{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T09:11:00Z","timestamp":1778663460978,"version":"3.51.4"},"reference-count":84,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:00:00Z","timestamp":1778630400000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Cell Int"],"DOI":"10.1186\/s12935-026-04285-4","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:14:26Z","timestamp":1775142866000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clonal hematopoiesis in the pathogenesis of non-hematologic diseases with therapeutic potential"],"prefix":"10.1186","volume":"26","author":[{"given":"Lu","family":"Lei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"4285_CR1","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1182\/blood.2019000989","volume":"136","author":"S Jaiswal","year":"2020","unstructured":"Jaiswal S. Clonal hematopoiesis and nonhematologic disorders. Blood. 2020;136:1606\u201314. https:\/\/doi.org\/10.1182\/blood.2019000989.","journal-title":"Blood"},{"key":"4285_CR2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2022.106787","volume":"113","author":"Y Kusne","year":"2022","unstructured":"Kusne Y, Xie Z, Patnaik MM. Clonal hematopoiesis: molecular and clinical implications. Leuk Res. 2022;113:106787. https:\/\/doi.org\/10.1016\/j.leukres.2022.106787.","journal-title":"Leuk Res"},{"key":"4285_CR3","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.stem.2022.05.006","volume":"29","author":"MA Florez","year":"2022","unstructured":"Florez MA, Tran BT, Wathan TK, DeGregori J, Pietras EM, King KY. Clonal hematopoiesis: mutation-specific adaptation to environmental change. Cell Stem Cell. 2022;29:882\u2013904. https:\/\/doi.org\/10.1016\/j.stem.2022.05.006.","journal-title":"Cell Stem Cell"},{"key":"4285_CR4","doi-asserted-by":"publisher","first-page":"2235","DOI":"10.1182\/blood.2023022222","volume":"142","author":"LD Weeks","year":"2023","unstructured":"Weeks LD, Ebert BL. Causes and consequences of clonal hematopoiesis. Blood. 2023;142:2235\u201346. https:\/\/doi.org\/10.1182\/blood.2023022222.","journal-title":"Blood"},{"key":"4285_CR5","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1182\/blood.2022018825","volume":"141","author":"C Vlasschaert","year":"2023","unstructured":"Vlasschaert C, Mack T, Heimlich JB, Niroula A, Uddin MM, Weinstock J, et al. A practical approach to curate clonal hematopoiesis of indeterminate potential in human genetic data sets. Blood. 2023;141:2214\u201323. https:\/\/doi.org\/10.1182\/blood.2022018825.","journal-title":"Blood"},{"key":"4285_CR6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/s41586-020-2819-2","volume":"586","author":"AG Bick","year":"2020","unstructured":"Bick AG, Weinstock JS, Nandakumar SK, Fulco CP, Bao EL, Zekavat SM, et al. Inherited Causes of Clonal Hematopoiesis in 97,691 TOPMed Whole Genomes. Nature. 2020;586:763\u20138. https:\/\/doi.org\/10.1038\/s41586-020-2819-2.","journal-title":"Nature"},{"key":"4285_CR7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2319364121","volume":"121","author":"K Wang","year":"2024","unstructured":"Wang K, Zhang W, Yi L, Zhao M, Li P-Y, Fu M-H, et al. The impact of age and number of mutations on the size of clonal hematopoiesis. Proc Natl Acad Sci U S A. 2024;121:e2319364121. https:\/\/doi.org\/10.1073\/pnas.2319364121.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"4285_CR8","doi-asserted-by":"publisher","first-page":"2115","DOI":"10.1182\/bloodadvances.2020004062","volume":"5","author":"IA van Zeventer","year":"2021","unstructured":"van Zeventer IA, Salzbrunn JB, de Graaf AO, van der Reijden BA, Boezen HM, Vonk JM, et al. Prevalence, predictors, and outcomes of clonal hematopoiesis in individuals aged \u226580 years. Blood Adv. 2021;5:2115\u201322. https:\/\/doi.org\/10.1182\/bloodadvances.2020004062.","journal-title":"Blood Adv"},{"key":"4285_CR9","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1182\/blood-2017-07-746453","volume":"131","author":"LI Shlush","year":"2018","unstructured":"Shlush LI. Age-related clonal hematopoiesis. Blood. 2018;131:496\u2013504. https:\/\/doi.org\/10.1182\/blood-2017-07-746453.","journal-title":"Blood"},{"key":"4285_CR10","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1038\/s41588-020-00710-0","volume":"52","author":"KL Bolton","year":"2020","unstructured":"Bolton KL, Ptashkin RN, Gao T, Braunstein L, Devlin SM, Kelly D, et al. Cancer therapy shapes the fitness landscape of clonal hematopoiesis. Nat Genet. 2020;52:1219\u201326. https:\/\/doi.org\/10.1038\/s41588-020-00710-0.","journal-title":"Nat Genet"},{"key":"4285_CR11","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1210\/jc.2018-00803","volume":"103","author":"L Boucai","year":"2018","unstructured":"Boucai L, Falcone J, Ukena J, Coombs CC, Zehir A, Ptashkin R, et al. Radioactive Iodine-Related Clonal Hematopoiesis in Thyroid Cancer Is Common and Associated With Decreased Survival. J Clin Endocrinol Metab. 2018;103:4216\u201323. https:\/\/doi.org\/10.1210\/jc.2018-00803.","journal-title":"J Clin Endocrinol Metab"},{"key":"4285_CR12","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1158\/2159-8290.CD-23-0090","volume":"13","author":"G Collord","year":"2023","unstructured":"Collord G, Behjati S. Childhood Cancer Treatment and Clonal Hematopoiesis. Cancer Discov. 2023;13:811\u20133. https:\/\/doi.org\/10.1158\/2159-8290.CD-23-0090.","journal-title":"Cancer Discov"},{"key":"4285_CR13","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.stem.2017.07.010","volume":"21","author":"CC Coombs","year":"2017","unstructured":"Coombs CC, Zehir A, Devlin SM, Kishtagari A, Syed A, Jonsson P, et al. Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes. Cell Stem Cell. 2017;21:374\u201382-e4. https:\/\/doi.org\/10.1016\/j.stem.2017.07.010.","journal-title":"Cell Stem Cell"},{"key":"4285_CR14","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.stem.2018.10.004","volume":"23","author":"JI Hsu","year":"2018","unstructured":"Hsu JI, Dayaram T, Tovy A, De Braekeleer E, Jeong M, Wang F, et al. PPM1D Mutations Drive Clonal Hematopoiesis in Response to Cytotoxic Chemotherapy. Cell Stem Cell. 2018;23:700\u201313-e6. https:\/\/doi.org\/10.1016\/j.stem.2018.10.004.","journal-title":"Cell Stem Cell"},{"key":"4285_CR15","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1016\/j.stem.2021.03.002","volume":"28","author":"D Hormaechea-Agulla","year":"2021","unstructured":"Hormaechea-Agulla D, Matatall KA, Le DT, Kain B, Long X, Kus P, et al. Chronic infection drives Dnmt3a-loss-of-function clonal hematopoiesis via IFN\u03b3 signaling. Cell Stem Cell. 2021;28:1428\u201342-e6. https:\/\/doi.org\/10.1016\/j.stem.2021.03.002.","journal-title":"Cell Stem Cell"},{"key":"4285_CR16","doi-asserted-by":"publisher","first-page":"686","DOI":"10.3390\/cells12050686","volume":"12","author":"SC Vorri","year":"2023","unstructured":"Vorri SC, Christodoulou I, Karanika S, Karantanos T. Human Immunodeficiency Virus and Clonal Hematopoiesis. Cells. 2023;12:686. https:\/\/doi.org\/10.3390\/cells12050686.","journal-title":"Cells"},{"key":"4285_CR17","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.yjmcc.2021.07.004","volume":"161","author":"CS Marnell","year":"2021","unstructured":"Marnell CS, Bick A, Natarajan P. Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease. J Mol Cell Cardiol. 2021;161:98\u2013105. https:\/\/doi.org\/10.1016\/j.yjmcc.2021.07.004.","journal-title":"J Mol Cell Cardiol"},{"key":"4285_CR18","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11912-023-01362-z","volume":"25","author":"L Joo","year":"2023","unstructured":"Joo L, Bradley CC, Lin SH, Scheet PA, Nead KT. Causes of Clonal Hematopoiesis: a Review. Curr Oncol Rep. 2023;25:211\u201320. https:\/\/doi.org\/10.1007\/s11912-023-01362-z.","journal-title":"Curr Oncol Rep"},{"key":"4285_CR19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI163968","volume":"133","author":"SK Pasupuleti","year":"2023","unstructured":"Pasupuleti SK, Ramdas B, Burns SS, Palam LR, Kanumuri R, Kumar R, et al. Obesity-induced inflammation exacerbates clonal hematopoiesis. J Clin Invest. 2023;133:e163968. https:\/\/doi.org\/10.1172\/JCI163968.","journal-title":"J Clin Invest"},{"key":"4285_CR20","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1146\/annurev-pathmechdis-051222-122724","volume":"19","author":"R Kanagal-Shamanna","year":"2024","unstructured":"Kanagal-Shamanna R, Beck DB, Calvo KR. Clonal Hematopoiesis, Inflammation, and Hematologic Malignancy. Annu Rev Pathol. 2024;19:479\u2013506. https:\/\/doi.org\/10.1146\/annurev-pathmechdis-051222-122724.","journal-title":"Annu Rev Pathol"},{"key":"4285_CR21","doi-asserted-by":"publisher","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","volume":"371","author":"G Genovese","year":"2014","unstructured":"Genovese G, K\u00e4hler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, et al. Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence. N Engl J Med. 2014;371:2477\u201387. https:\/\/doi.org\/10.1056\/NEJMoa1409405.","journal-title":"N Engl J Med"},{"key":"4285_CR22","doi-asserted-by":"publisher","DOI":"10.1172\/JCI180065","volume":"134","author":"WG Dunn","year":"2024","unstructured":"Dunn WG, McLoughlin MA, Vassiliou GS. Clonal hematopoiesis and hematological malignancy. J Clin Invest. 2024;134:e180065. https:\/\/doi.org\/10.1172\/JCI180065.","journal-title":"J Clin Invest"},{"key":"4285_CR23","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1001\/jamacardio.2023.5095","volume":"9","author":"K Zhao","year":"2024","unstructured":"Zhao K, Shen X, Liu H, Lin Z, Li J, Chen S, et al. Somatic and germline variants and coronary heart disease in a Chinese population. JAMA Cardiol. 2024;9:233\u201342. https:\/\/doi.org\/10.1001\/jamacardio.2023.5095.","journal-title":"JAMA Cardiol"},{"key":"4285_CR24","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.51927","volume":"7","author":"S Saadatagah","year":"2024","unstructured":"Saadatagah S, Uddin MM, Weeks LD, Niroula A, Ru M, Takahashi K, et al. Clonal hematopoiesis risk score and all-cause and cardiovascular mortality in older adults. JAMA Netw Open. 2024;7:e2351927. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.51927.","journal-title":"JAMA Netw Open"},{"key":"4285_CR25","doi-asserted-by":"publisher","first-page":"1996","DOI":"10.1016\/j.jacc.2023.03.401","volume":"81","author":"ED Gumuser","year":"2023","unstructured":"Gumuser ED, Schuermans A, Cho SMJ, Sporn ZA, Uddin MM, Paruchuri K, et al. Clonal hematopoiesis of indeterminate potential predicts adverse outcomes in patients with atherosclerotic cardiovascular disease. J Am Coll Cardiol. 2023;81:1996\u20132009. https:\/\/doi.org\/10.1016\/j.jacc.2023.03.401.","journal-title":"J Am Coll Cardiol"},{"key":"4285_CR26","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1161\/HYPERTENSIONAHA.123.22274","volume":"81","author":"C Liu","year":"2024","unstructured":"Liu C, Zhou Y-P, Lian T-Y, Li R-N, Ma J-S, Yang Y-J, et al. Clonal hematopoiesis of indeterminate potential in chronic thromboembolic pulmonary hypertension: a multicenter study. Hypertension. 2024;81:372\u201382. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.123.22274.","journal-title":"Hypertension"},{"key":"4285_CR27","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.53244","volume":"7","author":"A Schuermans","year":"2024","unstructured":"Schuermans A, Honigberg MC, Raffield LM, Yu B, Roberts MB, Kooperberg C, et al. Clonal hematopoiesis and incident heart failure with preserved ejection fraction. JAMA Netw Open. 2024;7:e2353244. https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.53244.","journal-title":"JAMA Netw Open"},{"key":"4285_CR28","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.1016\/j.jacc.2021.02.045","volume":"77","author":"MJ Rauh","year":"2021","unstructured":"Rauh MJ. Impact of clonal hematopoiesis in ischemic and nonischemic heart failure. J Am Coll Cardiol. 2021;77:1760\u20132. https:\/\/doi.org\/10.1016\/j.jacc.2021.02.045.","journal-title":"J Am Coll Cardiol"},{"key":"4285_CR29","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1161\/CIRCULATIONAHA.123.065597","volume":"149","author":"AE Lin","year":"2024","unstructured":"Lin AE, Bapat AC, Xiao L, Niroula A, Ye J, Wong WJ, et al. Clonal hematopoiesis of indeterminate potential with loss of Tet2 enhances risk for atrial fibrillation through Nlrp3 inflammasome activation. Circulation. 2024;149:1419\u201334. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.123.065597.","journal-title":"Circulation"},{"key":"4285_CR30","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1182\/blood.2024024187","volume":"144","author":"RL Zon","year":"2024","unstructured":"Zon RL, Sekar A, Clapham K, Oren O, Niroula A, Bick AG, et al. JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism. Blood. 2024;144:2149\u201354. https:\/\/doi.org\/10.1182\/blood.2024024187.","journal-title":"Blood"},{"key":"4285_CR31","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1158\/1078-0432.CCR-22-2598","volume":"29","author":"SC Reed","year":"2023","unstructured":"Reed SC, Croessmann S, Park BH. CHIP happens: clonal hematopoiesis of indeterminate potential and its relationship to solid tumors. Clin Cancer Res. 2023;29:1403\u201311. https:\/\/doi.org\/10.1158\/1078-0432.CCR-22-2598.","journal-title":"Clin Cancer Res"},{"key":"4285_CR32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20162-8","volume":"12","author":"Y Zhang","year":"2021","unstructured":"Zhang Y, Yao Y, Xu Y, Li L, Gong Y, Zhang K, et al. Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients. Nat Commun. 2021;12:11. https:\/\/doi.org\/10.1038\/s41467-020-20162-8.","journal-title":"Nat Commun"},{"key":"4285_CR33","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1200\/JCO.22.00857","volume":"41","author":"R Tian","year":"2023","unstructured":"Tian R, Wiley B, Liu J, Zong X, Truong B, Zhao S, et al. Clonal hematopoiesis and risk of incident lung cancer. J Clin Oncol. 2023;41:1423\u201333. https:\/\/doi.org\/10.1200\/JCO.22.00857.","journal-title":"J Clin Oncol"},{"key":"4285_CR34","doi-asserted-by":"publisher","first-page":"1594","DOI":"10.1056\/NEJMoa2413361","volume":"392","author":"O Pich","year":"2025","unstructured":"Pich O, Bernard E, Zagorulya M, Rowan A, Pospori C, Slama R, et al. Tumor-infiltrating clonal hematopoiesis. N Engl J Med. 2025;392:1594\u2013608. https:\/\/doi.org\/10.1056\/NEJMoa2413361.","journal-title":"N Engl J Med"},{"key":"4285_CR35","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.immuni.2017.07.020","volume":"47","author":"W Pan","year":"2017","unstructured":"Pan W, Zhu S, Qu K, Meeth K, Cheng J, He K, et al. The DNA methylcytosine dioxygenase Tet2 sustains immunosuppressive function of tumor-infiltrating myeloid cells to promote melanoma progression. Immunity. 2017;47:284\u201397-e5. https:\/\/doi.org\/10.1016\/j.immuni.2017.07.020.","journal-title":"Immunity"},{"key":"4285_CR36","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1111\/joim.20080","volume":"297","author":"H Wu","year":"2025","unstructured":"Wu H, Wei J, Yu Y, Wang N, Tan X. Clonal hematopoiesis of indeterminate potential and the risk of autoimmune diseases. J Intern Med. 2025;297:642\u201356. https:\/\/doi.org\/10.1111\/joim.20080.","journal-title":"J Intern Med"},{"key":"4285_CR37","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1017\/thg.2024.24","volume":"27","author":"J Zhang","year":"2024","unstructured":"Zhang J, Zhou C, Guan S. Association between rheumatoid arthritis and clonal hematopoiesis: a Mendelian randomization study. Twin Res Hum Genet. 2024;27:169\u201373. https:\/\/doi.org\/10.1017\/thg.2024.24.","journal-title":"Twin Res Hum Genet"},{"key":"4285_CR38","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1681\/ASN.2022030262","volume":"33","author":"A Niroula","year":"2022","unstructured":"Niroula A, Belizaire R. Clonal hematopoiesis and CKD progression. J Am Soc Nephrol. 2022;33:878\u20139. https:\/\/doi.org\/10.1681\/ASN.2022030262.","journal-title":"J Am Soc Nephrol"},{"key":"4285_CR39","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1038\/s41591-024-02854-6","volume":"30","author":"C Vlasschaert","year":"2024","unstructured":"Vlasschaert C, Robinson-Cohen C, Chen J, Akwo E, Parker AC, Silver SA, et al. Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. Nat Med. 2024;30:810\u20137. https:\/\/doi.org\/10.1038\/s41591-024-02854-6.","journal-title":"Nat Med"},{"key":"4285_CR40","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/s41586-023-05857-4","volume":"616","author":"WJ Wong","year":"2023","unstructured":"Wong WJ, Emdin C, Bick AG, Zekavat SM, Niroula A, Pirruccello JP, et al. Clonal haematopoiesis and risk of chronic liver disease. Nature. 2023;616:747\u201354. https:\/\/doi.org\/10.1038\/s41586-023-05857-4.","journal-title":"Nature"},{"key":"4285_CR41","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41575-023-00795-y","volume":"20","author":"J Hindson","year":"2023","unstructured":"Hindson J. Elucidating the link between clonal haematopoiesis and chronic liver disease. Nat Rev Gastroenterol Hepatol. 2023;20:345. https:\/\/doi.org\/10.1038\/s41575-023-00795-y.","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"4285_CR42","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1097\/HEP.0000000000000839","volume":"80","author":"A Marchetti","year":"2024","unstructured":"Marchetti A, Pelusi S, Marella A, Malvestiti F, Ricchiuti A, Ronzoni L, et al. Impact of clonal hematopoiesis of indeterminate potential on hepatocellular carcinoma in individuals with steatotic liver disease. Hepatology. 2024;80:816\u201327. https:\/\/doi.org\/10.1097\/HEP.0000000000000839.","journal-title":"Hepatology"},{"key":"4285_CR43","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1097\/HEP.0000000000000898","volume":"80","author":"Y-T Lee","year":"2024","unstructured":"Lee Y-T, Tseng H-R, Yang JD. Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: new kids on the block. Hepatology. 2024;80:763\u20135. https:\/\/doi.org\/10.1097\/HEP.0000000000000898.","journal-title":"Hepatology"},{"key":"4285_CR44","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/joim.20001","volume":"296","author":"X Liu","year":"2024","unstructured":"Liu X, Xue H, Wirdefeldt K, Song H, Smedby K, Fang F, et al. Clonal hematopoiesis of indeterminate potential and risk of neurodegenerative diseases. J Intern Med. 2024;296:327\u201335. https:\/\/doi.org\/10.1111\/joim.20001.","journal-title":"J Intern Med"},{"key":"4285_CR45","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1038\/s41591-023-02397-2","volume":"29","author":"H Bouzid","year":"2023","unstructured":"Bouzid H, Belk JA, Jan M, Qi Y, Sarnowski C, Wirth S, et al. Clonal hematopoiesis is associated with protection from Alzheimer\u2019s disease. Nat Med. 2023;29:1662\u201370. https:\/\/doi.org\/10.1038\/s41591-023-02397-2.","journal-title":"Nat Med"},{"key":"4285_CR46","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1038\/s41591-023-02406-4","volume":"29","author":"P S\u00e1nchez Vela","year":"2023","unstructured":"S\u00e1nchez Vela P, Trowbridge JJ, Levine RL. Clonal hematopoiesis, aging and Alzheimer\u2019s disease. Nat Med. 2023;29:1605\u20136. https:\/\/doi.org\/10.1038\/s41591-023-02406-4.","journal-title":"Nat Med"},{"key":"4285_CR47","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/s43587-023-00474-2","volume":"3","author":"Y Aman","year":"2023","unstructured":"Aman Y. Clonal hematopoiesis reduces risk of Alzheimer\u2019s disease. Nat Aging. 2023;3:909. https:\/\/doi.org\/10.1038\/s43587-023-00474-2.","journal-title":"Nat Aging"},{"key":"4285_CR48","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.stem.2023.05.004","volume":"30","author":"H HuergaEncabo","year":"2023","unstructured":"HuergaEncabo H, Aramburu IV, Garcia-Albornoz M, Piganeau M, Wood H, Song A, et al. Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils. Cell Stem Cell. 2023;30:781\u201399-e9. https:\/\/doi.org\/10.1016\/j.stem.2023.05.004.","journal-title":"Cell Stem Cell"},{"key":"4285_CR49","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41577-023-00843-3","volume":"23","author":"R Belizaire","year":"2023","unstructured":"Belizaire R, Wong WJ, Robinette ML, Ebert BL. Clonal haematopoiesis and dysregulation of the immune system. Nat Rev Immunol. 2023;23:595\u2013610. https:\/\/doi.org\/10.1038\/s41577-023-00843-3.","journal-title":"Nat Rev Immunol"},{"key":"4285_CR50","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1182\/blood-2018-05-853291","volume":"132","author":"X Qu","year":"2018","unstructured":"Qu X, Zhang S, Wang S, Wang Y, Li W, Huang Y, et al. TET2 deficiency leads to stem cell factor-dependent clonal expansion of dysfunctional erythroid progenitors. Blood. 2018;132:2406\u201317. https:\/\/doi.org\/10.1182\/blood-2018-05-853291.","journal-title":"Blood"},{"key":"4285_CR51","doi-asserted-by":"publisher","first-page":"C7","DOI":"10.1016\/j.jacc.2005.09.068","volume":"47","author":"E Falk","year":"2006","unstructured":"Falk E. Pathogenesis of atherosclerosis. J Am Coll Cardiol. 2006;47:C7-12. https:\/\/doi.org\/10.1016\/j.jacc.2005.09.068.","journal-title":"J Am Coll Cardiol"},{"key":"4285_CR52","doi-asserted-by":"publisher","DOI":"10.1172\/JCI155724","volume":"132","author":"W Liu","year":"2022","unstructured":"Liu W, \u00d6stberg N, Yalcinkaya M, Dou H, Endo-Umeda K, Tang Y, et al. Erythroid lineage Jak2V617F expression promotes atherosclerosis through erythrophagocytosis and macrophage ferroptosis. J Clin Invest. 2022;132:e155724. https:\/\/doi.org\/10.1172\/JCI155724.","journal-title":"J Clin Invest"},{"key":"4285_CR53","doi-asserted-by":"publisher","first-page":"3665","DOI":"10.1182\/bloodadvances.2023011445","volume":"8","author":"JB Heimlich","year":"2024","unstructured":"Heimlich JB, Bhat P, Parker AC, Jenkins MT, Vlasschaert C, Ulloa J, et al. Multiomic profiling of human clonal hematopoiesis reveals genotype and cell-specific inflammatory pathway activation. Blood Adv. 2024;8:3665\u201378. https:\/\/doi.org\/10.1182\/bloodadvances.2023011445.","journal-title":"Blood Adv"},{"key":"4285_CR54","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1126\/science.aag1381","volume":"355","author":"JJ Fuster","year":"2017","unstructured":"Fuster JJ, MacLauchlan S, Zuriaga MA, Polackal MN, Ostriker AC, Chakraborty R, et al. Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice. Science. 2017;355:842\u20137. https:\/\/doi.org\/10.1126\/science.aag1381.","journal-title":"Science"},{"key":"4285_CR55","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41586-021-03341-5","volume":"592","author":"TP Fidler","year":"2021","unstructured":"Fidler TP, Xue C, Yalcinkaya M, Hardaway B, Abramowicz S, Xiao T, et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature. 2021;592:296\u2013301. https:\/\/doi.org\/10.1038\/s41586-021-03341-5.","journal-title":"Nature"},{"key":"4285_CR56","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.cmet.2019.06.001","volume":"30","author":"I Vitale","year":"2019","unstructured":"Vitale I, Manic G, Coussens LM, Kroemer G, Galluzzi L. Macrophages and metabolism in the tumor microenvironment. Cell Metab. 2019;30:36\u201350. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.001.","journal-title":"Cell Metab"},{"key":"4285_CR57","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1158\/2159-8290.CD-14-0736","volume":"5","author":"M Kleppe","year":"2015","unstructured":"Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, et al. JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer Discov. 2015;5:316\u201331. https:\/\/doi.org\/10.1158\/2159-8290.CD-14-0736.","journal-title":"Cancer Discov"},{"key":"4285_CR58","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2018.00056","volume":"6","author":"EA Comen","year":"2018","unstructured":"Comen EA, Bowman RL, Kleppe M. Underlying causes and therapeutic targeting of the inflammatory tumor microenvironment. Front Cell Dev Biol. 2018;6:56. https:\/\/doi.org\/10.3389\/fcell.2018.00056.","journal-title":"Front Cell Dev Biol"},{"key":"4285_CR59","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1111\/cas.15294","volume":"113","author":"X Liu","year":"2022","unstructured":"Liu X, Sato N, Shimosato Y, Wang T-W, Denda T, Chang Y-H, et al. CHIP-associated mutant ASXL1 in blood cells promotes solid tumor progression. Cancer Sci. 2022;113:1182\u201394. https:\/\/doi.org\/10.1111\/cas.15294.","journal-title":"Cancer Sci"},{"key":"4285_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2024.103740","volume":"24","author":"CCP Giannotti","year":"2025","unstructured":"Giannotti CCP, do Nascimento RRNR, Terreri MT, Andrade LEC, Perazzio SF. Chromosome aberrations and autoimmunity: Immune-mediated diseases associated with 18p deletion and other chromosomal aberrations. Autoimmun Rev. 2025;24:103740. https:\/\/doi.org\/10.1016\/j.autrev.2024.103740.","journal-title":"Autoimmun Rev"},{"key":"4285_CR61","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1002\/ijc.1985.36.3.287","volume":"36","author":"Y Ueshima","year":"1985","unstructured":"Ueshima Y, Bird ML, Vardiman JW, Rowley JD. A 14;19 translocation in B-cell chronic lymphocytic leukemia: a new recurring chromosome aberration. Int J Cancer. 1985;36:287\u201390.","journal-title":"Int J Cancer"},{"key":"4285_CR62","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl6579","volume":"8","author":"T Nakao","year":"2022","unstructured":"Nakao T, Bick AG, Taub MA, Zekavat SM, Uddin MM, Niroula A, et al. Mendelian randomization supports bidirectional causality between telomere length and clonal hematopoiesis of indeterminate potential. Sci Adv. 2022;8:eabl6579. https:\/\/doi.org\/10.1126\/sciadv.abl6579.","journal-title":"Sci Adv"},{"key":"4285_CR63","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade9746","volume":"9","author":"AAZ Dawoud","year":"2023","unstructured":"Dawoud AAZ, Tapper WJ, Cross NCP. Age-related loss of chromosome Y is associated with levels of sex hormone binding globulin and clonal hematopoiesis defined by TET2 , TP53 , and CBL mutations. Sci Adv. 2023;9:eade9746. https:\/\/doi.org\/10.1126\/sciadv.ade9746.","journal-title":"Sci Adv"},{"key":"4285_CR64","doi-asserted-by":"publisher","DOI":"10.1200\/PO.23.00070","volume":"7","author":"S Franch-Exp\u00f3sito","year":"2023","unstructured":"Franch-Exp\u00f3sito S, Mehine M, Ptashkin RN, Bolton KL, Bandlamudi C, Srinivasan P, et al. Associations Between Cancer Predisposition Mutations and Clonal Hematopoiesis in Patients With Solid Tumors. JCO Precis Oncol. 2023;7:e2300070. https:\/\/doi.org\/10.1200\/PO.23.00070.","journal-title":"JCO Precis Oncol"},{"key":"4285_CR65","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1146\/annurev-genom-010422-091101","volume":"23","author":"M Armanios","year":"2022","unstructured":"Armanios M. The Role of Telomeres in Human Disease. Annu Rev Genomics Hum Genet. 2022;23:363\u201381. https:\/\/doi.org\/10.1146\/annurev-genom-010422-091101.","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"4285_CR66","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114869","volume":"43","author":"RE Wagner","year":"2024","unstructured":"Wagner RE, Arnetzl L, Britto-Borges T, Heit-Mondrzyk A, Bakr A, Sollier E, et al. SRSF2 safeguards efficient transcription of DNA damage and repair genes. Cell Rep. 2024;43:114869. https:\/\/doi.org\/10.1016\/j.celrep.2024.114869.","journal-title":"Cell Rep"},{"key":"4285_CR67","doi-asserted-by":"publisher","unstructured":"The role of alternative splicing in cancer: From oncogenesis to drug resistance. Drug Resistance Updates. Churchill Livingstone; 2020;53:100728. https:\/\/doi.org\/10.1016\/j.drup.2020.100728","DOI":"10.1016\/j.drup.2020.100728"},{"key":"4285_CR68","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1146\/annurev-med-042921-112347","volume":"74","author":"H Ahmad","year":"2023","unstructured":"Ahmad H, Jahn N, Jaiswal S. Clonal Hematopoiesis and Its Impact on Human Health. Annu Rev Med. 2023;74:249\u201360. https:\/\/doi.org\/10.1146\/annurev-med-042921-112347.","journal-title":"Annu Rev Med"},{"key":"4285_CR69","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1038\/s41581-023-00778-x","volume":"20","author":"C Vlasschaert","year":"2024","unstructured":"Vlasschaert C, Lanktree MB, Rauh MJ, Kelly TN, Natarajan P. Clonal haematopoiesis, ageing and kidney disease. Nat Rev Nephrol. 2024;20:161\u201374. https:\/\/doi.org\/10.1038\/s41581-023-00778-x.","journal-title":"Nat Rev Nephrol"},{"key":"4285_CR70","doi-asserted-by":"publisher","first-page":"1281850","DOI":"10.3389\/fcell.2023.1281850","volume":"11","author":"Y Ogura","year":"2023","unstructured":"Ogura Y, Mimura I. Epigenetic roles in clonal hematopoiesis and aging kidney-related chronic kidney disease. Front Cell Dev Biol. 2023;11:1281850. https:\/\/doi.org\/10.3389\/fcell.2023.1281850.","journal-title":"Front Cell Dev Biol"},{"key":"4285_CR71","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1158\/2159-8290.CD-21-0901","volume":"11","author":"T K\u00f6hnke","year":"2021","unstructured":"K\u00f6hnke T, Majeti R. Clonal Hematopoiesis: From Mechanisms to Clinical Intervention. Cancer Discov. 2021;11:2987\u201397. https:\/\/doi.org\/10.1158\/2159-8290.CD-21-0901.","journal-title":"Cancer Discov"},{"key":"4285_CR72","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s40262-023-01225-7","volume":"62","author":"TYJ Appeldoorn","year":"2023","unstructured":"Appeldoorn TYJ, Munnink THO, Morsink LM, Hooge MNL, Touw DJ. Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review. Clin Pharmacokinet. 2023;62:559\u201371. https:\/\/doi.org\/10.1007\/s40262-023-01225-7.","journal-title":"Clin Pharmacokinet"},{"key":"4285_CR73","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1016\/j.immuni.2022.06.022","volume":"55","author":"I Cobo","year":"2022","unstructured":"Cobo I, Tanaka TN, Chandra Mangalhara K, Lana A, Yeang C, Han C, et al. DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages. Immunity. 2022;55:1386\u2013401-e10. https:\/\/doi.org\/10.1016\/j.immuni.2022.06.022.","journal-title":"Immunity"},{"key":"4285_CR74","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/ni.3464","volume":"17","author":"X Li","year":"2016","unstructured":"Li X, Zhang Q, Ding Y, Liu Y, Zhao D, Zhao K, et al. Methyltransferase Dnmt3a upregulates HDAC9 to deacetylate the kinase TBK1 for activation of antiviral innate immunity. Nat Immunol. 2016;17:806\u201315. https:\/\/doi.org\/10.1038\/ni.3464.","journal-title":"Nat Immunol"},{"key":"4285_CR75","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/s44161-023-00281-3","volume":"2","author":"W Liu","year":"2023","unstructured":"Liu W, Yalcinkaya M, Maestre IF, Olszewska M, Ampomah PB, Heimlich JB, et al. Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis. Nat Cardiovasc Res. 2023;2:572\u201386. https:\/\/doi.org\/10.1038\/s44161-023-00281-3.","journal-title":"Nat Cardiovasc Res"},{"key":"4285_CR76","doi-asserted-by":"publisher","first-page":"681","DOI":"10.2147\/ITT.S485684","volume":"14","author":"T Schumertl","year":"2025","unstructured":"Schumertl T, Lokau J, Garbers C. IL-6 signaling in immunopathology: from basic biology to selective therapeutic intervention. Immunotargets Ther. 2025;14:681\u201395. https:\/\/doi.org\/10.2147\/ITT.S485684.","journal-title":"Immunotargets Ther"},{"key":"4285_CR77","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1093\/eurheartj\/ehae546","volume":"45","author":"MA Zuriaga","year":"2024","unstructured":"Zuriaga MA, Yu Z, Matesanz N, Truong B, Ramos-Neble BL, Asensio-L\u00f3pez MC, et al. Colchicine prevents accelerated atherosclerosis in TET2-mutant clonal haematopoiesis. Eur Heart J. 2024;45:4601\u201315. https:\/\/doi.org\/10.1093\/eurheartj\/ehae546.","journal-title":"Eur Heart J"},{"key":"4285_CR78","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1016\/j.cell.2017.07.032","volume":"170","author":"L Cimmino","year":"2017","unstructured":"Cimmino L, Dolgalev I, Wang Y, Yoshimi A, Martin GH, Wang J, et al. Restoration of TET2 function blocks aberrant self-renewal and leukemia progression. Cell. 2017;170:1079\u201395-e20. https:\/\/doi.org\/10.1016\/j.cell.2017.07.032.","journal-title":"Cell"},{"key":"4285_CR79","doi-asserted-by":"publisher","first-page":"3962","DOI":"10.1111\/cas.15094","volume":"112","author":"S Asada","year":"2021","unstructured":"Asada S, Kitamura T. Clonal hematopoiesis and associated diseases: a review of recent findings. Cancer Sci. 2021;112:3962\u201371. https:\/\/doi.org\/10.1111\/cas.15094.","journal-title":"Cancer Sci"},{"key":"4285_CR80","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57238-2","volume":"16","author":"KA Young","year":"2025","unstructured":"Young KA, Hosseini M, Mistry JJ, Morganti C, Mills TS, Cai X, et al. Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis. Nat Commun. 2025;16:3306. https:\/\/doi.org\/10.1038\/s41467-025-57238-2.","journal-title":"Nat Commun"},{"key":"4285_CR81","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1001\/jamacardio.2022.0386","volume":"7","author":"EC Svensson","year":"2022","unstructured":"Svensson EC, Madar A, Campbell CD, He Y, Sultan M, Healey ML, et al. TET2-driven clonal hematopoiesis and response to Canakinumab. JAMA Cardiol. 2022;7:521\u20138. https:\/\/doi.org\/10.1001\/jamacardio.2022.0386.","journal-title":"JAMA Cardiol"},{"key":"4285_CR82","doi-asserted-by":"publisher","first-page":"7471","DOI":"10.1182\/bloodadvances.2023011578","volume":"7","author":"J Woo","year":"2023","unstructured":"Woo J, Lu D, Lewandowski A, Xu H, Serrano P, Healey M, et al. Effects of IL-1\u03b2 inhibition on anemia and clonal hematopoiesis in the randomized CANTOS trial. Blood Adv. 2023;7:7471\u201384. https:\/\/doi.org\/10.1182\/bloodadvances.2023011578.","journal-title":"Blood Adv"},{"key":"4285_CR83","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1038\/s41591-025-03716-5","volume":"31","author":"N Furer","year":"2025","unstructured":"Furer N, Rappoport N, Milman O, Tavor S, Lifshitz A, Bercovich A, et al. A reference model of circulating hematopoietic stem cells across the lifespan with applications to diagnostics. Nat Med. 2025;31:2442\u201351. https:\/\/doi.org\/10.1038\/s41591-025-03716-5.","journal-title":"Nat Med"},{"key":"4285_CR84","doi-asserted-by":"publisher","DOI":"10.1200\/PO.21.00309","volume":"6","author":"A Singh","year":"2022","unstructured":"Singh A, Mencia-Trinchant N, Griffiths EA, Altahan A, Swaminathan M, Gupta M, et al. Mutant PPM1D- and TP53-Driven Hematopoiesis Populates the Hematopoietic Compartment in Response to Peptide Receptor Radionuclide Therapy. JCO Precis Oncol. 2022;6:e2100309. https:\/\/doi.org\/10.1200\/PO.21.00309.","journal-title":"JCO Precis Oncol"}],"container-title":["Cancer Cell International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12935-026-04285-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-026-04285-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-026-04285-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:30:19Z","timestamp":1778661019000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12935-026-04285-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,2]]},"references-count":84,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4285"],"URL":"https:\/\/doi.org\/10.1186\/s12935-026-04285-4","relation":{},"ISSN":["1475-2867"],"issn-type":[{"value":"1475-2867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,2]]},"assertion":[{"value":"15 May 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 April 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"193"}}