biol"},{"issue":"6","key":"3979_CR32","doi-asserted-by":"publisher","first-page":"670","DOI":"10.1007\/s00018-004-4464-6","volume":"62","author":"MP Mayer","year":"2005","unstructured":"Mayer MP, Bukau B. Hsp70 chaperones: cellular functions and molecular mechanism. Cell Mol Life Sci. 2005;62(6):670.","journal-title":"Cell Mol Life Sci"},{"issue":"19","key":"3979_CR33","doi-asserted-by":"publisher","first-page":"3641","DOI":"10.1016\/j.febslet.2007.04.045","volume":"581","author":"M Ni","year":"2007","unstructured":"Ni M, Lee AS. ER chaperones in mammalian development and human diseases. FEBS Lett. 2007;581(19):3641\u201351.","journal-title":"FEBS Lett"},{"key":"3979_CR34","unstructured":"Stofberg ML, Muzenda FL, Achilonu I, Strauss E, Zininga T. In Silico screening of selective ATP mimicking inhibitors targeting the Plasmodium falciparum Grp94. J Biomol Struct Dyn. 2024;(18):1\u201312."},{"issue":"4","key":"3979_CR35","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.ymeth.2004.10.010","volume":"35","author":"AS Lee","year":"2005","unstructured":"Lee AS. The ER chaperone and signaling regulator GRP78\/BiP as a monitor of endoplasmic reticulum stress. Methods. 2005;35(4):373\u201381.","journal-title":"Methods"},{"issue":"8","key":"3979_CR36","doi-asserted-by":"publisher","first-page":"2107","DOI":"10.1158\/1078-0432.CCR-12-2991","volume":"19","author":"YR Miao","year":"2013","unstructured":"Miao YR, Eckhardt BL, Cao Y, Pasqualini R, Argani P, Arap W, et al. Inhibition of established micrometastases by targeted drug delivery via cell surface\u2013associated GRP78. Clin Cancer Res. 2013;19(8):2107\u201316.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"3979_CR37","doi-asserted-by":"publisher","first-page":"865","DOI":"10.4161\/cc.7.7.5615","volume":"7","author":"EL Davenport","year":"2008","unstructured":"Davenport EL, Morgan GJ, Davies FE. Untangling the unfolded protein response. Cell Cycle. 2008;7(7):865\u20139.","journal-title":"Cell Cycle"},{"issue":"11","key":"3979_CR38","doi-asserted-by":"publisher","first-page":"e80071","DOI":"10.1371\/journal.pone.0080071","volume":"8","author":"Y Zhang","year":"2013","unstructured":"Zhang Y, Tseng CC, Tsai YL, Fu X, Schiff R, Lee AS. Cancer cells resistant to therapy promote cell surface relocalization of GRP78 which complexes with PI3K and enhances PI(3,4,5)P3 production. PLoS ONE. 2013;8(11):e80071.","journal-title":"PLoS ONE"},{"issue":"24","key":"3979_CR39","doi-asserted-by":"publisher","first-page":"6802","DOI":"10.1158\/1078-0432.CCR-13-1106","volume":"19","author":"R Liu","year":"2013","unstructured":"Liu R, Li X, Gao W, Zhou Y, Wey S, Mitra SK, et al. Monoclonal antibody against cell surface GRP78 as a novel agent in suppressing PI3K\/AKT signaling, tumor growth, and metastasis. Clin Cancer Res. 2013;19(24):6802\u201311.","journal-title":"Clin Cancer Res"},{"issue":"9","key":"3979_CR40","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1089\/ars.2009.2485","volume":"11","author":"M Wang","year":"2009","unstructured":"Wang M, Wey S, Zhang Y, Ye R, Lee AS. Role of the unfolded protein response regulator GRP78\/BiP in development, cancer, and neurological disorders. Antioxid Redox Signal. 2009;11(9):2307\u201316.","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"3979_CR41","doi-asserted-by":"publisher","first-page":"7849","DOI":"10.4049\/jimmunol.177.11.7849","volume":"177","author":"SS Mambula","year":"2006","unstructured":"Mambula SS, Calderwood SK. Heat shock protein 70 is secreted from tumor cells by a nonclassical pathway involving lysosomal endosomes. J Immunol. 2006;177(11):7849\u201357.","journal-title":"J Immunol"},{"issue":"16","key":"3979_CR42","doi-asserted-by":"publisher","first-page":"3631","DOI":"10.1242\/jcs.02494","volume":"118","author":"A Clayton","year":"2005","unstructured":"Clayton A, Turkes A, Navabi H, Mason MD, Tabi Z. Induction of heat shock proteins in B-cell exosomes. J Cell Sci. 2005;118(16):3631\u20138.","journal-title":"J Cell Sci"},{"issue":"6","key":"3979_CR43","doi-asserted-by":"publisher","first-page":"4299","DOI":"10.4049\/jimmunol.180.6.4299","volume":"180","author":"VL Vega","year":"2008","unstructured":"Vega VL, Rodr\u00edguez-Silva M, Frey T, Gehrmann M, Diaz JC, Steinem C, et al. Hsp70 translocates into the plasma membrane after stress and is released into the extracellular environment in a membrane-associated form that activates macrophages. J Immunol. 2008;180(6):4299\u2013307.","journal-title":"J Immunol"},{"issue":"11","key":"3979_CR44","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1093\/intimm\/12.11.1539","volume":"12","author":"S Basu","year":"2000","unstructured":"Basu S, Binder RJ, Suto R, Anderson KM, Srivastava PK. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-\u03baB pathway. Int Immunol. 2000;12(11):1539\u201346.","journal-title":"Int Immunol"},{"issue":"16","key":"3979_CR45","doi-asserted-by":"publisher","first-page":"6128","DOI":"10.1073\/pnas.0308180101","volume":"101","author":"RJ Binder","year":"2004","unstructured":"Binder RJ, Srivastava PK. Essential role of CD91 in re-presentation of gp96-chaperoned peptides. Proc Natl Acad Sci U S A. 2004;101(16):6128\u201333.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3979_CR46","doi-asserted-by":"crossref","unstructured":"Graner MW. In. HSP90 and immune modulation in cancer. Adv Cancer Res. 2016;129:191\u2013224.","DOI":"10.1016\/bs.acr.2015.10.001"},{"issue":"19","key":"3979_CR47","doi-asserted-by":"publisher","first-page":"3689","DOI":"10.1016\/j.febslet.2007.04.044","volume":"581","author":"SK Calderwood","year":"2007","unstructured":"Calderwood SK, Mambula SS, Gray PJ, Theriault JR. Extracellular heat shock proteins in cell signaling. FEBS Lett. 2007;581(19):3689\u201394.","journal-title":"FEBS Lett"},{"issue":"1","key":"3979_CR48","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1046\/j.1365-2141.2003.03929.x","volume":"120","author":"T Hayashi","year":"2003","unstructured":"Hayashi T, Hideshima T, Anderson KC. Novel therapies for multiple myeloma. Br J Haematol. 2003;120(1):10\u20137.","journal-title":"Br J Haematol"},{"issue":"10","key":"3979_CR49","doi-asserted-by":"publisher","first-page":"3407","DOI":"10.1073\/pnas.83.10.3407","volume":"83","author":"PK Srivastava","year":"1986","unstructured":"Srivastava PK, DeLeo AB, Old LJ. Tumor rejection antigens of chemically induced sarcomas of inbred mice. Proc Natl Acad Sci U S A. 1986;83(10):3407\u201311.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"3979_CR50","doi-asserted-by":"publisher","first-page":"2555","DOI":"10.1038\/sj.onc.1202292","volume":"17","author":"MS Sheikh","year":"1998","unstructured":"Sheikh MS, Antinore MJ, Huang Y, Fornace AJ. Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1. Oncogene. 1998;17(20):2555\u201363.","journal-title":"Oncogene"},{"issue":"1","key":"3979_CR51","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1476-8518-6-2","volume":"6","author":"CA Gullo","year":"2008","unstructured":"Gullo CA, Hwang WY, Poh CK, Au M, Cow G, Teoh G. Use of ultraviolet-light irradiated multiple myeloma cells as immunogens to generate tumor-specific cytolytic T lymphocytes. J Immune Based Ther Vaccines. 2008;6(1):2.","journal-title":"J Immune Based Ther Vaccines"},{"issue":"2","key":"3979_CR52","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1002\/ijc.11058","volume":"105","author":"X Wang","year":"2003","unstructured":"Wang X, Kazim L, Repasky EA, Subjeck JR. Immunization with tumor-derived ER chaperone grp170 elicits tumor\u2010specific CD8 + T\u2010cell responses and reduces pulmonary metastatic disease. Int J Cancer. 2003;105(2):226\u201331.","journal-title":"Int J Cancer"},{"issue":"1","key":"3979_CR53","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s12935-022-02665-0","volume":"22","author":"H Bakherad","year":"2022","unstructured":"Bakherad H, Ghasemi F, Hosseindokht M, Zare H. Nanobodies; new molecular instruments with special specifications for targeting, diagnosis and treatment of triple-negative breast cancer. Cancer Cell Int. 2022;22(1):245.","journal-title":"Cancer Cell Int"},{"key":"3979_CR54","doi-asserted-by":"publisher","first-page":"27829","DOI":"10.34172\/bi.2023.27829","volume":"14","author":"H Zare","year":"2023","unstructured":"Zare H, Bakherad H, Nasr Esfahani A, Norouzi M, Aghamollaei H, Mousavi Gargari SL, et al. Introduction of a new recombinant vaccine based on GRP78 for breast cancer immunotherapy and evaluation in a mouse model. Bioimpacts. 2023;14:27829.","journal-title":"Bioimpacts"},{"issue":"1","key":"3979_CR55","doi-asserted-by":"publisher","first-page":"73","DOI":"10.4103\/1735-5362.394822","volume":"19","author":"H Zare","year":"2024","unstructured":"Zare H, Bakherad H, Esfahani AN, Aghamollaei H, Gargari SLM, Aliomrani M, et al. Investigating the effect of cGRP78 vaccine against different cancer cells and its role in reducing melanoma metastasis. Res Pharm Sci. 2024;19(1):73\u201382.","journal-title":"Res Pharm Sci"},{"key":"3979_CR56","doi-asserted-by":"crossref","unstructured":"Brentville VA, Symonds P, Chua J, Skinner A, Daniels I, Cook KW et al. Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy. Front Immunol. 2022;13.","DOI":"10.3389\/fimmu.2022.1066185"},{"issue":"11","key":"3979_CR57","doi-asserted-by":"publisher","first-page":"5398","DOI":"10.4049\/jimmunol.152.11.5398","volume":"152","author":"H Udono","year":"1994","unstructured":"Udono H, Srivastava PK. Comparison of tumor-specific immunogenicities of stress-induced proteins gp96, Hsp90, and Hsp70. J Immunol. 1994;152(11):5398\u2013403.","journal-title":"J Immunol"},{"issue":"1","key":"3979_CR58","doi-asserted-by":"publisher","first-page":"e0211490","DOI":"10.1371\/journal.pone.0211490","volume":"14","author":"H Zheng","year":"2019","unstructured":"Zheng H, Liu L, Zhang H, Kan F, Wang S, Li Y, et al. Dendritic cells pulsed with placental gp96 promote tumor-reactive immune responses. PLoS ONE. 2019;14(1):e0211490.","journal-title":"PLoS ONE"},{"issue":"1","key":"3979_CR59","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1186\/s12935-021-02285-0","volume":"21","author":"M Hosseindokht","year":"2021","unstructured":"Hosseindokht M, Bakherad H, Zare H. Nanobodies: a tool to open new horizons in diagnosis and treatment of prostate cancer. Cancer Cell Int. 2021;21(1):580.","journal-title":"Cancer Cell Int"},{"issue":"38","key":"3979_CR60","doi-asserted-by":"publisher","first-page":"6333","DOI":"10.1016\/j.vaccine.2010.06.093","volume":"28","author":"W Huo","year":"2010","unstructured":"Huo W, Ye J, Liu R, Chen J, Li Q. Vaccination with a chaperone complex based on PSCA and GRP170 adjuvant enhances the CTL response and inhibits the tumor growth in mice. Vaccine. 2010;28(38):6333\u20137.","journal-title":"Vaccine"},{"issue":"7","key":"3979_CR61","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.imbio.2012.01.006","volume":"217","author":"B Yuan","year":"2012","unstructured":"Yuan B, Xian R, Wu X, Jing J, Chen K, Liu G, et al. Endoplasmic reticulum chaperone glucose regulated protein 170\u2013Pokemon complexes elicit a robust antitumor immune response in vivo. Immunobiology. 2012;217(7):738\u201342.","journal-title":"Immunobiology"},{"issue":"3","key":"3979_CR62","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.4049\/jimmunol.177.3.1543","volume":"177","author":"XY Wang","year":"2006","unstructured":"Wang XY, Arnouk H, Chen X, Kazim L, Repasky EA, Subjeck JR. Extracellular targeting of endoplasmic reticulum chaperone Glucose-regulated protein 170 enhances tumor immunity to a poorly immunogenic melanoma. J Immunol. 2006;177(3):1543\u201351.","journal-title":"J Immunol"},{"issue":"4","key":"3979_CR63","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3109\/02656730903485910","volume":"26","author":"H Arnouk","year":"2010","unstructured":"Arnouk H, Zynda ER, Wang XY, Hylander BL, Manjili MH, Repasky EA, et al. Tumour secreted grp170 chaperones full-length protein substrates and induces an adaptive anti-tumour immune response in vivo. Int J Hyperthermia. 2010;26(4):366\u201375.","journal-title":"Int J Hyperthermia"},{"issue":"5335","key":"3979_CR64","first-page":"117","volume":"278","author":"Y Tamura","year":"1997","unstructured":"Tamura Y, Peng P, Liu K, Daou M, Srivastava P. Immunotherapy of tumors with autologous Tumor-Derived heat shock protein preparations. Sci (1979). 1997;278(5335):117\u201320.","journal-title":"Sci (1979)"},{"issue":"3","key":"3979_CR65","doi-asserted-by":"publisher","first-page":"190","DOI":"10.2174\/0929866523666161220111833","volume":"24","author":"S Talebi","year":"2017","unstructured":"Talebi S, Bolhassani A, Azad T, Arashkia A, Modaresi M. Immuno-stimulating peptide derived from HMGB1 is more effective than the N-terminal domain of Gp96 as an endogenous adjuvant for improvement of protein vaccines. Protein Pept Lett. 2017;24(3):190\u20136.","journal-title":"Protein Pept Lett"},{"issue":"20","key":"3979_CR66","doi-asserted-by":"publisher","first-page":"9126","DOI":"10.1158\/0008-5472.CAN-05-0945","volume":"65","author":"S Liu","year":"2005","unstructured":"Liu S, Wang H, Yang Z, Kon T, Zhu J, Cao Y, et al. Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94\/gp96 expression. Cancer Res. 2005;65(20):9126\u201331.","journal-title":"Cancer Res"},{"issue":"8","key":"3979_CR67","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1007\/s12094-021-02570-4","volume":"23","author":"H Li","year":"2021","unstructured":"Li H, Sui X, Wang Z, Fu H, Wang Z, Yuan M, et al. A new antisarcoma strategy: Multisubtype heat shock protein\/peptide immunotherapy combined with PD-L1 immunological checkpoint inhibitors. Clin Transl Oncol. 2021;23(8):1688\u2013704.","journal-title":"Clin Transl Oncol"},{"issue":"5","key":"3979_CR68","doi-asserted-by":"publisher","first-page":"380","DOI":"10.3109\/02656736.2013.793406","volume":"29","author":"MW Graner","year":"2013","unstructured":"Graner MW, Romanoski A, Katsanis E. The \u2018peptidome\u2019 of tumour-derived chaperone-rich cell lysate anti-cancer vaccines reveals potential tumour antigens that stimulate tumour immunity. Int J Hyperthermia. 2013;29(5):380\u20139.","journal-title":"Int J Hyperthermia"},{"issue":"9","key":"3979_CR69","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1158\/2326-6066.CIR-15-0228","volume":"4","author":"G Fromm","year":"2016","unstructured":"Fromm G, de Silva S, Giffin L, Xu X, Rose J, Schreiber TH. Gp96-Ig\/costimulator (OX40L, ICOSL, or 4-1BBL) combination vaccine improves T-cell priming and enhances immunity, memory, and tumor elimination. Cancer Immunol Res. 2016;4(9):766\u201378.","journal-title":"Cancer Immunol Res"},{"issue":"7","key":"3979_CR70","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1158\/0008-5472.CAN-12-1740","volume":"73","author":"X Yu","year":"2013","unstructured":"Yu X, Guo C, Yi H, Qian J, Fisher PB, Subjeck JR, et al. A multifunctional chimeric chaperone serves as a novel immune modulator inducing therapeutic antitumor immunity. Cancer Res. 2013;73(7):2093\u2013103.","journal-title":"Cancer Res"},{"issue":"5","key":"3979_CR71","first-page":"261","volume":"24","author":"A \u2019Izadpanah","year":"2022","unstructured":"\u2019Izadpanah A, \u2019Delirezh N, \u2019Mahmodlou R. Ex vivo optimization of Glucose-Regulated protein 94\/glycoprotein 96 expressions in mammospheres; implication for breast cancer immunotherapy. Cell J. 2022;24(5):261\u20136.","journal-title":"Cell J"},{"issue":"8","key":"3979_CR72","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1080\/02656730802213384","volume":"24","author":"E Bleifuss","year":"2008","unstructured":"Bleifuss E, Bendz H, Sirch B, Thompson S, Brandl A, Milani V, et al. Differential capacity of chaperone-rich lysates in cross-presenting human endogenous and exogenous melanoma differentiation antigens. Int J Hyperthermia. 2008;24(8):623\u201337.","journal-title":"Int J Hyperthermia"},{"issue":"7","key":"3979_CR73","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.4049\/jimmunol.172.7.4195","volume":"172","author":"JC Baker-LePain","year":"2004","unstructured":"Baker-LePain JC, Sarzotti M, Nicchitta CV. Glucose-regulated protein 94\/glycoprotein 96 elicits bystander activation of CD4\u2009+\u2009T cell Th1 cytokine production in vivo. J Immunol. 2004;172(7):4195\u2013203.","journal-title":"J Immunol"},{"issue":"12","key":"3979_CR74","doi-asserted-by":"publisher","first-page":"6010","DOI":"10.4049\/jimmunol.1302312","volume":"191","author":"H Wang","year":"2013","unstructured":"Wang H, Yu X, Guo C, Zuo D, Fisher PB, Subjeck JR, et al. Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell\u2013targeted vaccination. J Immunol. 2013;191(12):6010\u201321.","journal-title":"J Immunol"},{"issue":"2","key":"3979_CR75","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1158\/0008-5472.CAN-05-2609","volume":"66","author":"JE Park","year":"2006","unstructured":"Park JE, Facciponte J, Chen X, MacDonald I, Repasky EA, Manjili MH, et al. Chaperoning function of stress protein grp170, a member of the hsp70 superfamily, is responsible for its immunoadjuvant activity. Cancer Res. 2006;66(2):1161\u20138.","journal-title":"Cancer Res"},{"key":"3979_CR76","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2022.103174","volume":"40","author":"A Serrano-Quintero","year":"2022","unstructured":"Serrano-Quintero A, Sequeda-Ju\u00e1rez A, P\u00e9rez-Hern\u00e1ndez CA, Sosa-Delgado SM, Mendez-Tenorio A, Ram\u00f3n-Gallegos E. Immunogenic analysis of epitope-based vaccine candidate induced by photodynamic therapy in MDA-MB-231 triple-negative breast cancer cells. Photodiagnosis Photodyn Ther. 2022;40:103174.","journal-title":"Photodiagnosis Photodyn Ther"},{"issue":"3","key":"3979_CR77","first-page":"909","volume":"6","author":"M Graner","year":"2000","unstructured":"Graner M, Raymond A, Romney D, He L, Whitesell L, Katsanis E. Immunoprotective activities of multiple chaperone proteins isolated from murine B-cell leukemia\/lymphoma. Clin Cancer Res. 2000;6(3):909\u201315.","journal-title":"Clin Cancer Res"},{"issue":"7","key":"3979_CR78","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1007\/s00262-006-0258-z","volume":"56","author":"HL Kim","year":"2007","unstructured":"Kim HL, Sun X, Subjeck JR, Wang XY. Evaluation of renal cell carcinoma vaccines targeting carbonic anhydrase IX using heat shock protein 110. Cancer Immunol Immunother. 2007;56(7):1097\u2013105.","journal-title":"Cancer Immunol Immunother"},{"issue":"6","key":"3979_CR79","doi-asserted-by":"publisher","first-page":"763","DOI":"10.2217\/fon.09.46","volume":"5","author":"CG Wood","year":"2009","unstructured":"Wood CG, Mulders P, Vitespen. A preclinical and clinical review. Future Oncol. 2009;5(6):763\u201374.","journal-title":"Future Oncol"},{"issue":"9633","key":"3979_CR80","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S0140-6736(08)60697-2","volume":"372","author":"C Wood","year":"2008","unstructured":"Wood C, Srivastava P, Bukowski R, Lacombe L, Gorelov AI, Gorelov S, et al. An adjuvant autologous therapeutic vaccine (HSPPC-96; vitespen) versus observation alone for patients at high risk of recurrence after nephrectomy for renal cell carcinoma: a multicentre, open-label, randomised phase III trial. Lancet. 2008;372(9633):145\u201354.","journal-title":"Lancet"},{"issue":"6","key":"3979_CR81","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1200\/JCO.2007.11.9941","volume":"26","author":"A Testori","year":"2008","unstructured":"Testori A, Richards J, Whitman E, Mann GB, Lutzky J, Camacho L, et al. Phase III comparison of vitespen, an autologous tumor-derived heat shock protein gp96 peptide complex vaccine, with physician\u2019s choice of treatment for stage IV melanoma: the C-100-21 study group. J Clin Oncol. 2008;26(6):955\u201362.","journal-title":"J Clin Oncol"},{"issue":"suppl6","key":"3979_CR82","doi-asserted-by":"publisher","first-page":"vi29","DOI":"10.1093\/neuonc\/nox168.110","volume":"19","author":"O Bloch","year":"2017","unstructured":"Bloch O, Shi Q, Anderson SK, Knopp M, Raizer J, Clarke J, et al. ATIM-14. ALLIANCE A071101: A PHASE II RANDOMIZED TRIAL COMPARING THE EFFICACY OF HEAT SHOCK PROTEIN PEPTIDE COMPLEX-96 (HSPPC-96) VACCINE GIVEN WITH BEVACIZUMAB VERSUS BEVACIZUMAB ALONE IN THE TREATMENT OF SURGICALLY RESECTABLE RECURRENT GLIOBLASTOMA. Neuro Oncol. 2017;19(suppl6):vi29\u201329.","journal-title":"Neuro Oncol"},{"issue":"14","key":"3979_CR83","doi-asserted-by":"publisher","first-page":"3575","DOI":"10.1158\/1078-0432.CCR-16-1369","volume":"23","author":"O Bloch","year":"2017","unstructured":"Bloch O, Lim M, Sughrue ME, Komotar RJ, Abrahams JM, O\u2019Rourke DM, et al. Autologous heat shock protein peptide vaccination for newly diagnosed glioblastoma: impact of peripheral PD-L1 expression on response to therapy. Clin Cancer Res. 2017;23(14):3575\u201384.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"3979_CR84","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1093\/neuonc\/not203","volume":"16","author":"O Bloch","year":"2014","unstructured":"Bloch O, Crane CA, Fuks Y, Kaur R, Aghi MK, Berger MS, et al. Heat-shock protein peptide complex\u201396 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro Oncol. 2014;16(2):274\u20139.","journal-title":"Neuro Oncol"},{"issue":"1","key":"3979_CR85","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1158\/1078-0432.CCR-08-1725","volume":"15","author":"CL Trimble","year":"2009","unstructured":"Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, et al. A phase I trial of a human papillomavirus DNA vaccine for HPV16\u2009+\u2009cervical intraepithelial neoplasia 2\/3. Clin Cancer Res. 2009;15(1):361\u20137.","journal-title":"Clin Cancer Res"},{"issue":"12","key":"3979_CR86","doi-asserted-by":"publisher","first-page":"4460","DOI":"10.1158\/1078-0432.CCR-05-0250","volume":"11","author":"Z Li","year":"2005","unstructured":"Li Z, Qiao Y, Liu B, Laska EJ, Chakravarthi P, Kulko JM, et al. Combination of Imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res. 2005;11(12):4460\u20138.","journal-title":"Clin Cancer Res"},{"key":"3979_CR87","unstructured":"University N, editor. A phase I and feasibility trial of heat shock protein peptide Complex-96 (HSPPC-96) vaccine for pediatric patients with newly diagnosed intracranial high grade glioma and recurrent. Resectable Intracranial High Grade Glioma and Ependymoma; 2016."},{"key":"3979_CR88","unstructured":"Phase A. II Trial of active specific immunotherapy in patients with indolent lymphoma using autologous lymphoma-Derived heat shock Protein-Peptide complex (HSPPC-96). 2004."},{"key":"3979_CR89","unstructured":"(NCI) NCI. Inc. A, Association ABT, editors. Phase I\/II Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine for Patients With Recurrent High Grade Glioma. 2006."},{"key":"3979_CR90","unstructured":"Cancer Institute and Hospital CA of MS. editor. GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Liver. 2019."},{"key":"3979_CR91","unstructured":"Phase A. I Pilot trial of immunotherapy with autologous Tumor-Derived gp96 heat shock Protein - Peptide complex (HSPPC-96) in patients with resected pancreatic adenocarcinoma. 1999."},{"key":"3979_CR92","unstructured":"(NCI) NCI. editor. A phase II trial of active specific immunotherapy in patients with recurrent soft tissue sarcoma using autologous Tumor-derived heat shock Protein-Peptide complex (HSPPC-96). 2000."},{"key":"3979_CR93","unstructured":"(NCI) NCI, Inc. A, editors. A Phase II Randomized Trial Comparing the Efficacy of Heat Shock Protein-Peptide Complex-96 (HSPPC-96) (NSC #725085, ALLIANCE IND # 15380) Vaccine Given With Bevacizumab Versus Bevacizumab Alone in the Treatment of Surgically Resectable Recurrent Glioblastoma Multiforme (GBM). 2013."},{"key":"3979_CR94","unstructured":"Phase A. 2, Multicenter, Randomized, Single-Blind Study of Vitespen (HSPPC-96, Oncophage) for Immune Response Assessment Following Treatment of Patients With Resectable Renal Cell Carcinoma at Intermediate Risk of Recurrence. 2010."},{"key":"3979_CR95","unstructured":"Inc. A, editor. PHASE 2, Multi-center, Single Arm Investigation of HSPPC-96 Vaccine With Temozolomide in Patients With Newly Diagnosed Glioblastoma Multiforme. 2009."},{"key":"3979_CR96","unstructured":"Institute DFC, County CH of, O, Calgary U of, editors. A Phase I Clinical Trial of Neo-antigen Heat Shock Protein Vaccine (rHSC-DIPGVax) in Combination With Checkpoint Blockade for the Treatment of Diffuse Intrinsic Pontine Glioma (DIPG) and Diffuse Midline Glioma in Childhood. 2021."},{"key":"3979_CR97","unstructured":"Clinical Trial Studying. A personalized cancer vaccine in patients with Non-metastatic kidney cancer (NCT00126178). 2012 Sep."},{"key":"3979_CR98","unstructured":"Trial to Compare the Routes of. Administration of an investigational, personalized, therapeutic cancer vaccine oncophage (HSPPC-96) in patients with metastatic renal cell carcinoma (NCT00082459). 2012 Sep."},{"key":"3979_CR99","unstructured":"Study of Heat Shock Protein-Peptide. Complex (HSPPC-96) Versus IL-2\/\u200bDTIC for Stage IV Melanoma (NCT00039000). 2012 Sep."},{"key":"3979_CR100","unstructured":"Study of the Feasibility. To derive vaccine from tumor tissue in patients with Non-Small cell lung cancer (NCT00098085). 2009 Mar."},{"key":"3979_CR101","unstructured":"Radiation Therapy Plus Temozolomide. and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM) (NCT03018288). 2025 Feb."},{"key":"3979_CR102","unstructured":"Survival Study Of Oncophage\u00ae vs. Observation In Patients With Kidney Cancer (NCT00033904). 2012 Sep."},{"issue":"2","key":"3979_CR103","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1046\/j.1365-2249.2003.02153.x","volume":"132","author":"AW Purcell","year":"2003","unstructured":"Purcell AW, Todd A, Kinoshita G, Lynch TA, Keech CL, Gething MJ, et al. Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity? Clin Exp Immunol. 2003;132(2):193\u2013200.","journal-title":"Clin Exp Immunol"},{"key":"3979_CR104","doi-asserted-by":"crossref","unstructured":"Duan X, Iwanowycz S, Ngoi S, Hill M, Zhao Q, Liu B. Molecular chaperone GRP94\/GP96 in cancers: oncogenesis and therapeutic target. Front Oncol. 2021;11.","DOI":"10.3389\/fonc.2021.629846"},{"issue":"4","key":"3979_CR105","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1096\/fj.11-197707","volume":"26","author":"D Zuo","year":"2012","unstructured":"Zuo D, Yu X, Guo C, Yi H, Chen X, Conrad DH, et al. Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage\u2010mediated pathogen sensing and innate immunity. FASEB J. 2012;26(4):1493\u2013505.","journal-title":"FASEB J"},{"issue":"2","key":"3979_CR106","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1038\/77835","volume":"1","author":"RJ Binder","year":"2000","unstructured":"Binder RJ, Han DK, Srivastava PK. CD91: a receptor for heat shock protein gp96. Nat Immunol. 2000;1(2):151\u20135.","journal-title":"Nat Immunol"}],"container-title":["Cancer Cell International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-025-03979-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12935-025-03979-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-025-03979-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T12:04:32Z","timestamp":1759493072000},"score":1,"resource":{"primary":{"URL":"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-03979-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,3]]},"references-count":106,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["3979"],"URL":"https:\/\/doi.org\/10.1186\/s12935-025-03979-5","relation":{},"ISSN":["1475-2867"],"issn-type":[{"value":"1475-2867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,3]]},"assertion":[{"value":"21 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 October 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"338"}}