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Here, it was investigated the association of INDEL variants in apoptotic genes\u2014rs10562972 (<jats:italic>FAS<\/jats:italic>), rs4197 (<jats:italic>FADD<\/jats:italic>), rs3834129 and rs59308963 (<jats:italic>CASP8<\/jats:italic>), rs61079693 (<jats:italic>CASP9<\/jats:italic>), rs4647655 (<jats:italic>CASP3<\/jats:italic>), rs11269260 (<jats:italic>BCL-2<\/jats:italic>), and rs17880560 (<jats:italic>TP53<\/jats:italic>)\u2014and the influence of genetic ancestry with susceptibility to malaria and parasite density in an admixed population from the Brazilian Amazon.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Total DNA was extracted from 126 malaria patients and 101 uninfected individuals for investigation of genetic ancestries and genotypic distribution of apoptosis-related variants by Multiplex PCR. Association analyses consisted of multivariate logistic regressions, considering the following comparisons: (i) DEL\/DEL genotype vs. INS\/DEL\u2009+\u2009INS\/INS; and (ii) INS\/INS vs. INS\/DEL\u2009+\u2009DEL\/DEL.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Individuals infected by <jats:italic>Plasmodium falciparum<\/jats:italic> had significantly higher African ancestry proportions in comparison to uninfected controls, <jats:italic>Plasmodium vivax,<\/jats:italic> and mixed infections. The INS\/INS genotype of rs3834129 (<jats:italic>CASP8<\/jats:italic>) seemed to increase the risk for <jats:italic>P. falciparum<\/jats:italic> infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.038; OR\u2009=\u20091.867; 95% CI 0.736\u20133.725), while the DEL\/DEL genotype presented a significant protective effect against infection by <jats:italic>P. falciparum<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.049; OR\u2009=\u20090.446; 95% CI 0.185\u20130.944) and mixed infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.026; OR\u2009=\u20090.545; 95% CI 0.281\u20130.996), and was associated with lower parasite density in <jats:italic>P. falciparum<\/jats:italic> malaria (<jats:italic>P<\/jats:italic>\u2009=\u20090.009; OR\u2009=\u20090.383; 95% CI 0.113\u20131.295). Additionally, the INS\/INS genotype of rs10562972 (<jats:italic>FAS<\/jats:italic>) was more frequent among individuals infected with <jats:italic>P. vivax<\/jats:italic> compared to <jats:italic>P. falciparum<\/jats:italic> (<jats:italic>P<\/jats:italic>\u2009=\u20090.036; OR\u2009=\u20092.493; 95% CI 1.104\u20134.551), and the DEL\/DEL genotype of rs17880560 (<jats:italic>TP53<\/jats:italic>) was significantly more present in patients with mono-infection by <jats:italic>P. vivax<\/jats:italic> than in individuals with mixed infection (<jats:italic>P<\/jats:italic>\u2009=\u20090.029; OR\u2009=\u20090.667; 95% CI 0.211\u20131.669).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>In conclusion, variants in apoptosis genes are associated with malaria susceptibility and parasite density, indicating the role of apoptosis-related genetic profiles in immune responses against malaria infection.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12936-023-04729-6","type":"journal-article","created":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T12:01:54Z","timestamp":1696420914000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association of apoptosis-related variants to malaria infection and parasite density in individuals from the Brazilian Amazon"],"prefix":"10.1186","volume":"22","author":[{"given":"Camille","family":"Sena-dos-Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna C.","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio S.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene Raiol","family":"de Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayara Nat\u00e1lia","family":"Santana-da-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella S.","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyla Patr\u00edcia T.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria R.","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marinete M.","family":"P\u00f3voa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maristela G.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ndrea","family":"Ribeiro-dos-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,10,4]]},"reference":[{"key":"4729_CR1","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1172\/JCI33996","volume":"118","author":"BM Greenwood","year":"2008","unstructured":"Greenwood BM, Fidock DA, Kyle DE, Kappe SHI, Alonso PL, Collins FH, et al. 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