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This case presentation emphasizes cardiological assessment of Brugada syndrome, presenting as life-threatening arrhythmia during anti-malarial treatment. Without screening and untreated, this disease may lead to sudden cardiac death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      This is a case of 23-year-old male who initially presented with palpitations followed by syncope and shortness of breath with a history of malaria. He had switched treatment from quinine to dihydroartemisinin-piperaquine (DHP). Further investigations revealed the ST elevation electrocardiogram pattern typical of Brugada syndrome, confirmed with flecainide challenge test\n                      <jats:italic>.<\/jats:italic>\n                      Subsequently, anti-malarial treatment was stopped and an Implantable Cardioverter Defibrillator (ICD) was inserted.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Another possible cause of arrhythmic events happened following anti-malarial consumption. This case highlights the possibility of proarrhytmogenic mechanism of malaria infection and anti-malarial drug resulting in typical manifestations of Brugada syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-024-05099-3","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T07:15:48Z","timestamp":1726730148000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Brugada syndrome precipitated by uncomplicated malaria treated with dihydroartemisinin piperaquine: a case report"],"prefix":"10.1186","volume":"23","author":[{"given":"Muzakkir","family":"Amir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irmayanti","family":"Mukhtar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pendrik","family":"Tandean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zaki","family":"Rahmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,17]]},"reference":[{"key":"5099_CR1","doi-asserted-by":"publisher","first-page":"25","DOI":"10.14797\/mdcj-10-1-25","volume":"10","author":"R Brugada","year":"2014","unstructured":"Brugada R, Campuzano O, Sarquella-Brugada G, Brugada J, Brugada P. 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