{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:34:01Z","timestamp":1787020441369,"version":"build-2736575974"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T00:00:00Z","timestamp":1714003200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universidad Cooperativa de Colombia Convocatoria de mediana cuant\u00eda"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Pregnancy Associated Malaria (PAM) include malaria in pregnancy (MiP), placental malaria (PM), and congenital malaria (CM). The evidence available in Colombia on PAM focuses on one of the presentations (MiP, PM or CM), and no study longitudinally analyses the infection from the pregnant woman, passing through the placenta, until culminating in the newborn. This study determined the frequency of MiP, PM, and CM caused by\n Plasmodium vivax, Plasmodium falciparum,<\/jats:italic>\n or mixed infections, according to Thick Blood Smear (TBS) and quantitative Polymerase Chain Reaction (qPCR). Identifying associated factors of PAM and clinical-epidemiological outcomes in northwestern Colombia.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Prospective study of 431\u00a0pregnant women, their placenta, and newborns registered in the data bank of the research Group \u201cSalud y Comunidad C\u00e9sar Uribe Piedrah\u00edta\u201d which collected information between 2014 and 2020 in endemic municipalities of the departments of C\u00f3rdoba and Antioquia. The frequency of infection was determined with 95%\u00a0confidence intervals. Comparisons were made with the Chi-square test, Student t-test, prevalence ratios, and control for confounding variables by log-binomial regression.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The frequency of MiP was 22.3% (4.6% using TBS), PM 24.8% (1.4% using TBS), and CM 11.8% (0% using TBS). Using TBS predominated\n P. vivax.<\/jats:italic>\n Using qPCR the proportions of\n P. vivax<\/jats:italic>\n and\n P. falciparum<\/jats:italic>\n were similar for MiP and PM, but\n P. falciparum<\/jats:italic>\n predominated in CM. The frequency was higher in nulliparous, and women with previous malaria. The main clinical effects of PAM were anaemia, low birth weight, and abnormal APGAR score.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The magnitude of infections was not detected with TBS because most cases were submicroscopic (TBS-negative, qPCR-positive). This confirmed the importance of improving the molecular detection of cases. PAM continue being underestimated in the country due to that in Colombia the control programme is based on TBS, despite its outcomes on maternal, and congenital health.<\/jats:p>\n <\/jats:sec>","DOI":"10.1186\/s12936-024-04948-5","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T01:01:52Z","timestamp":1714006912000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prospective study of malaria in pregnancy, placental and congenital malaria in Northwest Colombia"],"prefix":"10.1186","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7101-929X","authenticated-orcid":false,"given":"Jaiberth Antonio","family":"Cardona-Arias","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime","family":"Carmona-Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"4948_CR1","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/1475-2875-13-271","volume":"13","author":"V Moya-Alvarez","year":"2014","unstructured":"Moya-Alvarez V, Abellana R, Cot M. 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This study was classified as minimal risk and was endorsed by the Ethics Committee of the SIU (in Spanish Sede de Investigaci\u00f3n Univesitaria<\/i>), University of Antioquia, Minute 21-101-961. The participants signed the informed consent (of legal age) or assent (under 18\u00a0years of age), obtained in writing; it was also signed by a witness (external to the research group) and a member of the health team who explained its content. When it was possible, parental consent was obtained; however, according to rulings C-246\/17 and T-675-17 on the self-determination of minors, the Constitutional Court of the Republic of Colombia in 2017 defined that parental consent is not necessary in these cases given that at 14\u00a0years of age, it has been established that minors may have the maturity to begin assuming obligations and responsibilities in society such as marriage, consenting to sexual relations, and the right to privacy in the family environment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare that they have no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"116"}}