{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:37:42Z","timestamp":1787020662231,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T00:00:00Z","timestamp":1714348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"European Union and the African Union, which is coordination of the African Academy of Sciences.","award":["ARISE-PP-13"],"award-info":[{"award-number":["ARISE-PP-13"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Introduction: Malaria continues to be the leading cause of hospitalization and death in Angola, a country in sub-\nSaharan Africa. In 2023, in the first quarter, 2,744,682 cases were registered, and of these 2,673 patients died\ndue to malaria disease. Previous studies have shown that the ABO blood group can affect the progression of\nmalaria to severe conditions after\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      infection, while the sickle cell gene offers relative protection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>We investigated changes in the blood count according to blood groups (ABO\/Rh) and sickle cell\ntrait in patients with malaria in Luanda, capital of Angola.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology<\/jats:title>\n                    <jats:p>This was a longitudinal, prospective\nand observational study with 198 patients hospitalized for malaria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 198 patients studied,\n13(6.6%) were ABRh(+), 4(2.0%) were ARh(-), 49(24.7%) were ARh(+), 42(21, 2%) were BRh (+), 5(2.5%)\nwere ORh(-) and 85(42.9%) were ORh(+). For sickle cell trait, 145(73.2%) were AA, 37(18.7%) were AS and\n16(8.1%) were SS. No statistical relationship was observed between age group, sex, parasitemia, clinical\npicture, hematocrit, MCV, HCM, MCHC, leukocytes, NEUT, LINF and PTL values with blood groups\n(p&lt;0.05), but there was a relationship between values of hemoglobin and ABO\/Rh blood groups (p&gt;0.05).\nThere was no relationship between age, parasitemia, clinical condition, MCV, HCM and MCHC values,\nleukocytes, NEUT and LINF with sickle cell trait (p&lt;0.05), but there was a relationship between sex,\nhemoglobin and PTL and sickle cell values. sickle cell trait (p&gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>It is imperative to\ndifferentiate patients with malaria based on blood groups and sickle cell trait, taking into account mainly the\nblood count parameters that demonstrate that there are patients who, depending on blood group or sickle cell\ntrait, may react weakly to malaria infection regardless of the degree of parasitemia and medical prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-024-04886-2","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:02:57Z","timestamp":1714392177000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Blood count changes in malaria patients according to blood groups (ABO\/Rh) and sickle cell trait"],"prefix":"10.1186","volume":"23","author":[{"given":"Euclides N. M.","family":"Sacomboio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santo D.","family":"Zua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelino T.","family":"Tchivango","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio D.","family":"Pululu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adilson C. D.","family":"Caumba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina B. M.","family":"Paci\u00eancia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilson V.","family":"Sati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina G.","family":"Agostinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda S.","family":"Agostinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando G.","family":"Mazanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neusa B.","family":"Ntambo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cruz S.","family":"Sebasti\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana P.","family":"Paix\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Morais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"4886_CR1","unstructured":"Ministry of Health. Angola reports more cases of malaria in 2022, but mortality decreases by 10 percent. Lusa-Verangola, 2023. Accessed 08\/21\/2023. Available at: https:\/\/www.verangola.net\/va\/pt\/042023\/Saude\/35323\/Angola-notifica-mais-casos-de-mal%C3%A1ria-em-2022-mas-mortalidade-diminui-10-percent.htm."},{"key":"4886_CR2","unstructured":"Jornal de Angola. Angola prepares entry of the vaccine to reduce deaths from malaria. 2023. Accessed 08\/21\/2023. Available at: https:\/\/www.jornaldeangola.ao\/ao\/noticias\/angola-prepara-entrada-da-vacina-para-reduzir-mortes-por-malaria\/."},{"key":"4886_CR3","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/1475-2875-10-271","volume":"10","author":"A Driss","year":"2011","unstructured":"Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, Stiles JK. Genetic polymorphisms associated with susceptibility to malaria. Malar J. 2011;10:271.","journal-title":"Malar J"},{"key":"4886_CR4","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/nrmicro.2017.47","volume":"15","author":"M Wahlgren","year":"2017","unstructured":"Wahlgren M, Goel S, Akhouri RR. Plasmodium falciparum variant surface antigens and their roles in severe malaria. Nat Rev Microbiol. 2017;15:479\u201391.","journal-title":"Nat Rev Microbiol"},{"key":"4886_CR5","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.blre.2018.07.002","volume":"33","author":"A Degarege","year":"2018","unstructured":"Degarege A, Gebrezgi MT, Ibaneza G, Wahlgren M, Madhivanan P. Effect of ABO blood group on susceptibility to severe malaria: a systematic review and meta-analysis. Blood Rev. 2018;33:53\u201362.","journal-title":"Blood Rev"},{"key":"4886_CR6","doi-asserted-by":"crossref","unstructured":"Cserti-Gazdewich CM, Mayr WR, Dzik WH. Plasmodium falciparum malaria and immunogenetics of ABO, HLA and CD36 (platelet glycoprotein IV) Vox Sang. 2011;100:99\u2013111.","DOI":"10.1111\/j.1423-0410.2010.01429.x"},{"key":"4886_CR7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0145120","volume":"10","author":"K Moll","year":"2015","unstructured":"Moll K, Palmkvist M, Ch\u2019ng J, Kiwuwa MS, Wahlgren M. Plasmodium falciparum immunity evasion: blood group a rosettes impair PfEMP1 recognition. PLoS ONE. 2015;10: e0145120.","journal-title":"PLoS ONE"},{"key":"4886_CR8","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1038\/nm.3812","volume":"21","author":"S Goel","year":"2015","unstructured":"Goel S, Palmkvist M, Moll K, Joannin N, Lara P, Akhouri RR, et al. RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Nat Med. 2015;21:314\u20137.","journal-title":"Nat Med"},{"key":"4886_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0046188","volume":"7","author":"C Roucher","year":"2012","unstructured":"Roucher C, Rogier C, Dieye-Ba F, Sokhna C, Tall A, Trape JF. Changing malaria epidemiology and diagnostic criteria for Plasmodium falciparum clinical malaria. PLoS ONE. 2012;7: e46188.","journal-title":"PLoS ONE"},{"key":"4886_CR10","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2012.065","volume":"4","author":"L Luzzatto","year":"2012","unstructured":"Luzzatto L. Sickle cell anaemia and malaria. Mediterr J Hematol Infect Dis. 2012;4: e2012065.","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"4886_CR11","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1186\/s12879-021-06025-7","volume":"21","author":"P Kosiyo","year":"2021","unstructured":"Kosiyo P, Otieno W, Gitaka J, Munde EO, Ouma C. Haematological abnormalities in children with sickle cell disease and non-severe malaria infection in western Kenya. BMC Infect Dis. 2021;21:329.","journal-title":"BMC Infect Dis"},{"key":"4886_CR12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1111\/bjh.15011","volume":"180","author":"A Wonkam","year":"2018","unstructured":"Wonkam A, Mnika K, Ngo Bitoungui VJ, ChetchaChemegni B, Chimusa ER, Dandara C, et al. Clinical and genetic factors are associated with pain and hospitalisation rates in sickle cell anaemia in Cameroon. Br J Haematol. 2018;180:134\u201346.","journal-title":"Br J Haematol"},{"key":"4886_CR13","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.1498","volume":"6","author":"SS Cruz","year":"2023","unstructured":"Cruz SS, Sacomboio E, Francisco NM, Cassinela EK, Mateus A, David Z, et al. Blood pressure pattern among blood donors exposed to SARS-CoV-2 in Luanda, Angola: a retrospective study. Health Sci Rep. 2023;6: e1498.","journal-title":"Health Sci Rep"},{"key":"4886_CR14","first-page":"675","volume":"13","author":"ENM Sacomboio","year":"2022","unstructured":"Sacomboio ENM, Agostinho EMF, Tchivango AT, Cassinela EK, Rocha Silveira SD, da Costa M, et al. Sociodemographic clinical and blood group (ABO\/Rh) profile of Angolan individuals with HIV. J Clin Cell Immunol. 2022;13:675.","journal-title":"J Clin Cell Immunol"},{"key":"4886_CR15","doi-asserted-by":"crossref","unstructured":"Sacomboio ENM, Muhongo TO, Tchivango AT, Cassinela EK, Silveira SDR, Da Costa M, et al. Blood groups (ABO\/Rh) and sociodemographic and clinical profile among patients with leprosy in Angola. Preprints. 2022:2022090299.","DOI":"10.20944\/preprints202209.0299.v1"},{"key":"4886_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.34297\/AJBSR.2021.13.001821","volume":"13","author":"ENM Sacomboio","year":"2021","unstructured":"Sacomboio ENM. ABO\/Rh blood groups and chronic diseases in Angolan patients. Am J Biomed Sci Res. 2021;13:1.","journal-title":"Am J Biomed Sci Res"},{"key":"4886_CR17","first-page":"1","volume":"4","author":"ENM Sacomboio","year":"2021","unstructured":"Sacomboio ENM, Sassoke JL, Hungulo OFS, Ekundi-Valentim E, Cassinela EK, et al. Frequency of ABO\/Rh blood groups and social condition of hypertensive patients in Luanda. J Blood Disord Med. 2021;4:1\u20135.","journal-title":"J Blood Disord Med"},{"key":"4886_CR18","first-page":"605","volume":"7","author":"E Sacomboio","year":"2020","unstructured":"Sacomboio E, Sebasti\u00e3o D, Sacomboio F. Sickle cell trait and blood groups (ABO and Rh) in Angolans submitted to hemoglobin electrophoresis. Hematol Oncol Curr Res. 2020;7:605\u201316.","journal-title":"Hematol Oncol Curr Res"},{"key":"4886_CR19","unstructured":"Sacomboio ENM, Neto CR, Hungulo OFS, Valentim EE. Blood group (ABO\/Rh) and Clinical Conditions Common in Children with Nephrotic Syndrome and Sickle Cell Anemia in Angola. J Blood Disord Med. 2021;4."},{"key":"4886_CR20","doi-asserted-by":"publisher","first-page":"986","DOI":"10.21474\/IJAR01\/11360","volume":"8","author":"SS Zua","year":"2020","unstructured":"Zua SS, Filho-Sacomboio FC, Ekundi-Valentim E, Sacomboio ENM. Social and clinical factors affecting the uremic condition of Angolan patients with malaria. Int J Adv Res. 2020;8:986\u201398.","journal-title":"Int J Adv Res"},{"key":"4886_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2019.e00232","volume":"7","author":"ENM Sacomboio","year":"2020","unstructured":"Sacomboio ENM, Sebasti\u00e3o CS, Tchivango AT, Pecoits-Filho R, Calice-Silva V. Does parasitemia level increase the risk of acute kidney injury in patients with malaria? Results from an observational study in Angola. Scientific African. 2020;7: e00232.","journal-title":"Scientific African"},{"key":"4886_CR22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0267671","volume":"17","author":"ENM Sacomboio","year":"2022","unstructured":"Sacomboio ENM, dos Santos Sebasti\u00e3o C, Salvador STDC, Jo\u00e3o JA, Bapolo DVS, Francisco NM, et al. Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: an observational study. PLoS One. 2022;17: e0267671.","journal-title":"PLoS One."},{"issue":"2","key":"4886_CR23","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.actatropica.2012.03.013","volume":"123","author":"OK Amodu","year":"2012","unstructured":"Amodu OK, Olaniyan SA, Adeyemo AA, Troye-Blomberg M, Olumese PE, Omotade OO. Association of the sickle cell trait and the ABO blood group with clinical severity of malaria in southwest Nigeria. Acta Trop. 2012;123(2):72\u20137.","journal-title":"Acta Trop"},{"key":"4886_CR24","first-page":"73","volume":"6","author":"RE Akhigbe","year":"2011","unstructured":"Akhigbe RE, Ige SF, Adegunlola GJ, Adewumi MO, Azeez MO. Malaria, haemoglobin genotypes and abo blood groups in Ogbomoso, Nigeria. Int J Trop Med. 2011;6:73\u20136.","journal-title":"Int J Trop Med"},{"key":"4886_CR25","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/s40795-023-00709-w","volume":"9","author":"SK Tchum","year":"2023","unstructured":"Tchum SK, Sakyi SA, Arthur F, Adu B, Abubakar LA, Oppong FB, et al. Effect of iron fortification on anaemia and risk of malaria among Ghanaian pre-school children with haemoglobinopathies and different ABO blood groups. BMC Nutr. 2023;9:56.","journal-title":"BMC Nutr"},{"key":"4886_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2147\/PLMI.S61046","volume":"6","author":"FI Buseri","year":"2014","unstructured":"Buseri FI, Okonkwo C. Abnormal hemoglobin genotypes and ABO and rhesus blood groups associated with HIV infection among HIV-exposed infants in North Western Nigeria. Pathol Lab Med Int. 2014;6:15\u201320.","journal-title":"Pathol Lab Med Int"},{"key":"4886_CR27","first-page":"34","volume":"2","author":"FP Udomah","year":"2015","unstructured":"Udomah FP, Isaac IZ, Aliyu N, Erhabor O, Ahmed MH, Abdullahi N, et al. Haemoglobin electrophoretic patterns, ABO and Rhesus D blood groups distribution among antenatal women in Sokoto. Nigeria Obstet Gynecol Cases Rev. 2015;2:34.","journal-title":"Nigeria Obstet Gynecol Cases Rev"},{"key":"4886_CR28","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12879-019-4757-x","volume":"20","author":"NLE Eleonore","year":"2020","unstructured":"Eleonore NLE, Cumber S, Charlotte EE, Lucas EE, Edgar MML, Nkfusai CN, et al. Malaria in patients with sickle cell anaemia: burden, risk factors and outcome at the Laquintinie hospital. Cameroon BMC Infect Dis. 2020;20:40.","journal-title":"Cameroon BMC Infect Dis"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-024-04886-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12936-024-04886-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-024-04886-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T12:05:08Z","timestamp":1714392308000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-024-04886-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,29]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["4886"],"URL":"https:\/\/doi.org\/10.1186\/s12936-024-04886-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3327665\/v1","asserted-by":"object"}]},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,29]]},"assertion":[{"value":"5 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"126"}}