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Dried blood spots (DBS) were collected (n\u2009=\u2009197) and antibody presence against seven <jats:italic>Plasmodium<\/jats:italic> antigens was detected using a multiplex bead-based, IgG antibody assay. Demographic information was gathered through a questionnaire. Country customized cut-off values were generated from a Surinamese malaria-na\u00efve reference population (n\u2009=\u200950).<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Serological analysis for the reference population revealed cut-off values ranging from 14 MFI for LSA-1 to 177 MFI for PmMSP-1<jats:sub>19<\/jats:sub>. Seroprevalence against any of the three MSP-1<jats:sub>19<\/jats:sub> antibodies was similar in both regions and surpassed 75%. Single seropositivity against PfMSP-1<jats:sub>19<\/jats:sub> antibodies was higher in Stoelmanseiland (27.0%) than Benzdorp (9.3%), in line with the historical malaria burden of Stoelmanseiland, while the reverse was observed for PvMSP-1<jats:sub>19<\/jats:sub> antibodies. Despite sporadic reports of <jats:italic>P. malariae<\/jats:italic> infections, PmMSP-1<jats:sub>19<\/jats:sub> antibody presence was 39.6%. A more detailed examination of <jats:italic>P. falciparum<\/jats:italic> serology data displayed a higher seroprevalence in villagers (90.7%) than in Brazilians (64.6%) and a highly diverse antigenic response with 22 distinct antibody combinations.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The results on the malaria antibody signature of Maroon villagers and Brazilian miners living in Suriname displayed a high <jats:italic>Plasmodium<\/jats:italic> seroprevalence, especially for <jats:italic>P. falciparum<\/jats:italic> in villagers, still reflecting the historical malaria burden. The seroprevalence data for both regions and the observed combinations of <jats:italic>P. falciparum<\/jats:italic> antibodies provided a valuable dataset from a historically important region to the international malaria serology knowledge. First insight in malaria serology data for Suriname indicated that the use of other target groups and assessment of age-dependent seroprevalence are required to successfully use malaria serology as tool in the national elimination strategy.<\/jats:p>\n<\/jats:sec>","DOI":"10.1186\/s12936-020-03434-y","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T13:03:14Z","timestamp":1602162194000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Malaria serology data from the Guiana shield: first insight in IgG antibody responses to Plasmodium falciparum, Plasmodium vivax and Plasmodium malariae antigens in Suriname"],"prefix":"10.1186","volume":"19","author":[{"given":"Mergiory Y.","family":"Labadie-Bracho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah T.","family":"van Genderen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2001-9994","authenticated-orcid":false,"given":"Malti R.","family":"Adhin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"key":"3434_CR1","unstructured":"PAHO. 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Ethical approval for this study was received from the national ethics committee from the Ministry of Health in Suriname (Identifier VG 016-16).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"360"}}