{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:57:56Z","timestamp":1790809076069,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Malaria in Cambodia has decreased by 90.8% between 2010 and 2020, driven by the commitment of the National Center for Parasitology, Entomology and Malaria (CNM) and the achievements of the roll-out of a village malaria worker programme. However, in the first seven months of 2018, CNM identified a 207% increase (11,969 to 36,778) in confirmed malaria cases compared to the same months in the previous year. To address this increase, CNM developed the \u201cIntensification Plan\u201d (IP), implemented between October 2018 and December 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The structure of the IP was summarized, including the selection of sites, the interventions implemented in the selected health facility catchment areas (HFCAs) and the monitoring and evaluation process. Data on IP interventions were collected by CNM and civil society organisations. Data on malaria cases and tests from all HFCAs in Cambodia from January 2018 to December 2020 were sourced from the Cambodia Malaria Information System (MIS) and WHO Malaria Elimination Database. Malaria data from IP HFCAs and non-IP HFCAs was analysed and compared to present the changes in malaria testing and confirmed cases before and during implementation of the IP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between October 2018 and December 2020, through the IP 16,902 forest packs and 293,090 long-lasting insecticide treated nets were distributed. In the 45 HFCAs included in the IP, 431,143 malaria tests were performed and 29,819 malaria cases were diagnosed, 5364 (18%) of which were\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      \/mixed cases. During the intervention period, over all HFCAs included in IP,\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      \/mixed cases declined from 1029 to 39, a 96.2% decrease, and from 25.4\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      \/mixed cases per HFCA to 0.9. HFCAs not included in IP declined from 468 to 43 cases, a 90.8% decrease, showing that routine malaria activities in Cambodia were also playing an important contribution to malaria control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Over the course of IP implementation there was a substantial increase in malaria testing and both overall malaria cases and\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      \/mixed cases decreased month on month. The initiative yields lessons learned for Cambodia to reach the final stage of elimination as well as for other countries aiming to accelerate their malaria control programmes.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-022-04234-2","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:02:43Z","timestamp":1656720163000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Accelerating malaria elimination in Cambodia: an intensified approach for targeting at-risk populations"],"prefix":"10.1186","volume":"21","author":[{"given":"Siv","family":"Sovannaroth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengby","family":"Ngor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichka","family":"Khy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia C.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle K.","family":"Burbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sovann","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarath","family":"Mak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krung","family":"Siv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Manzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Olivier","family":"Guintran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Tuseo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rekol","family":"Huy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"4234_CR1","unstructured":"Ministry of Health Kingdom of Cambodia. Cambodia Malaria Elimination Action Framework (2016\u20132020). Phnom Penh, Cambodia; 2016."},{"key":"4234_CR2","unstructured":"WHO. Mekong Malaria Elimination Epidemiology Summary: Vol. 8, October\u2013December 2019; Vol. 12. Geneva, World Health Organization, 2020."},{"key":"4234_CR3","unstructured":"Ministry of Health Health Kingdom of Cambodia Cambodia Malaria Elimination Action Framework (2021\u20132025). Phnom Penh, Cambodia; 2021."},{"key":"4234_CR4","unstructured":"Ministry of Health Kingdom of Cambodia. The National Strategic Plan for Elimination of Malaria in the Kingdom of Cambodia 2011\u20132025. Phnom Penh, Cambodia; 2011."},{"key":"4234_CR5","volume-title":"World Malaria Report 2020","author":"WHO","year":"2021","unstructured":"WHO. World Malaria Report 2020. Geneva: World Health Organization; 2021."},{"key":"4234_CR6","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1186\/1475-2875-13-385","volume":"13","author":"RJ Maude","year":"2014","unstructured":"Maude RJ, Nguon C, Ly P, Bunkea T, Ngor P, Canavati de la Torre SE, et al. Spatial and temporal epidemiology of clinical malaria in Cambodia 2004\u20132013. Malar J. 2014;13:385.","journal-title":"Malar J"},{"key":"4234_CR7","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1186\/s12936-015-0773-5","volume":"14","author":"P Guyant","year":"2015","unstructured":"Guyant P, Canavati SE, Chea N, Ly P, Whittaker MA, Roca-Feltrer A, et al. Malaria and the mobile and migrant population in Cambodia: a population movement framework to inform strategies for malaria control and elimination. Malar J. 2015;14:252.","journal-title":"Malar J"},{"key":"4234_CR8","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/s12936-020-03482-4","volume":"19","author":"M Sandfort","year":"2020","unstructured":"Sandfort M, Vantaux A, Kim S, Obadia T, Pepey A, Gardais S, et al. Forest malaria in Cambodia: the occupational and spatial clustering of Plasmodium vivax and Plasmodium falciparum infection risk in a cross-sectional survey in Mondulkiri province, Cambodia. Malar J. 2020;19:413.","journal-title":"Malar J"},{"key":"4234_CR9","unstructured":"National Center for Parasitology, Entomology and Malaria. Cambodia Malaria Survey\u20142013. Phnom Penh, Cambodia; 2013."},{"key":"4234_CR10","unstructured":"National Center for Parasitology, Entomology and Malaria. Mobile, Migrant and other Underserved Populations in the context of Malaria Elimination Operational Guidelines. Phnom Penh, Cambodia; 2017."},{"key":"4234_CR11","unstructured":"National Center for Parasitology, Entomology and Malaria. Cambodia Malaria Information System [Internet]. Phnom Penh, Cambodia; 2021. http:\/\/mis.cnm.gov.kh\/"},{"key":"4234_CR12","unstructured":"World Health Organization. WHO Mekong Malaria Elimination Database [Internet]. http:\/\/medb-gms.org\/mme"},{"key":"4234_CR13","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1186\/s12936-021-03622-4","volume":"20","author":"A-S Stratil","year":"2021","unstructured":"Stratil A-S, Vernaeve L, Lopes S, Bourny Y, Mannion K, Hamade P, et al. Eliminating Plasmodium falciparum malaria: results from tailoring active case detection approaches to remote populations in forested border areas in north-eastern Cambodia. Malar J. 2021;20:108.","journal-title":"Malar J"},{"key":"4234_CR14","unstructured":"National Center for Parasitology, Entomology and Malaria. National treatment guidelines for malaria in the Kingdom of Cambodia. Phnom Penh, Cambodia; 2014."},{"key":"4234_CR15","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1136\/bmj.326.7382.219","volume":"326","author":"DG Altman","year":"2003","unstructured":"Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ. 2003;326:219.","journal-title":"BMJ"},{"key":"4234_CR16","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1186\/s12936-019-3000-y","volume":"18","author":"R Thomson","year":"2019","unstructured":"Thomson R, Sochea P, Sarath M, MacDonald A, Pratt A, Poyer S, et al. Rubber plantations and drug resistant malaria: a cross-sectional survey in Cambodia. Malar J. 2019;18:379.","journal-title":"Malar J"},{"key":"4234_CR17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.actatropica.2007.01.007","volume":"106","author":"L Dysoley","year":"2008","unstructured":"Dysoley L, Kaneko A, Eto H, Mita T, Socheat D, B\u00f6rkman A, et al. Changing patterns of forest malaria among the mobile adult male population in Chumkiri District, Cambodia. Acta Trop. 2008;106:207\u201312.","journal-title":"Acta Trop"},{"key":"4234_CR18","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s12936-020-03572-3","volume":"20","author":"A Kunkel","year":"2021","unstructured":"Kunkel A, Nguon C, Iv S, Chhim S, Peov D, Kong P, et al. Choosing interventions to eliminate forest malaria: preliminary results of two operational research studies inside Cambodian forests. Malar J. 2021;20:51.","journal-title":"Malar J"},{"key":"4234_CR19","unstructured":"National Center for Parasitology, Entomology and Malaria. Ensuring continuation of essential malaria services during COVID-19 pandemic in Cambodia. Phnom Penh, Cambodia; 2020."},{"key":"4234_CR20","unstructured":"WHO. The \u2018last mile\u2019 of malaria elimination in Cambodia [Internet]. 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