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Several data types can be used to inform transmission network inferences, yet the sensitivity of those inferences to different data types is not routinely evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The influence of different combinations of spatial, temporal, and travel-history data on transmission network inferences for\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      malaria were evaluated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The information content of these data types may be limited for inferring person-to-person transmission networks and may lead to an overestimate of transmission. Only when outbreaks were temporally focal or travel histories were accurate was the algorithm able to accurately estimate the reproduction number under control,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>c<\/jats:italic>\n                      <\/jats:sub>\n                      . Applying this approach to data from Eswatini indicated that inferences of\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>c<\/jats:italic>\n                      <\/jats:sub>\n                      and spatiotemporal patterns therein depend upon the choice of data types and assumptions about travel-history data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These results suggest that transmission network inferences made with routine malaria surveillance data should be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-022-04072-2","type":"journal-article","created":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T14:06:53Z","timestamp":1645452413000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Inferring person-to-person networks of Plasmodium falciparum transmission: are analyses of routine surveillance data up to the task?"],"prefix":"10.1186","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5245-5187","authenticated-orcid":false,"given":"John H.","family":"Huber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle S.","family":"Hsiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomcebo","family":"Dlamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibonakaliso","family":"Vilakati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nomcebo","family":"Nhlabathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasmus","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyasatu","family":"Ntshalintshali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Greenhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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Vienna, Austria: R Foundation for Statistical Computing; 2017."}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-022-04072-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12936-022-04072-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-022-04072-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,23]],"date-time":"2022-10-23T02:05:24Z","timestamp":1666490724000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-022-04072-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["4072"],"URL":"https:\/\/doi.org\/10.1186\/s12936-022-04072-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.08.24.20180844","asserted-by":"object"}]},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,21]]},"assertion":[{"value":"17 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Ethical approval was obtained from the Eswatini Ministry of Health, the University of California, San Francisco, and the University of Notre Dame (IRB 19\u201306-5408). All analyses with performed in accordance with relevant guidelines and regulations. Written informed consent was obtained from participants or a parent or guardian for children less than 18\u00a0years of age. From September 2015 until the end of the study, written assent was additionally obtained for children aged 12\u201317\u00a0years. All data were analyzed anonymously.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Written informed consent was obtained from participants or a parent or guardian for children under 18\u00a0years of age. From September 2015 until the end of the study, written assent was additionally obtained for children aged 12\u201317\u00a0years. All data were analysed anonymously.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"58"}}