{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T19:26:25Z","timestamp":1793042785306,"version":"4.5.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"funder":[{"DOI":"10.13039\/501100004761","name":"the Natural Science Foundation of Hunan Province","doi-asserted-by":"crossref","award":["2025JJ80595"],"award-info":[{"award-number":["2025JJ80595"]}],"id":[{"id":"10.13039\/501100004761","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hengyang Central Hospital Doctoral Research Start-up Fund","award":["HYZXYY2023091205"],"award-info":[{"award-number":["HYZXYY2023091205"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Cell Int"],"DOI":"10.1186\/s12935-025-04027-y","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:31:32Z","timestamp":1762522292000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Constructing a bladder cancer prognostic model related to exosome using machine learning and identifying THBS1 as a potential target"],"prefix":"10.1186","volume":"25","author":[{"given":"Huilong","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuchun","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueting","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaojin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,11,7]]},"reference":[{"key":"4027_CR1","doi-asserted-by":"publisher","first-page":"1941","DOI":"10.1002\/ijc.31937","volume":"144","author":"J Ferlay","year":"2019","unstructured":"Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Pi\u00f1eros M, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 2019;144:1941\u201353. https:\/\/doi.org\/10.1002\/ijc.31937.","journal-title":"Int J Cancer"},{"key":"4027_CR2","doi-asserted-by":"publisher","unstructured":"Rl HSJF. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71. https:\/\/doi.org\/10.3322\/caac.21660. Medline:33538338.","DOI":"10.3322\/caac.21660"},{"key":"4027_CR3","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.eururo.2020.03.055","volume":"79","author":"JA Witjes","year":"2021","unstructured":"Witjes JA, Bruins HM, Cathomas R, Comp\u00e9rat EM, Cowan NC, Gakis G, et al. European association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur Urol. 2021;79:82\u2013104. https:\/\/doi.org\/10.1016\/j.eururo.2020.03.055.","journal-title":"Eur Urol"},{"key":"4027_CR4","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1097\/JU.0000000000002242","volume":"207","author":"AP Mitra","year":"2022","unstructured":"Mitra AP, Cai J, Miranda G, Bhanvadia S, Quinn DI, Schuckman AK, et al. Management trends and outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder: evolution of the University of Southern California experience over 3,347 cases. J Urol. 2022;207:302\u201313. https:\/\/doi.org\/10.1097\/JU.0000000000002242.","journal-title":"J Urol"},{"key":"4027_CR5","doi-asserted-by":"publisher","DOI":"10.3390\/medsci8010015","volume":"8","author":"K Saginala","year":"2020","unstructured":"Saginala K, Barsouk A, Aluru JS, Rawla P, Padala SA, Barsouk A. Epidemiology of bladder cancer. Med Sci. 2020;8:15. https:\/\/doi.org\/10.3390\/medsci8010015.","journal-title":"Med Sci"},{"key":"4027_CR6","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau6977","volume":"367","author":"R Kalluri","year":"2020","unstructured":"Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020;367:eaau6977. https:\/\/doi.org\/10.1126\/science.aau6977.","journal-title":"Science"},{"key":"4027_CR7","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.cell.2019.02.029","volume":"177","author":"DK Jeppesen","year":"2019","unstructured":"Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, et al. Reassessment of exosome composition. Cell. 2019;177:428\u2013e44518. https:\/\/doi.org\/10.1016\/j.cell.2019.02.029. Medline:30951670.","journal-title":"Cell"},{"key":"4027_CR8","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1146\/annurev-biochem-013118-111902","volume":"88","author":"DM Pegtel","year":"2019","unstructured":"Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487\u2013514. https:\/\/doi.org\/10.1146\/annurev-biochem-013118-111902.","journal-title":"Annu Rev Biochem"},{"key":"4027_CR9","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-56498-2","volume":"16","author":"Y Teng","year":"2025","unstructured":"Teng Y, Luo C, Qiu X, Mu J, Sriwastva MK, Xu Q, et al. Plant-nanoparticles enhance anti-PD-L1 efficacy by shaping human commensal microbiota metabolites. Nat Commun. 2025;16:1295. https:\/\/doi.org\/10.1038\/s41467-025-56498-2.","journal-title":"Nat Commun"},{"key":"4027_CR10","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-01979-z","volume":"23","author":"Z He","year":"2024","unstructured":"He Z, Zhong Y, Regmi P, Lv T, Ma W, Wang J, et al. Exosomal long non-coding RNA TRPM2-AS promotes angiogenesis in gallbladder cancer through interacting with PABPC1 to activate NOTCH1 signaling pathway. Mol Cancer. 2024;23:65. https:\/\/doi.org\/10.1186\/s12943-024-01979-z.","journal-title":"Mol Cancer"},{"key":"4027_CR11","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1158\/1078-0432.CCR-24-1934","volume":"31","author":"C Xu","year":"2025","unstructured":"Xu C, Mannucci A, Esposito F, Oliveres H, Alonso-Ordu\u00f1a V, Yubero A, et al. An exosome-based liquid biopsy predicts depth of response and survival outcomes to cetuximab and panitumumab in metastatic colorectal cancer: the EXONERATE study. Clin Cancer Res. 2025;31:1002\u201315. https:\/\/doi.org\/10.1158\/1078-0432.CCR-24-1934.","journal-title":"Clin Cancer Res"},{"key":"4027_CR12","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03288-9","volume":"44","author":"Y Shen","year":"2025","unstructured":"Shen Y, Lin J, Jiang T, Shen X, Li Y, Fu Y, et al. Gc-derived exosomal circMAN1A2 promotes cancer progression and suppresses T-cell antitumour immunity by inhibiting FBXW11-mediated SFPQ degradation. J Exp Clin Cancer Res. 2025;44:24. https:\/\/doi.org\/10.1186\/s13046-025-03288-9.","journal-title":"J Exp Clin Cancer Res"},{"key":"4027_CR13","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-017-0542-8","volume":"10","author":"A Li","year":"2017","unstructured":"Li A, Zhang T, Zheng M, Liu Y, Chen Z. Exosomal proteins as potential markers of tumor diagnosis. J Hematol Oncol. 2017;10:175. https:\/\/doi.org\/10.1186\/s13045-017-0542-8.","journal-title":"J Hematol Oncol"},{"key":"4027_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28421-6","volume":"13","author":"Z Liu","year":"2022","unstructured":"Liu Z, Liu L, Weng S, Guo C, Dang Q, Xu H, et al. Machine learning-based integration develops an immune-derived LncRNA signature for improving outcomes in colorectal cancer. Nat Commun. 2022;13:816. https:\/\/doi.org\/10.1038\/s41467-022-28421-6.","journal-title":"Nat Commun"},{"key":"4027_CR15","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1341346","volume":"15","author":"X Hu","year":"2024","unstructured":"Hu X, Dong H, Qin W, Bin Y, Huang W, Kang M, et al. Machine learning-based identification of a consensus immune-derived gene signature to improve head and neck squamous cell carcinoma therapy and outcome. Front Pharmacol. 2024;15:1341346. https:\/\/doi.org\/10.3389\/fphar.2024.1341346.","journal-title":"Front Pharmacol"},{"key":"4027_CR16","doi-asserted-by":"publisher","first-page":"3580","DOI":"10.7150\/jca.94360","volume":"15","author":"R Wan","year":"2024","unstructured":"Wan R, Pan L, Wang Q, Shen G, Guo R, Qin Y, et al. Decoding gastric cancer: machine learning insights into the significance of COMMDs family in immunotherapy and diagnosis. J Cancer. 2024;15:3580\u201395. https:\/\/doi.org\/10.7150\/jca.94360.","journal-title":"J Cancer"},{"key":"4027_CR17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1295558","volume":"14","author":"H Wang","year":"2023","unstructured":"Wang H, Wang R, Luo L, Hong J, Chen X, Shen K, et al. An exosome-based specific transcriptomic signature for profiling regulation patterns and modifying tumor immune microenvironment infiltration in triple-negative breast cancer. Front Immunol. 2023;14:1295558. https:\/\/doi.org\/10.3389\/fimmu.2023.1295558.","journal-title":"Front Immunol"},{"key":"4027_CR18","doi-asserted-by":"publisher","DOI":"10.3390\/genes13122295","volume":"13","author":"W Chang","year":"2022","unstructured":"Chang W, Li H, Wu C, Zhong L, Zhu T, Chang Z, et al. Identification of an amino acid metabolism-related gene signature for predicting prognosis in lung adenocarcinoma. Genes. 2022;13:2295. https:\/\/doi.org\/10.3390\/genes13122295.","journal-title":"Genes"},{"key":"4027_CR19","doi-asserted-by":"publisher","first-page":"D1420","DOI":"10.1093\/nar\/gkaa1020","volume":"49","author":"D Sun","year":"2021","unstructured":"Sun D, Wang J, Han Y, Dong X, Ge J, Zheng R, et al. TISCH: a comprehensive web resource enabling interactive single-cell transcriptome visualization of tumor microenvironment. Nucleic Acids Res. 2021;49:D1420\u201330. https:\/\/doi.org\/10.1093\/nar\/gkaa1020. Medline:33179754.","journal-title":"Nucleic Acids Res"},{"key":"4027_CR20","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30342-3","volume":"13","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Chen F, Chandrashekar DS, Varambally S, Creighton CJ. Proteogenomic characterization of 2002 human cancers reveals pan-cancer molecular subtypes and associated pathways. Nat Commun. 2022;13:2669. https:\/\/doi.org\/10.1038\/s41467-022-30342-3.","journal-title":"Nat Commun"},{"key":"4027_CR21","doi-asserted-by":"publisher","DOI":"10.1038\/551S33a","volume":"551","author":"M Grayson","year":"2017","unstructured":"Grayson M. Bladder cancer. Nature. 2017;551:S33. https:\/\/doi.org\/10.1038\/551S33a.","journal-title":"Nature"},{"key":"4027_CR22","doi-asserted-by":"publisher","first-page":"237","DOI":"10.7150\/thno.21945","volume":"8","author":"C He","year":"2018","unstructured":"He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8:237\u201355. https:\/\/doi.org\/10.7150\/thno.21945.","journal-title":"Theranostics"},{"key":"4027_CR23","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1887552","volume":"10","author":"C Han","year":"2021","unstructured":"Han C, Zhang C, Wang H, Zhao L. Exosome-mediated communication between tumor cells and tumor-associated macrophages: implications for tumor microenvironment. Oncoimmunology. 2021;10:1887552. https:\/\/doi.org\/10.1080\/2162402X.2021.1887552.","journal-title":"Oncoimmunology"},{"key":"4027_CR24","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1002\/ijc.29649","volume":"137","author":"G Wichmann","year":"2015","unstructured":"Wichmann G, Rosolowski M, Krohn K, Kreuz M, Boehm A, Reiche A, et al. The role of HPV RNA transcription, immune response-related gene expression and disruptive TP53 mutations in diagnostic and prognostic profiling of head and neck cancer. Int J Cancer. 2015;137:2846\u201357. https:\/\/doi.org\/10.1002\/ijc.29649.","journal-title":"Int J Cancer"},{"key":"4027_CR25","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1038\/s41577-018-0044-0","volume":"18","author":"J Borst","year":"2018","unstructured":"Borst J, Ahrends T, B\u0105ba\u0142a N, Melief CJM, Kastenm\u00fcller W. CD4\u2009+\u2009T cell help in cancer immunology and immunotherapy. Nat Rev Immunol. 2018;18:635\u201347. https:\/\/doi.org\/10.1038\/s41577-018-0044-0.","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"4027_CR26","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/s43018-023-00521-2","volume":"4","author":"DE Speiser","year":"2023","unstructured":"Speiser DE, Chijioke O, Schaeuble K, M\u00fcnz C. CD4\u2009+\u2009T cells in cancer. Nat Cancer. 2023;4(3):317\u201329. https:\/\/doi.org\/10.1038\/s43018-023-00521-2.","journal-title":"Nat Cancer"},{"key":"4027_CR27","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1056\/NEJMoa2408154","volume":"391","author":"T Powles","year":"2024","unstructured":"Powles T, Catto JWF, Galsky MD, Al-Ahmadie H, Meeks JJ, Nishiyama H, et al. Perioperative durvalumab with neoadjuvant chemotherapy in operable bladder cancer. N Engl J Med. 2024;391:1773\u201386. https:\/\/doi.org\/10.1056\/NEJMoa2408154.","journal-title":"N Engl J Med"},{"issue":"1","key":"4027_CR28","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2023.2246319","volume":"12","author":"SN Bossio","year":"2023","unstructured":"Bossio SN, Abrate C, Tosello Boari J, Rodriguez C, Canale FP, Ramello MC, et al. CD39\u2009+\u2009conventional CD4\u2009+\u2009T cells with exhaustion traits and cytotoxic potential infiltrate tumors and expand upon CTLA-4 blockade. Oncoimmunology. 2023;12(1):2246319. https:\/\/doi.org\/10.1080\/2162402X.2023.2246319.","journal-title":"Oncoimmunology"},{"key":"4027_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00073","author":"GR Rossi","year":"2020","unstructured":"Rossi GR, Trindade ES, Souza-Fonseca-Guimaraes F. Tumor microenvironment-associated extracellular matrix components regulate NK cell function. Front Immunol. 2020. https:\/\/doi.org\/10.3389\/fimmu.2020.00073.","journal-title":"Front Immunol"},{"key":"4027_CR30","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1056\/NEJMoa2034442","volume":"384","author":"DF Bajorin","year":"2021","unstructured":"Bajorin DF, Witjes JA, Gschwend JE, Schenker M, Valderrama BP, Tomita Y, et al. Adjuvant nivolumab versus placebo in muscle-invasive urothelial carcinoma. N Engl J Med. 2021;384:2102\u201314. https:\/\/doi.org\/10.1056\/NEJMoa2034442.","journal-title":"N Engl J Med"},{"issue":"18","key":"4027_CR31","doi-asserted-by":"publisher","first-page":"3251","DOI":"10.1517\/14656566.8.18.3251","volume":"8","author":"F El Karak","year":"2007","unstructured":"El Karak F, Flechon A. Gemcitabine in bladder cancer. Expert Opin Pharmacother. 2007;8(18):3251\u20136. https:\/\/doi.org\/10.1517\/14656566.8.18.3251.","journal-title":"Expert Opin Pharmacother"},{"key":"4027_CR32","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1310\/hpj5002-103","volume":"50","author":"E Ryan Pritchard","year":"2015","unstructured":"Ryan Pritchard E, Waddell JA, Solimando DA. Gemcitabine and carboplatin (renally dosed) regimen for bladder cancer. Hosp Pharm. 2015;50:103\u20137. https:\/\/doi.org\/10.1310\/hpj5002-103.","journal-title":"Hosp Pharm"},{"key":"4027_CR33","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1080\/02841860701499382","volume":"47","author":"AB Als","year":"2008","unstructured":"Als AB, Sengelov L, Von Der Maase H. Gemcitabine and cisplatin in locally advanced and metastatic bladder cancer; 3- or 4-week schedule? Acta Oncol. 2008;47:110\u20139. https:\/\/doi.org\/10.1080\/02841860701499382.","journal-title":"Acta Oncol"},{"key":"4027_CR34","doi-asserted-by":"publisher","first-page":"536","DOI":"10.22038\/IJBMS.2022.61118.13528","volume":"25","author":"H Wang","year":"2022","unstructured":"Wang H, Shao Z, Xu Z, Ye B, Li M, Zheng Q, et al. Antiproliferative and apoptotic activity of gemcitabine-lauric acid conjugate on human bladder cancer cells. Iran J Basic Med Sci. 2022;25:536\u201342. https:\/\/doi.org\/10.22038\/IJBMS.2022.61118.13528.","journal-title":"Iran J Basic Med Sci"},{"key":"4027_CR35","doi-asserted-by":"publisher","first-page":"7364","DOI":"10.18632\/aging.204200","volume":"14","author":"Z Tang","year":"2022","unstructured":"Tang Z, Tang C, Sun C, Ying X, Shen R. M1 macrophage-derived exosomes synergistically enhance the anti- bladder cancer effect of gemcitabine. Aging. 2022;14:7364\u201377. https:\/\/doi.org\/10.18632\/aging.204200.","journal-title":"Aging"},{"key":"4027_CR36","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/cphy.c150011","volume":"6","author":"PJ Davis","year":"2015","unstructured":"Davis PJ, Sudha T, Lin H-Y, Mousa SA. Thyroid hormone, hormone analogs, and angiogenesis. Compr Physiol. 2015;6:353\u201362. https:\/\/doi.org\/10.1002\/cphy.c150011. Medline:26756636.","journal-title":"Compr Physiol"},{"key":"4027_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22084062","volume":"22","author":"A Kale","year":"2021","unstructured":"Kale A, Rogers NM, Ghimire K. Thrombospondin-1 CD47 signalling: from mechanisms to medicine. Int J Mol Sci. 2021;22:4062. https:\/\/doi.org\/10.3390\/ijms22084062.","journal-title":"Int J Mol Sci"},{"key":"4027_CR38","doi-asserted-by":"publisher","first-page":"4945","DOI":"10.2147\/IJGM.S329208","volume":"14","author":"X Zhang","year":"2021","unstructured":"Zhang X, Huang T, Li Y, Qiu H. Upregulation of THBS1 is related to immunity and chemotherapy resistance in gastric cancer. Int J Gen Med. 2021;14:4945\u201357. https:\/\/doi.org\/10.2147\/IJGM.S329208.","journal-title":"Int J Gen Med"},{"key":"4027_CR39","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094570","volume":"22","author":"S Kaur","year":"2021","unstructured":"Kaur S, Bronson SM, Pal-Nath D, Miller TW, Soto-Pantoja DR, Roberts DD. Functions of thrombospondin-1 in the tumor microenvironment. Int J Mol Sci. 2021;22:4570. https:\/\/doi.org\/10.3390\/ijms22094570.","journal-title":"Int J Mol Sci"},{"key":"4027_CR40","doi-asserted-by":"publisher","first-page":"e00085","DOI":"10.1042\/BSR20130060","volume":"33","author":"MAAK Folgueira","year":"2013","unstructured":"Folgueira MAAK, Maistro S, Katayama MLH, Roela RA, Mundim FGL, Nanogaki S, et al. Markers of breast cancer stromal fibroblasts in the primary tumour site associated with lymph node metastasis: a systematic review including our case series. Biosci Rep. 2013;33:e00085. https:\/\/doi.org\/10.1042\/BSR20130060. Medline:24229053.","journal-title":"Biosci Rep"},{"key":"4027_CR41","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20521-z","volume":"13","author":"U Ahmad","year":"2023","unstructured":"Ahmad U, Abdullah S, Chau DM, Chia SL, Yusoff K, Chan SC, et al. Analysis of PPI networks of transcriptomic expression identifies hub genes associated with Newcastle disease virus persistent infection in bladder cancer. Sci Rep. 2023;13:7323. https:\/\/doi.org\/10.1038\/s41598-022-20521-z.","journal-title":"Sci Rep"},{"key":"4027_CR42","doi-asserted-by":"publisher","first-page":"2303230","DOI":"10.1002\/advs.202303230","volume":"10","author":"T Liang","year":"2023","unstructured":"Liang T, Tao T, Wu K, Liu L, Xu W, Zhou D, et al. Cancer-associated fibroblast\u2010induced remodeling of tumor microenvironment in recurrent bladder cancer. Adv Sci. 2023;10:2303230. https:\/\/doi.org\/10.1002\/advs.202303230. Medline:37743226.","journal-title":"Adv Sci"},{"key":"4027_CR43","doi-asserted-by":"publisher","first-page":"183","DOI":"10.62347\/XNTC7030","volume":"12","author":"K Cao","year":"2024","unstructured":"Cao K, Shi H, Wu B, Lv Z, Yang R. Identification of ECM and EMT relevant genes involved in the progression of bladder cancer through bioinformatics analysis. Am J Clin Exp Urol. 2024;12:183\u201393. https:\/\/doi.org\/10.62347\/XNTC7030. Medline:39308592.","journal-title":"Am J Clin Exp Urol"}],"container-title":["Cancer Cell International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-025-04027-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12935-025-04027-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-025-04027-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:31:33Z","timestamp":1762522293000},"score":1,"resource":{"primary":{"URL":"https:\/\/cancerci.biomedcentral.com\/articles\/10.1186\/s12935-025-04027-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,7]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["4027"],"URL":"https:\/\/doi.org\/10.1186\/s12935-025-04027-y","relation":{},"ISSN":["1475-2867"],"issn-type":[{"value":"1475-2867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,7]]},"assertion":[{"value":"17 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 October 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All organizations included in this study obtained ethical approval from the Ethics Committee of the Affiliated Hengyang Hospital of Hunan Normal University & Hengyang Central Hospital (Approval ID: HYSZXYY2025075), and all patients have signed informed consent forms.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"392"}}