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One in three Ghanaians are said to have sickle cell disorders, whereas malaria continues to be one of the leading causes of mortality among children. This study determined the prevalence of sickle cell disorders and malaria infection among children aged 1\u201312\u00a0years in the Volta Region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a community-based cross-sectional survey that involved 938 children aged 1\u201312\u00a0years selected from three districts, one each from the 3 geographical zones of the Volta Region using a multistage sampling method. Demographic information was collected using a standard questionnaire and anthropometric indices were measured. Isoelectric focusing (IEF) electrophoresis was used to determine the Hb genotypes and sub-microscopic parasites were determined by PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of sickling screening positive was 16.0% with an overall prevalence of sickle cell disorders being 2.0%. Among the individual genotypes making up the sickle cell disorders, genotype HbSF was the highest (0.9% as compared to 0.2%; HbSS, 0.6%; HbSC and 0.3%; HbSCF). Microscopic<jats:italic>Plasmodium falciparum<\/jats:italic>parasitaemia was detected among 5.5% of the children and 14.2% sub-microscopic prevalence by PCR. Children with sickle cell disorders were more likely to have sub-microscopic parasitaemia (AOR\u2009=\u20095.51 95%CI (2.15, 14.10),<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) as well as anaemia (AOR\u2009=\u20093.03 95% CI (1.04, 8.82),<jats:italic>p<\/jats:italic>\u2009=\u20090.042), compared to those with normal genotypes. There was no significant difference observed between sickle cell disorders and growth and development of the children screened.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sickle cell disorders were significantly associated with sub-microscopic parasitaemia as well as anaemia in this study. Establishment of sickle cell clinics in the district and regional hospitals will help in the management of children with the disorder and also generate a national database on sickle cell disorders. National neonatal screening policies must also be put in place to help in early detection and management of these disorders.<\/jats:p><\/jats:sec>","DOI":"10.1186\/s12936-020-03500-5","type":"journal-article","created":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T20:03:53Z","timestamp":1606161833000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Prevalence of sickle cell disorders and malaria infection in children aged 1\u201312\u00a0years in the Volta Region, Ghana: a community-based study"],"prefix":"10.1186","volume":"19","author":[{"given":"Mavis","family":"Oppong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Lamptey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Kyei-Baafour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Aculley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer Addo","family":"Ofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Tornyigah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Kweku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Ofori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"3500_CR1","doi-asserted-by":"publisher","first-page":"a011684","DOI":"10.1101\/cshperspect.a011684","volume":"3","author":"BG Forget","year":"2013","unstructured":"Forget BG, Bunn HF. 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Permission was sought from the Regional Health Director as well as Health and Education Directorates of each of the districts. Permission was also sought from the chiefs and elders in the selected communities. A written informed consent was obtained from the parents\/guardians of the participants.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"426"}}