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The effect of seasonal malaria chemoprevention (SMC) with SP and AQ on gametocyte carriage was assessed in asymptomatic\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      infected children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study was carried out in eastern Gambia. Asymptomatic\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      malaria infected children aged 24\u201359\u00a0months old who were eligible to receive SMC (SMC group) and children 5\u20138\u00a0years that were not eligible to receive SMC (comparison group) were recruited. Gametocytaemia was determined by molecular methods before and after SMC administration. Gametocyte carriage between the groups was compared using the chi-squared test and within-person using conditional logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 2017 and 2018 malaria transmission seasons, 65 and 75 children were recruited in the SMC and comparison groups, respectively. Before SMC administration, gametocyte prevalence was 10.7% (7\/65) in the SMC group and 13.3% (10\/75) in the comparison group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.64). At day 13 (IQR 12, 13) after SMC administration, this was 9.4% (5\/53) in children who received at least the first dose of SMC treatment and 12.7% (9\/71) for those in the comparison group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.57). Similarly, there was no difference in prevalence of gametocytes between children that adhered to all 3-day doses of SMC treatment 15.6% (5\/32) and those in the comparison group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.68). In the SMC group, within-group gametocyte carriage was similar before and after SMC administration in children that received at least the first dose of SMC treatment (OR 0.6, 95% CI 0.14\u20132.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.48) and in those that adhered to all 3-day doses of SMC treatment (OR 1.0, 95% CI 0.20\u20134.95;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20091.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this study with relative low gametocyte prevalence prior to SMC treatment, no evidence was observed that SMC treatment increased gametocyte carriage in asymptomatic\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      malaria infected children.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-021-03706-1","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T08:02:56Z","timestamp":1616745776000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gametocyte carriage after seasonal malaria chemoprevention in Plasmodium falciparum infected asymptomatic children"],"prefix":"10.1186","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8585-8935","authenticated-orcid":false,"given":"Abdullahi","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelia","family":"Prom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Bradley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou","family":"Ndiath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blessed","family":"Etoketim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamadou","family":"Bah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Van Geertruyden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Drakeley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Achan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"key":"3706_CR1","volume-title":"World malaria report 2019","author":"WHO","year":"2019","unstructured":"WHO. 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Children\u2019s parents or legal representative provided written informed consent prior to screening and study participation.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Consent for publication of study results and data which do not identify specific individuals was granted by each child\u2019s parent or legal representative when they enrolled for the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"All authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing of interests"}}],"article-number":"169"}}