{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:25:20Z","timestamp":1789421120215,"version":"build-2803163510"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T00:00:00Z","timestamp":1734480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["INV-023065"],"award-info":[{"award-number":["INV-023065"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Malaria remains a significant public health concern, despite global efforts to combat the disease with highest burden in Africa. Reports of emerging artemisinin partial- resistance in East Africa emphasize the importance of molecular data to guide policy decisions. Hence the need for researchers to collaborate with National control programmes to conduct genomics surveillance of malaria to inform malaria control and elimination policies. This study explored genomic researchers\u2019 views on engaging with national control programmes to aid malaria elimination efforts in Africa.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This research employed an exploratory qualitative approach to investigate the views and experiences of malaria genomics researchers across 16 member countries of the Pathogen Genomic Diversity Network Africa (PDNA). In-depth interviews were conducted with each PDNA Principal Investigator, which were recorded, and transcribed verbatim. Subsequently, the data were analysed thematically with NVivo 12 qualitative data analysis software.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The study revealed that majority of malaria genomics researchers focused on understanding the genetic composition and adaptation of the malaria parasite, its vector, and human host. Their investigations delved into areas such as drug and insecticide resistance, parasite evolution, host interactions, human host susceptibility to malaria, diversity of vaccine candidates, and molecular surveillance of malaria. Challenges included limited funding, lack of interest and capacity among National Malaria Control Programmes (NMCP) to use research evidence effectively, and difficulties in communicating data implications to policymakers due to the absence of WHO-certified use cases. Despite these obstacles, researchers expressed a keen interest in forming partnerships with NMCPs to integrate genetic data into malaria control efforts in Africa. They also stressed the importance of enhancing researchers' ability to communicate findings to policymakers and local communities through policy briefs and innovative communication strategies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The study underscores the need to strengthen partnerships between genomic researchers and NMCPs to support malaria elimination in Africa. Furthermore, researchers should create practical frameworks for easy integration into WHO reporting formats to facilitate the use of molecular and genomic data in malaria control programme decision-making.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1186\/s12936-024-05205-5","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T18:16:04Z","timestamp":1734545764000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Researchers\u2019 perspectives on the integration of molecular and genomic data into malaria elimination programmes in Africa: a qualitative study"],"prefix":"10.1186","volume":"23","author":[{"given":"Paulina","family":"Tindana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Enos","family":"Sekwo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Baatiema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye","family":"Djimde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Pathogen Genomics Diversity Network, Africa (PDNA)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,12,18]]},"reference":[{"key":"5205_CR1","volume-title":"Compendium of WHO malaria guidance: prevention, diagnosis, treatment, surveillance and elimination","author":"WHO","year":"2019","unstructured":"WHO. Compendium of WHO malaria guidance: prevention, diagnosis, treatment, surveillance and elimination. Geneva: World Health Organization; 2019."},{"key":"5205_CR2","volume-title":"World malaria report 2023","author":"WHO","year":"2023","unstructured":"WHO. World malaria report 2023. Geneva: World Health Organization; 2023."},{"key":"5205_CR3","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1186\/s12936-020-03414-2","volume":"19","author":"J Wagman","year":"2020","unstructured":"Wagman J, Ciss\u00e9 I, Kone D, Fomba S, Eckert E, Mihigo J, et al. Rapid reduction of malaria transmission following the introduction of indoor residual spraying in previously unsprayed districts: an observational analysis of Mopti Region, Mali, in 2017. Malar J. 2020;19:340.","journal-title":"Malar J"},{"key":"5205_CR4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0275370","volume":"17","author":"TO Apinjoh","year":"2022","unstructured":"Apinjoh TO, Ntui VN, Chi HF, Moyeh MN, Toussi CT, Mayaba JM, et al. Intermittent preventive treatment with Sulphadoxine-Pyrimethamine (IPTp-SP) is associated with protection against sub-microscopic P. falciparum infection in pregnant women during the low transmission dry season in southwestern Cameroon: a semi-longitudinal study. PLoS ONE. 2022;17: e0275370.","journal-title":"PLoS ONE"},{"key":"5205_CR5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216486","volume":"14","author":"S Chatio","year":"2019","unstructured":"Chatio S, Ansah NA, Awuni DA, Oduro A, Ansah PO. Community acceptability of Seasonal Malaria Chemoprevention of morbidity and mortality in young children: a qualitative study in the Upper West Region of Ghana. PLoS ONE. 2019;14: e0216486.","journal-title":"PLoS ONE"},{"key":"5205_CR6","doi-asserted-by":"publisher","first-page":"943445","DOI":"10.3389\/fgene.2022.943445","volume":"13","author":"A Coulibaly","year":"2022","unstructured":"Coulibaly A, Diop MF, Kone A, Dara A, Ouattara A, Mulder N, et al. Genome-wide SNP analysis of Plasmodium falciparum shows differentiation at drug-resistance-associated loci among malaria transmission settings in southern Mali. Front Genet. 2022;13:943445.","journal-title":"Front Genet"},{"key":"5205_CR7","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12936-017-1872-2","volume":"16","author":"C Salom\u00e3o","year":"2017","unstructured":"Salom\u00e3o C, Sacarlal J, Gudo ES. Assessment of coverage of preventive treatment and insecticide-treated mosquito nets in pregnant women attending antenatal care services in 11 districts in Mozambique in 2011: the critical role of supply chain. Malar J. 2017;16:223.","journal-title":"Malar J"},{"key":"5205_CR8","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S1473-3099(10)70295-4","volume":"11","author":"AM van Eijk","year":"2011","unstructured":"van Eijk AM, Hill J, Alegana VA, Kirui V, Gething PW, ter Kuile FO, et al. Coverage of malaria protection in pregnant women in sub-Saharan Africa: a synthesis and analysis of national survey data. Lancet Infect Dis. 2011;11:190\u2013207.","journal-title":"Lancet Infect Dis"},{"key":"5205_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1002380","volume":"14","author":"J Hemingway","year":"2016","unstructured":"Hemingway J, Shretta R, Wells TNC, Bell D, Djimd\u00e9 AA, Achee N, et al. Tools and strategies for malaria control and elimination: what do we need to achieve a grand convergence in malaria? PLoS Biol. 2016;14: e1002380.","journal-title":"PLoS Biol"},{"key":"5205_CR10","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1473-3099(07)70026-9","volume":"7","author":"J Crawley","year":"2007","unstructured":"Crawley J, Hill J, Yartey J, Robalo M, Serufilira A, Ba-Nguz A, et al. From evidence to action? Challenges to policy change and programme delivery for malaria in pregnancy. Lancet Infect Dis. 2007;7:145\u201355.","journal-title":"Lancet Infect Dis"},{"key":"5205_CR11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgph.0000210","volume":"2","author":"H Mwenesi","year":"2022","unstructured":"Mwenesi H, Mbogo C, Casamitjana N, Castro MC, Itoe MA, Okonofua F, et al. Rethinking human resources and capacity building needs for malaria control and elimination in Africa. PLoS Glob Pub Health. 2022;2: e0000210.","journal-title":"PLoS Glob Pub Health"},{"key":"5205_CR12","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62997","volume":"10","author":"CG Jacob","year":"2021","unstructured":"Jacob CG, Thuy-Nhien N, Mayxay M, Maude RJ, Quang HH, Hongvanthong B, et al. Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination. Elife. 2021;10: e62997.","journal-title":"Elife"},{"key":"5205_CR13","unstructured":"Lumivero.\u00a0NVivo\u00a0(Version 12). 2023. www.lumivero.com. Accessed 19 July 2023."},{"key":"5205_CR14","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1186\/s12936-016-1547-4","volume":"15","author":"CA Mwendera","year":"2016","unstructured":"Mwendera CA, de Jager C, Longwe H, Phiri K, Hongoro C, Mutero CM. Facilitating factors and barriers to malaria research utilization for policy development in Malawi. Malar J. 2016;15:512.","journal-title":"Malar J"},{"key":"5205_CR15","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12936-015-0802-4","volume":"14","author":"P Guyant","year":"2015","unstructured":"Guyant P, Corbel V, Gu\u00e9rin PJ, Lautissier A, Nosten F, Boyer S, et al. Past and new challenges for malaria control and elimination: the role of operational research for innovation in designing interventions. Malar J. 2015;14:279.","journal-title":"Malar J"},{"key":"5205_CR16","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s12961-019-0518-y","volume":"18","author":"U Ezenwaka","year":"2020","unstructured":"Ezenwaka U, Mbachu C, Etiaba E, Uzochukwu B, Onwujekwe O. Integrating evidence from research into decision-making for controlling endemic tropical diseases in South East Nigeria: perceptions of producers and users of evidence on barriers and solutions. Health Res Policy Syst. 2020;18:4.","journal-title":"Health Res Policy Syst"},{"key":"5205_CR17","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1057\/s41599-022-01070-2","volume":"9","author":"FU Damba","year":"2022","unstructured":"Damba FU, Mtshali NG, Chimbari MJ. Barriers and facilitators of translating health research findings into policy in sub-Saharan Africa: a scoping review. Humanit Soc Sci Commun. 2022;9:65.","journal-title":"Humanit Soc Sci Commun"},{"key":"5205_CR18","doi-asserted-by":"publisher","first-page":"735990","DOI":"10.3389\/fitd.2021.735990","volume":"2","author":"U Ezenwaka","year":"2021","unstructured":"Ezenwaka U, Onwujekwe O. Getting evidence from health policy and systems research into policy and practice for controlling endemic tropical diseases in Nigeria: assessing knowledge, capacity, and use. Front Trop Dis. 2021;2:735990.","journal-title":"Front Trop Dis"},{"key":"5205_CR19","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12936-020-03330-5","volume":"19","author":"R Noviyanti","year":"2020","unstructured":"Noviyanti R, Miotto O, Barry A, Marfurt J, Siegel S, Thuy-Nhien N, et al. Implementing parasite genotyping into national surveillance frameworks: feedback from control programmes and researchers in the Asia-Pacific region. Malar J. 2020;19:271.","journal-title":"Malar J"},{"key":"5205_CR20","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/1475-2875-12-274","volume":"12","author":"AK Mbonye","year":"2013","unstructured":"Mbonye AK, Magnussen P. Translating health research evidence into policy and practice in Uganda. Malar J. 2013;12:274.","journal-title":"Malar J"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-024-05205-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12936-024-05205-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-024-05205-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T19:12:38Z","timestamp":1734549158000},"score":1,"resource":{"primary":{"URL":"https:\/\/malariajournal.biomedcentral.com\/articles\/10.1186\/s12936-024-05205-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,18]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12]]}},"alternative-id":["5205"],"URL":"https:\/\/doi.org\/10.1186\/s12936-024-05205-5","relation":{},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,18]]},"assertion":[{"value":"10 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 December 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ghana Health Service Ethics Review Committee. All participants signed an informed consent form either in-person or online prior to the interview.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval and consent to participate"}},{"value":"This manuscript does not contain any individual personal data. All direct quotes from participants have been anonymized to protect their identity.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"385"}}