{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:45:47Z","timestamp":1785714347494,"version":"3.56.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"},{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Cancer Cell Int"],"DOI":"10.1186\/s12935-026-04315-1","type":"journal-article","created":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T10:46:34Z","timestamp":1778237194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics analysis of the mechanism by ATP13A2 regulates the tumor microenvironment and prognosis in hepatocellular carcinoma"],"prefix":"10.1186","volume":"26","author":[{"given":"Yijie","family":"Weng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueqing","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahua","family":"Situ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xintian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danxian","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"issue":"6","key":"4315_CR1","first-page":"394","volume":"68","author":"F Bray","year":"2018","unstructured":"Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394\u2013424.","journal-title":"CA Cancer J Clin"},{"key":"4315_CR2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708","author":"RL Siegel","year":"2022","unstructured":"Siegel RL, Miller KD, Fuchs HE, et al. Cancer statistics, 2022. CA Cancer J Clin. 2022. https:\/\/doi.org\/10.3322\/caac.21708.","journal-title":"CA Cancer J Clin"},{"issue":"10360","key":"4315_CR3","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1016\/S0140-6736(22)01200-4","volume":"400","author":"A Vogel","year":"2022","unstructured":"Vogel A, Meyer T, Sapisochin G, et al. Hepatocellular carcinoma. Lancet. 2022;400(10360):1345\u201362. https:\/\/doi.org\/10.1016\/S0140-6736(22)01200-4.","journal-title":"Lancet"},{"issue":"1","key":"4315_CR4","first-page":"E18761429358008","volume":"17","author":"W Xu","year":"2024","unstructured":"Xu W, Liao S, Hu Y, et al. Upregulation of miR-3130-5p Enhances Hepatocellular Carcinoma Growth by Suppressing Ferredoxin 1[J]. Curr Mol Pharmacol. 2024;17(1):E18761429358008.","journal-title":"Curr Mol Pharmacol"},{"issue":"4","key":"4315_CR5","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2174\/0115665232308821240826075513","volume":"25","author":"L Qi","year":"2025","unstructured":"Qi L, Tan Y, Zhou Y, et al. Proteogenomic identification and analysis of KIF5B as a prognostic signature for hepatocellular carcinoma. Curr Gene Ther. 2025;25(4):532\u201345.","journal-title":"Curr Gene Ther"},{"issue":"4","key":"4315_CR6","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.1016\/j.ygeno.2020.03.013","volume":"112","author":"BH Zhang","year":"2020","unstructured":"Zhang BH, Yang J, Jiang L, et al. Development and validation of a 14-gene signature for prognosis prediction in hepatocellular carcinoma. Genomics. 2020;112(4):2763\u201371.","journal-title":"Genomics"},{"issue":"11","key":"4315_CR7","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1002\/cac2.12345","volume":"42","author":"K Cheng","year":"2022","unstructured":"Cheng K, Cai N, Zhu J, et al. Tumor\u2010associated macrophages in liver cancer: from mechanisms to therapy. Cancer Commun. 2022;42(11):1112\u201340.","journal-title":"Cancer Commun"},{"key":"4315_CR8","doi-asserted-by":"crossref","unstructured":"Matoba D, Noda T, Kobayashi S, et al. Tumor Endothelial Cells Induce M2 Macrophage Polarization via IL-4, Enhancing Tumor Growth in Hepatocellular Carcinoma. Cancer Sci. 2025;116(11):2972-85.","DOI":"10.1111\/cas.70179"},{"issue":"1","key":"4315_CR9","doi-asserted-by":"publisher","first-page":"25","DOI":"10.20892\/j.issn.2095-3941.2022.0449","volume":"20","author":"C Yao","year":"2023","unstructured":"Yao C, Wu S, Kong J, et al. Angiogenesis in hepatocellular carcinoma: mechanisms and anti-angiogenic therapies[J]. Cancer Biol Med. 2023;20(1):25.","journal-title":"Cancer Biol Med"},{"issue":"1","key":"4315_CR10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/hep.32099","volume":"75","author":"Y Lin","year":"2022","unstructured":"Lin Y, Cai Q, Chen Y, et al. CAFs shape myeloid-derived suppressor cells to promote stemness of intrahepatic cholangiocarcinoma through 5-lipoxygenase[J]. Hepatology. 2022;75(1):28\u201342.","journal-title":"Hepatology"},{"issue":"4","key":"4315_CR11","first-page":"187","volume":"45","author":"R Elias","year":"2018","unstructured":"Elias R, Hartshorn K, Rahma O, et al. Aging, immune senescence, and immunotherapy: a comprehensive review[C]\/\/Seminars in oncology. WB Saunders. 2018;45(4):187\u2013200.","journal-title":"WB Saunders"},{"key":"4315_CR12","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.csbj.2019.07.021","volume":"17","author":"NJ Hunt","year":"2019","unstructured":"Hunt NJ, Kang SWS, Lockwood GP, et al. Hallmarks of aging in the liver. Comput Struct Biotechnol J. 2019;17:1151\u201361.","journal-title":"Comput Struct Biotechnol J"},{"issue":"23","key":"4315_CR13","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242316880","volume":"24","author":"Q Li","year":"2023","unstructured":"Li Q, Lin Y, Liang G, et al. Autophagy and senescence: the molecular mechanisms and implications in liver diseases. Int J Mol Sci. 2023;24(23):16880.","journal-title":"Int J Mol Sci"},{"issue":"8","key":"4315_CR14","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.1111\/jgh.13717","volume":"32","author":"S Rey","year":"2017","unstructured":"Rey S, Quintavalle C, Burmeister K, et al. Liver damage and senescence increases in patients developing hepatocellular carcinoma[J]. J Gastroenterol Hepatol. 2017;32(8):1480\u20136.","journal-title":"J Gastroenterol Hepatol"},{"key":"4315_CR15","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101833","volume":"84","author":"Y He","year":"2023","unstructured":"He Y, Su Y, Duan C, et al. Emerging role of aging in the progression of NAFLD to HCC[J]. Ageing Res Rev. 2023;84:101833.","journal-title":"Ageing Res Rev"},{"issue":"1","key":"4315_CR16","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15691","volume":"8","author":"M Ogrodnik","year":"2017","unstructured":"Ogrodnik M, Miwa S, Tchkonia T, et al. Cellular senescence drives age-dependent hepatic steatosis. Nat Commun. 2017;8(1):15691.","journal-title":"Nat Commun"},{"key":"4315_CR17","doi-asserted-by":"crossref","unstructured":"Yang Y, Jn-Simon N, He Y, et al. A BCL-xL\/BCL-2 PROTAC effectively clears senescent cells in the liver and reduces MASH-driven hepatocellular carcinoma in mice[J]. Nature aging, 2025, 5(3): 386-400.","DOI":"10.1038\/s43587-025-00811-7"},{"issue":"5","key":"4315_CR18","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/ng.3538","volume":"48","author":"Z Zhu","year":"2016","unstructured":"Zhu Z, Zhang F, Hu H, et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48(5):481\u20137.","journal-title":"Nat Genet"},{"issue":"7871","key":"4315_CR19","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1038\/s41586-021-03634-9","volume":"596","author":"A Rao","year":"2021","unstructured":"Rao A, Barkley D, Fran\u00e7a GS, et al. Exploring tissue architecture using spatial transcriptomics. Nature. 2021;596(7871):211\u201320.","journal-title":"Nature"},{"issue":"7944","key":"4315_CR20","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","volume":"613","author":"MI Kurki","year":"2023","unstructured":"Kurki MI, Karjalainen J, Palta P, et al. FinnGen provides genetic insights from a well-phenotyped isolated population[J]. Nature. 2023;613(7944):508\u201318.","journal-title":"Nature"},{"key":"4315_CR21","doi-asserted-by":"crossref","unstructured":"Stelzer G, Rosen N, Plaschkes I, et al. The GeneCards suite: from gene data mining to disease genome sequence analyses[J]. Current protocols in bioinformatics, 2016, 54(1): 1.30. 1\u20131.30. 33.","DOI":"10.1002\/cpbi.5"},{"key":"4315_CR22","doi-asserted-by":"crossref","unstructured":"Li T, Fu J, Zeng Z, et al. TIMER2. 0 for analysis of tumor-infiltrating immune cells[J]. Nucleic acids research, 2020, 48(W1): W509-W514.","DOI":"10.1093\/nar\/gkaa407"},{"key":"4315_CR23","doi-asserted-by":"crossref","unstructured":"Ma L, Hernandez M O, Zhao Y, et al. Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer[J]. Cancer cell, 2019, 36(4): 418\u2013430. e6.","DOI":"10.1016\/j.ccell.2019.08.007"},{"issue":"1","key":"4315_CR24","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01876-x","volume":"22","author":"C Ma","year":"2023","unstructured":"Ma C, Yang C, Peng A, et al. Pan-cancer spatially resolved single-cell analysis reveals the crosstalk between cancer-associated fibroblasts and tumor microenvironment. Mol Cancer. 2023;22(1):170.","journal-title":"Mol Cancer"},{"key":"4315_CR25","doi-asserted-by":"publisher","first-page":"1263329","DOI":"10.3389\/fimmu.2023.1263329","volume":"14","author":"S Zhao","year":"2023","unstructured":"Zhao S, Wang Q, Ni K, et al. Combining single-cell sequencing and spatial transcriptome sequencing to identify exosome-related features of glioblastoma and constructing a prognostic model to identify BARD1 as a potential therapeutic target for GBM patients[J]. Front Immunol. 2023;14:1263329.","journal-title":"Front Immunol"},{"key":"4315_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12874-018-0482-1","volume":"18","author":"JL Katzman","year":"2018","unstructured":"Katzman JL, Shaham U, Cloninger A, et al. DeepSurv: personalized treatment recommender system using a Cox proportional hazards deep neural network[J]. BMC Med Res Methodol. 2018;18:1\u201312.","journal-title":"BMC Med Res Methodol"},{"key":"4315_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108200","author":"J Lei","year":"2023","unstructured":"Lei J, Xu X, Xu J, et al. The predictive value of modified-DeepSurv in overall survivals of patients with lung cancer. iScience. 2023. https:\/\/doi.org\/10.1016\/j.isci.2023.108200.","journal-title":"iScience"},{"issue":"1","key":"4315_CR28","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1007\/s11605-021-05099-7","volume":"27","author":"J Huang","year":"2023","unstructured":"Huang J, Xu S, Yu Z, et al. ATP13A2 is a prognostic biomarker and correlates with immune infiltrates in hepatocellular carcinoma. J Gastrointest Surg. 2023;27(1):56\u201366.","journal-title":"J Gastrointest Surg"},{"issue":"1","key":"4315_CR29","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s41531-024-00757-4","volume":"10","author":"J Sikora","year":"2024","unstructured":"Sikora J, Dovero S, Kinet R, et al. Nigral ATP13A2 depletion induces Parkinson\u2019s disease-related neurodegeneration in a pilot study in non-human primates. npj Park Dis. 2024;10(1):141.","journal-title":"npj Park Dis"},{"key":"4315_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13578-020-00506-z","volume":"10","author":"Q Chen","year":"2020","unstructured":"Chen Q, Zhong L, Zhou C, et al. Knockdown of Parkinson\u2019s disease-related gene ATP13A2 reduces tumorigenesis via blocking autophagic flux in colon cancer. Cell Biosci. 2020;10:1\u201312.","journal-title":"Cell Biosci"},{"key":"4315_CR31","doi-asserted-by":"crossref","unstructured":"Gr\u00fcnewald A, Arns B, Seibler P, et al. ATP13A2 mutations impair mitochondrial function in fibroblasts from patients with Kufor-Rakeb syndrome[J]. Neurobiology of aging, 2012, 33(8): 1843. e1\u20131843. e7.","DOI":"10.1016\/j.neurobiolaging.2011.12.035"},{"issue":"15","key":"4315_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26157030","volume":"26","author":"K Croucher","year":"2025","unstructured":"Croucher K, Lepp JK, Bechtold J, et al. Phenotype differences between ATP13A2 heterozygous and knockout mice across aging. Int J Mol Sci. 2025;26(15):7030.","journal-title":"Int J Mol Sci"},{"issue":"21","key":"4315_CR33","doi-asserted-by":"publisher","first-page":"3341","DOI":"10.1080\/15384101.2015.1093420","volume":"14","author":"S Martin","year":"2015","unstructured":"Martin S, Holemans T, Vangheluwe P. Unlocking atp13a2\/park9 activity. Cell Cycle. 2015;14(21):3341\u20132.","journal-title":"Cell Cycle"},{"issue":"4","key":"4315_CR34","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1523\/JNEUROSCI.3117-15.2016","volume":"36","author":"S Rajagopalan","year":"2016","unstructured":"Rajagopalan S, Rane A, Chinta SJ, et al. Regulation of ATP13A2 via PHD2-HIF1\u03b1 signaling is critical for cellular iron homeostasis: implications for Parkinson\u2019s disease. J Neurosci. 2016;36(4):1086\u201395.","journal-title":"J Neurosci"},{"issue":"2","key":"4315_CR35","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1111\/j.1471-4159.2012.07676.x","volume":"122","author":"Q Xu","year":"2012","unstructured":"Xu Q, Guo H, Zhang X, et al. Hypoxia regulation of ATP13A2 (PARK9) gene transcription. J Neurochem. 2012;122(2):251\u20139.","journal-title":"J Neurochem"},{"issue":"6","key":"4315_CR36","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1111\/cns.12514","volume":"22","author":"C Qiao","year":"2016","unstructured":"Qiao C, Yin N, Gu HY, et al. Atp13a2 deficiency aggravates astrocyte\u2010mediated neuroinflammation via NLRP 3 inflammasome activation. CNS Neurosci Ther. 2016;22(6):451\u201360.","journal-title":"CNS Neurosci Ther"},{"key":"4315_CR37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.134330","volume":"708","author":"S Moriya","year":"2019","unstructured":"Moriya S, Tan VP, Yee AKW, et al. pink1, atp13a2 and uchl1 expressions are affected by inflammation in the brain. Neurosci Lett. 2019;708:134330.","journal-title":"Neurosci Lett"},{"issue":"6","key":"4315_CR38","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/s41568-021-00347-z","volume":"21","author":"KJ Hiam-Galvez","year":"2021","unstructured":"Hiam-Galvez KJ, Allen BM, Spitzer MH. Systemic immunity in cancer. Nat Rev Cancer. 2021;21(6):345\u201359.","journal-title":"Nat Rev Cancer"},{"issue":"3","key":"4315_CR39","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1016\/j.jhep.2014.10.029","volume":"62","author":"OWH Yeung","year":"2015","unstructured":"Yeung OWH, Lo CM, Ling CC, et al. Alternatively activated (M2) macrophages promote tumour growth and invasiveness in hepatocellular carcinoma. J Hepatol. 2015;62(3):607\u201316.","journal-title":"J Hepatol"},{"issue":"4","key":"4315_CR40","doi-asserted-by":"publisher","first-page":"2828","DOI":"10.1002\/jcb.29514","volume":"121","author":"D Sun","year":"2020","unstructured":"Sun D, Luo T, Dong P, et al. M2-polarized tumor-associated macrophages promote epithelial-mesenchymal transition via activation of the AKT3\/PRAS40 signaling pathway in intrahepatic cholangiocarcinoma[J]. J Cell Biochem. 2020;121(4):2828\u201338.","journal-title":"J Cell Biochem"},{"key":"4315_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-020-01687-w","volume":"20","author":"H Yuan","year":"2020","unstructured":"Yuan H, Lin Z, Liu Y, et al. Intrahepatic cholangiocarcinoma induced M2-polarized tumor-associated macrophages facilitate tumor growth and invasiveness. Cancer Cell Int. 2020;20:1\u201314.","journal-title":"Cancer Cell Int"},{"key":"4315_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12032-016-0729-9","volume":"33","author":"F Zhu","year":"2016","unstructured":"Zhu F, Li X, Chen S, et al. Tumor-associated macrophage or chemokine ligand CCL17 positively regulates the tumorigenesis of hepatocellular carcinoma. Med Oncol. 2016;33:1\u201312.","journal-title":"Med Oncol"},{"issue":"1","key":"4315_CR43","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.yexcr.2018.09.001","volume":"372","author":"A Jamshidi-Parsian","year":"2018","unstructured":"Jamshidi-Parsian A, Griffin RJ, Kore RA, et al. Tumor-endothelial cell interaction in an experimental model of human hepatocellular carcinoma[J]. Exp Cell Res. 2018;372(1):16\u201324.","journal-title":"Exp Cell Res"},{"key":"4315_CR44","doi-asserted-by":"publisher","DOI":"10.1177\/1533033820971677","volume":"19","author":"S Lacin","year":"2020","unstructured":"Lacin S, Yalcin S. The prognostic value of circulating VEGF-A level in patients with hepatocellular cancer. Technol Cancer Res Treat. 2020;19:1533033820971677.","journal-title":"Technol Cancer Res Treat"},{"issue":"6","key":"4315_CR45","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13061360","volume":"13","author":"Y Wang","year":"2021","unstructured":"Wang Y, Liu D, Zhang T, et al. FGF\/FGFR signaling in hepatocellular carcinoma: from carcinogenesis to recent therapeutic intervention. Cancers. 2021;13(6):1360.","journal-title":"Cancers"},{"issue":"1","key":"4315_CR46","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-022-00406-z","volume":"10","author":"H Peng","year":"2022","unstructured":"Peng H, Zhu E, Zhang Y. Advances of cancer-associated fibroblasts in liver cancer. Biomarker research. 2022;10(1):59.","journal-title":"Biomarker research"},{"issue":"1","key":"4315_CR47","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jhep.2013.02.022","volume":"59","author":"B Sangro","year":"2013","unstructured":"Sangro B, Gomez-Martin C, de la Mata M, et al. A clinical trial of CTLA-4 blockade with tremelimumab in patients with hepatocellular carcinoma and chronic Hepatitis C. J Hepatol. 2013;59(1):81\u20138.","journal-title":"J Hepatol"},{"issue":"6","key":"4315_CR48","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1084\/jem.20112741","volume":"209","author":"T Yokosuka","year":"2012","unstructured":"Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, et al. Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2[J]. J Exp Med. 2012;209(6):1201\u201317.","journal-title":"J Exp Med"},{"issue":"10","key":"4315_CR49","doi-asserted-by":"publisher","first-page":"e1532","DOI":"10.1634\/theoncologist.2019-0591","volume":"25","author":"K Julien","year":"2020","unstructured":"Julien K, Leung HT, Fuertes C, et al. Nivolumab in advanced hepatocellular carcinoma: Safety profile and select treatment-related adverse events from the CheckMate 040 study[J]. Oncologist. 2020;25(10):e1532\u201340.","journal-title":"Oncologist"},{"key":"4315_CR50","doi-asserted-by":"crossref","unstructured":"Zheng Y, Wang S, Cai J, et al. The progress of immune checkpoint therapy in primary liver cancer[J]. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 2021, 1876(2): 188638.","DOI":"10.1016\/j.bbcan.2021.188638"}],"container-title":["Cancer Cell International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12935-026-04315-1","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-026-04315-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12935-026-04315-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T23:18:23Z","timestamp":1785712703000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12935-026-04315-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":50,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["4315"],"URL":"https:\/\/doi.org\/10.1186\/s12935-026-04315-1","relation":{},"ISSN":["1475-2867"],"issn-type":[{"value":"1475-2867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,8]]},"assertion":[{"value":"10 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 May 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This study did not require any ethics approval. Only secondary analyses were performed using publicly accessible data.","order":1,"name":"Ethics","label":"Ethics approval and consent to participate","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","label":"Consent for publication","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":3,"name":"Ethics","label":"Informed consent","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":4,"name":"Ethics","label":"Institutional review board","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","label":"Competing interests","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"276"}}