{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:28:13Z","timestamp":1774981693761,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T00:00:00Z","timestamp":1425513600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12936-015-0618-2","type":"journal-article","created":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T16:37:48Z","timestamp":1425487068000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Screening for an ivermectin slow-release formulation suitable for malaria vector control"],"prefix":"10.1186","volume":"14","author":[{"given":"Carlos","family":"Chaccour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel Irigoyen","family":"Barrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Gloria Gil","family":"Royo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Martinez","family":"Urbistondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Slater","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Hammann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Del Pozo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2015,3,5]]},"reference":[{"key":"618_CR1","volume-title":"World Malaria report 2014","author":"WHO","year":"2014","unstructured":"WHO. World Malaria report 2014. Geneva: World Health Organization; 2014."},{"key":"618_CR2","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1016\/S0140-6736(13)60024-0","volume":"383","author":"NJ White","year":"2014","unstructured":"White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM. Malaria. Lancet. 2014;383:723\u201335.","journal-title":"Lancet"},{"key":"618_CR3","unstructured":"Magill A. We can achieve a world free of malaria. In Impatient Optimists. Bill & Melinda Gates Foundation. 2014. \n                    http:\/\/www.impatientoptimists.org\/Posts\/2014\/04\/We-Can-Achieve-a-World-Free-of-Malaria\n                    \n                  . Accessed 17 Feb 2015"},{"key":"618_CR4","doi-asserted-by":"publisher","first-page":"e1000406","DOI":"10.1371\/journal.pmed.1000406","volume":"8","author":"PL Alonso","year":"2011","unstructured":"Alonso PL, Brown G, Arevalo-Herrera M, Binka F, Chitnis C, Collins F, et al. A research agenda to underpin malaria eradication. PLoS Med. 2011;8:e1000406.","journal-title":"PLoS Med"},{"key":"618_CR5","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/S0140-6736(10)61269-X","volume":"376","author":"B Moonen","year":"2010","unstructured":"Moonen B, Cohen JM, Snow RW, Slutsker L, Drakeley C, Smith DL, et al. Operational strategies to achieve and maintain malaria elimination. Lancet. 2010;376:1592\u2013603.","journal-title":"Lancet"},{"key":"618_CR6","volume-title":"The epidemiology and control of malaria","author":"G Macdonald","year":"1957","unstructured":"Macdonald G. The epidemiology and control of malaria. London: Oxford University Press; 1957."},{"key":"618_CR7","volume-title":"Global plan for insecticide resistance management in malaria vectors (GPIRM)","author":"WHO","year":"2012","unstructured":"WHO. Global plan for insecticide resistance management in malaria vectors (GPIRM). Geneva: World Health Organization; 2012."},{"key":"618_CR8","doi-asserted-by":"publisher","first-page":"e1000412","DOI":"10.1371\/journal.pmed.1000412","volume":"8","author":"JA Najera","year":"2011","unstructured":"Najera JA, Gonzalez-Silva M, Alonso PL. Some lessons for the future from the Global Malaria Eradication Programme (1955\u20131969). PLoS Med. 2011;8:e1000412.","journal-title":"PLoS Med"},{"key":"618_CR9","doi-asserted-by":"publisher","first-page":"e1000401","DOI":"10.1371\/journal.pmed.1000401","volume":"8","author":"The malERA Consultative Group on Vector Control","year":"2011","unstructured":"The malERA Consultative Group on Vector Control. A research agenda for malaria eradication: vector control. PLoS Med. 2011;8:e1000401.","journal-title":"PLoS Med"},{"key":"618_CR10","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3389\/fphys.2012.00199","volume":"3","author":"NJ Govella","year":"2012","unstructured":"Govella NJ, Ferguson H. Why use of interventions targeting outdoor biting mosquitoes will be necessary to achieve malaria elimination. Front Physiol. 2012;3:199.","journal-title":"Front Physiol"},{"key":"618_CR11","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.3201\/eid1809.120283","volume":"18","author":"J Stevenson","year":"2012","unstructured":"Stevenson J, St Laurent B, Lobo NF, Cooke MK, Kahindi SC, Oriango RM, et al. Novel vectors of malaria parasites in the western highlands of Kenya. Emerg Infect Dis. 2012;18:1547\u20139.","journal-title":"Emerg Infect Dis"},{"key":"618_CR12","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.1093\/infdis\/jis565","volume":"206","author":"N Moiroux","year":"2012","unstructured":"Moiroux N, Gomez MB, Pennetier C, Elanga E, Djenontin A, Chandre F, et al. Changes in Anopheles funestus biting behavior following universal coverage of long-lasting insecticidal nets in Benin. J Infect Dis. 2012;206:1622\u20139.","journal-title":"J Infect Dis"},{"key":"618_CR13","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/1475-2875-13-125","volume":"13","author":"S Sougoufara","year":"2014","unstructured":"Sougoufara S, Diedhiou SM, Doucoure S, Diagne N, Sembene PM, Harry M, et al. Biting by Anopheles funestus in broad daylight after use of long-lasting insecticidal nets: a new challenge to malaria elimination. Malar J. 2014;13:125.","journal-title":"Malar J"},{"key":"618_CR14","doi-asserted-by":"publisher","first-page":"e1000303","DOI":"10.1371\/journal.pmed.1000303","volume":"7","author":"HM Ferguson","year":"2010","unstructured":"Ferguson HM, Dornhaus A, Beeche A, Borgemeister C, Gottlieb M, Mulla MS, et al. Ecology: a prerequisite for malaria elimination and eradication. PLoS Med. 2010;7:e1000303.","journal-title":"PLoS Med"},{"key":"618_CR15","doi-asserted-by":"crossref","unstructured":"Time to contain artemisinin resistance [editorial]. Lancet. 2014;383:1438.","DOI":"10.1016\/S0140-6736(14)60700-5"},{"key":"618_CR16","volume-title":"Emergency response to artemisinin resistance in the Greater Mekong subregion: regional framework for action 2013\u20132015","author":"WHO","year":"2013","unstructured":"WHO. Emergency response to artemisinin resistance in the Greater Mekong subregion: regional framework for action 2013\u20132015. Geneva: World Health organization; 2013."},{"key":"618_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/1475-2875-8-31","volume":"8","author":"RJ Maude","year":"2009","unstructured":"Maude RJ, Pontavornpinyo W, Saralamba S, Aguas R, Yeung S, Dondorp AM, et al. The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia. Malar J. 2009;8:31.","journal-title":"Malar J"},{"key":"618_CR18","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1016\/S0140-6736(10)61963-0","volume":"376","author":"NJ White","year":"2010","unstructured":"White NJ. Artemisinin resistance\u2013the clock is ticking. Lancet. 2010;376:2051\u20132.","journal-title":"Lancet"},{"key":"618_CR19","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S1473-3099(13)70320-7","volume":"14","author":"J Kolaczinski","year":"2014","unstructured":"Kolaczinski J, Macdonald M, Meek S. Vector control to eliminate artemisinin resistant malaria in the Greater Mekong subregion. Lancet Infect Dis. 2014;14:9\u201311.","journal-title":"Lancet Infect Dis"},{"issue":"Suppl 1","key":"618_CR20","first-page":"73","volume":"44","author":"J Hii","year":"2013","unstructured":"Hii J, Rueda LM. Malaria vectors in the Greater Mekong Subregion: overview of malaria vectors and remaining challenges. Southeast Asian J Trop Med Public Health. 2013;44 Suppl 1:73\u2013165. discussion 306\u2013167.","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"618_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1086\/653208","volume":"202","author":"C Chaccour","year":"2010","unstructured":"Chaccour C, Lines J, Whitty CJ. Effect of ivermectin on Anopheles gambiae mosquitoes fed on humans: the potential of oral insecticides in malaria control. J Infect Dis. 2010;202:113\u20136.","journal-title":"J Infect Dis"},{"key":"618_CR22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.actatropica.2010.06.001","volume":"116","author":"KC Kobylinski","year":"2010","unstructured":"Kobylinski KC, Deus KM, Butters MP, Hongyu T, Gray M, da Silva IM, et al. The effect of oral anthelmintics on the survivorship and re-feeding frequency of anthropophilic mosquito disease vectors. Acta Trop. 2010;116:119\u201326.","journal-title":"Acta Trop"},{"key":"618_CR23","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1186\/1475-2875-9-365","volume":"9","author":"M Sylla","year":"2010","unstructured":"Sylla M, Kobylinski KC, Gray M, Chapman PL, Sarr MD, Rasgon JL, et al. Mass drug administration of ivermectin in south-eastern Senegal reduces the survivorship of wild-caught, blood fed malaria vectors. Malar J. 2010;9:365.","journal-title":"Malar J"},{"key":"618_CR24","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4269\/ajtmh.2011.11-0160","volume":"85","author":"KC Kobylinski","year":"2011","unstructured":"Kobylinski KC, Sylla M, Chapman PL, Sarr MD, Foy BD. Ivermectin mass drug administration to humans disrupts malaria parasite transmission in Senegalese villages. Am J Trop Med Hyg. 2011;85:3\u20135.","journal-title":"Am J Trop Med Hyg"},{"key":"618_CR25","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/1475-2875-12-153","volume":"12","author":"CJ Chaccour","year":"2013","unstructured":"Chaccour CJ, Kobylinski KC, Bassat Q, Bousema T, Drakeley C, Alonso P, et al. Ivermectin to reduce malaria transmission: a research agenda for a promising new tool for elimination. Malar J. 2013;12:153.","journal-title":"Malar J"},{"key":"618_CR26","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.pt.2011.05.007","volume":"27","author":"BD Foy","year":"2011","unstructured":"Foy BD, Kobylinski KC, da Silva IM, Rasgon JL, Sylla M. Endectocides for malaria control. Trends Parasitol. 2011;27:423\u20138.","journal-title":"Trends Parasitol"},{"key":"618_CR27","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.pt.2014.07.005","volume":"30","author":"S Omura","year":"2014","unstructured":"Omura S, Crump A. Ivermectin: panacea for resource-poor communities? Trends Parasitol. 2014;30:445\u201355.","journal-title":"Trends Parasitol"},{"key":"618_CR28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1186\/1475-2875-11-381","volume":"11","author":"KC Kobylinski","year":"2012","unstructured":"Kobylinski KC, Foy BD, Richardson JH. Ivermectin inhibits the sporogony of Plasmodium falciparum in Anopheles gambiae. Malar J. 2012;11:381.","journal-title":"Malar J"},{"key":"618_CR29","doi-asserted-by":"publisher","first-page":"1972","DOI":"10.1093\/infdis\/jiu351","volume":"210","author":"HC Slater","year":"2014","unstructured":"Slater HC, Walker PG, Bousema T, Okell LC, Ghani AC. The potential impact of adding Ivermectin to a mass treatment intervention to reduce malaria transmission: a modelling study. J Infect Dis. 2014;210:1972\u201380.","journal-title":"J Infect Dis"},{"key":"618_CR30","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1093\/cid\/ciu797","volume":"60","author":"AL Ouedraogo","year":"2015","unstructured":"Ouedraogo AL, Bastiaens GJ, Tiono AB, Guelbeogo WM, Kobylinski KC, Ouedraogo A, et al. Efficacy and safety of the mosquitocidal drug ivermectin to prevent malaria transmission after treatment: a double-blind, randomized, clinical trial. Clin Infect Dis. 2015;60:357\u201365.","journal-title":"Clin Infect Dis"},{"key":"618_CR31","first-page":"79","volume":"42","author":"MH Elkassaby","year":"1991","unstructured":"Elkassaby MH. Ivermectin uptake and distribution in the plasma and tissue of Sudanese and Mexican patients infected with Onchocerca volvulus. Trop Med Parasitol. 1991;42:79\u201381.","journal-title":"Trop Med Parasitol"},{"key":"618_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1208\/s12248-007-9000-9","volume":"10","author":"A Gonzalez Canga","year":"2008","unstructured":"Gonzalez Canga A, Sahagun Prieto AM, Diez Liebana MJ, Fernandez Martinez N, Sierra Vega M, Garcia Vieitez JJ. The pharmacokinetics and interactions of ivermectin in humans\u2013a mini-review. AAPS J. 2008;10:42\u20136.","journal-title":"AAPS J"},{"key":"618_CR33","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF02215150","volume":"9","author":"PK Lo","year":"1985","unstructured":"Lo PK, Fink DW, Williams JB, Blodinger J. Pharmacokinetic studies of ivermectin: effects of formulation. Vet Res Commun. 1985;9:251\u201368.","journal-title":"Vet Res Commun"},{"key":"618_CR34","doi-asserted-by":"publisher","first-page":"1564","DOI":"10.2460\/ajvr.67.9.1564","volume":"67","author":"CP Cunningham","year":"2006","unstructured":"Cunningham CP, Brown JM, Jacobson GA, Brandon MR, Martinod SR. Evaluation of a covered-rod silicone implant containing ivermectin for long-term prevention of heartworm infection in dogs. Am J Vet Res. 2006;67:1564\u20139.","journal-title":"Am J Vet Res"},{"key":"618_CR35","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/S0378-5173(03)00293-X","volume":"261","author":"H Maeda","year":"2003","unstructured":"Maeda H, Brandon M, Sano A. Design of controlled-release formulation for ivermectin using silicone. Int J Pharm. 2003;261:9\u201319.","journal-title":"Int J Pharm"},{"key":"618_CR36","unstructured":"Members of the Caucus on New and Underused Reproductive Health Technologies. Contraceptive implants. Available in the PATH website \n                    http:\/\/www.path.org\/publications\/files\/RHSC_implants_br.pdf\n                    \n                  , 2012. Accessed 17 Feb 2015."},{"key":"618_CR37","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/j.contraception.2011.02.007","volume":"84","author":"D Hubacher","year":"2011","unstructured":"Hubacher D, Olawo A, Manduku C, Kiarie J. Factors associated with uptake of subdermal contraceptive implants in a young Kenyan population. Contraception. 2011;84:413\u20137.","journal-title":"Contraception"},{"key":"618_CR38","unstructured":"Muchangi J. More Nairobi women prefer implants. In The Star newspaper. Nairobi, Kenya. 2013."},{"key":"618_CR39","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1292\/jvms.10-0424","volume":"73","author":"SM Trailovic","year":"2011","unstructured":"Trailovic SM, Nedeljkovic JT. Central and peripheral neurotoxic effects of ivermectin in rats. J Vet Med Sci. 2011;73:591\u20139.","journal-title":"J Vet Med Sci"},{"key":"618_CR40","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1016\/j.fct.2010.05.043","volume":"48","author":"G Eraslan","year":"2010","unstructured":"Eraslan G, Kanbur M, Liman BC, Cam Y, Karabacak M, Altinordulu S. Comparative pharmacokinetics of some injectable preparations containing ivermectin in dogs. Food Chem Toxicol. 2010;48:2181\u20135.","journal-title":"Food Chem Toxicol"},{"key":"618_CR41","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/BF01839011","volume":"16","author":"EW Scott","year":"1992","unstructured":"Scott EW, McKellar QA. The distribution and some pharmacokinetic parameters of ivermectin in pigs. Vet Res Commun. 1992;16:139\u201346.","journal-title":"Vet Res Commun"},{"key":"618_CR42","volume-title":"Guideline on bioanalytical method validation","author":"EMA","year":"2011","unstructured":"EMA. Guideline on bioanalytical method validation. London: European Medicines Agency; 2011."},{"key":"618_CR43","volume-title":"The biology of the laboratory rabbit","author":"PJ Manning","year":"2014","unstructured":"Manning PJ. The biology of the laboratory rabbit. 2nd ed. 2014.","edition":"2"},{"key":"618_CR44","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1038\/ncomms4136","volume":"5","author":"JT Griffin","year":"2014","unstructured":"Griffin JT, Ferguson NM, Ghani AC. Estimates of the changing age-burden of Plasmodium falciparum malaria disease in sub-Saharan Africa. Nat Commun. 2014;5:3136.","journal-title":"Nat Commun"},{"key":"618_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.ijantimicag.2007.08.023","volume":"31","author":"S Omura","year":"2008","unstructured":"Omura S. Ivermectin: 25\u00a0years and still going strong. Int J Antimicrob Agents. 2008;31:91\u20138.","journal-title":"Int J Antimicrob Agents"},{"key":"618_CR46","first-page":"562","volume":"82","author":"R Speare","year":"2004","unstructured":"Speare R, Durrheim D. Mass treatment with ivermectin: an underutilized public health strategy. Bull World Health Organ. 2004;82:562.","journal-title":"Bull World Health Organ"},{"key":"618_CR47","first-page":"256","volume":"43","author":"DC Chavasse","year":"1992","unstructured":"Chavasse DC, Post RJ, Lemoh PA, Whitworth JA. The effect of repeated doses of ivermectin on adult female Onchocerca volvulus in Sierra Leone. Trop Med Parasitol. 1992;43:256\u201362.","journal-title":"Trop Med Parasitol"},{"key":"618_CR48","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1007\/s002280050131","volume":"50","author":"OZ Baraka","year":"1996","unstructured":"Baraka OZ, Mahmoud BM, Marschke CK, Geary TG, Homeida MM, Williams JF. Ivermectin distribution in the plasma and tissues of patients infected with Onchocerca volvulus. Eur J Clin Pharmacol. 1996;50:407\u201310.","journal-title":"Eur J Clin Pharmacol"},{"key":"618_CR49","unstructured":"Kobylinski KCP, Alongkot UR, Schuster A, McCardle W, Foy BD, Tarning J, et al. Assessing ivermectin susceptibility of Greater Mekong Subregion malaria vectors. Poster session Annual meeting of the American Society of Tropical Medicine and Hygiene; 2014 Nov 2\u20136; New Orleans."},{"key":"618_CR50","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1603\/ME11164","volume":"49","author":"KM Deus","year":"2012","unstructured":"Deus KM, Saavedra-Rodriguez K, Butters MP, Black WCT, Foy BD. The effect of ivermectin in seven strains of Aedes aegypti (Diptera: Culicidae) including a genetically diverse laboratory strain and three permethrin resistant strains. J Med Entomol. 2012;49:356\u201363.","journal-title":"J Med Entomol"},{"key":"618_CR51","volume-title":"Malaria transmission blocking vaccines: An ideal public good","author":"WHO","year":"2000","unstructured":"WHO. Malaria transmission blocking vaccines: An ideal public good. Geneva: World Health Organization; 2000."}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0618-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12936-015-0618-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0618-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0618-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T18:39:55Z","timestamp":1553625595000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-015-0618-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,5]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["618"],"URL":"https:\/\/doi.org\/10.1186\/s12936-015-0618-2","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,5]]},"assertion":[{"value":"4 December 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 March 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"102"}}