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Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of the intervention was tested through a double-blind, randomized, placebo-controlled trial. The effect of SMC and the addition of AZ, on malaria transmission and on the life history traits of\n                      <jats:italic>Anopheles gambiae<\/jats:italic>\n                      mosquitoes have been investigated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The study included 438 children randomly selected from among participants in the SMC\u2009+\u2009AZ trial and 198 children from the same area who did not receive chemoprevention. For each participant in the SMC\u2009+\u2009AZ trial, blood was collected 14 to 21\u00a0days post treatment, examined for the presence of malaria sexual and asexual stages and provided as a blood meal to\n                      <jats:italic>An. gambiae<\/jats:italic>\n                      females using a direct membrane-feeding assay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The SMC treatment, with or without AZ, significantly reduced the prevalence of asexual\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      (LRT X\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u200969, P\u2009&lt;\u20090.0001) and the gametocyte prevalence (LRT X\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u200954, P\u2009&lt;\u20090.0001). In addition, the proportion of infectious feeds (LRT X\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u200961, P\u2009&lt;\u20090.0001) and the prevalence of oocysts among exposed mosquitoes (LRT\n                      <jats:italic>X<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>2<\/jats:italic>\n                      <\/jats:sup>\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u200922.8, P\u2009&lt;\u20090.001) was reduced when mosquitoes were fed on blood from treated children compared to untreated controls. The addition of AZ to SPAQ was associated with an increased proportion of infectious feeds (LRT X\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>1<\/jats:sub>\n                      \u2009=\u20095.2, P\u2009=\u20090.02), suggesting a significant effect of AZ on gametocyte infectivity. There was a slight negative effect of SPAQ and SPAQ\u2009+\u2009AZ on mosquito survival compared to mosquitoes fed with blood from control children (LRTX\n                      <jats:sup>2<\/jats:sup>\n                      <jats:sub>2<\/jats:sub>\n                      \u2009=\u2009330, P\u2009&lt;\u20090.0001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study demonstrates that SMC may contribute to a reduction in human to mosquito transmission of\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      , and the reduced mosquito longevity observed for females fed on treated blood may increase the benefit of this intervention in control of malaria. The addition of AZ to SPAQ in SMC appeared to enhance the infectivity of gametocytes providing further evidence that this combination is not an appropriate intervention.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-021-03855-3","type":"journal-article","created":{"date-parts":[[2021,7,27]],"date-time":"2021-07-27T03:03:11Z","timestamp":1627354991000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Effect of seasonal malaria chemoprevention plus azithromycin on Plasmodium falciparum transmission: gametocyte infectivity and mosquito fitness"],"prefix":"10.1186","volume":"20","author":[{"given":"Koudraogo Bienvenue","family":"Yam\u00e9ogo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakiswend\u00e9 Serge","family":"Yerbanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seydou Bienvenu","family":"Ouattara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck A.","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lef\u00e8vre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issaka","family":"Zongo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Niki\u00e8ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves Daniel","family":"Compaor\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halidou","family":"Tinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Chandramohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Greenwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien M. 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