{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:32:34Z","timestamp":1777984354754,"version":"3.51.4"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":35,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Malar J"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>An expanded portfolio of more effective WHO-prequalified insecticides for indoor residual sparing (IRS) is needed to provide additional options to disease control programmes and enhance their capacity to efficiently apply IRS rotations for managing vector resistance to insecticides. We investigated the efficacy and residual activity of Sovrenta\u00ae 15WP, a wettable powder formulation of the newly discovered isoxazoline insecticide isocycloseram, (active ingredient trademarked as PLINAZOLIN\u00ae technology) for IRS in laboratory bioassays and experimental hut studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Sovrenta\u00ae 15WP, was evaluated under laboratory conditions for 12\u00a0months at the dose of 120\u00a0mg a.i.\/m\n                      <jats:sup>2<\/jats:sup>\n                      on cement, mud and wood block substrates against insecticide-susceptible\n                      <jats:italic>Anopheles gambiae<\/jats:italic>\n                      sensu stricto Kisumu and pyrethroid-resistant\n                      <jats:italic>An. gambiae<\/jats:italic>\n                      sensu lato (s.l.) Cov\u00e8 strains. An experimental hut trial was also performed to investigate its efficacy and residual activity on cement and mud-plastered walls at the target dose of 120\u00a0mg a.i.\/m\n                      <jats:sup>2<\/jats:sup>\n                      over 12\u00a0months against wild free-flying pyrethroid-resistant\n                      <jats:italic>An. gambiae<\/jats:italic>\n                      sl at the Cov\u00e8 experimental hut station in Benin. Mosquito mortality was recorded every 24\u00a0h for up to 168\u00a0h post-exposure. Sovrenta\u00ae 15 WP was compared to Actellic\u00ae 300CS, a WHO\/PQ-listed pirimiphos-methyl IRS insecticide applied at 1000\u00a0mg a.i.\/m\n                      <jats:sup>2<\/jats:sup>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In laboratory cone bioassays, Sovrenta\u00ae 15WP induced\u2009&gt;\u200980% mortality of susceptible and pyrethroid-resistant\n                      <jats:italic>An. gambiae<\/jats:italic>\n                      sl for 11\u201312\u00a0months on cement, mud and wood block substrates. A total of 12,850 wild pyrethroid-resistant\n                      <jats:italic>An. gambiae<\/jats:italic>\n                      s.l. were collected in the experimental hut trial. Sovrenta\u00ae 15WP induced significantly higher mosquito mortality in the experimental huts over 12\u00a0months compared to Actellic\u00ae 300CS (68\u201372% vs 44\u201346%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The insecticide also demonstrated a delayed mortality effect against wild vector mosquitoes that increased gradually from 25 to 42% at 24\u00a0h to 68\u201372% at 168\u00a0h post-exposure. Vector mortality did not differ substantially between the different substrate types. The odds ratio describing the difference in overall mortality between Actellic\u00ae 300CS and Sovrenta\u00ae 15WP was 3.38 (95% CI: 2.90\u20133.94) in cement-walled huts, 2.49 (95% CI: 2.10\u20132.95) in mud-walled huts and 1.80 (95% CI:1.53\u20132.11) when data for both hut wall substrate types was combined. Using recent WHO guidelines for determining non-inferiority, Sovrenta\u00ae 15WP was non-inferior and superior to Actellic\u00ae 300CS for the primary end-point of mosquito mortality over the 12-month experimental hut trial. Mortality in in situ hut wall cone bioassays was\u2009&gt;\u200980% for 12\u00a0months with Sovrenta\u00ae 15WP and 9\u00a0months with Actellic\u00ae 300CS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sovrenta\u00ae 15WP provided extended control of pyrethroid-resistant malaria vectors when applied for IRS on local wall substrates. The insecticide presents a new effective IRS option for achieving improved malaria control and managing insecticide resistance through the rotation of IRS insecticides.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-026-05810-6","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:04:25Z","timestamp":1772172265000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Control of pyrethroid-resistant Anopheles gambiae s.l. with Sovrenta\u00ae 15WP, a new isoxazoline insecticide for indoor residual spraying"],"prefix":"10.1186","volume":"25","author":[{"given":"Renaud","family":"Govoetchan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abel","family":"Agbevo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juniace","family":"Ahoga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hospice","family":"Avanon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Syme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"N\u2019dombidge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Ariori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Todjinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurette","family":"Kiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corine","family":"Ngufor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"5810_CR1","unstructured":"WHO. 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Parasit Vectors. 2019;12(1):612.","journal-title":"Parasit Vectors"}],"container-title":["Malaria Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1186\/s12936-026-05810-6","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-026-05810-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/s12936-026-05810-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:51:23Z","timestamp":1775220683000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1186\/s12936-026-05810-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,27]]},"references-count":38,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["5810"],"URL":"https:\/\/doi.org\/10.1186\/s12936-026-05810-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-7490220\/v1","asserted-by":"object"}]},"ISSN":["1475-2875"],"issn-type":[{"value":"1475-2875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,27]]},"assertion":[{"value":"29 August 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the Ethics Review Committee of the Benin Ministry of Health (Ethical decision n\u00b021CNERS\/Dos-021 of 20 March 2023). Human volunteer sleepers who slept in the huts to attract mosquitoes gave informed consent before they participated in the study. The trial details and consent forms were explained to them in their local language by an interpreter. A stand-by nurse was available to sleepers throughout the study to assess any cases of fever and persistent headache. Any sleeper testing positive for malaria was immediately withdrawn from the study and treated effectively in line with local public health practices.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"150"}}