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The animal experiments were performed in accordance with the guidelines of the Animal Care and Use Committee at the IACUC of the Chinese Academy of Sciences, Hangzhou Institute of Medicine. All participating patients signed informed consent forms, and the study was approved by the Shanghai Outdo Biotech Ethics Committee (ethical approval number: YB M-05-02).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not application.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"121"}}