{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:30:42Z","timestamp":1792272642378,"version":"4.4.0"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,4,4]],"date-time":"2018-04-04T00:00:00Z","timestamp":1522800000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001724","name":"International Foundation for Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001724","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1186\/s12936-018-2283-8","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T11:01:53Z","timestamp":1524135713000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Isobolographic analysis of co-administration of two plant-derived antiplasmodial drug candidates, cryptolepine and xylopic acid, in Plasmodium berghei"],"prefix":"10.1186","volume":"17","author":[{"given":"Elvis O.","family":"Ameyaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodwo B.","family":"Asmah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert P.","family":"Biney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac T.","family":"Henneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phyllis","family":"Owusu-Agyei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Prah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold D.","family":"Forkuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,4]]},"reference":[{"key":"2283_CR1","volume-title":"World malaria report 2015","author":"WHO","year":"2016","unstructured":"WHO. World malaria report 2015. Geneva: World Health Organization; 2016."},{"key":"2283_CR2","volume-title":"World malaria report 2014","author":"WHO","year":"2015","unstructured":"WHO. World malaria report 2014. Geneva: World Health Organization; 2015."},{"key":"2283_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2013\/356107","volume":"2013","author":"JN Boampong","year":"2013","unstructured":"Boampong JN, Ameyaw EO, Aboagye B, Asare K, Kyei S, Donfack JH, et al. The curative and prophylactic effects of xylopic acid on Plasmodium berghei infection in mice. J Parasitol Res. 2013;2013:1\u20137.","journal-title":"J Parasitol Res"},{"key":"2283_CR4","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1093\/toxsci\/70.2.245","volume":"70","author":"C Ansah","year":"2002","unstructured":"Ansah C, Gooderham NJ. The popular herbal antimalarial, extract of Cryptolepis sanguinolenta, is potently cytotoxic. Toxicol Sci. 2002;70:245\u201351.","journal-title":"Toxicol Sci"},{"key":"2283_CR5","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1021\/jm9704816","volume":"41","author":"DE Bierer","year":"1998","unstructured":"Bierer DE, Fort DM, Mendez CD, Luo J, Imbach PA, Dubenko LG, et al. Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities. J Med Chem. 1998;41:894\u2013901.","journal-title":"J Med Chem"},{"key":"2283_CR6","doi-asserted-by":"publisher","first-page":"263","DOI":"10.5455\/jice.20160606124435","volume":"5","author":"EO Ameyaw","year":"2016","unstructured":"Ameyaw EO, Koffuor GA, Asare KK, Konja D, Du-bois A, Kyei S, et al. Cryptolepine, an indoloquinoline alkaloid, in the management of diabetes mellitus and its associated complications. J Intercult Ethnopharmacol. 2016;5:263.","journal-title":"J Intercult Ethnopharmacol"},{"key":"2283_CR7","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1002\/ptr.2794","volume":"23","author":"OA Olajide","year":"2009","unstructured":"Olajide OA, Ajayi AM, Wright CW. Anti-inflammatory properties of cryptolepine. Phytother Res. 2009;23:1421\u20135.","journal-title":"Phytother Res."},{"key":"2283_CR8","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1002\/jps.2600681212","volume":"68","author":"K Boakye-Yiadom","year":"1979","unstructured":"Boakye-Yiadom K, Heman-Ackah SM. Cryptolepine hydrochloride effect on Staphylococcus aureus. J Pharm Sci. 1979;68:1510\u20134.","journal-title":"J Pharm Sci"},{"key":"2283_CR9","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1021\/np9605246","volume":"60","author":"K Cimanga","year":"1997","unstructured":"Cimanga K, De Bruyne T, Pieters L, Vlietinck AJ, Turger CA. In vitro and in vivo antiplasmodial activity of cryptolepine and related alkaloids from Cryptolepis sanguinolenta. J Nat Prod. 1997;60:688\u201391.","journal-title":"J Nat Prod"},{"key":"2283_CR10","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1002\/ptr.2650090510","volume":"9","author":"G Kirby","year":"1995","unstructured":"Kirby G, Paine A, Warhurst D, Noamese B, Phillipson J. In vitro and in vivo antimalarial activity of cryptolepine: a plant-derived indoloquinoline. Phytother Res. 1995;9:359\u201363.","journal-title":"Phytother Res."},{"key":"2283_CR11","first-page":"551","volume":"27","author":"JO Santos de","year":"2015","unstructured":"de Santos JO, Pereira GR, Brand\u00e3o GC, Borgati TF, Arantes LM, Paula RC, et al. Synthesis, in vitro antimalarial activity and in silico studies of hybrid kauranoid 1,2,3-triazoles derived from naturally occurring diterpenes. J Braz Chem Soc. 2015;27:551\u201365.","journal-title":"J Braz Chem Soc"},{"key":"2283_CR12","doi-asserted-by":"publisher","first-page":"291","DOI":"10.4103\/0975-7406.103251","volume":"4","author":"E Woode","year":"2012","unstructured":"Woode E, Ameyaw EO, Boakye-Gyasi E, Abotsi WK. Analgesic effects of an ethanol extract of the fruits of Xylopia aethiopica (Dunal) A. Rich (Annonaceae) and the major constituent, xylopic acid in murine models. J Pharm Bioallied Sci. 2012;4:291.","journal-title":"J Pharm Bioallied Sci"},{"key":"2283_CR13","doi-asserted-by":"publisher","first-page":"172","DOI":"10.4103\/0974-8490.129041","volume":"6","author":"EO Ameyaw","year":"2014","unstructured":"Ameyaw EO, Woode E, Boakye-Gyasi E, Abotsi WK, Kyekyeku JO, Adosraku RK. Anti-allodynic and anti-hyperalgesic effects of an ethanolic extract and xylopic acid from the fruits of Xylopia aethiopica in murine models of neuropathic pain. Pharmacognosy Res. 2014;6:172.","journal-title":"Pharmacognosy Res."},{"key":"2283_CR14","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.jep.2016.02.023","volume":"184","author":"RP Biney","year":"2016","unstructured":"Biney RP, Benneh CK, Ameyaw EO, Boakye-Gyasi E, Woode E. Xylopia aethiopica fruit extract exhibits antidepressant-like effect via interaction with serotonergic neurotransmission in mice. J Ethnopharmacol. 2016;184:49\u201357.","journal-title":"J Ethnopharmacol"},{"key":"2283_CR15","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12936-016-1137-5","volume":"15","author":"AD Forkuo","year":"2016","unstructured":"Forkuo AD, Ansah C, Boadu KM, Boampong JN, Ameyaw EO, Gyan BA, et al. Synergistic anti-malarial action of cryptolepine and artemisinins. Malar J. 2016;15:89.","journal-title":"Malar J."},{"key":"2283_CR16","doi-asserted-by":"publisher","first-page":"263","DOI":"10.4236\/pp.2012.33035","volume":"3","author":"N Kuntworbe","year":"2012","unstructured":"Kuntworbe N, Alany R, Brimble M, Al-Kassas R. Isolation and development of a HPLC method for the detection and quantification of cryptolepine and its application in the determination of the total cryptolepine content in the root powder of Cryptolepis sanguinolenta. Pharmacol Pharm. 2012;3:263\u201374.","journal-title":"Pharmacol Pharm."},{"key":"2283_CR17","doi-asserted-by":"publisher","first-page":"2978","DOI":"10.1080\/13880209.2016.1199040","volume":"54","author":"E Woode","year":"2016","unstructured":"Woode E, Ameyaw EO, Boakye-Gyasi E, Abotsi WK, Oppong Kyekyeku J, Adosraku R, et al. Effects of an ethanol extract and the diterpene, xylopic acid, of Xylopia aethiopica fruits in murine models of musculoskeletal pain. Pharm Biol. 2016;54:2978\u201386.","journal-title":"Pharm Biol."},{"key":"2283_CR18","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2149\/tmh.32.15","volume":"32","author":"A Ishih","year":"2004","unstructured":"Ishih A, Suzuki T, Hasegawa T, Kachi S, Wang H-H, Terada M. In vivo evaluation of combination effects of chloroquine with Cepharanthin\u00ae or minocycline hydrochloride against blood-induced chloroquine-resistant Plasmodium berghei NK 65 infections. Trop Med Health. 2004;32:15\u20139.","journal-title":"Trop Med Health."},{"key":"2283_CR19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1475-2875-13-63","volume":"13","author":"GI Olasehinde","year":"2014","unstructured":"Olasehinde GI, Ojurongbe O, Adeyeba AO, Fagade OE, Valecha N, Ayanda IO, et al. In vitro studies on the sensitivity pattern of Plasmodium falciparum to anti-malarial drugs and local herbal extracts. Malar J. 2014;13:63.","journal-title":"Malar J."},{"key":"2283_CR20","doi-asserted-by":"publisher","first-page":"3187","DOI":"10.1021\/jm010929+","volume":"44","author":"CW Wright","year":"2001","unstructured":"Wright CW, Addae-Kyereme J, Breen AG, Brown JE, Cox MF, Croft SL, et al. Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents. J Med Chem. 2001;44:3187\u201394.","journal-title":"J Med Chem"},{"key":"2283_CR21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.neuropharm.2006.07.025","volume":"52","author":"HF Miranda","year":"2007","unstructured":"Miranda HF, Puig MM, Dursteler C, Prieto JC, Pinardi G. Dexketoprofen-induced antinociception in animal models of acute pain: synergy with morphine and paracetamol. Neuropharmacology. 2007;52:291\u20136.","journal-title":"Neuropharmacology"},{"key":"2283_CR22","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/0024-3205(89)90148-3","volume":"45","author":"RJ Tallarida","year":"1989","unstructured":"Tallarida RJ, Porreca F, Cowan A. Statistical analysis of drug-drug and site-site interactions with isobolograms. Life Sci. 1989;45:947\u201361.","journal-title":"Life Sci"},{"key":"2283_CR23","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.pbb.2007.10.005","volume":"88","author":"HF Miranda","year":"2008","unstructured":"Miranda HF, Prieto JC, Puig MM, Pinardi G. Isobolographic analysis of multimodal analgesia in an animal model of visceral acute pain. Pharmacol Biochem Behav. 2008;88:481\u20136.","journal-title":"Pharmacol Biochem Behav"},{"key":"2283_CR24","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/s12906-016-1098-9","volume":"16","author":"A Kefe","year":"2016","unstructured":"Kefe A, Giday M, Mamo H, Erko B. Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium. BMC Complement Altern Med. 2016;16:118.","journal-title":"BMC Complement Altern Med."},{"key":"2283_CR25","first-page":"279","volume":"44","author":"D Dikasso","year":"2006","unstructured":"Dikasso D, Makonnen E, Debella A, Abebe D, Urga K, Makonnen W, et al. Anti-malarial activity of Withania somnifera L. Dunal extracts in mice. Ethiop Med J. 2006;44:279\u201385.","journal-title":"Ethiop Med J"},{"key":"2283_CR26","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1126\/science.8009217","volume":"264","author":"LH Miller","year":"1994","unstructured":"Miller LH, Good MF, Milon G. Malaria pathogenesis. Science. 1994;264:1878\u201383.","journal-title":"Science"},{"key":"2283_CR27","first-page":"137","volume":"47","author":"C Ansah","year":"2013","unstructured":"Ansah C, Mensah K. A review of the anticancer potential of the antimalarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine. Ghana Med J. 2013;47:137\u201347.","journal-title":"Ghana Med J"},{"key":"2283_CR28","first-page":"288","volume":"5","author":"E Woode","year":"2012","unstructured":"Woode E, Alhassan A, Abaidoo CS. Effect of xylopic acid on sex hormones and spermatogenesis in male rats. Al Ameen J Med Sci. 2012;5:288\u201397.","journal-title":"Al Ameen J Med Sci."}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-018-2283-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12936-018-2283-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-018-2283-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T19:12:14Z","timestamp":1554318734000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-018-2283-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,4]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["2283"],"URL":"https:\/\/doi.org\/10.1186\/s12936-018-2283-8","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,4]]},"assertion":[{"value":"30 July 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 March 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 April 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"153"}}