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In Ethiopia, it has several vernacular names including\n                      <jats:italic>Abelbila<\/jats:italic>\n                      ,\n                      <jats:italic>Ashenda<\/jats:italic>\n                      ,\n                      <jats:italic>Amelmela<\/jats:italic>\n                      ,\n                      <jats:italic>Yeznjero Ageda<\/jats:italic>\n                      ,\n                      <jats:italic>Shemetmetie<\/jats:italic>\n                      and\n                      <jats:italic>Yezinjero Ageda<\/jats:italic>\n                      . The plant is endemic to Ethiopian highlands, where its rhizomes are traditionally used for the treatment of malaria, abdominal cramps and wound healing. In the present study, the 80% methanol extract of\n                      <jats:italic>K. foliosa<\/jats:italic>\n                      rhizomes and its constituents are tested against\n                      <jats:italic>Plasmodium berghei<\/jats:italic>\n                      in mice\n                      <jats:bold>.<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Isolation was carried out using column and preparative thin layer chromatography (PTLC). The chemical structures of the compounds were elucidated by spectroscopic methods (ESI\u2013MS, 1D and 2D-NMR). Peters\u2019 4-day suppressive test against\u00a0\n                      <jats:italic>P. berghei\u00a0<\/jats:italic>\n                      in mice was utilized for in vivo anti-malarial evaluation of the test substances.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Two compounds, namely knipholone and dianellin were isolated from the 80% methanolic extract of\n                      <jats:italic>K. foliosa<\/jats:italic>\n                      rhizomes, and characterized. The hydroalcoholic extract (400\u00a0mg\/kg) and knipholone (200\u00a0mg\/kg) showed the highest activity with chemosuppression values of 61.52 and 60.16%, respectively. From the dose\u2013response plot, the median effective (ED\n                      <jats:sub>50<\/jats:sub>\n                      ) doses of knipholone and dianellin were determined to be 81.25 and 92.31\u00a0mg\/kg, respectively. Molecular docking study revealed that knipholone had a strong binding affinity to\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      l-lactate dehydrogenase (pfLDH) target.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Results of the current study support the traditional use of the plant for the treatment of malaria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-020-03552-7","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T18:02:25Z","timestamp":1609524145000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["In vivo anti-malarial activity of the hydroalcoholic extract of rhizomes of Kniphofia foliosa and its constituents"],"prefix":"10.1186","volume":"20","author":[{"given":"Yonatan","family":"Alebachew","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Bisrat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon","family":"Tadesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1212-8688","authenticated-orcid":false,"given":"Kaleab","family":"Asres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,1]]},"reference":[{"key":"3552_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/j.cell.2016.07.055","volume":"167","author":"AF Cowman","year":"2016","unstructured":"Cowman AF, Healer J, Marapana D, Marsh K. 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