{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:35:15Z","timestamp":1787020515217,"version":"build-2736575974"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T00:00:00Z","timestamp":1548115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sysmex","award":["Malaria Study"],"award-info":[{"award-number":["Malaria Study"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1186\/s12936-019-2655-8","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T09:53:01Z","timestamp":1548237181000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Evaluation of automated malaria diagnosis using the Sysmex XN-30 analyser in a clinical setting"],"prefix":"10.1186","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0733-2860","authenticated-orcid":false,"given":"Evashin","family":"Pillay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanaz","family":"Khodaiji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda C.","family":"Bezuidenhout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monwabisi","family":"Litshie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8sa L.","family":"Coetzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,22]]},"reference":[{"key":"2655_CR1","unstructured":"WHO. World malaria report 2018. Geneva: World Health Organization; 2018. \n                    http:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2018\/en\/\n                    \n                  . Accessed 22 Nov 2018."},{"key":"2655_CR2","first-page":"4","volume":"61","author":"K Chotivanich","year":"2007","unstructured":"Chotivanich K, Silamut K, Day N. Laboratory diagnosis of malaria infection\u2014a short review of methods. N Z J Med Lab Sci. 2007;61:4\u20137.","journal-title":"N Z J Med Lab Sci."},{"key":"2655_CR3","unstructured":"WHO. Guidelines for the treatment of malaria. 3rd edition. Geneva: World Health Organization; 2015. \n                    http:\/\/www.who.int\/malaria\/publications\/atoz\/9789241549127\/en\/\n                    \n                  . Accessed 14 Nov 2018."},{"key":"2655_CR4","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/1475-2875-5-121","volume":"5","author":"RE Coleman","year":"2006","unstructured":"Coleman RE, Sattabongkot J, Promstaporm S, Maneechai N, Tippayachai B, Kengluecha A, et al. Comparison of PCR and microscopy for the detection of asymptomatic malaria in a Plasmodium falciparum\/vivax endemic area in Thailand. Malar J. 2006;5:121.","journal-title":"Malar J."},{"key":"2655_CR5","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1093\/infdis\/jit184","volume":"208","author":"H Hopkins","year":"2013","unstructured":"Hopkins H, Gonzalez IJ, Polley SD, Angutoko P, Ategeka J, Asiimwe C, et al. Highly sensitive detection of malaria parasitemia in a malaria-endemic setting: performance of a new loop-mediated isothermal amplification kit in a remote clinic in Uganda. J Infect Dis. 2013;208:645\u201352.","journal-title":"J Infect Dis"},{"key":"2655_CR6","unstructured":"WHO. New perspectives: malaria diagnosis\u2014report of a joint WHO\/USAID informal consultation, 25\u201327 October 1999. Geneva: World Health Organization; 2000. \n                    http:\/\/www.who.int\/tdr\/publications\/documents\/malaria-diagnosis.pdf\n                    \n                  . Accessed 26 Oct 2018."},{"key":"2655_CR7","first-page":"CD011431","volume":"12","author":"K Abba","year":"2014","unstructured":"Abba K, Kirkham AJ, Olliaro PL, Deeks JJ, Donegan S, Garner P, et al. Rapid diagnostic tests for diagnosing uncomplicated non-falciparum or Plasmodium vivax malaria in endemic countries. Cochrane Database Syst Rev. 2014;12:CD011431.","journal-title":"Cochrane Database Syst Rev."},{"key":"2655_CR8","first-page":"148","volume-title":"Blood cells: a practical guide","author":"BJ Bain","year":"1995","unstructured":"Bain BJ. Blood cells: a practical guide. 5th ed. London: Academic; 1995. p. 148\u201368.","edition":"5"},{"key":"2655_CR9","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1186\/s12936-018-2386-2","volume":"17","author":"G Sori","year":"2018","unstructured":"Sori G, Zewdie O, Tadele G, Samuel A. External quality assessment of malaria microscopy diagnosis in selected health facilities in Western Oromia, Ethiopia. Malar J. 2018;17:233.","journal-title":"Malar J."},{"key":"2655_CR10","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1128\/JCM.02155-16","volume":"55","author":"Y Eshel","year":"2017","unstructured":"Eshel Y, Houri-Yafin A, Benkuzari H, Lezmy N, Soni M, Charles M, et al. Evaluation of the Parasight platform for malaria diagnosis. J Clin Microbiol. 2017;55:768\u201375.","journal-title":"J Clin Microbiol"},{"key":"2655_CR11","first-page":"CD008998","volume":"4","author":"J Odaga","year":"2014","unstructured":"Odaga J, Sinclair D, Lokong JA, Donegan S, Hopkins H, Garner P. Rapid diagnostic tests versus clinical diagnosis for managing people with fever in malaria endemic settings. Cochrane Database Syst Rev. 2014;4:CD008998.","journal-title":"Cochrane Database Syst Rev."},{"key":"2655_CR12","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1186\/s12936-018-2371-9","volume":"17","author":"U Dalrymple","year":"2018","unstructured":"Dalrymple U, Arambepola R, Gething PW, Cameron E. How long do rapid diagnostic tests remain positive after anti-malarial treatment? Malar J. 2018;17:228.","journal-title":"Malar J."},{"key":"2655_CR13","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S0140-6736(05)74930-8","volume":"353","author":"MP Grobusch","year":"1999","unstructured":"Grobusch MP, Alpermann U, Schwenke S, Jelinek T, Warhurst DC. False-positive rapid tests for malaria in patients with rheumatoid factor. Lancet. 1999;353:297.","journal-title":"Lancet"},{"key":"2655_CR14","unstructured":"WHO. World malaria report 2017. Geneva: World Health Organization; 2017. \n                    http:\/\/www.who.int\/malaria\/publications\/world-malaria-report-2017\/en\/\n                    \n                  . Accessed 6 Nov 2018."},{"key":"2655_CR15","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1128\/CMR.00079-12","volume":"26","author":"B Singh","year":"2013","unstructured":"Singh B, Daneshvar C. Human infections and detection of Plasmodium knowlesi. Clin Microbiol Rev. 2013;26:165\u201384.","journal-title":"Clin Microbiol Rev"},{"key":"2655_CR16","first-page":"EC05-8","volume":"9","author":"A Singh","year":"2015","unstructured":"Singh A, Narang V, Sood N, Garg B, Gupta VK. Malaria diagnosis using automated analysers: a boon for hematopathologists in endemic areas. J Clin Diagn Res. 2015;9:EC05-8.","journal-title":"J Clin Diagn Res."},{"key":"2655_CR17","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1046\/j.1365-2141.1999.01199.x","volume":"104","author":"BV Mendelow","year":"1999","unstructured":"Mendelow BV, Lyons C, Nhlangothi P, Tana M, Munster M, Wypkema E, et al. Automated malaria detection by depolarization of laser light. Br J Haematol. 1999;104:499\u2013503.","journal-title":"Br J Haematol."},{"key":"2655_CR18","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1309\/0PL3C674M39D6GEN","volume":"126","author":"C Briggs","year":"2006","unstructured":"Briggs C, Da Costa A, Freeman L, Aucamp I, Ngubeni B, Machin SJ. Development of an automated malaria discriminant factor using VCS technology. Am J Clin Pathol. 2006;126:691\u20138.","journal-title":"Am J Clin Pathol"},{"key":"2655_CR19","doi-asserted-by":"publisher","first-page":"26","DOI":"10.4103\/0019-5359.103163","volume":"65","author":"S Mohapatra","year":"2011","unstructured":"Mohapatra S, Samantaray JC, Arulselvi S, Panda J, Munot K, Saxena R. Automated detection of malaria with haematology analyzer Sysmex XE-2100. Indian J Med Sci. 2011;65:26\u201331.","journal-title":"Indian J Med Sci"},{"key":"2655_CR20","doi-asserted-by":"publisher","first-page":"658","DOI":"10.5958\/2394-6792.2016.00122.8","volume":"3","author":"K Sunilkumar","year":"2016","unstructured":"Sunilkumar K, Naik P. Usefulness of automated hematology analyzer Sysmex XN 1000 in detection of malaria. Indian J Path Onc. 2016;3:658\u201361.","journal-title":"Indian J Path Onc."},{"key":"2655_CR21","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/S0169-4758(00)01742-7","volume":"16","author":"T H\u00e4nscheid","year":"2000","unstructured":"H\u00e4nscheid T, Valadas E, Grobusch MP. Automated malaria diagnosis using pigment detection. Parasitol Today. 2000;16:549\u201351.","journal-title":"Parasitol Today."},{"key":"2655_CR22","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/1097-0320(20011001)45:2<133::AID-CYTO1155>3.0.CO;2-K","volume":"45","author":"B Kramer","year":"2001","unstructured":"Kramer B, Grobusch MP, Suttorp N, Neukammer J, Rinneberg H. Relative frequency of malaria pigment-carrying monocytes of nonimmune and semi-immune patients from flow cytometric depolarized side scatter. Cytometry. 2001;45:133\u201340.","journal-title":"Cytometry"},{"key":"2655_CR23","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.actatropica.2012.03.005","volume":"123","author":"M Rebelo","year":"2012","unstructured":"Rebelo M, Shapiro HM, Amaral T, Melo-Cristino J, H\u00e4nscheid T. Haemozoin detection in infected erythrocytes for Plasmodium falciparum malaria diagnosis\u2014prospects and limitations. Acta Trop. 2012;123:58\u201361.","journal-title":"Acta Trop"},{"key":"2655_CR24","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s12936-018-2208-6","volume":"17","author":"T Tougan","year":"2018","unstructured":"Tougan T, Suzuki Y, Itagaki S, Izuka M, Toya Y, Uchihashi K, et al. An automated haematology analyzer XN-30 distinguishes developmental stages of falciparum malaria parasite cultured in vitro. Malar J. 2018;17:59.","journal-title":"Malar J."},{"key":"2655_CR25","doi-asserted-by":"publisher","first-page":"1304","DOI":"10.1126\/science.1058040","volume":"291","author":"JC Venter","year":"2001","unstructured":"Venter JC, Adams MD, Myers EW, Li PW, Mural RJ, Sutton GG, et al. The sequence of the human genome. Science. 2001;291:1304\u201351.","journal-title":"Science"},{"key":"2655_CR26","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/nature07327","volume":"455","author":"JM Carlton","year":"2008","unstructured":"Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, et al. Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature. 2008;455:757\u201363.","journal-title":"Nature"},{"key":"2655_CR27","volume-title":"Medical microbiology","author":"JM Crutcher","year":"1996","unstructured":"Crutcher JM, Hoffman SL. Malaria. In: Baron S, editor. Medical microbiology. 4th ed. Galveston: University of Texas medical branch at Galveston; 1996.","edition":"4"},{"key":"2655_CR28","unstructured":"WHO. Microscopy for the detection, identification and quantification of malaria parasites on stained thick and thin blood films in research settings. Geneva: World Health Organization; 2015. \n                    http:\/\/www.who.int\/tdr\/publications\/microscopy_detec_ident_quantif\/en\/\n                    \n                  . Accessed 10 Nov 2018."},{"key":"2655_CR29","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/0035-9203(95)90652-5","volume":"89","author":"VT Hang","year":"1995","unstructured":"Hang VT, Van Be T, Tran PN, Thanh LT, Van Hien L, O\u2019Brien E, et al. Screening donor blood for malaria by polymerase chain reaction. Trans R Soc Trop Med Hyg. 1995;89:44\u20137.","journal-title":"Trans R Soc Trop Med Hyg."},{"issue":"Suppl 1","key":"2655_CR30","first-page":"S49","volume":"29","author":"DA Armbruster","year":"2008","unstructured":"Armbruster DA, Pry T. Limit of blank, limit of detection and limit of quantitation. Clin Biochem Rev. 2008;29(Suppl 1):S49\u201352.","journal-title":"Clin Biochem Rev."},{"key":"2655_CR31","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1186\/s12936-015-0718-z","volume":"14","author":"J Reader","year":"2015","unstructured":"Reader J, Botha M, Theron A, Lauterbach SB, Rossouw C, Engelbrecht D, et al. Nowhere to hide: interrogating different metabolic parameters of Plasmodium falciparum gametocytes in a transmission blocking drug discovery pipeline towards malaria elimination. Malar J. 2015;14:213.","journal-title":"Malar J."},{"issue":"Suppl 1","key":"2655_CR32","first-page":"2097","volume":"130","author":"E Pillay","year":"2017","unstructured":"Pillay E, Litshie M, Coetzer TL. A new era in malaria diagnosis and surveillance using an automated analyzer. Blood. 2017;130(Suppl 1):2097.","journal-title":"Blood"},{"key":"2655_CR33","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12936-018-2313-6","volume":"17","author":"T Tougan","year":"2018","unstructured":"Tougan T, Suzuki Y, Izuka M, Aono K, Okazaki T, Toya Y, et al. Application of the automated haematology analyzer XN-30 in an experimental rodent model of malaria. Malar J. 2018;17:165.","journal-title":"Malar J."},{"key":"2655_CR34","unstructured":"WHO. Evidence review group on low-density malaria infections. Geneva: World Health Organization; 2017. \n                    http:\/\/www.who.int\/malaria\/mpac\/mpac-oct2017-erg-malaria-low-density-infections-session2.pdf\n                    \n                  . Accessed 20 Oct 2018."},{"key":"2655_CR35","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/j.pt.2013.07.005","volume":"29","author":"M Boura","year":"2013","unstructured":"Boura M, Frita R, Gois A, Carvalho T, H\u00e4nscheid T. The hemozoin conundrum: is malaria pigment immune-activating, inhibiting, or simply a bystander? Trends Parasitol. 2013;29:469\u201376.","journal-title":"Trends Parasitol."},{"key":"2655_CR36","unstructured":"WHO. Emergency response to artemisinin resistance in the Greater Mekong subregion. Geneva: World Health Organization; 2013. \n                    http:\/\/www.who.int\/malaria\/publications\/atoz\/9789241505321\/en\/\n                    \n                  . Accessed 28 Oct 2018."},{"key":"2655_CR37","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S1473-3099(17)30048-8","volume":"17","author":"M Imwong","year":"2017","unstructured":"Imwong M, Suwannasin K, Kunasol C, Sutawong K, Mayxay M, Rekol H, et al. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study. Lancet Infect Dis. 2017;17:491\u20137.","journal-title":"Lancet Infect Dis."},{"key":"2655_CR38","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12936-016-1289-3","volume":"15","author":"A Owusu-Ofori","year":"2016","unstructured":"Owusu-Ofori A, Gadzo D, Bates I. Transfusion-transmitted malaria: donor prevalence of parasitaemia and a survey of healthcare workers knowledge and practices in a district hospital in Ghana. Malar J. 2016;15:234.","journal-title":"Malar J."},{"key":"2655_CR39","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tracli.2017.03.002","volume":"24","author":"B Kouriba","year":"2017","unstructured":"Kouriba B, Diarra AB, Douyon I, Diabate DT, Kamissoko F, Guitteye H, et al. Plasmodium falciparum malaria prevalence among blood donors in Bamako, Mali. Transfus Clin Biol. 2017;24:62\u20137.","journal-title":"Transfus Clin Biol."},{"key":"2655_CR40","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1186\/1475-2875-12-465","volume":"12","author":"JRN Nansseu","year":"2013","unstructured":"Nansseu JRN, Noubiap JJN, Ndoula ST, Zeh AFM, Monamele CG. What is the best strategy for the prevention of transfusion\u2013transmitted malaria in sub-Saharan African countries where malaria is endemic? Malar J. 2013;12:465.","journal-title":"Malar J."},{"key":"2655_CR41","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1093\/cid\/cit130","volume":"56","author":"AK Owusu-Ofori","year":"2013","unstructured":"Owusu-Ofori AK, Betson M, Parry CM, Stothard JR, Bates I. Transfusion\u2013transmitted malaria in Ghana. Clin Infect Dis. 2013;56:1735\u201341.","journal-title":"Clin Infect Dis"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-019-2655-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/s12936-019-2655-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-019-2655-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T20:16:03Z","timestamp":1579637763000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-019-2655-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,22]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["2655"],"URL":"https:\/\/doi.org\/10.1186\/s12936-019-2655-8","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,22]]},"assertion":[{"value":"28 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"15"}}