{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:01:52Z","timestamp":1793638912968,"version":"4.5.1"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"1","funder":[{"name":"THRiVE consortium funded by Wellcometrust","award":["087540"],"award-info":[{"award-number":["087540"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1186\/s12936-016-1387-2","type":"journal-article","created":{"date-parts":[[2016,6,24]],"date-time":"2016-06-24T01:44:38Z","timestamp":1466732678000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Molecular monitoring of Plasmodium falciparum super-resistance to sulfadoxine\u2013pyrimethamine in Tanzania"],"prefix":"10.1186","volume":"15","author":[{"given":"Reginald A.","family":"Kavishe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Kaaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidsel","family":"Nag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Krogsgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Ginsbak","family":"Notland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adellaida A.","family":"Kavishe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deus","family":"Ishengoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cally","family":"Roper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alifrangis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,6,23]]},"reference":[{"key":"1387_CR1","volume-title":"World Malaria Report, 2008","author":"WHO","year":"2008","unstructured":"WHO. World Malaria Report, 2008. Geneva: World Health Organization; 2008."},{"key":"1387_CR2","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/ncomms1879","volume":"3","author":"M Cairns","year":"2012","unstructured":"Cairns M, Roca-Feltrer A, Garske T, Wilson AL, Diallo D, Milligan PJ, et al. Estimating the potential public health impact of seasonal malaria chemoprevention in African children. Nat Commun. 2012;3:881.","journal-title":"Nat Commun"},{"key":"1387_CR3","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0140-6736(12)60775-2","volume":"380","author":"J Crawley","year":"2012","unstructured":"Crawley J, Sismanidis C, Goodman T, Milligan P. Effect of intermittent preventive treatment for malaria during infancy on serological responses to measles and other vaccines used in the expanded programme on immunization: results from five randomised controlled trials. Lancet. 2012;380:1001\u201310.","journal-title":"Lancet"},{"key":"1387_CR4","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1186\/1475-2875-12-467","volume":"12","author":"RC Tine","year":"2013","unstructured":"Tine RC, Ndiaye P, Ndour CT, Faye B, Ndiaye JL, Sylla K, et al. Acceptability by community health workers in Senegal of combining community case management of malaria and seasonal malaria chemoprevention. Malar J. 2013;12:467.","journal-title":"Malar J"},{"key":"1387_CR5","volume-title":"World Malaria Report","author":"World Health Organization","year":"2015","unstructured":"World Health Organization. World Malaria Report. Geneva: World Health Organization; 2015."},{"key":"1387_CR6","doi-asserted-by":"crossref","first-page":"e12223","DOI":"10.1371\/journal.pone.0012223","volume":"5","author":"L Conteh","year":"2010","unstructured":"Conteh L, Patouillard E, Kweku M, Legood R, Greenwood B, Chandramohan D. Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children. PLoS ONE. 2010;5:e12223.","journal-title":"PLoS ONE"},{"key":"1387_CR7","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1093\/emboj\/17.14.3807","volume":"17","author":"T Triglia","year":"1998","unstructured":"Triglia T, Wang P, Sims PF, Hyde JE, Cowman AF. Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria. EMBO J. 1998;17:3807\u201315.","journal-title":"EMBO J"},{"key":"1387_CR8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0166-6851(89)90173-4","volume":"36","author":"JW Zolg","year":"1989","unstructured":"Zolg JW, Plitt JR, Chen GX, Palmer S. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol Biochem Parasitol. 1989;36:253\u201362.","journal-title":"Mol Biochem Parasitol"},{"key":"1387_CR9","doi-asserted-by":"crossref","first-page":"9109","DOI":"10.1073\/pnas.85.23.9109","volume":"85","author":"AF Cowman","year":"1988","unstructured":"Cowman AF, Morry MJ, Biggs BA, Cross GA, Foote SJ. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc Natl Acad Sci USA. 1988;85:9109\u201313.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1387_CR10","doi-asserted-by":"crossref","first-page":"9114","DOI":"10.1073\/pnas.85.23.9114","volume":"85","author":"DS Peterson","year":"1988","unstructured":"Peterson DS, Walliker D, Wellems TE. Evidence that a point mutation in dihydrofolate reductase-thymidylate synthase confers resistance to pyrimethamine in falciparum malaria. Proc Natl Acad Sci USA. 1988;85:9114\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1387_CR11","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1017\/S0031182011000746","volume":"138","author":"I Naidoo","year":"2011","unstructured":"Naidoo I, Roper C. Drug resistance maps to guide intermittent preventive treatment of malaria in African infants. Parasitology. 2011;138:1469\u201379.","journal-title":"Parasitology"},{"key":"1387_CR12","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.pt.2013.08.002","volume":"29","author":"I Naidoo","year":"2013","unstructured":"Naidoo I, Roper C. Mapping \u2018partially resistant\u2019, \u2018fully resistant\u2019, and \u2018super resistant\u2019 malaria. Trends Parasitol. 2013;29:505\u201315.","journal-title":"Trends Parasitol"},{"key":"1387_CR13","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1432-1033.1994.00397.x","volume":"224","author":"DR Brooks","year":"1994","unstructured":"Brooks DR, Wang P, Read M, Watkins WM, Sims PF, Hyde JE. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem. 1994;224:397\u2013405.","journal-title":"Eur J Biochem"},{"key":"1387_CR14","doi-asserted-by":"crossref","first-page":"7149","DOI":"10.1073\/pnas.91.15.7149","volume":"91","author":"T Triglia","year":"1994","unstructured":"Triglia T, Cowman AF. Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum. Proc Natl Acad Sci USA. 1994;91:7149\u201353.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1387_CR15","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1046\/j.1365-2958.1997.2821646.x","volume":"23","author":"P Wang","year":"1997","unstructured":"Wang P, Read M, Sims PF, Hyde JE. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. Mol Microbiol. 1997;23:979\u201386.","journal-title":"Mol Microbiol"},{"key":"1387_CR16","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1086\/338566","volume":"185","author":"JG Kublin","year":"2002","unstructured":"Kublin JG, Dzinjalamala FK, Kamwendo DD, Malkin EM, Cortese JF, Martino LM, Mukadam RA, Rogerson SJ, Lescano AG, Molyneux ME, Winstanley PA, Chimpeni P, et al. Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. J Infect Dis. 2002;185:380\u20138.","journal-title":"J Infect Dis"},{"key":"1387_CR17","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0035-9203(01)90250-0","volume":"95","author":"SA Omar","year":"2001","unstructured":"Omar SA, Adagu IS, Warhurst DC. Can pretreatment screening for dhps and dhfr point mutations in Plasmodium falciparum infections be used to predict sulfadoxine-pyrimethamine treatment failure? Trans R Soc Trop Med Hyg. 2001;95:315\u20139.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"1387_CR18","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1365-3156.2004.01239.x","volume":"9","author":"SG Staedke","year":"2004","unstructured":"Staedke SG, Sendagire H, Lamola S, Kamya MR, Dorsey G, Rosenthal PJ. Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health. 2004;9:624\u20139.","journal-title":"Trop Med Int Health"},{"key":"1387_CR19","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4269\/ajtmh.2003.69.238","volume":"69","author":"M Alifrangis","year":"2003","unstructured":"Alifrangis M, Lemnge MM, Ronn AM, Segeja MD, Magesa SM, Khalil IF, et al. Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine\/pyrimethamine resistance after introduction of treated bed nets. Am J Trop Med Hyg. 2003;69:238\u201343.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR20","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1475-2875-13-152","volume":"13","author":"SI Matondo","year":"2014","unstructured":"Matondo SI, Temba GS, Kavishe AA, Kauki JS, Kalinga A, van Zwetselaar M, et al. High levels of sulphadoxine-pyrimethamine resistance Pfdhfr-Pfdhps quintuple mutations: a cross sectional survey of six regions in Tanzania. Malar J. 2014;13:152.","journal-title":"Malar J"},{"key":"1387_CR21","volume-title":"Policy recommendation on Intermittent Preventive Treatment during infancy with sulphadoxine-pyrimethamine (SP-IPTi) for Plasmodium falciparum malaria control in Africa","author":"WHO","year":"2010","unstructured":"WHO. Policy recommendation on Intermittent Preventive Treatment during infancy with sulphadoxine-pyrimethamine (SP-IPTi) for Plasmodium falciparum malaria control in Africa. Geneva: World Health Organization; 2010."},{"key":"1387_CR22","doi-asserted-by":"crossref","first-page":"e73073","DOI":"10.1371\/journal.pone.0073073","volume":"8","author":"E Arinaitwe","year":"2013","unstructured":"Arinaitwe E, Ades V, Walakira A, Ninsiima B, Mugagga O, Patil TS, et al. Intermittent preventive therapy with sulfadoxine-pyrimethamine for malaria in pregnancy: a cross-sectional study from Tororo, Uganda. PLoS ONE. 2013;8:e73073.","journal-title":"PLoS ONE"},{"key":"1387_CR23","doi-asserted-by":"crossref","first-page":"9027","DOI":"10.1073\/pnas.0901415106","volume":"106","author":"WE Harrington","year":"2009","unstructured":"Harrington WE, Mutabingwa TK, Muehlenbachs A, Sorensen B, Bolla MC, Fried M, et al. Competitive facilitation of drug-resistant Plasmodium falciparum malaria parasites in pregnant women who receive preventive treatment. Proc Natl Acad Sci USA. 2009;106:9027\u201332.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1387_CR24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/cid\/cir376","volume":"53","author":"WE Harrington","year":"2011","unstructured":"Harrington WE, Mutabingwa TK, Kabyemela E, Fried M, Duffy PE. Intermittent treatment to prevent pregnancy malaria does not confer benefit in an area of widespread drug resistance. Clin Infect Dis. 2011;53:224\u201330.","journal-title":"Clin Infect Dis"},{"key":"1387_CR25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/tmi.12028","volume":"18","author":"JT Lin","year":"2013","unstructured":"Lin JT, Mbewe B, Taylor SM, Luntamo M, Meshnick SR, Ashorn P. Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria. Trop Med Int Health. 2013;18:175\u20138.","journal-title":"Trop Med Int Health"},{"issue":"12","key":"1387_CR26","first-page":"213","volume":"2013","author":"WHO-MPAC","year":"2013","unstructured":"WHO-MPAC. Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of, March 2013 meeting. Malar J. 2013;2013(12):213.","journal-title":"Malar J"},{"key":"1387_CR27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.4269\/ajtmh.2009.80.523","volume":"80","author":"M Alifrangis","year":"2009","unstructured":"Alifrangis M, Lusingu JP, Mmbando B, Dalgaard MB, Vestergaard LS, Ishengoma D, et al. Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene. Am J Trop Med Hyg. 2009;80:523\u20137.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR28","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1186\/s12936-015-0909-7","volume":"14","author":"V Braun","year":"2015","unstructured":"Braun V, Rempis E, Schnack A, Decker S, Rubaihayo J, Tumwesigye NM, et al. Lack of effect of intermittent preventive treatment for malaria in pregnancy and intense drug resistance in western Uganda. Malar J. 2015;14:372.","journal-title":"Malar J"},{"key":"1387_CR29","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1093\/infdis\/jiu836","volume":"211","author":"J Gutman","year":"2015","unstructured":"Gutman J, Kalilani L, Taylor S, Zhou Z, Wiegand RE, Thwai KL, et al. The A581G Mutation in the gene encoding Plasmodium falciparum dihydropteroate synthetase reduces the effectiveness of sulfadoxine-pyrimethamine preventive therapy in malawian pregnant women. J Infect Dis. 2015;211:1997\u20132005.","journal-title":"J Infect Dis"},{"key":"1387_CR30","doi-asserted-by":"crossref","first-page":"e56183","DOI":"10.1371\/journal.pone.0056183","volume":"8","author":"WE Harrington","year":"2013","unstructured":"Harrington WE, Morrison R, Fried M, Duffy PE. Intermittent preventive treatment in pregnant women is associated with increased risk of severe malaria in their offspring. PLoS ONE. 2013;8:e56183.","journal-title":"PLoS ONE"},{"key":"1387_CR31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3201\/eid1909.130133","volume":"19","author":"DT Minja","year":"2013","unstructured":"Minja DT, Schmiegelow C, Mmbando B, Bostrom S, Oesterholt M, Magistrado P, et al. Plasmodium falciparum mutant haplotype infection during pregnancy associated with reduced birthweight, Tanzania. Emerg Infect Dis. 2013;19:9.","journal-title":"Emerg Infect Dis"},{"key":"1387_CR32","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1111\/tmi.12595","volume":"20","author":"RM Chico","year":"2015","unstructured":"Chico RM, Cano J, Ariti C, Collier TJ, Chandramohan D, Roper C, et al. Influence of malaria transmission intensity and the 581G mutation on the efficacy of intermittent preventive treatment in pregnancy: systematic review and meta-analysis. Trop Med Int Health. 2015;20:1621\u201333.","journal-title":"Trop Med Int Health"},{"key":"1387_CR33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1186\/1475-2875-12-415","volume":"12","author":"A Mohammed","year":"2013","unstructured":"Mohammed A, Ndaro A, Kalinga A, Manjurano A, Mosha JF, Mosha DF, et al. Trends in chloroquine resistance marker, Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania. Malar J. 2013;12:415.","journal-title":"Malar J"},{"key":"1387_CR34","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/mp.51.4.215","volume":"51","author":"JM Polski","year":"1998","unstructured":"Polski JM, Kimzey S, Percival RW, Grosso LE. Rapid and effective processing of blood specimens for diagnostic PCR using filter paper and Chelex-100. Mol Pathol. 1998;51:215\u20137.","journal-title":"Mol Pathol"},{"key":"1387_CR35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.4269\/ajtmh.2005.72.155","volume":"72","author":"M Alifrangis","year":"2005","unstructured":"Alifrangis M, Enosse S, Pearce R, Drakeley C, Roper C, Khalil IF, et al. A simple, high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum chloroquine resistance transporter genes using polymerase chain reaction- and enzyme-linked immunosorbent assay-based technology. Am J Trop Med Hyg. 2005;72:155\u201362.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR36","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1046\/j.1365-3156.1997.d01-189.x","volume":"2","author":"T Jelinek","year":"1997","unstructured":"Jelinek T, Ronn AM, Curtis J, Duraisingh MT, Lemnge MM, Mhina J, et al. High prevalence of mutations in the dihydrofolate reductase gene of Plasmodium falciparum in isolates from Tanzania without evidence of an association to clinical sulfadoxine\/pyrimethamine resistance. Trop Med Int Health. 1997;2:1075\u20139.","journal-title":"Trop Med Int Health."},{"key":"1387_CR37","unstructured":"University of Mayland School of Medicine. PCR-allele-specific restriction analysis (ASRA): Protocols for Plasmodium falciparum drug resistance mutation analyses. University of Mayland 2002. Accessed 5 Oct 2013."},{"key":"1387_CR38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0035-9203(96)90129-7","volume":"90","author":"AM Ronn","year":"1996","unstructured":"Ronn AM, Msangeni HA, Mhina J, Wernsdorfer WH, Bygbjerg IC. High level of resistance of Plasmodium falciparum to sulfadoxine-pyrimethamine in children in Tanzania. Trans R Soc Trop Med Hyg. 1996;90:179\u201381.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"1387_CR39","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0035-9203(57)90039-1","volume":"51","author":"DF Clyde","year":"1957","unstructured":"Clyde DF, Shute GT. Resistance of Plasmodium falciparum in Tanganyika to pyrimethamine administered at weekly intervals. Trans R Soc Trop Med Hyg. 1957;51:505\u201313.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"1387_CR40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1471-4922(01)02067-0","volume":"17","author":"J Taverne","year":"2001","unstructured":"Taverne J. Tanzania phases out chloroquine for the treatment of malaria. Trends Parasitol. 2001;17:360.","journal-title":"Trends Parasitol"},{"key":"1387_CR41","doi-asserted-by":"crossref","first-page":"696","DOI":"10.4269\/ajtmh.2004.71.696","volume":"71","author":"K Mugittu","year":"2004","unstructured":"Mugittu K, Ndejembi M, Malisa A, Lemnge M, Premji Z, Mwita A, et al. Therapeutic efficacy of sulfadoxine-pyrimethamine and prevalence of resistance markers in Tanzania prior to revision of malaria treatment policy: Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase mutations in monitoring in vivo resistance. Am J Trop Med Hyg. 2004;71:696\u2013702.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR42","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1475-2875-7-4","volume":"7","author":"JD Njau","year":"2008","unstructured":"Njau JD, Goodman CA, Kachur SP, Mulligan J, Munkondya JS, McHomvu N, et al. The costs of introducing artemisinin-based combination therapy: evidence from district-wide implementation in rural Tanzania. Malar J. 2008;7:4.","journal-title":"Malar J"},{"key":"1387_CR43","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1475-2875-11-134","volume":"11","author":"NC Iriemenam","year":"2012","unstructured":"Iriemenam NC, Shah M, Gatei W, van Eijk AM, Ayisi J, Kariuki S, et al. Temporal trends of sulphadoxine-pyrimethamine (SP) drug-resistance molecular markers in Plasmodium falciparum parasites from pregnant women in western Kenya. Malar J. 2012;11:134.","journal-title":"Malar J"},{"key":"1387_CR44","doi-asserted-by":"crossref","first-page":"788","DOI":"10.4269\/ajtmh.2010.09-0401","volume":"82","author":"J Raman","year":"2010","unstructured":"Raman J, Little F, Roper C, Kleinschmidt I, Cassam Y, Maharaj R, et al. Five years of large-scale dhfr and dhps mutation surveillance following the phased implementation of artesunate plus sulfadoxine-pyrimethamine in Maputo Province, Southern Mozambique. Am J Trop Med Hyg. 2010;82:788\u201394.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR45","doi-asserted-by":"crossref","first-page":"755","DOI":"10.4269\/ajtmh.2010.825editorial","volume":"82","author":"JM Vinetz","year":"2010","unstructured":"Vinetz JM. Intermittent preventive treatment for malaria in sub-Saharan Africa: a halfway technology or a critical intervention? Am J Trop Med Hyg. 2010;82:755\u20136.","journal-title":"Am J Trop Med Hyg"},{"key":"1387_CR46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1475-2875-6-2","volume":"6","author":"M Sch\u00f6nfeld","year":"2007","unstructured":"Sch\u00f6nfeld M, Barreto MI, Schunk M, Maduhu I, Maboko L, Hoelscher M, et al. Molecular surveillance of drug-resistance associated mutations of Plasmodium falciparum in south-west Tanzania. Malar J. 2007;6:2.","journal-title":"Malar J"},{"key":"1387_CR47","doi-asserted-by":"crossref","first-page":"e4569","DOI":"10.1371\/journal.pone.0004569","volume":"4","author":"S Gesase","year":"2009","unstructured":"Gesase S, Gosling RD, Hashim R, Ord R, Naidoo I, Madebe R, et al. High resistance of Plasmodium falciparum to sulphadoxine\/pyrimethamine in northern Tanzania and the emergence of dhps resistance mutation at Codon 581. PLoS ONE. 2009;4:e4569.","journal-title":"PLoS ONE"},{"key":"1387_CR48","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1186\/1475-2875-13-264","volume":"13","author":"RA Kavishe","year":"2014","unstructured":"Kavishe RA, Paulo P, Kaaya RD, Kalinga A, van Zwetselaar M, Chilongola J, et al. Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania. Malar J. 2014;13:264.","journal-title":"Malar J"},{"key":"1387_CR49","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1086\/504269","volume":"193","author":"M Alifrangis","year":"2006","unstructured":"Alifrangis M, Dalgaard MB, Lusingu JP, Vestergaard LS, Staalsoe T, Jensen AT, et al. Occurrence of the Southeast Asian\/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania. J Infect Dis. 2006;193:1738\u201341.","journal-title":"J Infect Dis"},{"key":"1387_CR50","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1186\/1475-2875-12-397","volume":"12","author":"DK Pindolia","year":"2013","unstructured":"Pindolia DK, Garcia AJ, Huang Z, Smith DL, Alegana VA, Noor AM, et al. The demographics of human and malaria movement and migration patterns in East Africa. Malar J. 2013;12:397.","journal-title":"Malar J"},{"key":"1387_CR51","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/1475-2875-13-250","volume":"13","author":"DW Juma","year":"2014","unstructured":"Juma DW, Omondi AA, Ingasia L, Opot B, Cheruiyot A, Yeda R, et al. Trends in drug resistance codons in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase genes in Kenyan parasites from 2008 to 2012. Malar J. 2014;13:250.","journal-title":"Malar J"},{"key":"1387_CR52","doi-asserted-by":"crossref","first-page":"5475","DOI":"10.1128\/AAC.00507-15","volume":"59","author":"AK Mbonye","year":"2015","unstructured":"Mbonye AK, Birungi J, Yanow SK, Shokoples S, Malamba S, Alifrangis M, et al. Prevalence of Plasmodium falciparum resistance markers to sulfadoxine-pyrimethamine among pregnant women receiving intermittent preventive treatment for malaria in Uganda. Antimicrob Agents Chemother. 2015;59:5475\u201382.","journal-title":"Antimicrob Agents Chemother"},{"key":"1387_CR53","doi-asserted-by":"crossref","first-page":"e1000830","DOI":"10.1371\/journal.ppat.1000830","volume":"6","author":"S Vinayak","year":"2010","unstructured":"Vinayak S, Alam MT, Mixson-Hayden T, McCollum AM, Sem R, Shah NK, et al. Origin and evolution of sulfadoxine resistant Plasmodium falciparum. PLoS Pathog. 2010;6:e1000830.","journal-title":"PLoS Pathog"},{"key":"1387_CR54","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/1475-2875-13-252","volume":"13","author":"B Chipwaza","year":"2014","unstructured":"Chipwaza B, Mugasa JP, Mayumana I, Amuri M, Makungu C, Gwakisa PS. Self-medication with anti-malarials is a common practice in rural communities of Kilosa district in Tanzania despite the reported decline of malaria. Malar J. 2014;13:252.","journal-title":"Malar J"},{"key":"1387_CR55","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1475-2875-10-238","volume":"10","author":"FM Ringsted","year":"2011","unstructured":"Ringsted FM, Massawe IS, Lemnge MM, Bygbjerg IC. Saleability of anti-malarials in private drug shops in Muheza, Tanzania: a baseline study in an era of assumed artemisinin combination therapy (ACT). Malar J. 2011;10:238.","journal-title":"Malar J"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-016-1387-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:26:41Z","timestamp":1568075201000},"score":1,"resource":{"primary":{"URL":"http:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-016-1387-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,23]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["1387"],"URL":"https:\/\/doi.org\/10.1186\/s12936-016-1387-2","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,23]]},"article-number":"335"}}