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This study describes differences in IgG responses against antigens derived from the sporozoite (PfCSP), asexual stage parasite (PfEBA175) and the gametocyte (Pfs230), in addition to an <jats:italic>Anopheles gambiae<\/jats:italic> salivary gland antigen (gSG6-P1), in two communities in Ghana with similar blood stage malaria parasite prevalence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This study used archived plasma samples collected from an earlier cross-sectional study that enrolled volunteers aged from 6\u00a0months to 70\u00a0years from Simiw, peri-urban community (N\u2009=\u2009347) and Obom, rural community (N\u2009=\u2009291). An archived thick and thin blood smear for microscopy was used for the estimation of <jats:italic>Plasmodium<\/jats:italic> parasite density and species and DNA extraction from blood spots and <jats:italic>P. falciparum<\/jats:italic> confirmation was performed using PCR. This study used the stored plasma samples to determine IgG antibody levels to <jats:italic>P. falciparum<\/jats:italic> and <jats:italic>Anopheles<\/jats:italic> salivary antigens using indirect ELISA.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Individuals from Simiw had significantly higher levels of IgG against mosquito gSG6-P1 [median (95%CI)] [2.590 (2.452\u20132.783) ng\/mL] compared to those from Obom [2.119 (1.957\u20132.345) ng\/mL], p\u2009&lt;\u20090.0001. Both IgG responses against Pfs230proC (p\u2009=\u20090.0006), and PfCSP (p\u2009=\u20090.002) were significantly lower in volunteers from Simiw compared to the participants from Obom. The seroprevalence of PfEBA-175.5R (p\u2009=\u20090.8613), gSG6-P1 (p\u2009=\u20090.0704), PfCSP (p\u2009=\u20090.7798) IgG were all similar in Obom and Simiw. However, Pfs230 seroprevalence was significantly higher at Obom compared to Simiw (p\u2009=\u20090.0006). Spearman correlation analysis showed no significant association between IgG responses against gSG6-P1, PfCSP, Pfs230proC and PfEBA-175.5R and parasite density at both Obom and Simiw (p\u2009&gt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In conclusion, the study showed that participants from Simiw had higher concentrations of circulating gSG6-P1 IgG antibodies but lower concentrations of <jats:italic>P. falciparum<\/jats:italic> antibodies, PfCSP IgG and Pfs230proC IgG compared to participants from Obom.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12936-023-04557-8","type":"journal-article","created":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T16:02:04Z","timestamp":1681574524000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mosquito bites and stage-specific antibody responses against Plasmodium falciparum in southern Ghana"],"prefix":"10.1186","volume":"22","author":[{"given":"Sebastian Shine","family":"Kwapong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame Kumi","family":"Asare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwadwo Asamoah","family":"Kusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faustina","family":"Pappoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicaise","family":"Ndam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachida","family":"Tahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Poinsignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Eva","family":"Amoah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,15]]},"reference":[{"key":"4557_CR1","doi-asserted-by":"publisher","first-page":"1295381","DOI":"10.1155\/2020\/1295381","volume":"2020","author":"D Nureye","year":"2020","unstructured":"Nureye D, Assefa S. 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