{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:49Z","timestamp":1791353509768,"version":"4.3.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Vaccines have increasingly become some of the most effective public health tools for promoting health and reducing the burden of infectious diseases. The availability of a malaria vaccine for routine use will be a major milestone, nonetheless, trust by the public for the vaccine could pose a major challenge for its acceptance. Documented evidence such as the boycott of the oral polio vaccine in northern Nigeria and the failure of the Ebola vaccine trial in Ghana among others highlight the impact of public trust on vaccine acceptance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This is an explorative cross-sectional mixed-method study conducted in the Kassena Nankana districts. The study was conducted in the Kassena Nankana Districts between May and December 2020. A total of 390 structured questionnaires were administrated to mothers and caregivers of children under five years of age while 15 in-depth interviews were conducted with mothers and health workers. STATA software Version 16.0 was used to interpret the quantitative data, where bivariate and multivariate regression analysis was performed to determine the influence of trust on vaccine acceptance while QSR NVivo 12 software was used to code the qualitative data to aid the thematic analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The results revealed that the level of knowledge of the RTS,S vaccine among participants was high. About 95.4% of the mothers had good knowledge of the malaria vaccine and more than half 61.2% of them got information about the vaccine from the health facility. The level of trust for the malaria vaccine was equally high with 91.4% of the mothers reporting that the vaccine treats childhood malaria. In a bivariate analysis, educational status (P\u2009=\u20090.013), ethnicity (P\u2009=\u20090.008), marital status (P\u2009=\u20090.041), education on the vaccine and perceived ineffectiveness P\u2009&lt;\u20090.05, and trust for the malaria vaccine (P\u2009&lt;\u20090.05) were found to be statistically associated with vaccine acceptance. Compared with participants who agree that vaccines are harmless to children, those who disagree were significantly less likely to accept vaccines (OR\u2009=\u20090.25, 95%CI [0.08, 0.83], p\u2009=\u20090.017). The qualitative data correspondingly revealed that mothers trusted vaccines which thus accounted for the high uptake of the malaria vaccine in the districts.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The results of this study suggest that trust in the malaria vaccine is critical for its uptake. Therefore, efforts towards improving acceptance of the vaccine should be focused on building and sustaining trust for the vaccine among mothers and community members.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12936-024-05180-x","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T11:59:16Z","timestamp":1732881556000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Influence of trust on the acceptance of the RTS,S malaria vaccine in the Kassena-Nankana districts of Ghana"],"prefix":"10.1186","volume":"23","author":[{"given":"Eustace","family":"Bugase","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulina","family":"Tindana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"5180_CR1","doi-asserted-by":"crossref","unstructured":"Das JK, Salam RA, Arshad A, Lassi ZS, Bhutta ZA. Systematic review and meta-analysis of interventions to improve access\nand coverage of adolescent immunizations. J Adolesc Health. 2016;59(4S)S48.","DOI":"10.1016\/j.jadohealth.2016.07.005"},{"key":"5180_CR2","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1089\/vim.2017.0135","volume":"31","author":"A Kachikis","year":"2018","unstructured":"Kachikis A, Eckert LO, Englund J. Who is the target: mother or baby? Viral Immunol. 2018;31:184\u201394.","journal-title":"Viral Immunol"},{"key":"5180_CR3","unstructured":"Pearce A, Law C, Elliman D, Cole TJ, Bedford H, Millennium Cohort Study Child Health Group."},{"key":"5180_CR4","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1136\/bmj.39489.590671.25","volume":"336","author":"Factors associated with uptake of measles","year":"2008","unstructured":"Factors associated with uptake of measles. mumps, and rubella vaccine (MMR) and use of single antigen vaccines in a contemporary UK cohort: prospective cohort study. 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Report 2012: Estimates developed by the UN Inter- agency Group for Child Mortality Estimation. New York: United Nations Children\u2019s Fund, 2012"},{"key":"5180_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040073","volume":"4","author":"AS Jegede","year":"2007","unstructured":"Jegede AS. What led to the Nigerian boycott of the polio vaccination campaign? PLoS Med. 2007;4: e73.","journal-title":"PLoS Med"},{"key":"5180_CR10","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/473446a","volume":"473","author":"HJ Larson","year":"2011","unstructured":"Larson HJ, Ghinai I. Lessons from polio eradication. Nature. 2011;473:446\u20137.","journal-title":"Nature"},{"key":"5180_CR11","unstructured":"WHO. World Malaria Report. Geneva, World Health Organization, 2015, http:\/\/www.who.int.News.bulletin, 2019 http:\/\/myjoyonline.com"},{"key":"5180_CR12","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1093\/ije\/dys111","volume":"41","author":"AR Oduro","year":"2012","unstructured":"Oduro AR, Wak G, Azongo D, Debpuur C, Wontuo P, Kondayire F, et al. Profile of the Navrongo health and demographic surveillance system. Int J Epidemiol. 2012;41:968\u201376.","journal-title":"Int J Epidemiol"},{"key":"5180_CR13","unstructured":"Kassena Nankana Municipal Assembly. Annual Health Report of the Municipal 2015."},{"key":"5180_CR14","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1475-2875-12-63","volume":"12","author":"S Kasasa","year":"2013","unstructured":"Kasasa S, Asoala V, Gosoniu L, Anto F, Adjuik M, Tindana C, et al. Spatio-temporal malaria transmission patterns in Navrongo demographic surveillance site, northern Ghana. 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Oral informed consent was obtained before the interviews were conducted. The consent forms were translated into the preferred local language of the participants. All participants were informed before the start of the interview about project goals, how long the interview would last, their right to refuse being interviewed, the right to withdraw in the process of the interview and about the intended use of the results for scientific publications and also disseminate the findings to stakeholders. To ensure confidentiality, identification numbers were assigned to participants in the qualitative interviews instead of their names.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"365"}}