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The cluster randomized implementation of RTS,S by the Kenya Ministry of Health during the Malaria Vaccine Implementation Programme (MVIP) provided a unique opportunity to measure the impact of RTS,S on uncomplicated malaria cases reported through routine malaria case surveillance data in western Kenya.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From 23 implementing and 23 comparison subcounties in western Kenya, monthly numbers of confirmed uncomplicated malaria cases among individuals under 5 years of age (&lt;\u20095y) and 5 years of age and older (\u2265\u20095y) were extracted from the Kenya Health Management Information System, stored in a DHIS2 instance. Facilities that reported data\u2009\u2265\u200911 months per year from January 2015 through December 2022 (132 implementing, 139 comparison) were included in the analysis. Prevaccination data (January 2015\u2013December 2019) were used to predict counterfactual case counts during the evaluation period (January 2020\u2013December 2022), beginning when the first children vaccinated under MVIP became age-eligible for the third dose. Models of\u2009&lt;\u20095y malaria cases included a covariate for\u2009\u2265\u20095y malaria cases to control for non-RTS,S malaria control measures. The impact was estimated as the difference between predicted and observed cases across implementing and comparison areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The proportion of vaccine eligible children (RTS,S doses at 6, 7, 9, and 24 months) among all children\u2009&lt;\u20095y was small at the start of MVIP but was estimated to reach 60% by December 2022. During the 3-year evaluation period following dose-3 age-eligibility,\u2009&lt;\u20095y malaria cases were 2.3% lower than predicted in non-implementing facilities and 13.8% lower in implementing facilities, a reduction of 11.6%. The reduction was 5.6% during the first year of follow-up, increasing to 8.2% after two years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This analysis revealed that routine health data, although age-aggregated to both vaccine eligible and noneligible children\u2009&lt;\u20095 years, demonstrated a reduction in malaria cases throughout the evaluation period. A further reduction in cases was observed as more vaccine-eligible children comprised the under 5 population. High quality routine data can be used to monitor vaccine impact on clinical malaria.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/s12936-026-05973-2","type":"journal-article","created":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T08:06:14Z","timestamp":1781510774000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Malaria Vaccine Implementation Programme reduced clinical malaria in Kenya, 2020 to 2022"],"prefix":"10.1186","volume":"25","author":[{"given":"John A.","family":"Painter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Wallender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew N.","family":"Hill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Hamel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafiq","family":"Okine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane","family":"Furrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose","family":"Jalang\u2019o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibor K.","family":"Keitany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Kariuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Nyang\u2019au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Seda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron M.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Westercamp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,6,15]]},"reference":[{"key":"5973_CR1","doi-asserted-by":"crossref","unstructured":"RTS,S Clinical Trials Partnership, Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, et al. 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