{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:27:41Z","timestamp":1780471661541,"version":"3.54.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2015,5,15]],"date-time":"2015-05-15T00:00:00Z","timestamp":1431648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["A115501"],"award-info":[{"award-number":["A115501"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/s12936-015-0714-3","type":"journal-article","created":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T23:38:52Z","timestamp":1431560332000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["An assessment of the supply, programmatic use, and regulatory issues of single low-dose primaquine as a Plasmodium falciparum gametocytocide for sub-Saharan Africa"],"prefix":"10.1186","volume":"14","author":[{"given":"Ingrid","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenie","family":"Poirot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepika","family":"Kandula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimee","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roly","family":"Gosling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,5,15]]},"reference":[{"key":"714_CR1","unstructured":"WHO. World Malaria Report 2014. World Health Organization, Geneva"},{"key":"714_CR2","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/1475-2875-11-418","volume":"11","author":"NJ White","year":"2012","unstructured":"White NJ, Qiao LG, Qi G, Luzzatto L. Rationale for recommending a lower dose of primaquine as a Plasmodium falciparum gametocytocide in populations where G6PD deficiency is common. Malar J. 2012;11:418.","journal-title":"Malar J"},{"key":"714_CR3","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.ejmech.2008.08.011","volume":"44","author":"N Vale","year":"2009","unstructured":"Vale N, Moriera R, Gomes P. Primaquine revisited six years after its discovery. Eur J Med Chem. 2009;44:937\u201353.","journal-title":"Eur J Med Chem"},{"key":"714_CR4","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/S0140-6736(13)60310-4","volume":"382","author":"C Cotter","year":"2013","unstructured":"Cotter C, Sturrock HJ, Hsiang MS, Liu J, Phillips AA, Hwang J, et al. The changing epidemiology of malaria elimination: new strategies for new challenges. Lancet. 2013;382:900\u201311.","journal-title":"Lancet"},{"key":"714_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/S1473-3099(12)70198-6","volume":"13","author":"NJ White","year":"2013","unstructured":"White NJ. Primaquine to prevent transmission of falciparum malaria. Lancet. 2013;13:175\u201381.","journal-title":"Lancet"},{"key":"714_CR6","unstructured":"WHO and Global Malaria Programme: Updated WHO Policy Recommendation (October 2012). Single dose Primaquine as a gametocytocide in Plasmodium falciparum malaria. [\n                    http:\/\/www.who.int\/malaria\/pq_updated_policy_recommendation_en_102012.pdf\n                    \n                  ]"},{"key":"714_CR7","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1586\/17512433.2014.948421","volume":"7","author":"IT Chen","year":"2014","unstructured":"Chen IT, Gosling R. Targeting Plasmodium falciparum with primaquine: same efficacy, improved safety with a lower dose? Expert Rev Clin Pharm. 2014;7:681\u20136.","journal-title":"Expert Rev Clin Pharm"},{"key":"714_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1186\/1475-2875-11-360","volume":"11","author":"AC Eziefula","year":"2012","unstructured":"Eziefula AC, Gosling R, Hwang J, Hsiang MS, Bousema T, von Seidlein L, et al. Rationale for short course primaquine in Africa to interrupt malaria transmission. Malar J. 2012;11:360.","journal-title":"Malar J"},{"key":"714_CR9","volume-title":"Implementation of Low Dose Primaquine as a Gametocytocide in sub-Saharan Africa","author":"M Newman","year":"2013","unstructured":"Newman M, Rooney L, Kandula D, Shah R, Hwang J, Cohen J, et al. Implementation of Low Dose Primaquine as a Gametocytocide in sub-Saharan Africa. 2013. \n                    http:\/\/globalhealthsciences.ucsf.edu\/sites\/default\/files\/content\/ghg\/mei-primaquine-report.pdf\n                    \n                  ."},{"key":"714_CR10","unstructured":"Guideline on Submission of Documentation for Prequalification of Multisource (generic) Finished Pharmaceutical Products (FPPs) approved by Stringent Regulatory Authorities (SRAs) [\n                    http:\/\/apps.who.int\/prequal\/info_applicants\/Guidelines\/PQProcGenericSRA_July2011.pdf\n                    \n                  ]"},{"key":"714_CR11","unstructured":"Drug Master Files (DMFs) [\n                    http:\/\/www.fda.gov\/Drugs\/DevelopmentApprovalProcess\/FormsSubmissionRequirements\/DrugMasterFilesDMFs\/UCM2007046#dmffiles\n                    \n                  ]"},{"key":"714_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1191\/1478088706qp063oa","volume":"3","author":"V Braun","year":"2006","unstructured":"Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol. 2006;3:77\u2013101.","journal-title":"Qual Res Psychol"},{"key":"714_CR13","doi-asserted-by":"publisher","first-page":"74","DOI":"10.2471\/BLT.14.139113","volume":"93","author":"DJ Hayes","year":"2015","unstructured":"Hayes DJ, Buuren S, ter Kuile F, Stasinopoulos DM, Rigby RA, Terlouw A. Developing regional weight-for-age growth references for malaria-endemic countries to optimize age-based dosing of antimalarials. Bull World Health Organ. 2015;93:74\u201383.","journal-title":"Bull World Health Organ"},{"key":"714_CR14","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1002\/jps.23006","volume":"101","author":"A Nair","year":"2012","unstructured":"Nair A, Abrahamsson B, Barends DM, Groot DW, Kopp S, Polli JE, et al. Biowaiver monographs for immediate-release solid oral dosage forms: primaquine phosphate. J Pharm Sci. 2012;101:936\u201345.","journal-title":"J Pharm Sci"},{"key":"714_CR15","unstructured":"Single Low-dose Primaquine to Interrupt P. falciparum Transmission in Africa: A Roadmap Update. Meeting Summary. [\n                    http:\/\/globalhealthsciences.ucsf.edu\/sites\/default\/files\/content\/ghg\/mei-london-pq-summary.pdf\n                    \n                  ]"},{"key":"714_CR16","unstructured":"Global Report. UNAIDS report on the global AIDS epidemic 2013. [\n                    http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/UNAIDS_Global_Report_2013_en_1.pdf\n                    \n                  ]"},{"issue":"Suppl 7A","key":"714_CR17","doi-asserted-by":"publisher","first-page":"27S","DOI":"10.1016\/j.amjmed.2003.12.010","volume":"116","author":"PS Belperio","year":"2004","unstructured":"Belperio PS, Rhew DC. Prevalence and outcomes of anemia in individuals with human immunodeficiency virus: a systematic review of the literature. Am J Med. 2004;116(Suppl 7A):27S\u201343.","journal-title":"Am J Med"},{"key":"714_CR18","first-page":"CD008846","volume":"12","author":"E Poirot","year":"2013","unstructured":"Poirot E, Skarbinski J, Sinclair D, Kachur SP, Slutsker L, Hwang J. Mass drug administration for malaria. Cochrane Database Syst Rev. 2013;12:CD008846.","journal-title":"Cochrane Database Syst Rev"},{"key":"714_CR19","doi-asserted-by":"publisher","first-page":"e1001339","DOI":"10.1371\/journal.pmed.1001339","volume":"9","author":"RE Howes","year":"2012","unstructured":"Howes RE, Piel FB, Patil AP, Nyangiri OA, Gething PW, Dewi M, et al. G6PD deficiency prevalence and estimates of affected populations in malaria endemic countries: a geostatistical model-based map. PLoS Med. 2012;9:e1001339.","journal-title":"PLoS Med"},{"key":"714_CR20","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1475-2875-12-112","volume":"12","author":"L von Seidlein","year":"2013","unstructured":"von Seidlein L, Auburn S, Espino F, Shanks D, Cheng Q, McCarthy J, et al. Review of key knowledge gaps in glucose-6-phosphate dehydrogenase deficiency detection with regard to the safe clinical deployment of 8-aminoquinoline treatment regimens: a workshop report. Malar J. 2013;12:112.","journal-title":"Malar J"},{"key":"714_CR21","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1073\/pnas.48.1.9","volume":"48","author":"E Beutler","year":"1962","unstructured":"Beutler E, Yeh M, Fairbanks VF. The normal human female as a mosaic of X-chromosome activity: studies using the gene for G-6-PD-deficiency as a marker. Proc Natl Acad Sci U S A. 1962;48:9\u201316.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"714_CR22","unstructured":"World Health Organization Invitations for Expressions of Interest (EOIs) [\n                    http:\/\/apps.who.int\/prequal\/info_applicants\/info_for_applicants_EOIs.htm\n                    \n                  ]"},{"key":"714_CR23","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1475-2875-12-79","volume":"12","author":"AB Tiono","year":"2013","unstructured":"Tiono AB, Ou\u00e9draogo A, Ogutu B, Diarra A, Coulibaly S, Gansan\u00e9 A, et al. A controlled, parallel, cluster-randomized trial of community-wide screening and treatment of asymptomatic carriers of Plasmodium falciparum in Burkina Faso. Malar J. 2013;12:79.","journal-title":"Malar J"},{"key":"714_CR24","doi-asserted-by":"crossref","unstructured":"Cook J, Xu W, Msellem M, Vonk M, Bergstr\u00f6m B, Gosling R, et al. Mass screening and treatment on the basis of results of a Plasmodium falciparum-specific rapid diagnostic test did not reduce malaria incidence in Zanzibar. J Infect Dis. 2014;pii: jiu655. [Epub ahead of print]","DOI":"10.1093\/infdis\/jiu655"},{"key":"714_CR25","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1186\/1475-2875-12-221","volume":"12","author":"JF Mosha","year":"2013","unstructured":"Mosha JF, Sturrock HJ, Greenhouse B, Greenwood B, Sutherland CJ, Gadalla N, et al. Epidemiology of subpatent Plasmodium falciparum infection: implications for detection of hotspots with imperfect diagnostics. Malar J. 2013;12:221.","journal-title":"Malar J"},{"key":"714_CR26","doi-asserted-by":"publisher","first-page":"e37166","DOI":"10.1371\/journal.pone.0037166","volume":"7","author":"RJ Maude","year":"2012","unstructured":"Maude RJ, Socheat D, Nguon C, Saroth P, Dara P, Li G, et al. Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance. PLoS One. 2012;7:e37166.","journal-title":"PLoS One"},{"key":"714_CR27","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1186\/1475-2875-13-418","volume":"13","author":"EA Ashley","year":"2014","unstructured":"Ashley EA, Recht J, White NJ. Primaquine: the risks and the benefits. Malar J. 2014;13:418.","journal-title":"Malar J"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0714-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12936-015-0714-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0714-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-015-0714-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,15]],"date-time":"2020-05-15T07:28:51Z","timestamp":1589527731000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-015-0714-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,15]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["714"],"URL":"https:\/\/doi.org\/10.1186\/s12936-015-0714-3","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,15]]},"assertion":[{"value":"4 February 2015","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 May 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"204"}}